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Anthony Purcell

Professor

 https://orcid.org/0000-0003-0532-8331

Accepting PhD Students

1989 …2022
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Research Output 1989 2019

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16 Citations (Scopus)

Quantifying epitope presentation using mass spectrometry

Croft, N. P., Purcell, A. W. & Tscharke, D. C., 2015, In : Molecular Immunology. 68, 2 - Part A, p. 77 - 80 4 p.

Research output: Contribution to journal › Article › Other › peer-review

126 Citations (Scopus)

Quantitative and qualitative influences of tapasin on the class I peptide repertoire

Purcell, A. W., Gorman, J. J., Garcia-Peydró, M., Paradela, A., Burrows, S. R., Talbo, G. H., Laham, N., Chen Au Peh, A. P., Reynolds, E. C., López de Castro, J. A. & McCluskey, J., 15 Jan 2001, In : Journal of Immunology. 166, 2, p. 1016-1027 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
5 Citations (Scopus)

Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain

Dagley, L. F., White, C. A., Liao, Y., Shi, W., Smyth, G. K., Orian, J. M., Emili, A. & Purcell, A. W., 2014, In : Proteomics. 14, 2-3, p. 241 - 261 21 p.

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Quokka: A comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome

Li, F., Li, C., Marquez-Lago, T. T., Leier, A., Akutsu, T., Purcell, A. W., Smith, A. I., Lithgow, T., Daly, R. J., Song, J. & Chou, K-C., 15 Dec 2018, In : Bioinformatics. 34, 24, p. 4223-4231 9 p., bty522.

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

Safavi-Hemami, H., Li, Q., Jackson, R. L., Song, A. S., Boomsma, W., Bandyopadhyay, P. K., Gruber, C. W., Purcell, A. W., Yandell, M., Olivera, B. M. & Ellgaard, L., 22 Mar 2016, In : Proceedings of the National Academy of Sciences. 113, 12, p. 3227-3232 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
13 Citations (Scopus)

Rapid microscale in-gel processing and digestion of proteins using surface acoustic waves

Kulkarni, K., Ramarathinam, S., Friend, J., Yeo, L., Purcell, A. & Perlmutter, P., 2010, In : Lab on a Chip. 10, 12, p. 1518 - 1520 3 p.

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjogren's syndrome

Reed, J. H., Dudek, N. L., Osborne, S. E., Kaufmann, K. M., Jackson, M. W., Purcell, A. W. & Gordon, T. P., 2010, In : Arthritis and Rheumatism. 62, 5, p. 1448 - 1456 9 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Nguyen, T. H. O., Mifsud, N. A., Stewart, L. A., Rose, M. J., Etto, T. L., Williamson, N. A., Purcell, A. W., Kotsimbos, T. C. & Schwarer, A., 2008, In : Protein Expression and Purification. 61, 1, p. 22 - 30 9 p.

Research output: Contribution to journal › Article › Research › peer-review

166 Citations (Scopus)

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Krishnamurthy, B., Dudek, N. L., McKenzie, M. D., Purcell, A. W., Brooks, A. G., Gellert, S., Colman, P. G., Harrison, L. C., Lew, A. M., Thomas, H. E. & Kay, T. W. H., 1 Dec 2006, In : Journal of Clinical Investigation. 116, 12, p. 3258-3265 8 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Response to Comment on "A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands"

Faridi, P., Li, C., Ramarathinam, S. H., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Croft, N. P. & Purcell, A. W., 16 Aug 2019, In : Science Immunology. 4, 38, 4 p., eaaw8457.

Research output: Contribution to journal › Article › Other › peer-review

Open Access
12 Citations (Scopus)

Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDA Ro (SS-A) in experimental autoimmunity

Gordon, T. P., Kinoshita, G., Cavill, D., Keech, C., Farris, A. D., Kaufman, K., McCluskey, J. & Purcell, A. W., 27 Jul 2002, In : Scandinavian Journal of Immunology. 56, 2, p. 168-173 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
51 Citations (Scopus)

Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes

Schittenhelm, R. B., Lim Kam Sian, T. C. C., Wilmann, P. G., Dudek, N. L. & Purcell, A. W., 2015, In : Arthritis and Rheumatology. 67, 3, p. 702 - 713 12 p.

