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Research Output 1989 2019

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28 Citations (Scopus)

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

Chong, Y. P., Chan, A. S., Chan, K. C., Williamson, N. A., Lerner, E. C., Smithgall, T. E., Bjorge, J. D., Fujita, D. J., Purcell, A. W., Scholz, G., Mulhern, T. D. & Cheng, H. C., 3 Nov 2006, In : Journal of Biological Chemistry. 281, 44, p. 32988-32999 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
78 Citations (Scopus)

CTL recognition of a bulged viral peptide involves biased TCR selection

Miles, J. J., Elhassen, D., Borg, N. A., Silins, S. L., Tynan, F. E., Burrows, J. M., Purcell, A. W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S. R. & McCluskey, J., 2005, In : Journal of Immunology. 175, 6, p. 3826 - 3834 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

CTL Recognition of an Altered Peptide Associated with Asparagine Bond Rearrangement: Implications for Immunity and Vaccine Design

Chen, W., Ede, N. J., Jackson, D. C., McCluskey, J. & Purcell, A. W., 1 Aug 1996, In : Journal of Immunology. 157, 3, p. 1000-1005 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells

Ternette, N., Yang, H., Partridge, T., Llano, A., Cedeno, S., Fischer, R., Charles, P. D., Dudek, N. L., Mothe, B., Crespo, M., Fischer, W. M., Korber, B., Nielsen, M., Borrow, P., Purcell, A. W., Brander, C., Dorrell, L., Kessler, B. M. & Hanke, T., 2016, In : European Journal of Immunology. 46, 1, p. 60-69 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate

Ia, K. K., Jeschke, G. R., Deng, Y., Kamaruddin, M. A., Williamson, N. A., Scanlon, D. B., Culvenor, J. G., Hossain, M. I., Purcell, A. W., Liu, S., Zhu, H-J., Catimel, B., Turk, B. E. & Cheng, H-C., 9 Aug 2011, In : Biochemistry. 50, 31, p. 6667-6677 11 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)

Determinant spreading: Lessons from animal models and human disease

McCluskey, J., Farris, A. D., Keech, C. L., Purcell, A. W., Rischmueller, M., Kinoshita, G., Reynolds, P. & Gordon, T. P., 1 Aug 1998, In : Immunological Reviews. 164, p. 209-229 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential Roles of Plasma Protein Corona on Immune Cell Association and Cytokine Secretion of Oligomeric and Fibrillar Beta-Amyloid

Faridi, A., Yang, W., Kelly, H. G., Wang, C., Faridi, P., Purcell, A. W., Davis, T. P., Chen, P., Kent, S. J. & Ke, P. C., 11 Nov 2019, In : Biomacromolecules. 20, 11, p. 4208-4217 10 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring

Tan, C. T., Croft, N. P., Dudek, N. L., Williamson, N. A. & Purcell, A. W., 2011, In : Proteomics. 11, 11, p. 2336 - 2340 5 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

Robinson, S., Safavi-Hemami, H., Raghuraman, S. C., Imperial, J. S., Papenfuss, A. T., Teichert, R. W., Purcell, A. W., Olivera, B. M. & Norton, R. S., 2015, In : Journal of Proteomics. 114, p. 38 - 47 10 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Discovery of an archetypal protein transport system in bacterial outer membranes

Selkrig, J., Mosbahi, K., Webb, C. T., Belousoff, M. J., Perry, A. J., Wells, T. J., Morris, F. C., Leyton, D. L., Totsika, M., Phan, M-D., Celik, N., Kelly, M., Oates, C., Hartland, E. L., Robins-Browne, R. M., Ramarathinam, S. H., Purcell, A. W., Schembri, M. A., Strugnell, R. A., Henderson, I. R. & 2 others, Walker, D. & Lithgow, T. J., 2012, In : Nature Structural and Molecular Biology. 19, 5 (S 1), p. 506 - 510 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Discovery of novel disease-specific and membrane-associated candidate markers in a mouse model of multiple sclerosis

Dagley, L. F., Croft, N. P., Isserlin, R., Olsen, J. B., Fong, V., Emili, A. & Purcell, A. W., 2014, In : Molecular & Cellular Proteomics. 13, 1, p. 679 - 700 22 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Disparate thermodynamics governing T cell receptor-MHC-1 interactions implicate extrinsic factors in guiding MHC restriction

Ely, L. K., Beddoe, T. C., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J., 2006, In : Proceedings of the National Academy of Sciences. 103, 17, p. 6641 - 6646 6 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

Robinson, S., Safavi-Hemami, H., McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In : PLoS ONE. 9, e87648, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 others, Holdsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Koutsakos, M., McWilliam, H. E. G., Aktepe, T. E., Fritzlar, S., Illing, P. T., Mifsud, N. A., Purcell, A. W., Rockman, S., Reading, P. C., Vivian, J. P., Rossjohn, J., Brooks, A. G., Mackenzie, J. M., Mintern, J. D., Villadangos, J. A., Nguyen, T. H. O. & Kedzierska, K., 29 May 2019, In : Frontiers in Immunology. 10, 12 p., 1158.

