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Research Output 1989 2019

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2010
80 Citations (Scopus)

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Burrows, S. R., Chen, Z., Archbold, J. K., Tynan, F. E., Beddoe, T. C., Kjer-Nielsen, L., Miles, J. J., Khanna, R., Moss, D. J., Liu, Y. C., Gras, S., Kostenko, L., Brennan, R. M., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 23, p. 10608 - 10613 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins

Safavi-Hemami, H., Bulaj, G., Olivera, B. M., Williamson, N. A. & Purcell, A. W., 23 Apr 2010, In : Journal of Biological Chemistry. 285, 17, p. 12735-12746 12 p.

Research output: Contribution to journalArticleOtherpeer-review

31 Citations (Scopus)

Molecular markers of preterm labor in the choriodecidua

Shankar, R., Johnson, M. P., Williamson, N. A., Cullinane, F., Purcell, A. W., Moses, E. K. & Brennecke, S. P., Mar 2010, In : Reproductive Sciences. 17, 3, p. 297-310 14 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold

Valkenburg, S. A., Gras, S., Guillonneau, C., La Gruta, N. L., Thomas, P. G., Purcell, A. W., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2010, In : PLoS Pathogens. 6, 8 (e1001039), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Proteomic interrogation of venom delivery in marine cone snails: Novel insights into the role of the venom bulb

Safavi-Hemami, H., Young, N. D., Williamson, N. A. & Purcell, A. W., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 5610-5619 10 p.

Research output: Contribution to journalArticleOtherpeer-review

13 Citations (Scopus)

Rapid microscale in-gel processing and digestion of proteins using surface acoustic waves

Kulkarni, K., Ramarathinam, S., Friend, J., Yeo, L., Purcell, A. & Perlmutter, P., 2010, In : Lab on a Chip. 10, 12, p. 1518 - 1520 3 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjogren's syndrome

Reed, J. H., Dudek, N. L., Osborne, S. E., Kaufmann, K. M., Jackson, M. W., Purcell, A. W. & Gordon, T. P., 2010, In : Arthritis and Rheumatism. 62, 5, p. 1448 - 1456 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Pang, S. S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M. A., King, G. F., Wang, C. C., Chew, S. H., La Gruta, N. L., Williams, N. K., Beddoe, T. C., Tiganis, T., Cowieson, N. P., Godfrey, D. I., Purcell, A. W., Wilce, M. CJ., McCluskey, J. & Rossjohn, J., 2010, In : Nature. 467, 7317, p. 844 - 848 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
3 Citations (Scopus)

A novel strategy for the targeted analysis of protein and peptide metabolites

Williamson, N. A., Reilly, C., Tan, C. T., Ramarathinam, S. H., Jones, A., Hunter, C. L., Rooney, F. R. & Purcell, A. W., 2 Jan 2011, In : Proteomics. 11, 2, p. 183-192 10 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells

Fernandez, S., Tanaskovic, S., Helbig, K., Rajasuriar, R., Kramski, M., Murray, J. M., Beard, M. R., Purcell, A. W., Lewin, S. R., Price, P. & French, M., 2011, In : Journal of Infectious Diseases. 204, 12, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate

Ia, K. K., Jeschke, G. R., Deng, Y., Kamaruddin, M. A., Williamson, N. A., Scanlon, D. B., Culvenor, J. G., Hossain, M. I., Purcell, A. W., Liu, S., Zhu, H-J., Catimel, B., Turk, B. E. & Cheng, H-C., 9 Aug 2011, In : Biochemistry. 50, 31, p. 6667-6677 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring

Tan, C. T., Croft, N. P., Dudek, N. L., Williamson, N. A. & Purcell, A. W., 2011, In : Proteomics. 11, 11, p. 2336 - 2340 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?

Safavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22546 - 22557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis

Pham, H., Doerrbecker, J., Ramp, A. A., D'Souza, C. S., Gorasia, D. G., Purcell, A. W., Ayers, M. & Orian, J. M., Mar 2011, In : Journal of Neuroimmunology. 232, 1-2, p. 51-62 12 p.

