Accepting PhD Students

PhD projects

Cancer Immunology Autoimmunity (Diabetes, arthritis, psoriasis, MS) Antigen processing and presentation Vaccine design Bioinformatics

1989 …2022

Research output per year

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Research Output

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Article

Identification and synthesis of altered peptides modulating T cell recognition of a synthetic peptide antigen.

Ede, N. J., Chen, W., McCluskey, J., Jackson, D. C. & Purcell, A. W., 1 Jan 1995, In : Biomedical Peptides, Proteins & Nucleic Acids: Structure, Synthesis & Biological Activity. 1, 4, p. 231-234 4 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant form of each complex

Macdonald, W., Williams, D. S., Gorman, J. J., Kjer-Nielsen, L., Brooks, A. G., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2002, In : FEBS Letters. 527, 1-3, p. 27 - 32 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Identification of an I-Ad restricted peptide on the 65-kilodalton heat shock protein of Mycobacterium avium

Nagabhushanam, V., Purcell, A. W., Mannering, S., Germano, S., Praszkier, J. & Cheers, C., 26 Nov 2002, In : Immunology and Cell Biology. 80, 6, p. 574-583 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins

Safavi-Hemami, H., Bulaj, G., Olivera, B. M., Williamson, N. A. & Purcell, A. W., 23 Apr 2010, In : Journal of Biological Chemistry. 285, 17, p. 12735-12746 12 p.

Research output: Contribution to journalArticleOtherpeer-review

23 Citations (Scopus)

Identification of native and posttranslationally modified HLA-B*57:01- restricted HIV envelope derived epitopes using immunoproteomics

Ramarathinam, S. H., Gras, S., Alcantara, S., Yeung, A. W. S., Mifsud, N. A., Sonza, S., Illing, P., Glaros, E. N., Center, R. J., Thomas, S. R., Kent, S. J., Ternette, N., Purcell, D. F. J., Rossjohn, J. & Purcell, A. W., Jun 2018, In : Proteomics. 18, 12, 11 p., 1700253.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

Martin, A. M., Almeida, C. A., Cameron, P., Purcell, A. W., Nolan, D., James, I., McCluskey, J., Phillips, E., Landay, A. & Mallal, S., 1 Jun 2007, In : AIDS. 21, 10, p. 1233-1244 12 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Illing, P. T., Vivian, J. P., Dudek, N. L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J. J., Kjer-Nielsen, L., Gras, S., Williamson, N. A., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 486, 7404, p. 554 - 558 5 p.

Research output: Contribution to journalArticleResearchpeer-review

413 Citations (Scopus)

Immunodominance hierarchies and gender bias in direct Tcd8-cell alloreactivity

Mifsud, N. A., Purcell, A. W., Chen, W. W., Holdsworth, R., Tait, B. D. & McCluskey, J., 2008, In : American Journal of Transplantation. 8, 1, p. 121 - 132 12 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Improved peptide-MHC class II interaction prediction through integration of eluted ligand and peptide affinity data

Garde, C., Ramarathinam, S. H., Jappe, E. C., Nielsen, M., Kringelum, J. V., Trolle, T. & Purcell, A. W., 1 Jul 2019, In : Immunogenetics. 71, 7, p. 445-454 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Inability to detect cross-reactive memory T cells challenges the frequency of heterologous immunity among common viruses

Rowntree, L. C., Nguyen, T. H. O., Halim, H., Purcell, A. W., Rossjohn, J., Gras, S., Kotsimbos, T. C. & Mifsud, N. A., 15 Jun 2018, In : Journal of Immunology. 200, 12, p. 3993-4003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

In-depth mining of the immunopeptidome of an acute myeloid leukemia cell line using complementary ligand enrichment and data acquisition strategies

Pandey, K., Mifsud, N. A., Lim Kam Sian, T. C. C., Ayala, R., Ternette, N., Ramarathinam, S. H. & Purcell, A. W., Jul 2020, In : Molecular Immunology. 123, p. 7-17 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Induction of amphipathic helical peptide structures in RP-HPLC.

