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Research Output 1989 2019

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2004
4 Citations (Scopus)

The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 1 Aug 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425-1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance

Webb, A. I., Borg, N. A., Dunstone, M. A., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Carbone, F. R., Bottomley, S. P., Aguilar, M. I., Purcell, A. W. & Rossjohn, J., 2004, In : Journal of Immunology. 173, 1, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
39 Citations (Scopus)

A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation

Petersen, J. L., Hickman-Miller, H. D., McIlhaney, M. M., Vargas, S. E., Purcell, A. W., Hildebrand, W. H. & Solheim, J. C., 15 Jan 2005, In : Journal of Immunology. 174, 2, p. 962-969 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)

Antagonism of antiviral and allogeneic activity of a human public ctl clonotype by a single altered peptide ligand: Implications for allograft rejection

Ely, L. K., Green, K. J., Beddoe, T. C., Clements, C. S., Miles, J. J., Bottomley, S. P., Zernich, D., Kjer-Nielsen, L., Purcell, A. W., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Immunology. 174, 9, p. 5593 - 5601 9 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

CTL recognition of a bulged viral peptide involves biased TCR selection

Miles, J. J., Elhassen, D., Borg, N. A., Silins, S. L., Tynan, F. E., Burrows, J. M., Purcell, A. W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S. R. & McCluskey, J., 2005, In : Journal of Immunology. 175, 6, p. 3826 - 3834 9 p.

Research output: Contribution to journalArticleResearchpeer-review

125 Citations (Scopus)

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance

Tynan, F. E., Borg, N., Miles, J. J., Beddoe, T. C., Elhassen, D., Silins, S. L., van Zuylen, W. JM., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2005, In : Journal of Biological Chemistry. 280, 25, p. 23900 - 23909 10 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J. & Doherty, P. C., 2005, In : Nature Immunology. 6, 4, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Qualitative and quantitative differences in peptides bound to HLA-B27 in the presence of mouse versus human tapasin define a role for tapasin as a size-dependent peptide editor

Sesma, L., Galocha, B., Vázquez, M., Purcell, A. W., Marcilla, M., McCluskey, J. & López De Castro, J. A., 15 Jun 2005, In : Journal of Immunology. 174, 12, p. 7833-7844 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
47 Citations (Scopus)

T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo

Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A. J., Perlmutter, P., McCluskey, J., Aguilar, M-I., Rossjohn, J. & Purcell, A. W., 2005, In : Journal of Immunology. 175, 6, p. 3810 - 3818 9 p.

Research output: Contribution to journalArticleResearchpeer-review

210 Citations (Scopus)

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Borg, N. A., Ely, L. K., Beddoe, T. C., Macdonald, W. A., Reid, H. H., Clements, C. S., Purcell, A. W., Kjer-Nielsen, L., Miles, J. J., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 2, p. 171 - 180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Tynan, F. E., Elhassen, D., Purcell, A. W., Burrows, J. M., Borg, N. A., Miles, J. J., Williamson, N. A., Green, K. J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1249 - 1260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

Mannering, S. I., Harrison, L. C., Williamson, N. A., Morris, J. S., Thearle, D. J., Jensen, K. P., Kay, T. W., Rossjohn, J., Falk, B. A., Nepom, G. T. & Purcell, A. W., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1191 - 1197 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
28 Citations (Scopus)

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

Chong, Y. P., Chan, A. S., Chan, K. C., Williamson, N. A., Lerner, E. C., Smithgall, T. E., Bjorge, J. D., Fujita, D. J., Purcell, A. W., Scholz, G., Mulhern, T. D. & Cheng, H. C., 3 Nov 2006, In : Journal of Biological Chemistry. 281, 44, p. 32988-32999 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
48 Citations (Scopus)

Disparate thermodynamics governing T cell receptor-MHC-1 interactions implicate extrinsic factors in guiding MHC restriction

Ely, L. K., Beddoe, T. C., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J., 2006, In : Proceedings of the National Academy of Sciences. 103, 17, p. 6641 - 6646 6 p.

