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?-Amino acid-containing hybrid peptides - New opportunities in peptidomimetics

Aguilar, M. I., Purcell, A. W., Devi, R., Lew, R. A., Rossjohn, J., Smith, A. I. & Perlmutter, P., 2007, In : Organic and Biomolecular Chemistry. 5, 18, p. 2884 - 2890 7 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation

Petersen, J. L., Hickman-Miller, H. D., McIlhaney, M. M., Vargas, S. E., Purcell, A. W., Hildebrand, W. H. & Solheim, J. C., 15 Jan 2005, In : Journal of Immunology. 174, 2, p. 962-969 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
39 Citations (Scopus)

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A comprehensive analysis of constitutive naturally processed and presented HLA-C*04:01 (Cw4)-specific peptides

Schittenhelm, R. B., Dudek, N. L., Croft, N. P., Ramarathinam, S. & Purcell, A. W., 2014, In : Tissue Antigens. 83, 3, p. 174 - 179 6 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

A comprehensive analysis of peptides presented by HLA-A1

Giam, K. L., Ayala-Perez, R., Illing, P. T. T., Schittenhelm, R. B., Croft, N. P., Purcell, A. W. & Dudek, N. L., 2015, In : Tissue Antigens. 85, 6, p. 492 - 496 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Lim Kam Sian, T. C. C., Indumathy, S., Halim, H., Greule, A., Cryle, M. J., Bowness, P., Rossjohn, J., Gras, S., Purcell, A. W. & Schittenhelm, R. B., 27 Dec 2019, In : Journal of Biological Chemistry. 294, 52, p. 20185-20195 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Allelic polymorphism in the T cell receptor and its impact on immune responses

Gras, S., Chen, Z., Miles, J. J., Liu, Y. C., Bell, M. J., Sullivan, L. C., Kjer-Nielsen, L., Brennan, R. M., Burrows, J. M., Neller, M. A., Khanna, R., Purcell, A. W., Brooks, A. G., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2010, In : The Journal of Experimental Medicine. 207, 7, p. 1555 - 1567 13 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design

Ebert, L. M., Liu, Y. C., Clements, C. S., Robson, N. C., Jackson, H. M., Markby, J. L., Dimopoulos, N., Tan, B. S., Luescher, I. F., Davis, I. D., Rossjohn, J., Cebon, J., Purcell, A. W. & Chen, W., 2009, In : Cancer Research. 69, 3, p. 1046 - 1054 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

A modular BAM complex in the outer membrane of the alpha-proteobacterium caulobacter crescentus

Anwari, K., Poggio, S., Perry, A., Gatsos, X., Ramarathinam, S. H., Williamson, N. A., Noinaj, N., Buchanan, S., Gabriel, K., Purcell, A. W., Jacobs-Wagner, C. & Lithgow, T., 2010, In : PLoS ONE. 5, 1 (e8619), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Scally, S., Petersen, J., Law, S. C. CHENG., Dudek, N. L., Nel, H. J., Loh, K. L., Wijeyewickrema, L. C., Eckle, S. B. G., van Heemst, J., Pike, R. N., McCluskey, J., Toes, R. E., La Gruta, N. L., Purcell, A. W., Reid, H. H., Thomas, R. & Rossjohn, J., 2013, In : The Journal of Experimental Medicine. 210, 12, p. 2569 - 2582 14 p.

Research output: Contribution to journalArticleResearchpeer-review

204 Citations (Scopus)

A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism

Liu, Y. C., Chen, Z., Neller, M. A., Miles, J. J., Purcell, A. W., McCluskey, J., Burrows, S. R., Rossjohn, J. & Gras, S., 2014, In : Journal of Biological Chemistry. 289, 24, p. 16688 - 16698 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes

Leyton, D. L., Johnson, M. D., Thapa, R., Huysmans, G., Dunstan, R. A., Celik, N., Shen, H-H., Loo, D., Belousoff, M. J., Purcell, A. W., Henderson, I. R., Beddoe, T. C., Rossjohn, J., Martin, L. L., Strugnell, R. A. & Lithgow, T. J., 2014, In : Nature Communications. 5, (Art. No.: 4239), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, α-Helix to β-Sheet Transition, and Formation of β-Barrel Intermediates

