Accepting PhD Students

PhD projects

Cancer Immunology Autoimmunity (Diabetes, arthritis, psoriasis, MS) Antigen processing and presentation Vaccine design Bioinformatics

1989 …2020

Research output per year

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Research Output

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Article

Preemptive priming readily overcomes structure-based mechanisms of virus escape

Valkenburg, S. A., Gras, S., Guillonneau, C., Hatten, L. A., Bird, N. L., Twist, K-A., Abd Halim, N. H., Jackson, D. C., Purcell, A. W., Turner, S. J., Doherty, P. C., Rossjohn, J. & Kedzierska, K., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5570 - 5575 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

Rowntree, L. C., van den Heuvel, H., Sun, J., D'Orsogna, L. J., Nguyen, T. H. O., Claas, F. H. J., Rossjohn, J., Kotsimbos, T. C., Purcell, A. W. & Mifsud, N. A., 19 Feb 2020, In : Frontiers in Immunology. 11, 13 p., 248.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : PLoS Pathogens. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Probing the binding behavior and conformational states of globular proteins in reversed-phased high-performance liquid chromatography

Purcell, A. W., Aguilar, M. I. & Hearn, M. T. W., 1 Jul 1999, In : Analytical Chemistry. 71, 13, p. 2440-2451 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes

Pathiraja, V., Kuehlich, J., Campbell, P. D., Krishnamurthy, B., Loudovaris, T., Coates, P. T. H., Brodnicki, T. C., O'Connell, P. J., Kedzierska, K., Rodda, C. P., Bergman, P. B., Hill, E., Purcell, A. W., Dudek, N. L., Thomas, H. E., Kay, T. W. H. & Mannering, S. I., 2015, In : Diabetes. 64, 1, p. 172 - 182 11 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold

Valkenburg, S. A., Gras, S., Guillonneau, C., La Gruta, N. L., Thomas, P. G., Purcell, A. W., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2010, In : PLoS Pathogens. 6, 8 (e1001039), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Proteomic interrogation of venom delivery in marine cone snails: Novel insights into the role of the venom bulb

Safavi-Hemami, H., Young, N. D., Williamson, N. A. & Purcell, A. W., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 5610-5619 10 p.

Research output: Contribution to journalArticleOtherpeer-review

26 Citations (Scopus)

Qualitative and quantitative differences in peptides bound to HLA-B27 in the presence of mouse versus human tapasin define a role for tapasin as a size-dependent peptide editor

Sesma, L., Galocha, B., Vázquez, M., Purcell, A. W., Marcilla, M., McCluskey, J. & López De Castro, J. A., 15 Jun 2005, In : Journal of Immunology. 174, 12, p. 7833-7844 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Wu, T., Guan, J., Handel, A., Tscharke, D. C., Sidney, J., Sette, A., Wakim, L. M., Sng, X. Y. X., Thomas, P. G., Croft, N. P., Purcell, A. W. & La Gruta, N. L., 28 Jun 2019, In : Nature Communications. 10, 1, 14 p., 2846.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Quantifying epitope presentation using mass spectrometry

Croft, N. P., Purcell, A. W. & Tscharke, D. C., 2015, In : Molecular Immunology. 68, 2 - Part A, p. 77 - 80 4 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)

Quantitative and qualitative influences of tapasin on the class I peptide repertoire

Purcell, A. W., Gorman, J. J., Garcia-Peydró, M., Paradela, A., Burrows, S. R., Talbo, G. H., Laham, N., Chen Au Peh, A. P., Reynolds, E. C., López de Castro, J. A. & McCluskey, J., 15 Jan 2001, In : Journal of Immunology. 166, 2, p. 1016-1027 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
127 Citations (Scopus)

Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain

Dagley, L. F., White, C. A., Liao, Y., Shi, W., Smyth, G. K., Orian, J. M., Emili, A. & Purcell, A. W., 2014, In : Proteomics. 14, 2-3, p. 241 - 261 21 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Quokka: A comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome

Li, F., Li, C., Marquez-Lago, T. T., Leier, A., Akutsu, T., Purcell, A. W., Smith, A. I., Lithgow, T., Daly, R. J., Song, J. & Chou, K-C., 15 Dec 2018, In : Bioinformatics. 34, 24, p. 4223-4231 9 p., bty522.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

Safavi-Hemami, H., Li, Q., Jackson, R. L., Song, A. S., Boomsma, W., Bandyopadhyay, P. K., Gruber, C. W., Purcell, A. W., Yandell, M., Olivera, B. M. & Ellgaard, L., 22 Mar 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3227-3232 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Rapid microscale in-gel processing and digestion of proteins using surface acoustic waves