Research output: Contribution to journalArticleOtherpeer-review

489 Citations (Scopus)

Linear ubiquitination prevents inflammation and regulates immune signalling

Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W. L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J. & Walczak, H., 31 Mar 2011, In : Nature. 471, 7340, p. 591-596 6 p.

Research output: Contribution to journalArticleOtherpeer-review

24 Citations (Scopus)

Peptidomimetics: modifying peptides in the pursuit of better vaccines

Croft, N. P. & Purcell, A. W., 2011, In : Expert Review of Vaccines. 10, 2, p. 211 - 226 16 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway

Safavi-Hemami, H., Siero, W. A., Gorasia, D. G., Young, N. D., MacMillan, D., Williamson, N. A. & Purcell, A. W., 2 Sep 2011, In : Journal of Proteome Research. 10, 9, p. 3904-3919 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

Reilly, C. B., Ramarathinam, S. H., Williamson, N. A. & Purcell, A. W., 17 Jan 2011, In : Proteome Science. 9, 7 p., 2.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Day, E. B., Guillonneau, C., Gras, S., La Gruta, N. L., Vignali, D., Doherty, P., Purcell, A., Rossjohn, J. & Turner, S., 2011, In : Proceedings of the National Academy of Sciences. 108, 23, p. 9536 - 9541 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

β2-glycoprotein I and protection from anti-SSA/Ro60- associated cardiac manifestations of neonatal lupus

Reed, J. H., Clancy, R. M., Purcell, A. W., Kim, M. Y., Gordon, T. P. & Buyon, J. P., 1 Jul 2011, In : Journal of Immunology. 187, 1, p. 520-526 7 p.

Research output: Contribution to journalArticleOtherpeer-review

2012
32 Citations (Scopus)

A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule

Gras, S., Wilmann, P., Chen, Z., Abd Halim, N. H., Liu, Y. C., Kjer-Nielsen, L., Purcell, A. W., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2012, In : Journal of Immunology. 188, 1, p. 311-321 11 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease

Broughton, S. E., Petersen, J., Theodossis, A., Scally, S. W., Loh, K. L., Thompson, A., van Bergen, J., Kooy-Winkelaar, Y., Henderson, K. N., Beddoe, T. C., Tye-Din, J. A., Mannering, S. I., Purcell, A. W., McCluskey, J., Anderson, R. P., Koning, F., Reid, H. H. & Rossjohn, J., 2012, In : Immunity. 37, 4, p. 611 - 621 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Constitutive and inflammatory immunopeptidome of pancreatic beta-cells

Dudek, N. L., Tan, C. T., Gorasia, D. G., Croft, N. P., Illing, P. T. & Purcell, A. W., 2012, In : Diabetes. 61, 11, p. 3018 - 3025 8 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Discovery of an archetypal protein transport system in bacterial outer membranes

Selkrig, J., Mosbahi, K., Webb, C. T., Belousoff, M. J., Perry, A. J., Wells, T. J., Morris, F. C., Leyton, D. L., Totsika, M., Phan, M-D., Celik, N., Kelly, M., Oates, C., Hartland, E. L., Robins-Browne, R. M., Ramarathinam, S. H., Purcell, A. W., Schembri, M. A., Strugnell, R. A., Henderson, I. R. & 2 others, Walker, D. & Lithgow, T. J., 2012, In : Nature Structural and Molecular Biology. 19, 5 (S 1), p. 506 - 510 5 p.

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)

Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex

Bharadwaj, M., Illing, P., Theodossis, A., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Annual Review of Pharmacology and Toxicology. 52, p. 401 - 431 31 p.