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

RP-HPLC binding domains of proteins

Aguilar, M-I., Clayton, D. J., Holt, P., Kronina, V., Boysen, R. I., Purcell, A. W. & Hearn, M. T. W., 1998, In : Analytical Chemistry. p. 5010 - 5018 9 p.

Research output: Contribution to journal › Article › Research › peer-review

29 Citations (Scopus)

Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02: 01 ligands

Scull, K. E., Dudek, N. L., Corbett, A. J., Ramarathinam, S. H., Gorasia, D. G., Williamson, N. A. & Purcell, A. W., Jun 2012, In : Molecular Immunology. 51, 2, p. 136-142 7 p.

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients

Gresle, M. M., Liu, Y., Dagley, L. F., Haartsen, J., Pearson, F., Purcell, A. W., Laverick, L., Petzold, A., Lucas, R. M., van der Walt, A., Prime, H., Lazarus, K-J. L., Taylor, B. V., Morris, D. R., Shaw, G. P. J. & Butzkueven, H., 1 Nov 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 11, p. 1209-1213 5 p.

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Simultaneous quantification of viral antigen expression kinetics using data-independent (DIA) mass spectrometry

Croft, N. P., de Verteuil, D. A., Smith, S. A., Wong, Y. C., Schittenhelm, R. B., Tscharke, D. C. & Purcell, A. W., 2015, In : Molecular & Cellular Proteomics. 14, 5, p. 1361 - 1372 12 p.

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway

Safavi-Hemami, H., Siero, W. A., Gorasia, D. G., Young, N. D., MacMillan, D., Williamson, N. A. & Purcell, A. W., 2 Sep 2011, In : Journal of Proteome Research. 10, 9, p. 3904-3919 16 p.

Research output: Contribution to journal › Article › Research › peer-review

58 Citations (Scopus)

Specialized insulin is used for chemical warfare by fish-hunting cone snails

Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, L. & Olivera, B. M., 2015, In : Proceedings of the National Academy of Sciences. 112, 6, p. 1743 - 1748 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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34 Citations (Scopus)

Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity

Kinoshita, G., Keech, C. L., Sontheimer, R. D., Purcell, A., McCluskey, J. & Gordon, T. P., 9 Feb 1998, In : Lupus. 7, 1, p. 7-11 5 p.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

Reilly, C. B., Ramarathinam, S. H., Williamson, N. A. & Purcell, A. W., 17 Jan 2011, In : Proteome Science. 9, 7 p., 2.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
15 Citations (Scopus)

Structural and biological basis of CTL escape in coronavirus-infected mice

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : Journal of Immunology. 180, 6, p. 3926 - 3937 12 p.

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes

Trujillo, J. A., Gras, S., Twist, K-A., Croft, N. P., Channappanavar, R., Rossjohn, J., Purcell, A. W. & Perlman, S., 2014, In : Journal of Immunology. 192, 11, p. 5245 - 5256 12 p.

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Structural and regulatory diversity shape HLA-C protein expression levels

Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortes, A., Barber, T., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., Carrington, M., McVean, G., Purcell, A. W., Rossjohn, J. & Fugger, L., 26 Jun 2017, In : Nature Communications. 8, 12 p., 15924.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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27 Citations (Scopus)

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Day, E. B., Guillonneau, C., Gras, S., La Gruta, N. L., Vignali, D., Doherty, P., Purcell, A., Rossjohn, J. & Turner, S., 2011, In : Proceedings of the National Academy of Sciences. 108, 23, p. 9536 - 9541 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File
8 Citations (Scopus)

