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Research Output 1989 2019

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Article
1992
64 Citations (Scopus)
1993
44 Citations (Scopus)
1995
41 Citations (Scopus)
7 Citations (Scopus)

Identification and synthesis of altered peptides modulating T cell recognition of a synthetic peptide antigen.

Ede, N. J., Chen, W., McCluskey, J., Jackson, D. C. & Purcell, A. W., 1 Jan 1995, In : Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity. 1, 4, p. 231-234 4 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Induction of amphipathic helical peptide structures in RP-HPLC.

Purcell, A. W., Aguilar, M. I., Wettenhall, R. E. & Hearn, M. T., 1 Jan 1995, In : Peptide Research. 8, 3, p. 160-170 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
46 Citations (Scopus)

CTL Recognition of an Altered Peptide Associated with Asparagine Bond Rearrangement: Implications for Immunity and Vaccine Design

Chen, W., Ede, N. J., Jackson, D. C., McCluskey, J. & Purcell, A. W., 1 Aug 1996, In : Journal of Immunology. 157, 3, p. 1000-1005 6 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice

Reynolds, P., Gordon, T. P., Purcell, A. W., Jackson, D. C. & McCluskey, J., 1 Nov 1996, In : Journal of Experimental Medicine. 184, 5, p. 1857-1870 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

Nonprecipitating anti-La(SS-B) autoantibodies in primary Sjogren's syndrome

Beer, R. G., Rischmueller, M., Coates, T., Purcell, A. W., Keech, C. L., McCluskey, J. & Gordon, T. P., 1 Jan 1996, In : Clinical Immunology and Immunopathology. 79, 3, p. 314-318 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The accessibility of the prosthetic group biotin during monomeric avidin affinity chromatography

Purcell, A. W. & Wallace, J. C., 1 Jan 1996, In : Analytical Biochemistry. 238, 2, p. 213-216 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
24 Citations (Scopus)

Avoidance of self-reactivity results in skewed CTL responses to rare components of synthetic immunogens

Purcell, A. W., Chen, W., Ede, N. J., Gorman, J. J., Fecondo, J. V., Jackson, D. C., Zhao, Y. & McCluskey, J., 1 Feb 1998, In : Journal of Immunology. 160, 3, p. 1085-1090 6 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)

Determinant spreading: Lessons from animal models and human disease

McCluskey, J., Farris, A. D., Keech, C. L., Purcell, A. W., Rischmueller, M., Kinoshita, G., Reynolds, P. & Gordon, T. P., 1 Aug 1998, In : Immunological Reviews. 164, p. 209-229 21 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Elucidation of functionally significant structural modifications by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with post-source decay

German, J. J., Purcell, A. W., Ferguson, B. L., Lopaticki, S., Morrow, C. J. & Mineva, E., 12 Sep 1998, In : Journal of Protein Chemistry. 17, 6, p. 526-527 2 p.

Research output: Contribution to journalArticleOtherpeer-review

26 Citations (Scopus)

RP-HPLC binding domains of proteins

Aguilar, M-I., Clayton, D. J., Holt, P., Kronina, V., Boysen, R. I., Purcell, A. W. & Hearn, M. T. W., 1998, In : Analytical Chemistry. p. 5010 - 5018 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Spreading of the immune response from 52 kDaRo and 60 kDaRo to calreticulin in experimental autoimmunity

Kinoshita, G., Keech, C. L., Sontheimer, R. D., Purcell, A., McCluskey, J. & Gordon, T. P., 9 Feb 1998, In : Lupus. 7, 1, p. 7-11 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1999
23 Citations (Scopus)

Comparison between the isocratic and gradient retention behaviour of polypeptides in reversed-phase liquid chromatographic environments

Purcell, A. W., Zhao, G. L., Aguilar, M. I. & Hearn, M. T. W., 6 Aug 1999, In : Journal of Chromatography A. 852, 1, p. 43-57 15 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice

Kinoshita, G., Purcell, A. W., Keech, C. L., Farris, A. D., McCluskey, J. & Gordon, T. P., 1 Jan 1999, In : Clinical and Experimental Immunology. 115, 2, p. 268-274 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

Probing the binding behavior and conformational states of globular proteins in reversed-phased high-performance liquid chromatography

Purcell, A. W., Aguilar, M. I. & Hearn, M. T. W., 1 Jul 1999, In : Analytical Chemistry. 71, 13, p. 2440-2451 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
22 Citations (Scopus)

Endogenous and exogenous factors contributing to the surface expression of HLA B27 on mutant APC

Purcell, A. W., Kelly, A. J., Peh, C. A., Dudek, N. L. & McCluskey, J., 1 Feb 2000, In : Human Immunology. 61, 2, p. 120-130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Tapasin-mediated retention and optimization of peptide ligands during the assembly of class I molecules

Barnden, M. J., Purcell, A. W., Gorman, J. J. & McCluskey, J., 1 Jul 2000, In : Journal of Immunology. 165, 1, p. 322-330 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2001
126 Citations (Scopus)

Quantitative and qualitative influences of tapasin on the class I peptide repertoire

Purcell, A. W., Gorman, J. J., Garcia-Peydró, M., Paradela, A., Burrows, S. R., Talbo, G. H., Laham, N., Chen Au Peh, A. P., Reynolds, E. C., López de Castro, J. A. & McCluskey, J., 15 Jan 2001, In : Journal of Immunology. 166, 2, p. 1016-1027 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2002
31 Citations (Scopus)

Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant form of each complex

Macdonald, W., Williams, D. S., Gorman, J. J., Kjer-Nielsen, L., Brooks, A. G., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2002, In : FEBS Letters. 527, 1-3, p. 27 - 32 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Identification of an I-Ad restricted peptide on the 65-kilodalton heat shock protein of Mycobacterium avium

Nagabhushanam, V., Purcell, A. W., Mannering, S., Germano, S., Praszkier, J. & Cheers, C., 26 Nov 2002, In : Immunology and Cell Biology. 80, 6, p. 574-583 10 p.

Research output: Contribution to journalArticleResearchpeer-review

252 Citations (Scopus)

Optimization of the MHC class I peptide cargo is dependent on tapasin

Williams, A. P., Peh, C. A., Purcell, A. W., McCluskey, J. & Elliott, T., 1 Jan 2002, In : Immunity. 16, 4, p. 509-520 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDA Ro (SS-A) in experimental autoimmunity

Gordon, T. P., Kinoshita, G., Cavill, D., Keech, C., Farris, A. D., Kaufman, K., McCluskey, J. & Purcell, A. W., 27 Jul 2002, In : Scandinavian Journal of Immunology. 56, 2, p. 168-173 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
58 Citations (Scopus)

The 1.5 Å crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Structure. 10, 11, p. 1521-1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The 1.5 Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immonodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Structure. 10, 11, p. 1521 - 1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

The central role played by peptides in the immune response and the design of peptide-based vaccines against infectious diseases and cancer

Jackson, D. C., Purcell, A. W., Fitzmaurice, C. J., Zeng, W. & Hart, D. N. J., 1 Jan 2002, In : Current Drug Targets. 3, 2, p. 175-196 22 p.

Research output: Contribution to journalArticleResearchpeer-review

The production, purification and crystallization of a soluble heterdimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., Macdonald, W. A., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131 - 2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., MacDonald, W. A., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Dec 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131-2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

The structure of HLA-B8 complexed to an immunodominant viral determinant: Peptide-induced conformational changes and a mode of MHC class I dimerization

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Journal of Immunology. 169, 9, p. 5153-5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and a mode of MHC class 1 dimerisation1

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 2002, In : Journal of Immunology. 169, 9, p. 5153 - 5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
154 Citations (Scopus)

A naturally selected dimorphism within the HLA-B44 supertype alters Class I structure, peptide repertoire, and T cell recognition

Macdonald, W. A., Purcell, A. W., Mifsud, N. A., Ely, L. K., Williams, D. S., Chang, L., Gorman, J. J., Clements, C. S., Kjer-Nielsen, L., Koelle, D. M., Burrows, S. R., Tait, B. D., Holdsworth, R., Brooks, A. G., Lovrecz, G. O., Lu, L., Rossjohn, J. & McCluskey, J., 2003, In : Journal of Experimental Medicine. 198, 5, p. 679 - 691 13 p.

