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PhD projects

Cancer Immunology Autoimmunity (Diabetes, arthritis, psoriasis, MS) Antigen processing and presentation Vaccine design Bioinformatics

1989 …2022

Research output per year

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Research Output

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Article
2002

The 1.5 Å crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Structure. 10, 11, p. 1521-1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

The 1.5 Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immonodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Structure. 10, 11, p. 1521 - 1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The central role played by peptides in the immune response and the design of peptide-based vaccines against infectious diseases and cancer

Jackson, D. C., Purcell, A. W., Fitzmaurice, C. J., Zeng, W. & Hart, D. N. J., 1 Jan 2002, In : Current Drug Targets. 3, 2, p. 175-196 22 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

The production, purification and crystallization of a soluble heterdimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., Macdonald, W. A., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131 - 2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., MacDonald, W. A., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Dec 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131-2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The structure of HLA-B8 complexed to an immunodominant viral determinant: Peptide-induced conformational changes and a mode of MHC class I dimerization

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Journal of Immunology. 169, 9, p. 5153-5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and a mode of MHC class 1 dimerisation1

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 2002, In : Journal of Immunology. 169, 9, p. 5153 - 5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Quantitative and qualitative influences of tapasin on the class I peptide repertoire

Purcell, A. W., Gorman, J. J., Garcia-Peydró, M., Paradela, A., Burrows, S. R., Talbo, G. H., Laham, N., Chen Au Peh, A. P., Reynolds, E. C., López de Castro, J. A. & McCluskey, J., 15 Jan 2001, In : Journal of Immunology. 166, 2, p. 1016-1027 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
127 Citations (Scopus)
2000

Endogenous and exogenous factors contributing to the surface expression of HLA B27 on mutant APC

Purcell, A. W., Kelly, A. J., Peh, C. A., Dudek, N. L. & McCluskey, J., 1 Feb 2000, In : Human Immunology. 61, 2, p. 120-130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Tapasin-mediated retention and optimization of peptide ligands during the assembly of class I molecules

Barnden, M. J., Purcell, A. W., Gorman, J. J. & McCluskey, J., 1 Jul 2000, In : Journal of Immunology. 165, 1, p. 322-330 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
82 Citations (Scopus)
1999

Comparison between the isocratic and gradient retention behaviour of polypeptides in reversed-phase liquid chromatographic environments

Purcell, A. W., Zhao, G. L., Aguilar, M. I. & Hearn, M. T. W., 6 Aug 1999, In : Journal of Chromatography A. 852, 1, p. 43-57 15 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice

Kinoshita, G., Purcell, A. W., Keech, C. L., Farris, A. D., McCluskey, J. & Gordon, T. P., 1 Jan 1999, In : Clinical and Experimental Immunology. 115, 2, p. 268-274 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)

Probing the binding behavior and conformational states of globular proteins in reversed-phased high-performance liquid chromatography

Purcell, A. W., Aguilar, M. I. & Hearn, M. T. W., 1 Jul 1999, In : Analytical Chemistry. 71, 13, p. 2440-2451 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
1998

Avoidance of self-reactivity results in skewed CTL responses to rare components of synthetic immunogens

Purcell, A. W., Chen, W., Ede, N. J., Gorman, J. J., Fecondo, J. V., Jackson, D. C., Zhao, Y. & McCluskey, J., 1 Feb 1998, In : Journal of Immunology. 160, 3, p. 1085-1090 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Determinant spreading: Lessons from animal models and human disease

McCluskey, J., Farris, A. D., Keech, C. L., Purcell, A. W., Rischmueller, M., Kinoshita, G., Reynolds, P. & Gordon, T. P., 1 Aug 1998, In : Immunological Reviews. 164, p. 209-229 21 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)

Elucidation of functionally significant structural modifications by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with post-source decay

German, J. J., Purcell, A. W., Ferguson, B. L., Lopaticki, S., Morrow, C. J. & Mineva, E., 12 Sep 1998, In : Journal of Protein Chemistry. 17, 6, p. 526-527 2 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

RP-HPLC binding domains of proteins

Aguilar, M-I., Clayton, D. J., Holt, P., Kronina, V., Boysen, R. I., Purcell, A. W. & Hearn, M. T. W., 1998, In : Analytical Chemistry. p. 5010 - 5018 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity

Kinoshita, G., Keech, C. L., Sontheimer, R. D., Purcell, A., McCluskey, J. & Gordon, T. P., 9 Feb 1998, In : Lupus. 7, 1, p. 7-11 5 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
1996

CTL Recognition of an Altered Peptide Associated with Asparagine Bond Rearrangement: Implications for Immunity and Vaccine Design

Chen, W., Ede, N. J., Jackson, D. C., McCluskey, J. & Purcell, A. W., 1 Aug 1996, In : Journal of Immunology. 157, 3, p. 1000-1005 6 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice

Reynolds, P., Gordon, T. P., Purcell, A. W., Jackson, D. C. & McCluskey, J., 1 Nov 1996, In : Journal of Experimental Medicine. 184, 5, p. 1857-1870 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
59 Citations (Scopus)

Nonprecipitating anti-La(SS-B) autoantibodies in primary Sjogren's syndrome

Beer, R. G., Rischmueller, M., Coates, T., Purcell, A. W., Keech, C. L., McCluskey, J. & Gordon, T. P., 1 Jan 1996, In : Clinical Immunology and Immunopathology. 79, 3, p. 314-318 5 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

The accessibility of the prosthetic group biotin during monomeric avidin affinity chromatography

Purcell, A. W. & Wallace, J. C., 1 Jan 1996, In : Analytical Biochemistry. 238, 2, p. 213-216 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
1995
41 Citations (Scopus)

Identification and synthesis of altered peptides modulating T cell recognition of a synthetic peptide antigen.

Ede, N. J., Chen, W., McCluskey, J., Jackson, D. C. & Purcell, A. W., 1 Jan 1995, In : Biomedical Peptides, Proteins & Nucleic Acids: Structure, Synthesis & Biological Activity. 1, 4, p. 231-234 4 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Induction of amphipathic helical peptide structures in RP-HPLC.

Purcell, A. W., Aguilar, M. I., Wettenhall, R. E. & Hearn, M. T., 1 Jan 1995, In : Peptide Research. 8, 3, p. 160-170 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
1993
44 Citations (Scopus)
1992
64 Citations (Scopus)