Accepting PhD Students

PhD projects

Cancer Immunology Autoimmunity (Diabetes, arthritis, psoriasis, MS) Antigen processing and presentation Vaccine design Bioinformatics

1989 …2020

Research output per year

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Research Output

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Article
Article

Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family

Heinz, E., Stubenrauch, C. J., Grinter, R., Croft, N. P., Purcell, A. W., Strugnell, R. A., Dougan, G. & Lithgow, T., 13 Jun 2016, In : Genome Biology and Evolution. 8, 6, p. 1690-1705 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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24 Citations (Scopus)

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space

Gentle, I. E., Perry, A. J., Alcock, F. H., Likic, V. A., Dolezal, P., Ng, E. T., Purcell, A. W., McConnville, M., Naderer, T., Chanez, A-L., Charriere, F., Aschinger, C., Schneider, A., Tokatlidis, K. & Lithgow, T. J., 2007, In : Molecular Biology and Evolution. 24, 5, p. 1149 - 1160 12 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Constitutive and inflammatory immunopeptidome of pancreatic beta-cells

Dudek, N. L., Tan, C. T., Gorasia, D. G., Croft, N. P., Illing, P. T. & Purcell, A. W., 2012, In : Diabetes. 61, 11, p. 3018 - 3025 8 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition

Theodossis, A., Guillonneau, C., Welland, A. D., Ely, L. K., Clements, C. S., Williamson, N. A., Webb, A. I., Wilce, J. A., Mulder, R. J., Dunstone, M. A., Doherty, P. C., McCluskey, J., Purcell, A. W., Turner, S. J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5534 - 5539 6 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3

Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T. C., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J. & Rossjohn, J., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 20, p. 7675 - 7680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

Chong, Y. P., Chan, A. S., Chan, K. C., Williamson, N. A., Lerner, E. C., Smithgall, T. E., Bjorge, J. D., Fujita, D. J., Purcell, A. W., Scholz, G., Mulhern, T. D. & Cheng, H. C., 3 Nov 2006, In : The Journal of Biological Chemistry. 281, 44, p. 32988-32999 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

CTL recognition of a bulged viral peptide involves biased TCR selection

Miles, J. J., Elhassen, D., Borg, N. A., Silins, S. L., Tynan, F. E., Burrows, J. M., Purcell, A. W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S. R. & McCluskey, J., 2005, In : Journal of Immunology. 175, 6, p. 3826 - 3834 9 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

CTL Recognition of an Altered Peptide Associated with Asparagine Bond Rearrangement: Implications for Immunity and Vaccine Design

Chen, W., Ede, N. J., Jackson, D. C., McCluskey, J. & Purcell, A. W., 1 Aug 1996, In : Journal of Immunology. 157, 3, p. 1000-1005 6 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells

Ternette, N., Yang, H., Partridge, T., Llano, A., Cedeno, S., Fischer, R., Charles, P. D., Dudek, N. L., Mothe, B., Crespo, M., Fischer, W. M., Korber, B., Nielsen, M., Borrow, P., Purcell, A. W., Brander, C., Dorrell, L., Kessler, B. M. & Hanke, T., 2016, In : European Journal of Immunology. 46, 1, p. 60-69 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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28 Citations (Scopus)

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate

Ia, K. K., Jeschke, G. R., Deng, Y., Kamaruddin, M. A., Williamson, N. A., Scanlon, D. B., Culvenor, J. G., Hossain, M. I., Purcell, A. W., Liu, S., Zhu, H-J., Catimel, B., Turk, B. E. & Cheng, H-C., 9 Aug 2011, In : Biochemistry. 50, 31, p. 6667-6677 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Determinant spreading: Lessons from animal models and human disease

McCluskey, J., Farris, A. D., Keech, C. L., Purcell, A. W., Rischmueller, M., Kinoshita, G., Reynolds, P. & Gordon, T. P., 1 Aug 1998, In : Immunological Reviews. 164, p. 209-229 21 p.

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)

Differential Roles of Plasma Protein Corona on Immune Cell Association and Cytokine Secretion of Oligomeric and Fibrillar Beta-Amyloid

Faridi, A., Yang, W., Kelly, H. G., Wang, C., Faridi, P., Purcell, A. W., Davis, T. P., Chen, P., Kent, S. J. & Ke, P. C., 11 Nov 2019, In : Biomacromolecules. 20, 11, p. 4208-4217 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring

Tan, C. T., Croft, N. P., Dudek, N. L., Williamson, N. A. & Purcell, A. W., 2011, In : Proteomics. 11, 11, p. 2336 - 2340 5 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

