Accepting PhD Students

PhD projects

Cancer Immunology Autoimmunity (Diabetes, arthritis, psoriasis, MS) Antigen processing and presentation Vaccine design Bioinformatics

1989 …2020

Research output per year

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Research Output

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Article
2009

The shaping of T cell receptor recognition by self-tolerance

Gras, S., Burrows, S. R., Kjer-Nielsen, L., Clements, C. S., Liu, Y. C., Sullivan, L. C., Bell, M. J., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 2, p. 193 - 203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)
2008

Can α- and β-Alanine Containing Peptides Be Distinguished Based on the CID Spectra of Their Protonated Ions?

Lam, A. K. Y., Ramarathinam, S. H., Purcell, A. W. & O'Hair, R. A. J., Dec 2008, In : Journal of the American Society for Mass Spectrometry. 19, 12, p. 1743-1754 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

Kedzierska, K., Guillonneau, C., Gras, S., Hatton, L. A., Webby, R., Purcell, A. W., Rossjohn, J., Doherty, P. C. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 49, p. 19408 - 19413 5 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Chessman, D., Kostenko, L., Lethborg, T., Purcell, A. W., Williamson, N. A., Chen, Z., Kjer-Nielsen, L., Mifsud, N. A., Tait, B. D., Holdsworth, R., Almeida, C. A., Nolan, D., Macdonald, W. A., Archbold, J. K., Kellerher, A. D., Marriott, D., Mallal, S., Bharadwaj, M., Rossjohn, J. & McCluskey, J., 2008, In : Immunity. 28, 6, p. 822 - 832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

241 Citations (Scopus)

Immunodominance hierarchies and gender bias in direct Tcd8-cell alloreactivity

Mifsud, N. A., Purcell, A. W., Chen, W. W., Holdsworth, R., Tait, B. D. & McCluskey, J., 2008, In : American Journal of Transplantation. 8, 1, p. 121 - 132 12 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : PLoS Pathogens. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Nguyen, T. H. O., Mifsud, N. A., Stewart, L. A., Rose, M. J., Etto, T. L., Williamson, N. A., Purcell, A. W., Kotsimbos, T. C. & Schwarer, A., 2008, In : Protein Expression and Purification. 61, 1, p. 22 - 30 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structural and biological basis of CTL escape in coronavirus-infected mice

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : Journal of Immunology. 180, 6, p. 3926 - 3937 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

T-cells behaving badly: Structural insights into alloreactivity and autoimmunity

Ely, L. K., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2008, In : Current Opinion in Immunology. 20, 5, p. 575 - 580 6 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

The enantioselective total synthesis and unambiguous proof of the absolute stereochemistry of pervilleine C

Kulkarni, K. P., Zhao, A. Y., Purcell, A. W. & Perlmutter, P., 2008, In : Synlett. 2008, 14, p. 2209 - 2212 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2007

?-Amino acid-containing hybrid peptides - New opportunities in peptidomimetics

Aguilar, M. I., Purcell, A. W., Devi, R., Lew, R. A., Rossjohn, J., Smith, A. I. & Perlmutter, P., 2007, In : Organic and Biomolecular Chemistry. 5, 18, p. 2884 - 2890 7 p.

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease

Henderson, K., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N., Beissbarth, T., Tatham, A., Mannering, S. I., Purcell, A. W., Dudek, N. L., van Heel, D. A., McCluskey, J., Rossjohn, J. & Anderson, R. P., 2007, In : Immunity. 27, 1, p. 23 - 34 12 p.

Research output: Contribution to journalArticleResearchpeer-review

119 Citations (Scopus)

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Tynan, F. E., Reid, H. H., Kjer-Nielsen, L., Miles, J. J., Wilce, M. C. J., Kostenko, L., Borg, N., Williamson, N. A., Beddoe, T. C., Purcell, A. W., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2007, In : Nature Immunology. 8, 3, p. 268 - 276 9 p.

Research output: Contribution to journalArticleResearchpeer-review

163 Citations (Scopus)

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space

Gentle, I. E., Perry, A. J., Alcock, F. H., Likic, V. A., Dolezal, P., Ng, E. T., Purcell, A. W., McConnville, M., Naderer, T., Chanez, A-L., Charriere, F., Aschinger, C., Schneider, A., Tokatlidis, K. & Lithgow, T. J., 2007, In : Molecular Biology and Evolution. 24, 5, p. 1149 - 1160 12 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

Etto, T., Stewart, L., Nguyen, T. H. O., Williamson, N., Purcell, A. & Schwarer, A., 2007, In : Protein Expression and Purification. 54, 1, p. 176 - 182 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