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Newcombe, E. A., Ruff, K. M., Sethi, A., Ormsby, A. R., Ramdzan, Y. M., Fox, A. H., Purcell, A. W., Gooley, P. R., Pappu, R. V. & Hatters, D. M., 11 May 2018, In : Journal of Molecular Biology. 430, 10, p. 1442-1458 17 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File
82 Citations (Scopus)

Tapasin-mediated retention and optimization of peptide ligands during the assembly of class I molecules

Barnden, M. J., Purcell, A. W., Gorman, J. J. & McCluskey, J., 1 Jul 2000, In : Journal of Immunology. 165, 1, p. 322-330 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
43 Citations (Scopus)

TAP genes and immunity

McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Current Opinion in Immunology. 16, 5, p. 651 - 659 9 p.

Research output: Contribution to journal › Article › Research › peer-review

159 Citations (Scopus)

T cell allorecognition via molecular mimicry

Macdonald, W. A., Chen, Z., Gras, S., Archbold, J. K., Tynan, F. E., Clements, C. S., Bharadwaj, M., Kjer-Nielsen, L., Saunders, P. M., Wilce, M. C. J., Crawford, F., Stadinsky, B., Jackson, D., Brooks, A., Purcell, A. W., Kappler, J., Burrows, S. R., Rossjohn, J. & McCluskey, J., 2009, In : Immunity. 31, 6, p. 897 - 908 12 p.

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., Miners, K. L., McLaren, J. E., Grant, E. J., Haigh, O. L., Watkins, T. S., Suliman, S., Iwany, S., Jimenez, J., Calderon, R., Tamara, K. L., Leon, S. R., Murray, M. B., Mayfield, J. A., Altman, J. D. & 8 others, Purcell, A. W., Miles, J. J., Godfrey, D. I., Gras, S., Price, D. A., Van Rhijn, I., Moody, D. B. & Rossjohn, J., 1 Apr 2018, In : Nature Immunology. 19, 4, p. 397-406 10 p.

Research output: Contribution to journal › Article › Research › peer-review

73 Citations (Scopus)

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

Law, S. C. C., Street, S., Yu, C. H. A., Capini, C., Ramnoruth, S., Nel, H. J., van Gorp, E., Hyde, C., Lau, K., Pahau, H., Purcell, A. W. & Thomas, R., 17 May 2012, In : Arthritis Research and Therapy. 14, 3, R118.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
6 Citations (Scopus)

T cell cross-reactivity between a highly immunogenic EBV epitope and a self-peptide naturally presented by HLA-B*18:01+ cells

Rist, M. J., Hibbert, K. M., Croft, N. P., Smith, C., Neller, M. A., Burrows, J. M., Miles, J. J., Purcell, A. W., Rossjohn, J., Gras, S. & Burrows, S. R., 2015, In : Journal of Immunology. 194, 10, p. 4668 - 4675 8 p.

Research output: Contribution to journal › Article › Research › peer-review

47 Citations (Scopus)

T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo

Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A. J., Perlmutter, P., McCluskey, J., Aguilar, M-I., Rossjohn, J. & Purcell, A. W., 2005, In : Journal of Immunology. 175, 6, p. 3810 - 3818 9 p.

Research output: Contribution to journal › Article › Research › peer-review

210 Citations (Scopus)

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journal › Article › Research › peer-review

60 Citations (Scopus)

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Beringer, D. X., Kleijwegt, F. S., Wiede, F., Van Der Slik, A. R., Loh, K. K. L., Petersen, J., Dudek, N. L., Duinkerken, G., Laban, S., Joosten, A. M., Vivian, J. P., Chen, Z., Uldrich, A. P., Godfrey, D. I., McCluskey, J., Price, D. A., Radford, K. J., Purcell, A. W., Nikolic, T., Reid, H. H. & 3 others, Tiganis, T., Roep, B. O. & Rossjohn, J., 2015, In : Nature Immunology. 16, 11, p. 1153 - 1161 9 p.

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

T-cells behaving badly: Structural insights into alloreactivity and autoimmunity

Ely, L. K., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2008, In : Current Opinion in Immunology. 20, 5, p. 575 - 580 6 p.