Sun, Y., Kakinen, A., Xing, Y., Faridi, P., Nandakumar, A., Purcell, A. W., Davis, T. P., Ke, P. C. & Ding, F., May 2019, In : Small. 15, 18, 10 p., 1805166.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A naturally selected dimorphism within the HLA-B44 supertype alters Class I structure, peptide repertoire, and T cell recognition

Macdonald, W. A., Purcell, A. W., Mifsud, N. A., Ely, L. K., Williams, D. S., Chang, L., Gorman, J. J., Clements, C. S., Kjer-Nielsen, L., Koelle, D. M., Burrows, S. R., Tait, B. D., Holdsworth, R., Brooks, A. G., Lovrecz, G. O., Lu, L., Rossjohn, J. & McCluskey, J., 2003, In : The Journal of Experimental Medicine. 198, 5, p. 679 - 691 13 p.

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant

Nivarthi, U. K., Gras, S., Kjer-Nielsen, L., Berry, R., Lucet, I. S., Miles, J., Tracy, S. L., Purcell, A. W., Bowden, D. S., Hellard, M. E., Rossjohn, J., McCluskey, J. & Bharadwaj, M., 2014, In : Journal of Immunology. 193, 11, p. 5402 - 5413 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

An open-source computational and data resource to analyze digital maps of immunopeptidomes

Caron, E., Espona, L., Kowalewski, D. J., Schuster, H., Ternette, N., Alpizar, A., Schittenhelm, R. B., Ramarathinam, S., Arlehamn, C. S. L., Koh, C. C. G., Gillet, L. C., Rabsteyn, A., Navarro, P., Kim, S., Lam, H. H. N., Sturm, T., Marcilla, M., Sette, A., Campbell, D. S., Deutsch, E. W. & 5 others, Moritz, R. L., Purcell, A. W., Rammensee, H-G., Stevanovic, S. & Aebersold, R., 2015, In : eLife. 4, July 2015, p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
52 Citations (Scopus)

A novel strategy for the targeted analysis of protein and peptide metabolites

Williamson, N. A., Reilly, C., Tan, C. T., Ramarathinam, S. H., Jones, A., Hunter, C. L., Rooney, F. R. & Purcell, A. W., 2 Jan 2011, In : Proteomics. 11, 2, p. 183-192 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Antagonism of antiviral and allogeneic activity of a human public ctl clonotype by a single altered peptide ligand: Implications for allograft rejection

Ely, L. K., Green, K. J., Beddoe, T. C., Clements, C. S., Miles, J. J., Bottomley, S. P., Zernich, D., Kjer-Nielsen, L., Purcell, A. W., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Immunology. 174, 9, p. 5593 - 5601 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

Tran, T. B., Cheah, S-E., Yu, H. H., Bergen, P. J., Nation, R. L., Creek, D. J., Purcell, A., Forrest, A., Doi, Y., Song, J., Velkov, T. & Li, J., 1 Jun 2016, In : Journal of Antibiotics. 69, 6, p. 415-421 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Beddoe, T. C., Chen, Z., Clements, C. S., Ely, L. K., Bushell, S. R., Vivian, J. P., Kjer-Nielsen, L., Pang, S. S., Dunstone, M. A., Liu, Y. C., Macdonald, W. A., Perugini, M. A., Wilce, M. C. J., Burrows, S. R., Purcell, A. W., Tiganis, T., Bottomley, S. P., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 6, p. 777 - 788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Application of quantitative proteomics technologies to the biomarker discovery pipeline for multiple sclerosis

Dagley, L. F., Emili, A. & Purcell, A. W., 2013, In : Proteomics - Clinical Applications. 7, 1-2, p. 91 - 108 18 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A prominent role of PDIA6 in processing of misfolded proinsulin