Martin, A. M., Almeida, C. A., Cameron, P., Purcell, A. W., Nolan, D., James, I., McCluskey, J., Phillips, E., Landay, A. & Mallal, S., 1 Jun 2007, In : AIDS. 21, 10, p. 1233-1244 12 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

More than one reason to rethink the use of peptides in vaccine design

Purcell, A. W., McCluskey, J. & Rossjohn, J., 2007, In : Nature Reviews Drug Discovery. 6, 5, p. 404 - 414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

440 Citations (Scopus)

Post translationally modified peptides: New targets in autoimmune disease

Lau, K. & Purcell, A. W., 2 Aug 2007, In : Chimica Oggi. 25, p. 6-9 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)

Winkel, K., Carroll, T., Williamson, N. A., Ignjatovic, V., Fung, K., Purcell, A. W. & Fry, B. G., 15 Dec 2007, In : Toxicon. 50, 8, p. 1041-1052 12 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2006

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

Chong, Y. P., Chan, A. S., Chan, K. C., Williamson, N. A., Lerner, E. C., Smithgall, T. E., Bjorge, J. D., Fujita, D. J., Purcell, A. W., Scholz, G., Mulhern, T. D. & Cheng, H. C., 3 Nov 2006, In : The Journal of Biological Chemistry. 281, 44, p. 32988-32999 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

Disparate thermodynamics governing T cell receptor-MHC-1 interactions implicate extrinsic factors in guiding MHC restriction

Ely, L. K., Beddoe, T. C., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 17, p. 6641 - 6646 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Krishnamurthy, B., Dudek, N. L., McKenzie, M. D., Purcell, A. W., Brooks, A. G., Gellert, S., Colman, P. G., Harrison, L. C., Lew, A. M., Thomas, H. E. & Kay, T. W. H., 1 Dec 2006, In : Journal of Clinical Investigation. 116, 12, p. 3258-3265 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
168 Citations (Scopus)

Tumors reveal their secrets to cytotoxic T cells

Williamson, N. A., Rossjohn, J. & Purcell, A. W., 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 40, p. 14649 - 14650 2 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
2005

A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation

Petersen, J. L., Hickman-Miller, H. D., McIlhaney, M. M., Vargas, S. E., Purcell, A. W., Hildebrand, W. H. & Solheim, J. C., 15 Jan 2005, In : Journal of Immunology. 174, 2, p. 962-969 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
40 Citations (Scopus)

Antagonism of antiviral and allogeneic activity of a human public ctl clonotype by a single altered peptide ligand: Implications for allograft rejection

Ely, L. K., Green, K. J., Beddoe, T. C., Clements, C. S., Miles, J. J., Bottomley, S. P., Zernich, D., Kjer-Nielsen, L., Purcell, A. W., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Immunology. 174, 9, p. 5593 - 5601 9 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

CTL recognition of a bulged viral peptide involves biased TCR selection

Miles, J. J., Elhassen, D., Borg, N. A., Silins, S. L., Tynan, F. E., Burrows, J. M., Purcell, A. W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S. R. & McCluskey, J., 2005, In : Journal of Immunology. 175, 6, p. 3826 - 3834 9 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance

Tynan, F. E., Borg, N., Miles, J. J., Beddoe, T. C., Elhassen, D., Silins, S. L., van Zuylen, W. JM., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2005, In : The Journal of Biological Chemistry. 280, 25, p. 23900 - 23909 10 p.

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J. & Doherty, P. C., 2005, In : Nature Immunology. 6, 4, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

122 Citations (Scopus)

Qualitative and quantitative differences in peptides bound to HLA-B27 in the presence of mouse versus human tapasin define a role for tapasin as a size-dependent peptide editor

Sesma, L., Galocha, B., Vázquez, M., Purcell, A. W., Marcilla, M., McCluskey, J. & López De Castro, J. A., 15 Jun 2005, In : Journal of Immunology. 174, 12, p. 7833-7844 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo

Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A. J., Perlmutter, P., McCluskey, J., Aguilar, M-I., Rossjohn, J. & Purcell, A. W., 2005, In : Journal of Immunology. 175, 6, p. 3810 - 3818 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

218 Citations (Scopus)

The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Borg, N. A., Ely, L. K., Beddoe, T. C., Macdonald, W. A., Reid, H. H., Clements, C. S., Purcell, A. W., Kjer-Nielsen, L., Miles, J. J., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 2, p. 171 - 180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Tynan, F. E., Elhassen, D., Purcell, A. W., Burrows, J. M., Borg, N. A., Miles, J. J., Williamson, N. A., Green, K. J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1249 - 1260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

Mannering, S. I., Harrison, L. C., Williamson, N. A., Morris, J. S., Thearle, D. J., Jensen, K. P., Kay, T. W., Rossjohn, J., Falk, B. A., Nepom, G. T. & Purcell, A. W., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1191 - 1197 7 p.