Kulkarni, K., Ramarathinam, S., Friend, J., Yeo, L., Purcell, A. & Perlmutter, P., 2010, In : Lab on a Chip. 10, 12, p. 1518 - 1520 3 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjogren's syndrome

Reed, J. H., Dudek, N. L., Osborne, S. E., Kaufmann, K. M., Jackson, M. W., Purcell, A. W. & Gordon, T. P., 2010, In : Arthritis & Rheumatism. 62, 5, p. 1448 - 1456 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Nguyen, T. H. O., Mifsud, N. A., Stewart, L. A., Rose, M. J., Etto, T. L., Williamson, N. A., Purcell, A. W., Kotsimbos, T. C. & Schwarer, A., 2008, In : Protein Expression and Purification. 61, 1, p. 22 - 30 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Krishnamurthy, B., Dudek, N. L., McKenzie, M. D., Purcell, A. W., Brooks, A. G., Gellert, S., Colman, P. G., Harrison, L. C., Lew, A. M., Thomas, H. E. & Kay, T. W. H., 1 Dec 2006, In : Journal of Clinical Investigation. 116, 12, p. 3258-3265 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
168 Citations (Scopus)
Open Access
4 Citations (Scopus)

Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDA Ro (SS-A) in experimental autoimmunity

Gordon, T. P., Kinoshita, G., Cavill, D., Keech, C., Farris, A. D., Kaufman, K., McCluskey, J. & Purcell, A. W., 27 Jul 2002, In : Scandinavian Journal of Immunology. 56, 2, p. 168-173 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes

Schittenhelm, R. B., Lim Kam Sian, T. C. C., Wilmann, P. G., Dudek, N. L. & Purcell, A. W., 2015, In : Arthritis & Rheumatology. 67, 3, p. 702 - 713 12 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

RP-HPLC binding domains of proteins

Aguilar, M-I., Clayton, D. J., Holt, P., Kronina, V., Boysen, R. I., Purcell, A. W. & Hearn, M. T. W., 1998, In : Analytical Chemistry. p. 5010 - 5018 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02: 01 ligands

Scull, K. E., Dudek, N. L., Corbett, A. J., Ramarathinam, S. H., Gorasia, D. G., Williamson, N. A. & Purcell, A. W., Jun 2012, In : Molecular Immunology. 51, 2, p. 136-142 7 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients

Gresle, M. M., Liu, Y., Dagley, L. F., Haartsen, J., Pearson, F., Purcell, A. W., Laverick, L., Petzold, A., Lucas, R. M., van der Walt, A., Prime, H., Lazarus, K-J. L., Taylor, B. V., Morris, D. R., Shaw, G. P. J. & Butzkueven, H., 1 Nov 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 11, p. 1209-1213 5 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Simultaneous quantification of viral antigen expression kinetics using data-independent (DIA) mass spectrometry

Croft, N. P., de Verteuil, D. A., Smith, S. A., Wong, Y. C., Schittenhelm, R. B., Tscharke, D. C. & Purcell, A. W., 2015, In : Molecular & Cellular Proteomics. 14, 5, p. 1361 - 1372 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway

Safavi-Hemami, H., Siero, W. A., Gorasia, D. G., Young, N. D., MacMillan, D., Williamson, N. A. & Purcell, A. W., 2 Sep 2011, In : Journal of Proteome Research. 10, 9, p. 3904-3919 16 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Specialized insulin is used for chemical warfare by fish-hunting cone snails

Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, L. & Olivera, B. M., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743 - 1748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
72 Citations (Scopus)

Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity

Kinoshita, G., Keech, C. L., Sontheimer, R. D., Purcell, A., McCluskey, J. & Gordon, T. P., 9 Feb 1998, In : Lupus. 7, 1, p. 7-11 5 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

Reilly, C. B., Ramarathinam, S. H., Williamson, N. A. & Purcell, A. W., 17 Jan 2011, In : Proteome Science. 9, 7 p., 2.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Structural and biological basis of CTL escape in coronavirus-infected mice

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : Journal of Immunology. 180, 6, p. 3926 - 3937 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes

Trujillo, J. A., Gras, S., Twist, K-A., Croft, N. P., Channappanavar, R., Rossjohn, J., Purcell, A. W. & Perlman, S., 2014, In : Journal of Immunology. 192, 11, p. 5245 - 5256 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Structural and regulatory diversity shape HLA-C protein expression levels

Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortes, A., Barber, T., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., Carrington, M., McVean, G., Purcell, A. W., Rossjohn, J. & Fugger, L., 26 Jun 2017, In : Nature Communications. 8, 12 p., 15924.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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37 Citations (Scopus)

