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Research Output 1989 2019

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5 Citations (Scopus)

Identification of native and posttranslationally modified HLA-B*57:01- restricted HIV envelope derived epitopes using immunoproteomics

Ramarathinam, S. H., Gras, S., Alcantara, S., Yeung, A. W. S., Mifsud, N. A., Sonza, S., Illing, P., Glaros, E. N., Center, R. J., Thomas, S. R., Kent, S. J., Ternette, N., Purcell, D. F. J., Rossjohn, J. & Purcell, A. W., Jun 2018, In : Proteomics. 18, 12, 11 p., 1700253.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

Martin, A. M., Almeida, C. A., Cameron, P., Purcell, A. W., Nolan, D., James, I., McCluskey, J., Phillips, E., Landay, A. & Mallal, S., 1 Jun 2007, In : AIDS. 21, 10, p. 1233-1244 12 p.

Research output: Contribution to journalArticleResearchpeer-review

390 Citations (Scopus)

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Illing, P. T., Vivian, J. P., Dudek, N. L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J. J., Kjer-Nielsen, L., Gras, S., Williamson, N. A., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 486, 7404, p. 554 - 558 5 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Immunodominance hierarchies and gender bias in direct Tcd8-cell alloreactivity

Mifsud, N. A., Purcell, A. W., Chen, W. W., Holdsworth, R., Tait, B. D. & McCluskey, J., 2008, In : American Journal of Transplantation. 8, 1, p. 121 - 132 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Inability to detect cross-reactive memory T cells challenges the frequency of heterologous immunity among common viruses

Rowntree, L. C., Nguyen, T. H. O., Halim, H., Purcell, A. W., Rossjohn, J., Gras, S., Kotsimbos, T. C. & Mifsud, N. A., 15 Jun 2018, In : Journal of Immunology. 200, 12, p. 3993-4003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Induction of amphipathic helical peptide structures in RP-HPLC.

Purcell, A. W., Aguilar, M. I., Wettenhall, R. E. & Hearn, M. T., 1 Jan 1995, In : Peptide Research. 8, 3, p. 160-170 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Ingestion of oats and barley in patients with celiac disease mobilizes cross-reactive T cells activated by avenin peptides and immuno-dominant hordein peptides

Hardy, M. Y., Tye-Din, J. A., Stewart, J. A., Schmitz, F., Dudek, N. L., Hanchapola, I., Purcell, A. W. & Anderson, R. P., 2015, In : Journal of Autoimmunity. 56, p. 56 - 65 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

In Immunopeptidomics We Need a Sniper Instead of a Shotgun

Faridi, P., Purcell, A. W. & Croft, N. P., 1 Jun 2018, In : Proteomics. 18, 12, 4 p., 1700464.

Research output: Contribution to journalArticleOtherpeer-review

16 Citations (Scopus)

Isolation and characterization of naturally processed MHC-bound peptides from the surface of antigen-presenting cells.

Purcell, A. W., 1 Jan 2004, In : Methods in molecular biology (Clifton, N.J.). 251, p. 291-306 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Tubb, V. M., Schrikkema, D. S., Croft, N. P., Purcell, A. W., Linnemann, C., Freriks, M. R., Chen, F., Long, H. M., Lee, S. P. & Bendle, G. M., 13 Jul 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 14 p., 70.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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81 Citations (Scopus)

Kinetics of antigen expression and epitope presentation during virus infection

Croft, N. P., Smith, S. A., Wong, Y. C., Tan, C. T., Dudek, N. L., Flesch, I. E. A., Lin, L. C. W., Tscharke, D. C. & Purcell, A. W., 2013, In : PLoS Pathogens. 9, 1 (Art. ID: :e1003129), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
120 Citations (Scopus)

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J. & Doherty, P. C., 2005, In : Nature Immunology. 6, 4, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

490 Citations (Scopus)

Linear ubiquitination prevents inflammation and regulates immune signalling

Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W. L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J. & Walczak, H., 31 Mar 2011, In : Nature. 471, 7340, p. 591-596 6 p.

Research output: Contribution to journalArticleOtherpeer-review

14 Citations (Scopus)

Mass spectral identification of Vc1.1 and differential distribution of conopeptides in the venom duct of conus victoriae. effect of post-translational modifications and disulfide isomerisation on bioactivity

Townsend, A., Livett, B. G., Bingham, J. P., Truong, H. T., Karas, J. A., O'Donnell, P., Williamson, N. A., Purcell, A. W. & Scanlon, D., Sep 2009, In : International Journal of Peptide Research and Therapeutics. 15, 3, p. 195-203 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Mass spectrometry–based identification of MHC-bound peptides for immunopeptidomics

Purcell, A. W., Ramarathinam, S. H. & Ternette, N., Jun 2019, In : Nature Protocols. 14, 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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52 Citations (Scopus)

Membrane proteomics by high performance liquid chromatography-tandem mass spectrometry: Analytical approaches and challenges