Gorasia, D. G., Dudek, N. L., Safavi-Hemami, H., Ayala-Perez, R., Schittenhelm, R. B., Saunders, P. M., Wee, S., Mangum, J. E., Hubbard, M. J. & Purcell, A. W., 2016, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1864, 6, p. 715 - 723 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A sensitive method for detecting proliferation of rare autoantigen- specific human T cells

Mannering, S. I., Morris, J. S., Jensen, K. P., Purcell, A. W., Honeyman, M. C., Van Endert, P. M. & Harrison, L. C., 1 Jan 2003, In : Journal of Immunological Methods. 283, 1-2, p. 173-183 11 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Assembly of the secretion pores GspD, Wza and CsgG into bacterial outer membranes does not require the Omp85 proteins BamA or TamA

Dunstan, R. A., Hay, I. D., Wilksch, J. J., Schittenhelm, R. B., Purcell, A. W., Clark, J. M., Costin, A., Ramm, G., Strugnell, R. A. & Lithgow, T. J., 2015, In : Molecular Microbiology. 97, 4, p. 616 - 629 14 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS

Dunstan, R. A., Heinz, E., Wijeyewickrema, L. C., Pike, R. N., Purcell, A. W., Evans, T. J., Praszkier, J., Robins-Browne, R. M., Strugnell, R. A., Korotkov, K. V. & Lithgow, T. J., 2013, In : PLoS Pathogens. 9, 1 (Art # e1003117), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

Association of stress proteins with autoantigens: A possible mechanism for triggering autoimmunity?

Purcell, A. W., Todd, A., Kinoshita, G., Lynch, T. A., Keech, C. L., Gething, M. J. & Gordon, T. P., 1 May 2003, In : Clinical and Experimental Immunology. 132, 2, p. 193-200 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease

Henderson, K., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N., Beissbarth, T., Tatham, A., Mannering, S. I., Purcell, A. W., Dudek, N. L., van Heel, D. A., McCluskey, J., Rossjohn, J. & Anderson, R. P., 2007, In : Immunity. 27, 1, p. 23 - 34 12 p.

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)

A structural basis for the selection of dominant T cell receptors in antiviral immunity

Kjer-Nielsen, L., Clements, C. S., Purcell, A. W., Brooks, A. G., Whisstock, J. C., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2003, In : Immunity. 18, 1, p. 53 - 64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

278 Citations (Scopus)

A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule

Gras, S., Wilmann, P., Chen, Z., Abd Halim, N. H., Liu, Y. C., Kjer-Nielsen, L., Purcell, A. W., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2012, In : Journal of Immunology. 188, 1, p. 311-321 11 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Tynan, F. E., Reid, H. H., Kjer-Nielsen, L., Miles, J. J., Wilce, M. C. J., Kostenko, L., Borg, N., Williamson, N. A., Beddoe, T. C., Purcell, A. W., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2007, In : Nature Immunology. 8, 3, p. 268 - 276 9 p.

Research output: Contribution to journalArticleResearchpeer-review

160 Citations (Scopus)

Avoidance of self-reactivity results in skewed CTL responses to rare components of synthetic immunogens

Purcell, A. W., Chen, W., Ede, N. J., Gorman, J. J., Fecondo, J. V., Jackson, D. C., Zhao, Y. & McCluskey, J., 1 Feb 1998, In : Journal of Immunology. 160, 3, p. 1085-1090 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease

Broughton, S. E., Petersen, J., Theodossis, A., Scally, S. W., Loh, K. L., Thompson, A., van Bergen, J., Kooy-Winkelaar, Y., Henderson, K. N., Beddoe, T. C., Tye-Din, J. A., Mannering, S. I., Purcell, A. W., McCluskey, J., Anderson, R. P., Koning, F., Reid, H. H. & Rossjohn, J., 2012, In : Immunity. 37, 4, p. 611 - 621 11 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Can α- and β-Alanine Containing Peptides Be Distinguished Based on the CID Spectra of Their Protonated Ions?