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Day, E. B., Guillonneau, C., Gras, S., La Gruta, N. L., Vignali, D., Doherty, P., Purcell, A., Rossjohn, J. & Turner, S., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 23, p. 9536 - 9541 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Newcombe, E. A., Ruff, K. M., Sethi, A., Ormsby, A. R., Ramdzan, Y. M., Fox, A. H., Purcell, A. W., Gooley, P. R., Pappu, R. V. & Hatters, D. M., 11 May 2018, In : Journal of Molecular Biology. 430, 10, p. 1442-1458 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Tapasin-mediated retention and optimization of peptide ligands during the assembly of class I molecules

Barnden, M. J., Purcell, A. W., Gorman, J. J. & McCluskey, J., 1 Jul 2000, In : Journal of Immunology. 165, 1, p. 322-330 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
82 Citations (Scopus)

TAP genes and immunity

McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Current Opinion in Immunology. 16, 5, p. 651 - 659 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

T cell allorecognition via molecular mimicry

Macdonald, W. A., Chen, Z., Gras, S., Archbold, J. K., Tynan, F. E., Clements, C. S., Bharadwaj, M., Kjer-Nielsen, L., Saunders, P. M., Wilce, M. C. J., Crawford, F., Stadinsky, B., Jackson, D., Brooks, A., Purcell, A. W., Kappler, J., Burrows, S. R., Rossjohn, J. & McCluskey, J., 2009, In : Immunity. 31, 6, p. 897 - 908 12 p.

Research output: Contribution to journalArticleResearchpeer-review

166 Citations (Scopus)

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., Miners, K. L., McLaren, J. E., Grant, E. J., Haigh, O. L., Watkins, T. S., Suliman, S., Iwany, S., Jimenez, J., Calderon, R., Tamara, K. L., Leon, S. R., Murray, M. B., Mayfield, J. A., Altman, J. D. & 8 others, Purcell, A. W., Miles, J. J., Godfrey, D. I., Gras, S., Price, D. A., Van Rhijn, I., Moody, D. B. & Rossjohn, J., 1 Apr 2018, In : Nature Immunology. 19, 4, p. 397-406 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

Law, S. C. C., Street, S., Yu, C. H. A., Capini, C., Ramnoruth, S., Nel, H. J., van Gorp, E., Hyde, C., Lau, K., Pahau, H., Purcell, A. W. & Thomas, R., 17 May 2012, In : Arthritis Research & Therapy. 14, 3, R118.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
79 Citations (Scopus)

T cell cross-reactivity between a highly immunogenic EBV epitope and a self-peptide naturally presented by HLA-B*18:01+ cells

Rist, M. J., Hibbert, K. M., Croft, N. P., Smith, C., Neller, M. A., Burrows, J. M., Miles, J. J., Purcell, A. W., Rossjohn, J., Gras, S. & Burrows, S. R., 2015, In : Journal of Immunology. 194, 10, p. 4668 - 4675 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo

Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A. J., Perlmutter, P., McCluskey, J., Aguilar, M-I., Rossjohn, J. & Purcell, A. W., 2005, In : Journal of Immunology. 175, 6, p. 3810 - 3818 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Petersen, J., Ciacchi, L., Tran, M. T., Loh, K. L., Kooy-Winkelaar, Y., Croft, N. P., Hardy, M. Y., Chen, Z., McCluskey, J., Anderson, R. P., Purcell, A. W., Tye-Din, J. A., Koning, F., Reid, H. H. & Rossjohn, J., Jan 2020, In : Nature Structural & Molecular Biology. 27, p. 49-61 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

218 Citations (Scopus)

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Beringer, D. X., Kleijwegt, F. S., Wiede, F., Van Der Slik, A. R., Loh, K. K. L., Petersen, J., Dudek, N. L., Duinkerken, G., Laban, S., Joosten, A. M., Vivian, J. P., Chen, Z., Uldrich, A. P., Godfrey, D. I., McCluskey, J., Price, D. A., Radford, K. J., Purcell, A. W., Nikolic, T., Reid, H. H. & 3 others, Tiganis, T., Roep, B. O. & Rossjohn, J., 2015, In : Nature Immunology. 16, 11, p. 1153 - 1161 9 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

T-cells behaving badly: Structural insights into alloreactivity and autoimmunity

Ely, L. K., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2008, In : Current Opinion in Immunology. 20, 5, p. 575 - 580 6 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Tentacle Transcriptomes of the Speckled Anemone (Actiniaria: Actiniidae: Oulactis sp.): Venom-Related Components and Their Domain Structure

Mitchell, M. L., Tonkin-Hill, G. Q., Morales, R. A. V., Purcell, A. W., Papenfuss, A. T. & Norton, R. S., Apr 2020, In : Marine Biotechnology. 22, p. 207-219 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

The 1.5 Å crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Structure. 10, 11, p. 1521-1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

The 1.5 Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immonodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Structure. 10, 11, p. 1521 - 1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review