Accepting PhD Students

PhD projects

Cancer Immunology Autoimmunity (Diabetes, arthritis, psoriasis, MS) Antigen processing and presentation Vaccine design Bioinformatics

1989 …2022

Research output per year

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Research Output

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Article
Article

The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Borg, N. A., Ely, L. K., Beddoe, T. C., Macdonald, W. A., Reid, H. H., Clements, C. S., Purcell, A. W., Kjer-Nielsen, L., Miles, J. J., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 2, p. 171 - 180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

The cellular redox environment alters antigen presentation

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. TT., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W., 2014, In : The Journal of Biological Chemistry. 289, 40, p. 27979 - 27991 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The central role played by peptides in the immune response and the design of peptide-based vaccines against infectious diseases and cancer

Jackson, D. C., Purcell, A. W., Fitzmaurice, C. J., Zeng, W. & Hart, D. N. J., 1 Jan 2002, In : Current Drug Targets. 3, 2, p. 175-196 22 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

The enantioselective total synthesis and unambiguous proof of the absolute stereochemistry of pervilleine C

Kulkarni, K. P., Zhao, A. Y., Purcell, A. W. & Perlmutter, P., 2008, In : Synlett. 2008, 14, p. 2209 - 2212 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule

Liu, Y. C., Chen, Z., Burrows, S. R., Purcell, A. W., McCluskey, J., Rossjohn, J. & Gras, S., 2012, In : The Journal of Biological Chemistry. 287, 15, p. 12267 - 12276 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 Diabetes

Purcell, A. W., Sechi, S. & DiLorenzo, T. P., 1 May 2019, In : Diabetes. 68, 5, p. 879-886 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Tynan, F. E., Elhassen, D., Purcell, A. W., Burrows, J. M., Borg, N. A., Miles, J. J., Williamson, N. A., Green, K. J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1249 - 1260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

Mannering, S. I., Harrison, L. C., Williamson, N. A., Morris, J. S., Thearle, D. J., Jensen, K. P., Kay, T. W., Rossjohn, J., Falk, B. A., Nepom, G. T. & Purcell, A. W., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1191 - 1197 7 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis

Ting, Y. T., Petersen, J., Ramarathinam, S. H., Scally, S. W., Loh, K. L., Thomas, R., Suri, A., Baker, D. G., Purcell, A. W., Reid, H. H. & Rossjohn, J., 2 Mar 2018, In : The Journal of Biological Chemistry. 293, 9, p. 3236-3251 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C∗06: 02 molecule

Mobbs, J. I., Illing, P. T., Dudek, N. L., Brooks, A. G., Baker, D. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., 20 Oct 2017, In : The Journal of Biological Chemistry. 292, 42, p. 17203-17215 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)

Winkel, K., Carroll, T., Williamson, N. A., Ignjatovic, V., Fung, K., Purcell, A. W. & Fry, B. G., 15 Dec 2007, In : Toxicon. 50, 8, p. 1041-1052 12 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype

PHIIDO Study Group, 17 Oct 2016, In : Vaccine. 34, 44, p. 5251-5261 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The production, purification and crystallization of a soluble heterdimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., Macdonald, W. A., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131 - 2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., MacDonald, W. A., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Dec 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131-2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The production and purification of the human T-cell receptors, the CD3and CD3heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425 - 1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 1 Aug 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425-1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The protein import channel in the outer mitosomal membrane of Giardia intestinalis

Dagley, M. J., Dolezal, P., Likic, V. A., Smid, O., Purcell, A. W., Buchanan, S. K., Tachezy, J. & Lithgow, T. J., 2009, In : Molecular Biology and Evolution. 26, 9, p. 1941 - 1947 7 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The shaping of T cell receptor recognition by self-tolerance

Gras, S., Burrows, S. R., Kjer-Nielsen, L., Clements, C. S., Liu, Y. C., Sullivan, L. C., Bell, M. J., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 2, p. 193 - 203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Pang, S. S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M. A., King, G. F., Wang, C. C., Chew, S. H., La Gruta, N. L., Williams, N. K., Beddoe, T. C., Tiganis, T., Cowieson, N. P., Godfrey, D. I., Purcell, A. W., Wilce, M. CJ., McCluskey, J. & Rossjohn, J., 2010, In : Nature. 467, 7317, p. 844 - 848 7 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance

Webb, A. I., Borg, N. A., Dunstone, M. A., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Carbone, F. R., Bottomley, S. P., Aguilar, M. I., Purcell, A. W. & Rossjohn, J., 2004, In : Journal of Immunology. 173, 1, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