Research output: Contribution to journalArticleResearchpeer-review

166 Citations (Scopus)

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Krishnamurthy, B., Dudek, N. L., McKenzie, M. D., Purcell, A. W., Brooks, A. G., Gellert, S., Colman, P. G., Harrison, L. C., Lew, A. M., Thomas, H. E. & Kay, T. W. H., 1 Dec 2006, In : Journal of Clinical Investigation. 116, 12, p. 3258-3265 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)

Tumors reveal their secrets to cytotoxic T cells

Williamson, N. A., Rossjohn, J. & Purcell, A. W., 2006, In : Proceedings of the National Academy of Sciences. 103, 40, p. 14649 - 14650 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
77 Citations (Scopus)

?-Amino acid-containing hybrid peptides - New opportunities in peptidomimetics

Aguilar, M. I., Purcell, A. W., Devi, R., Lew, R. A., Rossjohn, J., Smith, A. I. & Perlmutter, P., 2007, In : Organic and Biomolecular Chemistry. 5, 18, p. 2884 - 2890 7 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease

Henderson, K., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N., Beissbarth, T., Tatham, A., Mannering, S. I., Purcell, A. W., Dudek, N. L., van Heel, D. A., McCluskey, J., Rossjohn, J. & Anderson, R. P., 2007, In : Immunity. 27, 1, p. 23 - 34 12 p.

Research output: Contribution to journalArticleResearchpeer-review

159 Citations (Scopus)

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Tynan, F. E., Reid, H. H., Kjer-Nielsen, L., Miles, J. J., Wilce, M. C. J., Kostenko, L., Borg, N., Williamson, N. A., Beddoe, T. C., Purcell, A. W., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2007, In : Nature Immunology. 8, 3, p. 268 - 276 9 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space

Gentle, I. E., Perry, A. J., Alcock, F. H., Likic, V. A., Dolezal, P., Ng, E. T., Purcell, A. W., McConnville, M., Naderer, T., Chanez, A-L., Charriere, F., Aschinger, C., Schneider, A., Tokatlidis, K. & Lithgow, T. J., 2007, In : Molecular Biology and Evolution. 24, 5, p. 1149 - 1160 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

Etto, T., Stewart, L., Nguyen, T. H. O., Williamson, N., Purcell, A. & Schwarer, A., 2007, In : Protein Expression and Purification. 54, 1, p. 176 - 182 7 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

Martin, A. M., Almeida, C. A., Cameron, P., Purcell, A. W., Nolan, D., James, I., McCluskey, J., Phillips, E., Landay, A. & Mallal, S., 1 Jun 2007, In : AIDS. 21, 10, p. 1233-1244 12 p.

Research output: Contribution to journalArticleResearchpeer-review

401 Citations (Scopus)

More than one reason to rethink the use of peptides in vaccine design

Purcell, A. W., McCluskey, J. & Rossjohn, J., 2007, In : Nature Reviews Drug Discovery. 6, 5, p. 404 - 414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Post translationally modified peptides: New targets in autoimmune disease

Lau, K. & Purcell, A. W., 2 Aug 2007, In : Chimica Oggi. 25, p. 6-9 4 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)

Winkel, K., Carroll, T., Williamson, N. A., Ignjatovic, V., Fung, K., Purcell, A. W. & Fry, B. G., 15 Dec 2007, In : Toxicon. 50, 8, p. 1041-1052 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
4 Citations (Scopus)

Can α- and β-Alanine Containing Peptides Be Distinguished Based on the CID Spectra of Their Protonated Ions?

