Accepting PhD Students

PhD projects

Cancer Immunology Autoimmunity (Diabetes, arthritis, psoriasis, MS) Antigen processing and presentation Vaccine design Bioinformatics

1989 …2022

Research output per year

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Research Output

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Article
2020

Acute experimental infection of bats and ferrets with Hendra virus: Insights into the early host response of the reservoir host and susceptible model species

Woon, A. P., Boyd, V., Todd, S., Smith, I., Klein, R., Woodhouse, I. B., Riddell, S., Crameri, G., Bingham, J., Wang, L. F., Purcell, A. W., Middleton, D. & Baker, M. L., 30 Mar 2020, In : PLoS Pathogens. 16, 3, 22 p., e1008412.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Human Plasma Protein Corona of Aβ Amyloid and Its Impact on Islet Amyloid Polypeptide Cross-Seeding

Nandakumar, A., Xing, Y., Aranha, R. R., Faridi, A., Kakinen, A., Javed, I., Koppel, K., Pilkington, E. H., Purcell, A. W., Davis, T. P., Faridi, P., Ding, F. & Ke, P. C., 10 Feb 2020, In : Biomacromolecules. 21, 2, p. 988-998 11 p.

Research output: Contribution to journalArticleResearchpeer-review

In-depth mining of the immunopeptidome of an acute myeloid leukemia cell line using complementary ligand enrichment and data acquisition strategies

Pandey, K., Mifsud, N. A., Lim Kam Sian, T. C. C., Ayala, R., Ternette, N., Ramarathinam, S. H. & Purcell, A. W., Jul 2020, In : Molecular Immunology. 123, p. 7-17 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., O’Neill, P. M., Purcell, A. W., Park, K. B. & Naisbitt, D. J., Mar 2020, In : Allergy. 75, 3, p. 636-647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

Rowntree, L. C., van den Heuvel, H., Sun, J., D'Orsogna, L. J., Nguyen, T. H. O., Claas, F. H. J., Rossjohn, J., Kotsimbos, T. C., Purcell, A. W. & Mifsud, N. A., 19 Feb 2020, In : Frontiers in Immunology. 11, 13 p., 248.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Petersen, J., Ciacchi, L., Tran, M. T., Loh, K. L., Kooy-Winkelaar, Y., Croft, N. P., Hardy, M. Y., Chen, Z., McCluskey, J., Anderson, R. P., Purcell, A. W., Tye-Din, J. A., Koning, F., Reid, H. H. & Rossjohn, J., Jan 2020, In : Nature Structural & Molecular Biology. 27, p. 49-61 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Tentacle Transcriptomes of the Speckled Anemone (Actiniaria: Actiniidae: Oulactis sp.): Venom-Related Components and Their Domain Structure

Mitchell, M. L., Tonkin-Hill, G. Q., Morales, R. A. V., Purcell, A. W., Papenfuss, A. T. & Norton, R. S., Apr 2020, In : Marine Biotechnology. 22, p. 207-219 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Lim Kam Sian, T. C. C., Indumathy, S., Halim, H., Greule, A., Cryle, M. J., Bowness, P., Rossjohn, J., Gras, S., Purcell, A. W. & Schittenhelm, R. B., 27 Dec 2019, In : Journal of Biological Chemistry. 294, 52, p. 20185-20195 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, α-Helix to β-Sheet Transition, and Formation of β-Barrel Intermediates

Sun, Y., Kakinen, A., Xing, Y., Faridi, P., Nandakumar, A., Purcell, A. W., Davis, T. P., Ke, P. C. & Ding, F., May 2019, In : Small. 15, 18, 10 p., 1805166.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Differential Roles of Plasma Protein Corona on Immune Cell Association and Cytokine Secretion of Oligomeric and Fibrillar Beta-Amyloid

Faridi, A., Yang, W., Kelly, H. G., Wang, C., Faridi, P., Purcell, A. W., Davis, T. P., Chen, P., Kent, S. J. & Ke, P. C., 11 Nov 2019, In : Biomacromolecules. 20, 11, p. 4208-4217 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Koutsakos, M., McWilliam, H. E. G., Aktepe, T. E., Fritzlar, S., Illing, P. T., Mifsud, N. A., Purcell, A. W., Rockman, S., Reading, P. C., Vivian, J. P., Rossjohn, J., Brooks, A. G., Mackenzie, J. M., Mintern, J. D., Villadangos, J. A., Nguyen, T. H. O. & Kedzierska, K., 29 May 2019, In : Frontiers in Immunology. 10, 12 p., 1158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide

Faridi, A., Sun, Y., Mortimer, M., Aranha, R. R., Nandakumar, A., Li, Y., Javed, I., Kakinen, A., Fan, Q., Purcell, A. W., Davis, T. P., Ding, F., Faridi, P. & Ke, P. C., Nov 2019, In : Nano Research. 12, 11, p. 2827-2834 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Human CD8 + T cell cross-reactivity across influenza A, B and C viruses

Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S., Chua, B. Y., Wong, C. Y., Allen, E. K., Teng, D., Dash, P., Boyd, D. F., Grzelak, L., Zeng, W., Hurt, A. C., Barr, I., Rockman, S. & 17 others, Jackson, D. C., Kotsimbos, T. C., Cheng, A. C., Richards, M., Westall, G. P., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Wakim, L. M., Rossjohn, J., Vijaykrishna, D., Luciani, F., Thomas, P. G., Gras, S., Purcell, A. W. & Kedzierska, K., 18 Feb 2019, In : Nature Immunology. 20, p. 613-625 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Improved peptide-MHC class II interaction prediction through integration of eluted ligand and peptide affinity data

Garde, C., Ramarathinam, S. H., Jappe, E. C., Nielsen, M., Kringelum, J. V., Trolle, T. & Purcell, A. W., 1 Jul 2019, In : Immunogenetics. 71, 7, p. 445-454 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Mass spectrometry–based identification of MHC-bound peptides for immunopeptidomics

Purcell, A. W., Ramarathinam, S. H. & Ternette, N., Jun 2019, In : Nature Protocols. 14, 6, p. 1687-1707 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Physical and toxicological profiles of human IAPP amyloids and plaques

Kakinen, A., Sun, Y., Javed, I., Faridi, A., Pilkington, E. H., Faridi, P., Purcell, A. W., Zhou, R., Ding, F., Lin, S., Ke, P. C. & Davis, T. P., 15 Jan 2019, In : Science Bulletin. 64, 1, p. 26-35 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Positive-unlabelled learning of glycosylation sites in the human proteome

Li, F., Zhang, Y., Purcell, A. W., Webb, G. I., Chou, K-C., Lithgow, T., Li, C. & Song, J., 6 Mar 2019, In : BMC Bioinformatics. 20, 1, 17 p., 112.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Wu, T., Guan, J., Handel, A., Tscharke, D. C., Sidney, J., Sette, A., Wakim, L. M., Sng, X. Y. X., Thomas, P. G., Croft, N. P., Purcell, A. W. & La Gruta, N. L., 28 Jun 2019, In : Nature Communications. 10, 1, 14 p., 2846.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)
Open Access
3 Citations (Scopus)

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 Diabetes

Purcell, A. W., Sechi, S. & DiLorenzo, T. P., 1 May 2019, In : Diabetes. 68, 5, p. 879-886 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi-Hemami, H., Teilum, K. & Ellgaard, L., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 22, p. 8745-8759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods

Li, F., Wang, Y., Li, C., Marquez-Lago, T. T., Leier, A., Rawlings, N. D., Haffari, G., Revote, J., Akutsu, T., Chou, K-C., Purcell, A. W., Pike, R. N., Webb, G. I., Smith, A. I., Lithgow, T., Daly, R. J., Whisstock, J. C. & Song, J., 27 Nov 2019, In : Briefings in Bioinformatics. 20, 6, p. 2150-2166 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Identification of native and posttranslationally modified HLA-B*57:01- restricted HIV envelope derived epitopes using immunoproteomics

Ramarathinam, S. H., Gras, S., Alcantara, S., Yeung, A. W. S., Mifsud, N. A., Sonza, S., Illing, P., Glaros, E. N., Center, R. J., Thomas, S. R., Kent, S. J., Ternette, N., Purcell, D. F. J., Rossjohn, J. & Purcell, A. W., Jun 2018, In : Proteomics. 18, 12, 11 p., 1700253.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Inability to detect cross-reactive memory T cells challenges the frequency of heterologous immunity among common viruses