The structure of HLA-B8 complexed to an immunodominant viral determinant: Peptide-induced conformational changes and a mode of MHC class I dimerization

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Journal of Immunology. 169, 9, p. 5153-5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and a mode of MHC class 1 dimerisation1

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 2002, In : Journal of Immunology. 169, 9, p. 5153 - 5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The SysteMHC Atlas project

Shao, W., Pedrioli, P. G. A., Wolski, W., Scurtescu, C., Schmid, E., Vizcaíno, J. A., Courcelles, M., Schuster, H., Kowalewski, D., Marino, F., Arlehamn, C. S. L., Vaughan, K., Peters, B., Sette, A., Ottenhoff, T. H. M., Meijgaarden, K. E., Nieuwenhuizen, N., Kaufmann, S. H. E., Schlapbach, R., Castle, J. C. & 26 others, Nesvizhskii, A. I., Nielsen, M., Deutsch, E. W., Campbell, D. S., Moritz, R. L., Zubarev, R. A., Ytterberg, A. J., Purcell, A. W., Marcilla, M., Paradela, A., Wang, Q., Costello, C. E., Ternette, N., Van Veelen, P. A., Van Els, C. A. C. M., Heck, A. J. R., De Souza, G. A., Sollid, L. M., Admon, A., Stevanovic, S., Rammensee, H. G., Thibault, P., Perreault, C., Bassani-Sternberg, M., Aebersold, R. & Caron, E., 1 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1237-D1247 11 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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39 Citations (Scopus)

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi-Hemami, H., Teilum, K. & Ellgaard, L., 1 Jan 2019, In : The Journal of Biological Chemistry. 294, 22, p. 8745-8759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

The use of CRISPR/Cas9 gene editing to confirm congenic contaminations in host-pathogen interaction studies

Ferrand, J., Croft, N. P., Pépin, G., Diener, K. R., Wu, D., Mangan, N. E., Pedersen, J., Behlke, M. A., Hayball, J. D., Purcell, A. W., Ferrero, R. L. & Gantier, M. P., 19 Mar 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 10 p., 87.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones

Mitchell, M. L., Hamilton, B. R., Madio, B., Morales, R. A. V., Tonkin-Hill, G. Q., Papenfuss, A. T., Purcell, A. W., King, G. F., Undheim, E. A. B. & Norton, R. S., 2017, In : Australian Journal of Chemistry. 70, 11, p. 1235-1237 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Tracking protein aggregation and mislocalization in cells with flow cytometry

Ramdzan, Y. M., Polling, S., Chia, C. P. Z., Ng, I. H. W., Ormsby, A. R., Croft, N. P., Purcell, A. W., Bogoyevitch, M. A., Ng, D. CH., Gleeson, P. A. & Hatters, D. M., 2012, In : Nature Methods. 9, 5, p. 467 - 470 4 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Tumors reveal their secrets to cytotoxic T cells

Williamson, N. A., Rossjohn, J. & Purcell, A. W., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14649 - 14650 2 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods

Li, F., Wang, Y., Li, C., Marquez-Lago, T. T., Leier, A., Rawlings, N. D., Haffari, G., Revote, J., Akutsu, T., Chou, K-C., Purcell, A. W., Pike, R. N., Webb, G. I., Smith, A. I., Lithgow, T., Daly, R. J., Whisstock, J. C. & Song, J., 27 Nov 2019, In : Briefings in Bioinformatics. 20, 6, p. 2150-2166 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Unravelling conotoxin folding and molecular diversity

Purcell, A. W. & Safavi-Hemami, H., 2012, In : Australian Biochemist. 43, 2, p. 4 - 6 3 p.

Research output: Contribution to journalArticleOther

Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

Rawlinson, S. M., Zhao, T., Rozario, A. M., Rootes, C. L., McMillan, P. J., Purcell, A. W., Woon, A., Marsh, G. A., Lieu, K. G., Wang, L-F., Netter, H. J., Bell, T. D. M., Stewart, C. R. & Moseley, G. W., 3 Aug 2018, In : Nature Communications. 9, 1, 12 p., 3057.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

β2-glycoprotein I and protection from anti-SSA/Ro60- associated cardiac manifestations of neonatal lupus

Reed, J. H., Clancy, R. M., Purcell, A. W., Kim, M. Y., Gordon, T. P. & Buyon, J. P., 1 Jul 2011, In : Journal of Immunology. 187, 1, p. 520-526 7 p.

Research output: Contribution to journalArticleOtherpeer-review

24 Citations (Scopus)