Purcell, A. W., Aguilar, M. I., Wettenhall, R. E. & Hearn, M. T., 1 Jan 1995, In : Peptide Research. 8, 3, p. 160-170 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Ingestion of oats and barley in patients with celiac disease mobilizes cross-reactive T cells activated by avenin peptides and immuno-dominant hordein peptides

Hardy, M. Y., Tye-Din, J. A., Stewart, J. A., Schmitz, F., Dudek, N. L., Hanchapola, I., Purcell, A. W. & Anderson, R. P., 2015, In : Journal of Autoimmunity. 56, p. 56 - 65 10 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

In Immunopeptidomics We Need a Sniper Instead of a Shotgun

Faridi, P., Purcell, A. W. & Croft, N. P., 1 Jun 2018, In : Proteomics. 18, 12, 4 p., 1700464.

Research output: Contribution to journalArticleOtherpeer-review

21 Citations (Scopus)

Isolation and characterization of naturally processed MHC-bound peptides from the surface of antigen-presenting cells.

Purcell, A. W., 1 Jan 2004, In : Methods in molecular biology (Clifton, N.J.). 251, p. 291-306 16 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Tubb, V. M., Schrikkema, D. S., Croft, N. P., Purcell, A. W., Linnemann, C., Freriks, M. R., Chen, F., Long, H. M., Lee, S. P. & Bendle, G. M., 13 Jul 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 14 p., 70.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Kinetics of antigen expression and epitope presentation during virus infection

Croft, N. P., Smith, S. A., Wong, Y. C., Tan, C. T., Dudek, N. L., Flesch, I. E. A., Lin, L. C. W., Tscharke, D. C. & Purcell, A. W., 2013, In : PLoS Pathogens. 9, 1 (Art. ID: :e1003129), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
85 Citations (Scopus)

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J. & Doherty, P. C., 2005, In : Nature Immunology. 6, 4, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

122 Citations (Scopus)

Linear ubiquitination prevents inflammation and regulates immune signalling

Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W. L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J. & Walczak, H., 31 Mar 2011, In : Nature. 471, 7340, p. 591-596 6 p.

Research output: Contribution to journalArticleOtherpeer-review

510 Citations (Scopus)

Mass spectral identification of Vc1.1 and differential distribution of conopeptides in the venom duct of conus victoriae. effect of post-translational modifications and disulfide isomerisation on bioactivity

Townsend, A., Livett, B. G., Bingham, J. P., Truong, H. T., Karas, J. A., O'Donnell, P., Williamson, N. A., Purcell, A. W. & Scanlon, D., Sep 2009, In : International Journal of Peptide Research and Therapeutics. 15, 3, p. 195-203 9 p.

Research output: Contribution to journalArticleOtherpeer-review

14 Citations (Scopus)

Mass spectrometry–based identification of MHC-bound peptides for immunopeptidomics

Purcell, A. W., Ramarathinam, S. H. & Ternette, N., Jun 2019, In : Nature Protocols. 14, 6, p. 1687-1707 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Membrane proteomics by high performance liquid chromatography-tandem mass spectrometry: Analytical approaches and challenges

Vuckovic, D., Dagley, L. F., Purcell, A. W. & Emili, A., 2013, In : Proteomics. 13, 3-4, p. 404 - 423 20 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Pymm, P., Illing, P. T., Ramarathinam, S. H., O'Connor, G. M., Hughes, V. A., Hitchen, C., Price, D. A., Ho, B. K., McVicar, D. W., Brooks, A. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., Apr 2017, In : Nature Structural & Molecular Biology. 24, 4, p. 387-394 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE)