Lam, A. K. Y., Ramarathinam, S. H., Purcell, A. W. & O'Hair, R. A. J., Dec 2008, In : Journal of the American Society for Mass Spectrometry. 19, 12, p. 1743-1754 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

CD1a on Langerhans cells controls inflammatory skin disease

Kim, J. H., Hu, Y., Yongqing, T., Kim, J., Hughes, V. A., Le Nours, J., Marquez, E. A., Purcell, A. W., Wan, Q., Sugita, M., Rossjohn, J. & Winau, F., Oct 2016, In : Nature Immunology. 17, 10, p. 1159-1166 8 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells

Fernandez, S., Tanaskovic, S., Helbig, K., Rajasuriar, R., Kramski, M., Murray, J. M., Beard, M. R., Purcell, A. W., Lewin, S. R., Price, P. & French, M., 2011, In : Journal of Infectious Diseases. 204, 12, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Characterization of the antigen processing machinery and endogenous peptide presentation of a Bat MHC class I molecule

Wynne, J. W., Woon, A. P., Dudek, N. L., Croft, N. P., Ng, J. H. J., Baker, M. L., Wang, L-F. & Purcell, A. W., 1 Jun 2016, In : Journal of Immunology. 196, 11, p. 4468-4476 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients

Benham, H., Nel, H. J., Law, S. C. C., Mehd, A. M., Street, S. E. A., Ramnoruth, N., Pahau, H., Lee, B. T., Ng, J., Brunck, M. E. G., Hyde, C., Trouw, L. A., Dudek, N. L., Purcell, A. W., O'Sullivan, B. J., Connolly, J. E., Paul, S. K., Cao, K-A. L. & Thomas, R., 2015, In : Science Translational Medicine. 7, 290, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

150 Citations (Scopus)

Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization

Safavi-Hemami, H., Hu, H., Gorasia, D. G., Bandyopadhyay, P. K., Veith, P. D., Young, N. D., Reynolds, E. C., Yandell, M., Olivera, B. M. & Purcell, A. W., 2014, In : Molecular & Cellular Proteomics. 13, 4, p. 938 - 953 16 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Comparative transcriptomics highlights the role of the activator protein 1 transcription factor in the host response to Ebolavirus

Wynne, J. W., Todd, S., Boyd, V., Tachedjian, M., Klein, R., Shiell, B., Dearnley, M., McAuley, A. J., Woon, A. P., Purcell, A. W., Marsh, G. A. & Baker, M. L., 1 Dec 2017, In : Journal of Virology. 91, 23, 21 p., e01174-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Comparison between the isocratic and gradient retention behaviour of polypeptides in reversed-phase liquid chromatographic environments

Purcell, A. W., Zhao, G. L., Aguilar, M. I. & Hearn, M. T. W., 6 Aug 1999, In : Journal of Chromatography A. 852, 1, p. 43-57 15 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

Kedzierska, K., Guillonneau, C., Gras, S., Hatton, L. A., Webby, R., Purcell, A. W., Rossjohn, J., Doherty, P. C. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 49, p. 19408 - 19413 5 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
41 Citations (Scopus)

Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family

Heinz, E., Stubenrauch, C. J., Grinter, R., Croft, N. P., Purcell, A. W., Strugnell, R. A., Dougan, G. & Lithgow, T., 13 Jun 2016, In : Genome Biology and Evolution. 8, 6, p. 1690-1705 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space

Gentle, I. E., Perry, A. J., Alcock, F. H., Likic, V. A., Dolezal, P., Ng, E. T., Purcell, A. W., McConnville, M., Naderer, T., Chanez, A-L., Charriere, F., Aschinger, C., Schneider, A., Tokatlidis, K. & Lithgow, T. J., 2007, In : Molecular Biology and Evolution. 24, 5, p. 1149 - 1160 12 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Constitutive and inflammatory immunopeptidome of pancreatic beta-cells

Dudek, N. L., Tan, C. T., Gorasia, D. G., Croft, N. P., Illing, P. T. & Purcell, A. W., 2012, In : Diabetes. 61, 11, p. 3018 - 3025 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)