Lam, A. K. Y., Ramarathinam, S. H., Purcell, A. W. & O'Hair, R. A. J., Dec 2008, In : Journal of the American Society for Mass Spectrometry. 19, 12, p. 1743-1754 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

Kedzierska, K., Guillonneau, C., Gras, S., Hatton, L. A., Webby, R., Purcell, A. W., Rossjohn, J., Doherty, P. C. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 49, p. 19408 - 19413 5 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

232 Citations (Scopus)

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Chessman, D., Kostenko, L., Lethborg, T., Purcell, A. W., Williamson, N. A., Chen, Z., Kjer-Nielsen, L., Mifsud, N. A., Tait, B. D., Holdsworth, R., Almeida, C. A., Nolan, D., Macdonald, W. A., Archbold, J. K., Kellerher, A. D., Marriott, D., Mallal, S., Bharadwaj, M., Rossjohn, J. & McCluskey, J., 2008, In : Immunity. 28, 6, p. 822 - 832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Immunodominance hierarchies and gender bias in direct Tcd8-cell alloreactivity

Mifsud, N. A., Purcell, A. W., Chen, W. W., Holdsworth, R., Tait, B. D. & McCluskey, J., 2008, In : American Journal of Transplantation. 8, 1, p. 121 - 132 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : PLoS Pathogens. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Nguyen, T. H. O., Mifsud, N. A., Stewart, L. A., Rose, M. J., Etto, T. L., Williamson, N. A., Purcell, A. W., Kotsimbos, T. C. & Schwarer, A., 2008, In : Protein Expression and Purification. 61, 1, p. 22 - 30 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structural and biological basis of CTL escape in coronavirus-infected mice

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : Journal of Immunology. 180, 6, p. 3926 - 3937 12 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

T-cells behaving badly: Structural insights into alloreactivity and autoimmunity

Ely, L. K., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2008, In : Current Opinion in Immunology. 20, 5, p. 575 - 580 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The enantioselective total synthesis and unambiguous proof of the absolute stereochemistry of pervilleine C

Kulkarni, K. P., Zhao, A. Y., Purcell, A. W. & Perlmutter, P., 2008, In : Synlett. 2008, 14, p. 2209 - 2212 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
41 Citations (Scopus)

A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design

Ebert, L. M., Liu, Y. C., Clements, C. S., Robson, N. C., Jackson, H. M., Markby, J. L., Dimopoulos, N., Tan, B. S., Luescher, I. F., Davis, I. D., Rossjohn, J., Cebon, J., Purcell, A. W. & Chen, W., 2009, In : Cancer Research. 69, 3, p. 1046 - 1054 9 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Beddoe, T. C., Chen, Z., Clements, C. S., Ely, L. K., Bushell, S. R., Vivian, J. P., Kjer-Nielsen, L., Pang, S. S., Dunstone, M. A., Liu, Y. C., Macdonald, W. A., Perugini, M. A., Wilce, M. C. J., Burrows, S. R., Purcell, A. W., Tiganis, T., Bottomley, S. P., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 6, p. 777 - 788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Mass spectral identification of Vc1.1 and differential distribution of conopeptides in the venom duct of conus victoriae. effect of post-translational modifications and disulfide isomerisation on bioactivity

Townsend, A., Livett, B. G., Bingham, J. P., Truong, H. T., Karas, J. A., O'Donnell, P., Williamson, N. A., Purcell, A. W. & Scanlon, D., Sep 2009, In : International Journal of Peptide Research and Therapeutics. 15, 3, p. 195-203 9 p.