Lill, J. R., Van Veelen, P. A., Tenzer, S., Admon, A., Caron, E., Elias, J. E., Heck, A. J. R., Marcilla, M., Marino, F., Müller, M., Peters, B., Purcell, A., Sette, A., Sturm, T., Ternette, N. & Vizcaino, J. A., 1 Jun 2018, In : Proteomics. 18, 12, 7 p., 1800110.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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8 Citations (Scopus)

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma

Woods, K., Knights, A. J., Anaka, M., Schittenhelm, R. B., Purcell, A. W., Behren, A. & Cebon, J., 16 Feb 2016, In : Journal for ImmunoTherapy of Cancer. 4, 14 p., 10.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

Faridi, A., Sun, Y., Okazaki, Y., Peng, G., Gao, J., Kakinen, A., Faridi, P., Zhao, M., Javed, I., Purcell, A. W., Davis, T. P., Lin, S., Oda, R., Ding, F. & Ke, P. C., 22 Nov 2018, In : Small. 14, 47, 13 p., 1802825.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., O’Neill, P. M., Purcell, A. W., Park, K. B. & Naisbitt, D. J., Mar 2020, In : Allergy. 75, 3, p. 636-647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails

Safavi-Hemami, H., Gorasia, D. G., Steiner, A. M., Williamson, N. A., Karas, J., Gajewiak, J., Olivera, B. M., Bulaj, G. & Purcell, A. W., 2012, In : Journal of Biological Chemistry. 287, 41, p. 34288 - 34303 16 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice

Kinoshita, G., Purcell, A. W., Keech, C. L., Farris, A. D., McCluskey, J. & Gordon, T. P., 1 Jan 1999, In : Clinical and Experimental Immunology. 115, 2, p. 268-274 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)

Molecular markers of preterm labor in the choriodecidua

Shankar, R., Johnson, M. P., Williamson, N. A., Cullinane, F., Purcell, A. W., Moses, E. K. & Brennecke, S. P., Mar 2010, In : Reproductive Sciences. 17, 3, p. 297-310 14 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

More than one reason to rethink the use of peptides in vaccine design

Purcell, A. W., McCluskey, J. & Rossjohn, J., 2007, In : Nature Reviews Drug Discovery. 6, 5, p. 404 - 414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

429 Citations (Scopus)

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

MR1 presents microbial vitamin B metabolites to MAIT cells

Kjer-Nielsen, L., Patel, O. G., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N. A., Purcell, A. W., Dudek, N. L., McConville, M. J., O'Hair, R. AJ., Khairallah, G. N., Godfrey, D. I., Fairlie, D. P., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 491, 7426, p. 717 - 723 7 p.

Research output: Contribution to journalArticleResearchpeer-review

575 Citations (Scopus)

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Zernich, D., Purcell, A. W., Macdonald, W. A., Kjer-Nielsen, L., Ely, L. K., Laham, N., Crockford, T., Mifsud, N. A., Bharadwaj, M., Chang, L., Tait, B. D., Holdsworth, R., Brooks, A. G., Bottomley, S. P., Beddoe, T. C., Peh, C. A., Rossjohn, J. & McCluskey, J., 2004, In : Journal of Experimental Medicine. 200, 1, p. 13 - 24 12 p.

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Archbold, J. K., Macdonald, W. A., Gras, S., Ely, L. K., Miles, J. J., Bell, M. J., Brennan, R. M., Beddoe, T. C., Wilce, M. C. J., Clements, C. S., Purcell, A. W., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2009, In : Journal of Experimental Medicine. 206, 1, p. 209 - 219 11 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Nonprecipitating anti-La(SS-B) autoantibodies in primary Sjogren's syndrome

Beer, R. G., Rischmueller, M., Coates, T., Purcell, A. W., Keech, C. L., McCluskey, J. & Gordon, T. P., 1 Jan 1996, In : Clinical Immunology and Immunopathology. 79, 3, p. 314-318 5 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