Robinson, S., Safavi-Hemami, H., Raghuraman, S. C., Imperial, J. S., Papenfuss, A. T., Teichert, R. W., Purcell, A. W., Olivera, B. M. & Norton, R. S., 2015, In : Journal of Proteomics. 114, p. 38 - 47 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Discovery of an archetypal protein transport system in bacterial outer membranes

Selkrig, J., Mosbahi, K., Webb, C. T., Belousoff, M. J., Perry, A. J., Wells, T. J., Morris, F. C., Leyton, D. L., Totsika, M., Phan, M-D., Celik, N., Kelly, M., Oates, C., Hartland, E. L., Robins-Browne, R. M., Ramarathinam, S. H., Purcell, A. W., Schembri, M. A., Strugnell, R. A., Henderson, I. R. & 2 others, Walker, D. & Lithgow, T. J., 2012, In : Nature Structural & Molecular Biology. 19, 5 (S 1), p. 506 - 510 5 p.

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

Discovery of novel disease-specific and membrane-associated candidate markers in a mouse model of multiple sclerosis

Dagley, L. F., Croft, N. P., Isserlin, R., Olsen, J. B., Fong, V., Emili, A. & Purcell, A. W., 2014, In : Molecular & Cellular Proteomics. 13, 1, p. 679 - 700 22 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Disparate thermodynamics governing T cell receptor-MHC-1 interactions implicate extrinsic factors in guiding MHC restriction

Ely, L. K., Beddoe, T. C., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6641 - 6646 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

Robinson, S., Safavi-Hemami, H., McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In : PLoS ONE. 9, e87648, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
68 Citations (Scopus)

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 others, Holdsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Koutsakos, M., McWilliam, H. E. G., Aktepe, T. E., Fritzlar, S., Illing, P. T., Mifsud, N. A., Purcell, A. W., Rockman, S., Reading, P. C., Vivian, J. P., Rossjohn, J., Brooks, A. G., Mackenzie, J. M., Mintern, J. D., Villadangos, J. A., Nguyen, T. H. O. & Kedzierska, K., 29 May 2019, In : Frontiers in Immunology. 10, 12 p., 1158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex

Bharadwaj, M., Illing, P., Theodossis, A., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Annual Review of Pharmacology and Toxicology. 52, p. 401 - 431 31 p.

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

Keller, A. N., Eckle, S. B. G., Xu, W., Liu, L., Hughes, V. A., Mak, J. Y. W., Meehan, B. S., Pediongco, T., Birkinshaw, R. W., Chen, Z., Wang, H., D'Souza, C., Kjer-Nielsen, L., Gherardin, N. A., Godfrey, D. I., Kostenko, L., Corbett, A. J., Purcell, A. W., Fairlie, D. P., McCluskey, J. & 1 others, Rossjohn, J., Apr 2017, In : Nature Immunology. 18, 4, p. 402-411 14 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Elucidation of functionally significant structural modifications by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with post-source decay

German, J. J., Purcell, A. W., Ferguson, B. L., Lopaticki, S., Morrow, C. J. & Mineva, E., 12 Sep 1998, In : Journal of Protein Chemistry. 17, 6, p. 526-527 2 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?

Safavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 2011, In : The Journal of Biological Chemistry. 286, 25, p. 22546 - 22557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Endogenous and exogenous factors contributing to the surface expression of HLA B27 on mutant APC

Purcell, A. W., Kelly, A. J., Peh, C. A., Dudek, N. L. & McCluskey, J., 1 Feb 2000, In : Human Immunology. 61, 2, p. 120-130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Epitope discovery and their use in peptide based vaccines

Dudek, N. L., Perlmutter, P., Aguilar, M. I., Croft, N. & Purcell, A. W., 2010, In : Current Pharmaceutical Design. 16, 28, p. 3149 - 3157 9 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis

Pham, H., Doerrbecker, J., Ramp, A. A., D'Souza, C. S., Gorasia, D. G., Purcell, A. W., Ayers, M. & Orian, J. M., Mar 2011, In : Journal of Neuroimmunology. 232, 1-2, p. 51-62 12 p.

Research output: Contribution to journalArticleOtherpeer-review

11 Citations (Scopus)

Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

Etto, T., Stewart, L., Nguyen, T. H. O., Williamson, N., Purcell, A. & Schwarer, A., 2007, In : Protein Expression and Purification. 54, 1, p. 176 - 182 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Webb, A. I., Dunstone, M. A., Chen, W., Aguilar, M. I., Chen, Q., Jackson, H., Chang, L., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : The Journal of Biological Chemistry. 279, 22, p. 23438 - 23446 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Maifiah, M. H. M., Cheah, S-E., Johnson, M. D., Han, M., Boyce, J. D., Thamlikitkul, V., Forrest, A., Kaye, K. S., Hertzog, P., Purcell, A. W., Song, J., Velkov, T., Creek, D. J. & Li, J., 29 Feb 2016, In : Scientific Reports. 6, 17 p., 22287.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide

Faridi, A., Sun, Y., Mortimer, M., Aranha, R. R., Nandakumar, A., Li, Y., Javed, I., Kakinen, A., Fan, Q., Purcell, A. W., Davis, T. P., Ding, F., Faridi, P. & Ke, P. C., Nov 2019, In : Nano Research. 12, 11, p. 2827-2834 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Burrows, S. R., Chen, Z., Archbold, J. K., Tynan, F. E., Beddoe, T. C., Kjer-Nielsen, L., Miles, J. J., Khanna, R., Moss, D. J., Liu, Y. C., Gras, S., Kostenko, L., Brennan, R. M., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 23, p. 10608 - 10613 6 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice

Reynolds, P., Gordon, T. P., Purcell, A. W., Jackson, D. C. & McCluskey, J., 1 Nov 1996, In : Journal of Experimental Medicine. 184, 5, p. 1857-1870 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
59 Citations (Scopus)

Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule

Liu, Y. C., Miles, J. J., Neller, M. A., Gostick, E., Price, D. A., Purcell, A. W., McCluskey, J., Burrows, S. R., Rossjohn, J. & Gras, S., 2013, In : The Journal of Biological Chemistry. 288, 22, p. 15442 - 15454 13 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

High molecular weight components of the injected venom of fish-hunting cone snails target the vascular system

Safavi-Hemami, H., Moller, C., Mari, F. MARI. & Purcell, A. W., 2013, In : Journal of Proteomics. 91, p. 97 - 105 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
44 Citations (Scopus)
64 Citations (Scopus)

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance

Tynan, F. E., Borg, N., Miles, J. J., Beddoe, T. C., Elhassen, D., Silins, S. L., van Zuylen, W. JM., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2005, In : The Journal of Biological Chemistry. 280, 25, p. 23900 - 23909 10 p.

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

HIVed, a knowledgebase for differentially expressed human genes and proteins during HIV infection, replication and latency

Li, C., Ramarathinam, S. H., Revote, J., Khoury, G., Song, J. & Purcell, A. W., 30 Mar 2017, In : Scientific Reports. 7, 45509.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

HLA peptide length preferences control CD8+ T cell responses

Rist, M. J., Theodossis, A., Croft, N. P., Neller, M. A., Welland, A. D., Chen, Z., Sullivan, L. C., Burrows, J. M., Miles, J. J., Brennan, R. M., Gras, S., Khanna, R., Brooks, A., McCluskey, J., Purcell, A. W., Rossjohn, J. & Burrows, S. R., 2013, In : Journal of Immunology. 191, 2, p. 561-571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Hormone-like peptides in the venoms of marine cone snails

Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A., Norton, R. S. & Safavi-Hemami, H., 1 Apr 2017, In : General and Comparative Endocrinology. 244, p. 11-18 8 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Human CD8 + T cell cross-reactivity across influenza A, B and C viruses

Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S., Chua, B. Y., Wong, C. Y., Allen, E. K., Teng, D., Dash, P., Boyd, D. F., Grzelak, L., Zeng, W., Hurt, A. C., Barr, I., Rockman, S. & 17 others, Jackson, D. C., Kotsimbos, T. C., Cheng, A. C., Richards, M., Westall, G. P., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Wakim, L. M., Rossjohn, J., Vijaykrishna, D., Luciani, F., Thomas, P. G., Gras, S., Purcell, A. W. & Kedzierska, K., 18 Feb 2019, In : Nature Immunology. 20, p. 613-625 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Human leukocyte antigen-associated drug hypersensitivity

Illing, P. T., Vivian, J. P., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2013, In : Current Opinion in Immunology. 25, 1, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Chessman, D., Kostenko, L., Lethborg, T., Purcell, A. W., Williamson, N. A., Chen, Z., Kjer-Nielsen, L., Mifsud, N. A., Tait, B. D., Holdsworth, R., Almeida, C. A., Nolan, D., Macdonald, W. A., Archbold, J. K., Kellerher, A. D., Marriott, D., Mallal, S., Bharadwaj, M., Rossjohn, J. & McCluskey, J., 2008, In : Immunity. 28, 6, p. 822 - 832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

241 Citations (Scopus)

Human Plasma Protein Corona of Aβ Amyloid and Its Impact on Islet Amyloid Polypeptide Cross-Seeding

Nandakumar, A., Xing, Y., Aranha, R. R., Faridi, A., Kakinen, A., Javed, I., Koppel, K., Pilkington, E. H., Purcell, A. W., Davis, T. P., Faridi, P., Ding, F. & Ke, P. C., 10 Feb 2020, In : Biomacromolecules. 21, 2, p. 988-998 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)