Research output: Contribution to journalArticleResearchpeer-review

388 Citations (Scopus)

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Illing, P. T., Vivian, J. P., Dudek, N. L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J. J., Kjer-Nielsen, L., Gras, S., Williamson, N. A., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 486, 7404, p. 554 - 558 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails

Safavi-Hemami, H., Gorasia, D. G., Steiner, A. M., Williamson, N. A., Karas, J., Gajewiak, J., Olivera, B. M., Bulaj, G. & Purcell, A. W., 2012, In : Journal of Biological Chemistry. 287, 41, p. 34288 - 34303 16 p.

Research output: Contribution to journalArticleResearchpeer-review

516 Citations (Scopus)

MR1 presents microbial vitamin B metabolites to MAIT cells

Kjer-Nielsen, L., Patel, O. G., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N. A., Purcell, A. W., Dudek, N. L., McConville, M. J., O'Hair, R. AJ., Khairallah, G. N., Godfrey, D. I., Fairlie, D. P., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 491, 7426, p. 717 - 723 7 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02: 01 ligands

Scull, K. E., Dudek, N. L., Corbett, A. J., Ramarathinam, S. H., Gorasia, D. G., Williamson, N. A. & Purcell, A. W., Jun 2012, In : Molecular Immunology. 51, 2, p. 136-142 7 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

Law, S. C. C., Street, S., Yu, C. H. A., Capini, C., Ramnoruth, S., Nel, H. J., van Gorp, E., Hyde, C., Lau, K., Pahau, H., Purcell, A. W. & Thomas, R., 17 May 2012, In : Arthritis Research and Therapy. 14, 3, R118.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule

Liu, Y. C., Chen, Z., Burrows, S. R., Purcell, A. W., McCluskey, J., Rossjohn, J. & Gras, S., 2012, In : Journal of Biological Chemistry. 287, 15, p. 12267 - 12276 10 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Tracking protein aggregation and mislocalization in cells with flow cytometry

Ramdzan, Y. M., Polling, S., Chia, C. P. Z., Ng, I. H. W., Ormsby, A. R., Croft, N. P., Purcell, A. W., Bogoyevitch, M. A., Ng, D. CH., Gleeson, P. A. & Hatters, D. M., 2012, In : Nature Methods. 9, 5, p. 467 - 470 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Unravelling conotoxin folding and molecular diversity

Purcell, A. W. & Safavi-Hemami, H., 2012, In : Australian Biochemist. 43, 2, p. 4 - 6 3 p.

Research output: Contribution to journalArticleOther

2013
194 Citations (Scopus)

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Scally, S., Petersen, J., Law, S. C. CHENG., Dudek, N. L., Nel, H. J., Loh, K. L., Wijeyewickrema, L. C., Eckle, S. B. G., van Heemst, J., Pike, R. N., McCluskey, J., Toes, R. E., La Gruta, N. L., Purcell, A. W., Reid, H. H., Thomas, R. & Rossjohn, J., 2013, In : Journal of Experimental Medicine. 210, 12, p. 2569 - 2582 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Application of quantitative proteomics technologies to the biomarker discovery pipeline for multiple sclerosis

Dagley, L. F., Emili, A. & Purcell, A. W., 2013, In : Proteomics - Clinical Applications. 7, 1-2, p. 91 - 108 18 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS

Dunstan, R. A., Heinz, E., Wijeyewickrema, L. C., Pike, R. N., Purcell, A. W., Evans, T. J., Praszkier, J., Robins-Browne, R. M., Strugnell, R. A., Korotkov, K. V. & Lithgow, T. J., 2013, In : PLoS Pathogens. 9, 1 (Art # e1003117), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule

Liu, Y. C., Miles, J. J., Neller, M. A., Gostick, E., Price, D. A., Purcell, A. W., McCluskey, J., Burrows, S. R., Rossjohn, J. & Gras, S., 2013, In : Journal of Biological Chemistry. 288, 22, p. 15442 - 15454 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

High molecular weight components of the injected venom of fish-hunting cone snails target the vascular system

Safavi-Hemami, H., Moller, C., Mari, F. MARI. & Purcell, A. W., 2013, In : Journal of Proteomics. 91, p. 97 - 105 9 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