Chang, L., Kjer-Nielsen, L., Flynn, S., Brooks, A. G., Mannering, S. I., Honeyman, M. C., Harrison, L. C., McCluskey, J. & Purcell, A. W., 1 Nov 2003, In : Tissue Antigens. 62, 5, p. 408-417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Optimisation of peptide-based cytotoxic T-cell determinants using non-natural amino acids

Webb, A. I., Aguilar, M-I. & Purcell, A. W., 2003, In : Letters in Peptide Science. 10, 5, p. 561 - 569 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Optimization of the MHC class I peptide cargo is dependent on tapasin

Williams, A. P., Peh, C. A., Purcell, A. W., McCluskey, J. & Elliott, T., 1 Jan 2002, In : Immunity. 16, 4, p. 509-520 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
257 Citations (Scopus)

Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes

Gorasia, D. G., Dudek, N. L., Veith, P. D., Shankar, R., Safavi-Hemami, H., Williamson, N. A., Reynolds, E. C., Hubbard, M. J. & Purcell, A. W., 2015, In : Journal of Proteome Research. 14, 2, p. 688 - 699 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Peptidomimetics: modifying peptides in the pursuit of better vaccines

Croft, N. P. & Purcell, A. W., 2011, In : Expert Review of Vaccines. 10, 2, p. 211 - 226 16 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Phosphorylated self-peptides alter human leukocyte antigen class l-restricted antigen presentation and generate tumor-specific epitopes

Petersen, J., Wurzbacher, S. J., Williamson, N. A., Ramarathinam, S. H., Reid, H. H., Nair, A. K. N., Zhao, A. Y., Nastovska, R., Rudge, G., Rossjohn, J. & Purcell, A. W., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2776 - 2781 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Physical and toxicological profiles of human IAPP amyloids and plaques

Kakinen, A., Sun, Y., Javed, I., Faridi, A., Pilkington, E. H., Faridi, P., Purcell, A. W., Zhou, R., Ding, F., Lin, S., Ke, P. C. & Davis, T. P., 15 Jan 2019, In : Science Bulletin. 64, 1, p. 26-35 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Positive-unlabelled learning of glycosylation sites in the human proteome

Li, F., Zhang, Y., Purcell, A. W., Webb, G. I., Chou, K-C., Lithgow, T., Li, C. & Song, J., 6 Mar 2019, In : BMC Bioinformatics. 20, 1, 17 p., 112.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

Post translationally modified peptides: New targets in autoimmune disease

Lau, K. & Purcell, A. W., 2 Aug 2007, In : Chimica Oggi. 25, p. 6-9 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Post-translationally modified T cell epitopes: Immune recognition and immunotherapy

Petersen, J., Purcell, A. W. & Rossjohn, J., 2009, In : Journal of Molecular Medicine. 87, 11, p. 1045 - 1051 7 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Martin, A. M., Nolan, D., Gaudieri, S., Almeida, C. A., Nolan, R., James, I., Carvalho, F., Phillips, E., Christiansen, F. T., Purcell, A. W., McCluskey, J. & Mallal, S., 23 Mar 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4180-4185 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
389 Citations (Scopus)

Preemptive priming readily overcomes structure-based mechanisms of virus escape

Valkenburg, S. A., Gras, S., Guillonneau, C., Hatten, L. A., Bird, N. L., Twist, K-A., Abd Halim, N. H., Jackson, D. C., Purcell, A. W., Turner, S. J., Doherty, P. C., Rossjohn, J. & Kedzierska, K., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5570 - 5575 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

Rowntree, L. C., van den Heuvel, H., Sun, J., D'Orsogna, L. J., Nguyen, T. H. O., Claas, F. H. J., Rossjohn, J., Kotsimbos, T. C., Purcell, A. W. & Mifsud, N. A., 19 Feb 2020, In : Frontiers in Immunology. 11, 13 p., 248.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : PLoS Pathogens. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)