Research output: Contribution to journalArticleOtherpeer-review

73 Citations (Scopus)

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Archbold, J. K., Macdonald, W. A., Gras, S., Ely, L. K., Miles, J. J., Bell, M. J., Brennan, R. M., Beddoe, T. C., Wilce, M. C. J., Clements, C. S., Purcell, A. W., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2009, In : Journal of Experimental Medicine. 206, 1, p. 209 - 219 11 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Phosphorylated self-peptides alter human leukocyte antigen class l-restricted antigen presentation and generate tumor-specific epitopes

Petersen, J., Wurzbacher, S. J., Williamson, N. A., Ramarathinam, S. H., Reid, H. H., Nair, A. K. N., Zhao, A. Y., Nastovska, R., Rudge, G., Rossjohn, J. & Purcell, A. W., 2009, In : Proceedings of the National Academy of Sciences. 106, 8, p. 2776 - 2781 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Post-translationally modified T cell epitopes: Immune recognition and immunotherapy

Petersen, J., Purcell, A. W. & Rossjohn, J., 2009, In : Journal of Molecular Medicine. 87, 11, p. 1045 - 1051 7 p.

Research output: Contribution to journalArticleResearchpeer-review

159 Citations (Scopus)

T cell allorecognition via molecular mimicry

Macdonald, W. A., Chen, Z., Gras, S., Archbold, J. K., Tynan, F. E., Clements, C. S., Bharadwaj, M., Kjer-Nielsen, L., Saunders, P. M., Wilce, M. C. J., Crawford, F., Stadinsky, B., Jackson, D., Brooks, A., Purcell, A. W., Kappler, J., Burrows, S. R., Rossjohn, J. & McCluskey, J., 2009, In : Immunity. 31, 6, p. 897 - 908 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

The A-chain of insulin is a hot-spot for CD4 + T cell epitopes in human type 1 diabetes

Mannering, S. I., Pang, S. H., Williamson, N. A., Naselli, G., Reynolds, E. C., O'Brien-Simpson, N. M., Purcell, A. W. & Harrison, L. C., May 2009, In : Clinical and Experimental Immunology. 156, 2, p. 226-231 6 p.

Research output: Contribution to journalArticleOtherpeer-review

42 Citations (Scopus)

The protein import channel in the outer mitosomal membrane of Giardia intestinalis

Dagley, M. J., Dolezal, P., Likic, V. A., Smid, O., Purcell, A. W., Buchanan, S. K., Tachezy, J. & Lithgow, T. J., 2009, In : Molecular Biology and Evolution. 26, 9, p. 1941 - 1947 7 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

The shaping of T cell receptor recognition by self-tolerance

Gras, S., Burrows, S. R., Kjer-Nielsen, L., Clements, C. S., Liu, Y. C., Sullivan, L. C., Bell, M. J., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 2, p. 193 - 203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
57 Citations (Scopus)

Allelic polymorphism in the T cell receptor and its impact on immune responses

Gras, S., Chen, Z., Miles, J. J., Liu, Y. C., Bell, M. J., Sullivan, L. C., Kjer-Nielsen, L., Brennan, R. M., Burrows, J. M., Neller, M. A., Khanna, R., Purcell, A. W., Brooks, A. G., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2010, In : Journal of Experimental Medicine. 207, 7, p. 1555 - 1567 13 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

A modular BAM complex in the outer membrane of the alpha-proteobacterium caulobacter crescentus

Anwari, K., Poggio, S., Perry, A., Gatsos, X., Ramarathinam, S. H., Williamson, N. A., Noinaj, N., Buchanan, S., Gabriel, K., Purcell, A. W., Jacobs-Wagner, C. & Lithgow, T., 2010, In : PLoS ONE. 5, 1 (e8619), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition

Theodossis, A., Guillonneau, C., Welland, A. D., Ely, L. K., Clements, C. S., Williamson, N. A., Webb, A. I., Wilce, J. A., Mulder, R. J., Dunstone, M. A., Doherty, P. C., McCluskey, J., Purcell, A. W., Turner, S. J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 12, p. 5534 - 5539 6 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Epitope discovery and their use in peptide based vaccines

Dudek, N. L., Perlmutter, P., Aguilar, M. I., Croft, N. & Purcell, A. W., 2010, In : Current Pharmaceutical Design. 16, 28, p. 3149 - 3157 9 p.

Research output: Contribution to journalArticleResearchpeer-review