HLA peptide length preferences control CD8+ T cell responses

Rist, M. J., Theodossis, A., Croft, N. P., Neller, M. A., Welland, A. D., Chen, Z., Sullivan, L. C., Burrows, J. M., Miles, J. J., Brennan, R. M., Gras, S., Khanna, R., Brooks, A., McCluskey, J., Purcell, A. W., Rossjohn, J. & Burrows, S. R., 2013, In : Journal of Immunology. 191, 2, p. 561-571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Human leukocyte antigen-associated drug hypersensitivity

Illing, P. T., Vivian, J. P., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2013, In : Current Opinion in Immunology. 25, 1, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Kinetics of antigen expression and epitope presentation during virus infection

Croft, N. P., Smith, S. A., Wong, Y. C., Tan, C. T., Dudek, N. L., Flesch, I. E. A., Lin, L. C. W., Tscharke, D. C. & Purcell, A. W., 2013, In : PLoS Pathogens. 9, 1 (Art. ID: :e1003129), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
52 Citations (Scopus)

Membrane proteomics by high performance liquid chromatography-tandem mass spectrometry: Analytical approaches and challenges

Vuckovic, D., Dagley, L. F., Purcell, A. W. & Emili, A., 2013, In : Proteomics. 13, 3-4, p. 404 - 423 20 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Preemptive priming readily overcomes structure-based mechanisms of virus escape

Valkenburg, S. A., Gras, S., Guillonneau, C., Hatten, L. A., Bird, N. L., Twist, K-A., Abd Halim, N. H., Jackson, D. C., Purcell, A. W., Turner, S. J., Doherty, P. C., Rossjohn, J. & Kedzierska, K., 2013, In : Proceedings of the National Academy of Sciences. 110, 14, p. 5570 - 5575 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014
24 Citations (Scopus)

A comprehensive analysis of constitutive naturally processed and presented HLA-C*04:01 (Cw4)-specific peptides

Schittenhelm, R. B., Dudek, N. L., Croft, N. P., Ramarathinam, S. & Purcell, A. W., 2014, In : Tissue Antigens. 83, 3, p. 174 - 179 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism

Liu, Y. C., Chen, Z., Neller, M. A., Miles, J. J., Purcell, A. W., McCluskey, J., Burrows, S. R., Rossjohn, J. & Gras, S., 2014, In : Journal of Biological Chemistry. 289, 24, p. 16688 - 16698 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes

Leyton, D. L., Johnson, M. D., Thapa, R., Huysmans, G., Dunstan, R. A., Celik, N., Shen, H-H., Loo, D., Belousoff, M. J., Purcell, A. W., Henderson, I. R., Beddoe, T. C., Rossjohn, J., Martin, L. L., Strugnell, R. A. & Lithgow, T. J., 2014, In : Nature Communications. 5, (Art. No.: 4239), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant

Nivarthi, U. K., Gras, S., Kjer-Nielsen, L., Berry, R., Lucet, I. S., Miles, J., Tracy, S. L., Purcell, A. W., Bowden, D. S., Hellard, M. E., Rossjohn, J., McCluskey, J. & Bharadwaj, M., 2014, In : Journal of Immunology. 193, 11, p. 5402 - 5413 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization

Safavi-Hemami, H., Hu, H., Gorasia, D. G., Bandyopadhyay, P. K., Veith, P. D., Young, N. D., Reynolds, E. C., Yandell, M., Olivera, B. M. & Purcell, A. W., 2014, In : Molecular & Cellular Proteomics. 13, 4, p. 938 - 953 16 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Discovery of novel disease-specific and membrane-associated candidate markers in a mouse model of multiple sclerosis

Dagley, L. F., Croft, N. P., Isserlin, R., Olsen, J. B., Fong, V., Emili, A. & Purcell, A. W., 2014, In : Molecular & Cellular Proteomics. 13, 1, p. 679 - 700 22 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

Robinson, S., Safavi-Hemami, H., McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In : PLoS ONE. 9, e87648, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access