Research output: Contribution to journalArticleResearchpeer-review

145 Citations (Scopus)
2004

Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3

Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T. C., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J. & Rossjohn, J., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 20, p. 7675 - 7680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Webb, A. I., Dunstone, M. A., Chen, W., Aguilar, M. I., Chen, Q., Jackson, H., Chang, L., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : The Journal of Biological Chemistry. 279, 22, p. 23438 - 23446 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Isolation and characterization of naturally processed MHC-bound peptides from the surface of antigen-presenting cells.

Purcell, A. W., 1 Jan 2004, In : Methods in molecular biology (Clifton, N.J.). 251, p. 291-306 16 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Zernich, D., Purcell, A. W., Macdonald, W. A., Kjer-Nielsen, L., Ely, L. K., Laham, N., Crockford, T., Mifsud, N. A., Bharadwaj, M., Chang, L., Tait, B. D., Holdsworth, R., Brooks, A. G., Bottomley, S. P., Beddoe, T. C., Peh, C. A., Rossjohn, J. & McCluskey, J., 2004, In : Journal of Experimental Medicine. 200, 1, p. 13 - 24 12 p.

Research output: Contribution to journalArticleResearchpeer-review

118 Citations (Scopus)

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Martin, A. M., Nolan, D., Gaudieri, S., Almeida, C. A., Nolan, R., James, I., Carvalho, F., Phillips, E., Christiansen, F. T., Purcell, A. W., McCluskey, J. & Mallal, S., 23 Mar 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4180-4185 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
393 Citations (Scopus)

TAP genes and immunity

McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Current Opinion in Immunology. 16, 5, p. 651 - 659 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

The production and purification of the human T-cell receptors, the CD3and CD3heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425 - 1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 1 Aug 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425-1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance

Webb, A. I., Borg, N. A., Dunstone, M. A., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Carbone, F. R., Bottomley, S. P., Aguilar, M. I., Purcell, A. W. & Rossjohn, J., 2004, In : Journal of Immunology. 173, 1, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2003

A naturally selected dimorphism within the HLA-B44 supertype alters Class I structure, peptide repertoire, and T cell recognition

Macdonald, W. A., Purcell, A. W., Mifsud, N. A., Ely, L. K., Williams, D. S., Chang, L., Gorman, J. J., Clements, C. S., Kjer-Nielsen, L., Koelle, D. M., Burrows, S. R., Tait, B. D., Holdsworth, R., Brooks, A. G., Lovrecz, G. O., Lu, L., Rossjohn, J. & McCluskey, J., 2003, In : Journal of Experimental Medicine. 198, 5, p. 679 - 691 13 p.

Research output: Contribution to journalArticleResearchpeer-review

157 Citations (Scopus)

A sensitive method for detecting proliferation of rare autoantigen- specific human T cells

Mannering, S. I., Morris, J. S., Jensen, K. P., Purcell, A. W., Honeyman, M. C., Van Endert, P. M. & Harrison, L. C., 1 Jan 2003, In : Journal of Immunological Methods. 283, 1-2, p. 173-183 11 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

Association of stress proteins with autoantigens: A possible mechanism for triggering autoimmunity?

Purcell, A. W., Todd, A., Kinoshita, G., Lynch, T. A., Keech, C. L., Gething, M. J. & Gordon, T. P., 1 May 2003, In : Clinical and Experimental Immunology. 132, 2, p. 193-200 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
46 Citations (Scopus)

A structural basis for the selection of dominant T cell receptors in antiviral immunity

Kjer-Nielsen, L., Clements, C. S., Purcell, A. W., Brooks, A. G., Whisstock, J. C., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2003, In : Immunity. 18, 1, p. 53 - 64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

280 Citations (Scopus)

Human T-cells recognise N-terminally Fmoc-modified peptide

Mannering, S. I., Purcell, A. W., Honeyman, M. C., McCluskey, J. & Harrison, L. C., 1 Jan 2003, In : Vaccine. 21, 25-26, p. 3638-3646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

Chang, L., Kjer-Nielsen, L., Flynn, S., Brooks, A. G., Mannering, S. I., Honeyman, M. C., Harrison, L. C., McCluskey, J. & Purcell, A. W., 1 Nov 2003, In : Tissue Antigens. 62, 5, p. 408-417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)