Vuckovic, D., Dagley, L. F., Purcell, A. W. & Emili, A., 2013, In : Proteomics. 13, 3-4, p. 404 - 423 20 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Pymm, P., Illing, P. T., Ramarathinam, S. H., O'Connor, G. M., Hughes, V. A., Hitchen, C., Price, D. A., Ho, B. K., McVicar, D. W., Brooks, A. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., Apr 2017, In : Nature Structural and Molecular Biology. 24, 4, p. 387-394 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE)

Lill, J. R., Van Veelen, P. A., Tenzer, S., Admon, A., Caron, E., Elias, J. E., Heck, A. J. R., Marcilla, M., Marino, F., Müller, M., Peters, B., Purcell, A., Sette, A., Sturm, T., Ternette, N. & Vizcaino, J. A., 1 Jun 2018, In : Proteomics. 18, 12, 7 p., 1800110.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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12 Citations (Scopus)

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma

Woods, K., Knights, A. J., Anaka, M., Schittenhelm, R. B., Purcell, A. W., Behren, A. & Cebon, J., 16 Feb 2016, In : Journal for ImmunoTherapy of Cancer. 4, 14 p., 10.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

Faridi, A., Sun, Y., Okazaki, Y., Peng, G., Gao, J., Kakinen, A., Faridi, P., Zhao, M., Javed, I., Purcell, A. W., Davis, T. P., Lin, S., Oda, R., Ding, F. & Ke, P. C., 22 Nov 2018, In : Small. 14, 47, 13 p., 1802825.

Research output: Contribution to journalArticleResearchpeer-review

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., O’Neill, P. M., Purcell, A. W., Park, K. B. & Naisbitt, D. J., 24 Sep 2019, (Accepted/In press) In : Allergy. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails

Safavi-Hemami, H., Gorasia, D. G., Steiner, A. M., Williamson, N. A., Karas, J., Gajewiak, J., Olivera, B. M., Bulaj, G. & Purcell, A. W., 2012, In : Journal of Biological Chemistry. 287, 41, p. 34288 - 34303 16 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice

Kinoshita, G., Purcell, A. W., Keech, C. L., Farris, A. D., McCluskey, J. & Gordon, T. P., 1 Jan 1999, In : Clinical and Experimental Immunology. 115, 2, p. 268-274 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Molecular markers of preterm labor in the choriodecidua

Shankar, R., Johnson, M. P., Williamson, N. A., Cullinane, F., Purcell, A. W., Moses, E. K. & Brennecke, S. P., Mar 2010, In : Reproductive Sciences. 17, 3, p. 297-310 14 p.

Research output: Contribution to journalArticleResearchpeer-review

404 Citations (Scopus)

More than one reason to rethink the use of peptides in vaccine design

Purcell, A. W., McCluskey, J. & Rossjohn, J., 2007, In : Nature Reviews Drug Discovery. 6, 5, p. 404 - 414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.

Research output: Contribution to journalArticleResearchpeer-review

518 Citations (Scopus)

MR1 presents microbial vitamin B metabolites to MAIT cells

Kjer-Nielsen, L., Patel, O. G., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N. A., Purcell, A. W., Dudek, N. L., McConville, M. J., O'Hair, R. AJ., Khairallah, G. N., Godfrey, D. I., Fairlie, D. P., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 491, 7426, p. 717 - 723 7 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Zernich, D., Purcell, A. W., Macdonald, W. A., Kjer-Nielsen, L., Ely, L. K., Laham, N., Crockford, T., Mifsud, N. A., Bharadwaj, M., Chang, L., Tait, B. D., Holdsworth, R., Brooks, A. G., Bottomley, S. P., Beddoe, T. C., Peh, C. A., Rossjohn, J. & McCluskey, J., 2004, In : Journal of Experimental Medicine. 200, 1, p. 13 - 24 12 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Archbold, J. K., Macdonald, W. A., Gras, S., Ely, L. K., Miles, J. J., Bell, M. J., Brennan, R. M., Beddoe, T. C., Wilce, M. C. J., Clements, C. S., Purcell, A. W., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2009, In : Journal of Experimental Medicine. 206, 1, p. 209 - 219 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Nonprecipitating anti-La(SS-B) autoantibodies in primary Sjogren's syndrome

Beer, R. G., Rischmueller, M., Coates, T., Purcell, A. W., Keech, C. L., McCluskey, J. & Gordon, T. P., 1 Jan 1996, In : Clinical Immunology and Immunopathology. 79, 3, p. 314-318 5 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

Chang, L., Kjer-Nielsen, L., Flynn, S., Brooks, A. G., Mannering, S. I., Honeyman, M. C., Harrison, L. C., McCluskey, J. & Purcell, A. W., 1 Nov 2003, In : Tissue Antigens. 62, 5, p. 408-417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Optimisation of peptide-based cytotoxic T-cell determinants using non-natural amino acids

Webb, A. I., Aguilar, M-I. & Purcell, A. W., 2003, In : Letters in Peptide Science. 10, 5, p. 561 - 569 9 p.