Research output: Contribution to journalArticleResearchpeer-review

119 Citations (Scopus)

A sensitive method for detecting proliferation of rare autoantigen- specific human T cells

Mannering, S. I., Morris, J. S., Jensen, K. P., Purcell, A. W., Honeyman, M. C., Van Endert, P. M. & Harrison, L. C., 1 Jan 2003, In : Journal of Immunological Methods. 283, 1-2, p. 173-183 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Association of stress proteins with autoantigens: A possible mechanism for triggering autoimmunity?

Purcell, A. W., Todd, A., Kinoshita, G., Lynch, T. A., Keech, C. L., Gething, M. J. & Gordon, T. P., 1 May 2003, In : Clinical and Experimental Immunology. 132, 2, p. 193-200 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
273 Citations (Scopus)

A structural basis for the selection of dominant T cell receptors in antiviral immunity

Kjer-Nielsen, L., Clements, C. S., Purcell, A. W., Brooks, A. G., Whisstock, J. C., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2003, In : Immunity. 18, 1, p. 53 - 64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Human T-cells recognise N-terminally Fmoc-modified peptide

Mannering, S. I., Purcell, A. W., Honeyman, M. C., McCluskey, J. & Harrison, L. C., 1 Jan 2003, In : Vaccine. 21, 25-26, p. 3638-3646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

Chang, L., Kjer-Nielsen, L., Flynn, S., Brooks, A. G., Mannering, S. I., Honeyman, M. C., Harrison, L. C., McCluskey, J. & Purcell, A. W., 1 Nov 2003, In : Tissue Antigens. 62, 5, p. 408-417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Optimisation of peptide-based cytotoxic T-cell determinants using non-natural amino acids

Webb, A. I., Aguilar, M-I. & Purcell, A. W., 2003, In : Letters in Peptide Science. 10, 5, p. 561 - 569 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
98 Citations (Scopus)

Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3

Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T. C., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J. & Rossjohn, J., 2004, In : Proceedings of the National Academy of Sciences. 101, 20, p. 7675 - 7680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Webb, A. I., Dunstone, M. A., Chen, W., Aguilar, M. I., Chen, Q., Jackson, H., Chang, L., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Journal of Biological Chemistry. 279, 22, p. 23438 - 23446 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Isolation and characterization of naturally processed MHC-bound peptides from the surface of antigen-presenting cells.

Purcell, A. W., 1 Jan 2004, In : Methods in molecular biology (Clifton, N.J.). 251, p. 291-306 16 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Zernich, D., Purcell, A. W., Macdonald, W. A., Kjer-Nielsen, L., Ely, L. K., Laham, N., Crockford, T., Mifsud, N. A., Bharadwaj, M., Chang, L., Tait, B. D., Holdsworth, R., Brooks, A. G., Bottomley, S. P., Beddoe, T. C., Peh, C. A., Rossjohn, J. & McCluskey, J., 2004, In : Journal of Experimental Medicine. 200, 1, p. 13 - 24 12 p.

Research output: Contribution to journalArticleResearchpeer-review

386 Citations (Scopus)

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Martin, A. M., Nolan, D., Gaudieri, S., Almeida, C. A., Nolan, R., James, I., Carvalho, F., Phillips, E., Christiansen, F. T., Purcell, A. W., McCluskey, J. & Mallal, S., 23 Mar 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4180-4185 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
42 Citations (Scopus)

TAP genes and immunity

McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Current Opinion in Immunology. 16, 5, p. 651 - 659 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The production and purification of the human T-cell receptors, the CD3and CD3heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425 - 1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review