Research output: Contribution to journalArticleResearchpeer-review

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116 Citations (Scopus)

Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex

Bharadwaj, M., Illing, P., Theodossis, A., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Annual Review of Pharmacology and Toxicology. 52, p. 401 - 431 31 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

Keller, A. N., Eckle, S. B. G., Xu, W., Liu, L., Hughes, V. A., Mak, J. Y. W., Meehan, B. S., Pediongco, T., Birkinshaw, R. W., Chen, Z., Wang, H., D'Souza, C., Kjer-Nielsen, L., Gherardin, N. A., Godfrey, D. I., Kostenko, L., Corbett, A. J., Purcell, A. W., Fairlie, D. P., McCluskey, J. & 1 others, Rossjohn, J., Apr 2017, In : Nature Immunology. 18, 4, p. 402-411 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Elucidation of functionally significant structural modifications by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with post-source decay

German, J. J., Purcell, A. W., Ferguson, B. L., Lopaticki, S., Morrow, C. J. & Mineva, E., 12 Sep 1998, In : Journal of Protein Chemistry. 17, 6, p. 526-527 2 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)

Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?

Safavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22546 - 22557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Endogenous and exogenous factors contributing to the surface expression of HLA B27 on mutant APC

Purcell, A. W., Kelly, A. J., Peh, C. A., Dudek, N. L. & McCluskey, J., 1 Feb 2000, In : Human Immunology. 61, 2, p. 120-130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Epitope discovery and their use in peptide based vaccines

Dudek, N. L., Perlmutter, P., Aguilar, M. I., Croft, N. & Purcell, A. W., 2010, In : Current Pharmaceutical Design. 16, 28, p. 3149 - 3157 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis

Pham, H., Doerrbecker, J., Ramp, A. A., D'Souza, C. S., Gorasia, D. G., Purcell, A. W., Ayers, M. & Orian, J. M., Mar 2011, In : Journal of Neuroimmunology. 232, 1-2, p. 51-62 12 p.

Research output: Contribution to journalArticleOtherpeer-review

Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

Etto, T., Stewart, L., Nguyen, T. H. O., Williamson, N., Purcell, A. & Schwarer, A., 2007, In : Protein Expression and Purification. 54, 1, p. 176 - 182 7 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Webb, A. I., Dunstone, M. A., Chen, W., Aguilar, M. I., Chen, Q., Jackson, H., Chang, L., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Journal of Biological Chemistry. 279, 22, p. 23438 - 23446 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Maifiah, M. H. M., Cheah, S-E., Johnson, M. D., Han, M., Boyce, J. D., Thamlikitkul, V., Forrest, A., Kaye, K. S., Hertzog, P., Purcell, A. W., Song, J., Velkov, T., Creek, D. J. & Li, J., 29 Feb 2016, In : Scientific Reports. 6, 17 p., 22287.

Research output: Contribution to journalArticleResearchpeer-review

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Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide

Faridi, A., Sun, Y., Mortimer, M., Aranha, R. R., Nandakumar, A., Li, Y., Javed, I., Kakinen, A., Fan, Q., Purcell, A. W., Davis, T. P., Ding, F., Faridi, P. & Ke, P. C., Nov 2019, In : Nano Research. 12, 11, p. 2827-2834 8 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Burrows, S. R., Chen, Z., Archbold, J. K., Tynan, F. E., Beddoe, T. C., Kjer-Nielsen, L., Miles, J. J., Khanna, R., Moss, D. J., Liu, Y. C., Gras, S., Kostenko, L., Brennan, R. M., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 23, p. 10608 - 10613 6 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice

Reynolds, P., Gordon, T. P., Purcell, A. W., Jackson, D. C. & McCluskey, J., 1 Nov 1996, In : Journal of Experimental Medicine. 184, 5, p. 1857-1870 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule

Liu, Y. C., Miles, J. J., Neller, M. A., Gostick, E., Price, D. A., Purcell, A. W., McCluskey, J., Burrows, S. R., Rossjohn, J. & Gras, S., 2013, In : Journal of Biological Chemistry. 288, 22, p. 15442 - 15454 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

High molecular weight components of the injected venom of fish-hunting cone snails target the vascular system

Safavi-Hemami, H., Moller, C., Mari, F. MARI. & Purcell, A. W., 2013, In : Journal of Proteomics. 91, p. 97 - 105 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)
64 Citations (Scopus)
125 Citations (Scopus)

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance

Tynan, F. E., Borg, N., Miles, J. J., Beddoe, T. C., Elhassen, D., Silins, S. L., van Zuylen, W. JM., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2005, In : Journal of Biological Chemistry. 280, 25, p. 23900 - 23909 10 p.