Research output: Contribution to journalArticleResearchpeer-review

252 Citations (Scopus)

Optimization of the MHC class I peptide cargo is dependent on tapasin

Williams, A. P., Peh, C. A., Purcell, A. W., McCluskey, J. & Elliott, T., 1 Jan 2002, In : Immunity. 16, 4, p. 509-520 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes

Gorasia, D. G., Dudek, N. L., Veith, P. D., Shankar, R., Safavi-Hemami, H., Williamson, N. A., Reynolds, E. C., Hubbard, M. J. & Purcell, A. W., 2015, In : Journal of Proteome Research. 14, 2, p. 688 - 699 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Peptidomimetics: modifying peptides in the pursuit of better vaccines

Croft, N. P. & Purcell, A. W., 2011, In : Expert Review of Vaccines. 10, 2, p. 211 - 226 16 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Phosphorylated self-peptides alter human leukocyte antigen class l-restricted antigen presentation and generate tumor-specific epitopes

Petersen, J., Wurzbacher, S. J., Williamson, N. A., Ramarathinam, S. H., Reid, H. H., Nair, A. K. N., Zhao, A. Y., Nastovska, R., Rudge, G., Rossjohn, J. & Purcell, A. W., 2009, In : Proceedings of the National Academy of Sciences. 106, 8, p. 2776 - 2781 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Physical and toxicological profiles of human IAPP amyloids and plaques

Kakinen, A., Sun, Y., Javed, I., Faridi, A., Pilkington, E. H., Faridi, P., Purcell, A. W., Zhou, R., Ding, F., Lin, S., Ke, P. C. & Davis, T. P., 15 Jan 2019, In : Science Bulletin. 64, 1, p. 26-35 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Positive-unlabelled learning of glycosylation sites in the human proteome

Li, F., Zhang, Y., Purcell, A. W., Webb, G. I., Chou, K-C., Lithgow, T., Li, C. & Song, J., 6 Mar 2019, In : BMC Bioinformatics. 20, 1, 17 p., 112.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Post translationally modified peptides: New targets in autoimmune disease

Lau, K. & Purcell, A. W., 2 Aug 2007, In : Chimica Oggi. 25, p. 6-9 4 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Post-translationally modified T cell epitopes: Immune recognition and immunotherapy

Petersen, J., Purcell, A. W. & Rossjohn, J., 2009, In : Journal of Molecular Medicine. 87, 11, p. 1045 - 1051 7 p.

Research output: Contribution to journalArticleResearchpeer-review

386 Citations (Scopus)

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Martin, A. M., Nolan, D., Gaudieri, S., Almeida, C. A., Nolan, R., James, I., Carvalho, F., Phillips, E., Christiansen, F. T., Purcell, A. W., McCluskey, J. & Mallal, S., 23 Mar 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4180-4185 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Preemptive priming readily overcomes structure-based mechanisms of virus escape

Valkenburg, S. A., Gras, S., Guillonneau, C., Hatten, L. A., Bird, N. L., Twist, K-A., Abd Halim, N. H., Jackson, D. C., Purcell, A. W., Turner, S. J., Doherty, P. C., Rossjohn, J. & Kedzierska, K., 2013, In : Proceedings of the National Academy of Sciences. 110, 14, p. 5570 - 5575 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : PLoS Pathogens. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Probing the binding behavior and conformational states of globular proteins in reversed-phased high-performance liquid chromatography

Purcell, A. W., Aguilar, M. I. & Hearn, M. T. W., 1 Jul 1999, In : Analytical Chemistry. 71, 13, p. 2440-2451 12 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes

Pathiraja, V., Kuehlich, J., Campbell, P. D., Krishnamurthy, B., Loudovaris, T., Coates, P. T. H., Brodnicki, T. C., O'Connell, P. J., Kedzierska, K., Rodda, C. P., Bergman, P. B., Hill, E., Purcell, A. W., Dudek, N. L., Thomas, H. E., Kay, T. W. H. & Mannering, S. I., 2015, In : Diabetes. 64, 1, p. 172 - 182 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold

Valkenburg, S. A., Gras, S., Guillonneau, C., La Gruta, N. L., Thomas, P. G., Purcell, A. W., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2010, In : PLoS Pathogens. 6, 8 (e1001039), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Proteomic interrogation of venom delivery in marine cone snails: Novel insights into the role of the venom bulb

Safavi-Hemami, H., Young, N. D., Williamson, N. A. & Purcell, A. W., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 5610-5619 10 p.

Research output: Contribution to journalArticleOtherpeer-review

15 Citations (Scopus)

Qualitative and quantitative differences in peptides bound to HLA-B27 in the presence of mouse versus human tapasin define a role for tapasin as a size-dependent peptide editor

Sesma, L., Galocha, B., Vázquez, M., Purcell, A. W., Marcilla, M., McCluskey, J. & López De Castro, J. A., 15 Jun 2005, In : Journal of Immunology. 174, 12, p. 7833-7844 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Wu, T., Guan, J., Handel, A., Tscharke, D. C., Sidney, J., Sette, A., Wakim, L. M., Sng, X. Y. X., Thomas, P. G., Croft, N. P., Purcell, A. W. & La Gruta, N. L., 28 Jun 2019, In : Nature Communications. 10, 1, 14 p., 2846.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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