Research output: Contribution to journal › Article › Research › peer-review

58 Citations (Scopus)

The 1.5 Å crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Structure. 10, 11, p. 1521-1532 12 p.

Research output: Contribution to journal › Article › Research › peer-review

The 1.5 Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immonodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Structure. 10, 11, p. 1521 - 1532 12 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

The accessibility of the prosthetic group biotin during monomeric avidin affinity chromatography

Purcell, A. W. & Wallace, J. C., 1 Jan 1996, In : Analytical Biochemistry. 238, 2, p. 213-216 4 p.

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

The A-chain of insulin is a hot-spot for CD4 + T cell epitopes in human type 1 diabetes

Mannering, S. I., Pang, S. H., Williamson, N. A., Naselli, G., Reynolds, E. C., O'Brien-Simpson, N. M., Purcell, A. W. & Harrison, L. C., May 2009, In : Clinical and Experimental Immunology. 156, 2, p. 226-231 6 p.

Research output: Contribution to journal › Article › Other › peer-review

5 Citations (Scopus)

The beta cell immunopeptidome

Dudek, N. L. & Purcell, A. W., 2014, In : Vitamins and Hormones-Advances in Research and Applications. 95, p. 115 - 144 30 p.

Research output: Contribution to journal › Article › Research › peer-review

136 Citations (Scopus)

The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Borg, N. A., Ely, L. K., Beddoe, T. C., Macdonald, W. A., Reid, H. H., Clements, C. S., Purcell, A. W., Kjer-Nielsen, L., Miles, J. J., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 2, p. 171 - 180 10 p.

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

The cellular redox environment alters antigen presentation

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. TT., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W., 2014, In : Journal of Biological Chemistry. 289, 40, p. 27979 - 27991 13 p.

Research output: Contribution to journal › Article › Research › peer-review

36 Citations (Scopus)

The central role played by peptides in the immune response and the design of peptide-based vaccines against infectious diseases and cancer

Jackson, D. C., Purcell, A. W., Fitzmaurice, C. J., Zeng, W. & Hart, D. N. J., 1 Jan 2002, In : Current Drug Targets. 3, 2, p. 175-196 22 p.

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

The enantioselective total synthesis and unambiguous proof of the absolute stereochemistry of pervilleine C

Kulkarni, K. P., Zhao, A. Y., Purcell, A. W. & Perlmutter, P., 2008, In : Synlett. 2008, 14, p. 2209 - 2212 4 p.

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule

Liu, Y. C., Chen, Z., Burrows, S. R., Purcell, A. W., McCluskey, J., Rossjohn, J. & Gras, S., 2012, In : Journal of Biological Chemistry. 287, 15, p. 12267 - 12276 10 p.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 Diabetes

Purcell, A. W., Sechi, S. & DiLorenzo, T. P., 1 May 2019, In : Diabetes. 68, 5, p. 879-886 8 p.

Research output: Contribution to journal › Article › Research › peer-review

69 Citations (Scopus)

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Tynan, F. E., Elhassen, D., Purcell, A. W., Burrows, J. M., Borg, N. A., Miles, J. J., Williamson, N. A., Green, K. J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1249 - 1260 12 p.

Research output: Contribution to journal › Article › Research › peer-review

137 Citations (Scopus)

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

Mannering, S. I., Harrison, L. C., Williamson, N. A., Morris, J. S., Thearle, D. J., Jensen, K. P., Kay, T. W., Rossjohn, J., Falk, B. A., Nepom, G. T. & Purcell, A. W., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1191 - 1197 7 p.

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis

Ting, Y. T., Petersen, J., Ramarathinam, S. H., Scally, S. W., Loh, K. L., Thomas, R., Suri, A., Baker, D. G., Purcell, A. W., Reid, H. H. & Rossjohn, J., 2 Mar 2018, In : Journal of Biological Chemistry. 293, 9, p. 3236-3251 16 p.

Research output: Contribution to journal › Article › Research › peer-review