Research output: Contribution to journalArticleResearchpeer-review

HIVed, a knowledgebase for differentially expressed human genes and proteins during HIV infection, replication and latency

Li, C., Ramarathinam, S. H., Revote, J., Khoury, G., Song, J. & Purcell, A. W., 30 Mar 2017, In : Scientific Reports. 7, 45509.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

HLA peptide length preferences control CD8+ T cell responses

Rist, M. J., Theodossis, A., Croft, N. P., Neller, M. A., Welland, A. D., Chen, Z., Sullivan, L. C., Burrows, J. M., Miles, J. J., Brennan, R. M., Gras, S., Khanna, R., Brooks, A., McCluskey, J., Purcell, A. W., Rossjohn, J. & Burrows, S. R., 2013, In : Journal of Immunology. 191, 2, p. 561-571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Hormone-like peptides in the venoms of marine cone snails

Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A., Norton, R. S. & Safavi-Hemami, H., 1 Apr 2017, In : General and Comparative Endocrinology. 244, p. 11-18 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Human CD8 + T cell cross-reactivity across influenza A, B and C viruses

Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S., Chua, B. Y., Wong, C. Y., Allen, E. K., Teng, D., Dash, P., Boyd, D. F., Grzelak, L., Zeng, W., Hurt, A. C., Barr, I., Rockman, S. & 17 others, Jackson, D. C., Kotsimbos, T. C., Cheng, A. C., Richards, M., Westall, G. P., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Wakim, L. M., Rossjohn, J., Vijaykrishna, D., Luciani, F., Thomas, P. G., Gras, S., Purcell, A. W. & Kedzierska, K., 18 Feb 2019, In : Nature Immunology. 20, p. 613-625 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)
55 Citations (Scopus)

Human leukocyte antigen-associated drug hypersensitivity

Illing, P. T., Vivian, J. P., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2013, In : Current Opinion in Immunology. 25, 1, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

232 Citations (Scopus)

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Chessman, D., Kostenko, L., Lethborg, T., Purcell, A. W., Williamson, N. A., Chen, Z., Kjer-Nielsen, L., Mifsud, N. A., Tait, B. D., Holdsworth, R., Almeida, C. A., Nolan, D., Macdonald, W. A., Archbold, J. K., Kellerher, A. D., Marriott, D., Mallal, S., Bharadwaj, M., Rossjohn, J. & McCluskey, J., 2008, In : Immunity. 28, 6, p. 822 - 832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Human T-cells recognise N-terminally Fmoc-modified peptide

Mannering, S. I., Purcell, A. W., Honeyman, M. C., McCluskey, J. & Harrison, L. C., 1 Jan 2003, In : Vaccine. 21, 25-26, p. 3638-3646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

Ramdzan, Y. M., Trubetskov, M. M., Ormsby, A. R., Newcombe, E. A., Sui, X., Tobin, M. J., Bongiovanni, M. N., Gras, S. L., Dewson, G., Miller, J. M. L., Finkbeiner, S., Moily, N. S., Niclis, J., Parish, C. L., Purcell, A. W., Baker, M. J., Wilce, J. A., Waris, S., Stojanovski, D., Böcking, T. & 4 others, Ang, C-S., Ascher, D. B., Reid, G. E. & Hatters, D. M., 2 May 2017, In : Cell Reports. 19, 5, p. 919-927 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Identification and synthesis of altered peptides modulating T cell recognition of a synthetic peptide antigen.

Ede, N. J., Chen, W., McCluskey, J., Jackson, D. C. & Purcell, A. W., 1 Jan 1995, In : Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity. 1, 4, p. 231-234 4 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant form of each complex

Macdonald, W., Williams, D. S., Gorman, J. J., Kjer-Nielsen, L., Brooks, A. G., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2002, In : FEBS Letters. 527, 1-3, p. 27 - 32 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Identification of an I-Ad restricted peptide on the 65-kilodalton heat shock protein of Mycobacterium avium

Nagabhushanam, V., Purcell, A. W., Mannering, S., Germano, S., Praszkier, J. & Cheers, C., 26 Nov 2002, In : Immunology and Cell Biology. 80, 6, p. 574-583 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins

Safavi-Hemami, H., Bulaj, G., Olivera, B. M., Williamson, N. A. & Purcell, A. W., 23 Apr 2010, In : Journal of Biological Chemistry. 285, 17, p. 12735-12746 12 p.

Research output: Contribution to journalArticleOtherpeer-review