Rowntree, L. C., Nguyen, T. H. O., Halim, H., Purcell, A. W., Rossjohn, J., Gras, S., Kotsimbos, T. C. & Mifsud, N. A., 15 Jun 2018, In : Journal of Immunology. 200, 12, p. 3993-4003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

In Immunopeptidomics We Need a Sniper Instead of a Shotgun

Faridi, P., Purcell, A. W. & Croft, N. P., 1 Jun 2018, In : Proteomics. 18, 12, 4 p., 1700464.

Research output: Contribution to journalArticleOtherpeer-review

21 Citations (Scopus)

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Tubb, V. M., Schrikkema, D. S., Croft, N. P., Purcell, A. W., Linnemann, C., Freriks, M. R., Chen, F., Long, H. M., Lee, S. P. & Bendle, G. M., 13 Jul 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 14 p., 70.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE)

Lill, J. R., Van Veelen, P. A., Tenzer, S., Admon, A., Caron, E., Elias, J. E., Heck, A. J. R., Marcilla, M., Marino, F., Müller, M., Peters, B., Purcell, A., Sette, A., Sturm, T., Ternette, N. & Vizcaino, J. A., 1 Jun 2018, In : Proteomics. 18, 12, 7 p., 1800110.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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8 Citations (Scopus)

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

Faridi, A., Sun, Y., Okazaki, Y., Peng, G., Gao, J., Kakinen, A., Faridi, P., Zhao, M., Javed, I., Purcell, A. W., Davis, T. P., Lin, S., Oda, R., Ding, F. & Ke, P. C., 22 Nov 2018, In : Small. 14, 47, 13 p., 1802825.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Quokka: A comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome

Li, F., Li, C., Marquez-Lago, T. T., Leier, A., Akutsu, T., Purcell, A. W., Smith, A. I., Lithgow, T., Daly, R. J., Song, J. & Chou, K-C., 15 Dec 2018, In : Bioinformatics. 34, 24, p. 4223-4231 9 p., bty522.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Newcombe, E. A., Ruff, K. M., Sethi, A., Ormsby, A. R., Ramdzan, Y. M., Fox, A. H., Purcell, A. W., Gooley, P. R., Pappu, R. V. & Hatters, D. M., 11 May 2018, In : Journal of Molecular Biology. 430, 10, p. 1442-1458 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., Miners, K. L., McLaren, J. E., Grant, E. J., Haigh, O. L., Watkins, T. S., Suliman, S., Iwany, S., Jimenez, J., Calderon, R., Tamara, K. L., Leon, S. R., Murray, M. B., Mayfield, J. A., Altman, J. D. & 8 others, Purcell, A. W., Miles, J. J., Godfrey, D. I., Gras, S., Price, D. A., Van Rhijn, I., Moody, D. B. & Rossjohn, J., 1 Apr 2018, In : Nature Immunology. 19, 4, p. 397-406 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis

Ting, Y. T., Petersen, J., Ramarathinam, S. H., Scally, S. W., Loh, K. L., Thomas, R., Suri, A., Baker, D. G., Purcell, A. W., Reid, H. H. & Rossjohn, J., 2 Mar 2018, In : Journal of Biological Chemistry. 293, 9, p. 3236-3251 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

The SysteMHC Atlas project

Shao, W., Pedrioli, P. G. A., Wolski, W., Scurtescu, C., Schmid, E., Vizcaíno, J. A., Courcelles, M., Schuster, H., Kowalewski, D., Marino, F., Arlehamn, C. S. L., Vaughan, K., Peters, B., Sette, A., Ottenhoff, T. H. M., Meijgaarden, K. E., Nieuwenhuizen, N., Kaufmann, S. H. E., Schlapbach, R., Castle, J. C. & 26 others, Nesvizhskii, A. I., Nielsen, M., Deutsch, E. W., Campbell, D. S., Moritz, R. L., Zubarev, R. A., Ytterberg, A. J., Purcell, A. W., Marcilla, M., Paradela, A., Wang, Q., Costello, C. E., Ternette, N., Van Veelen, P. A., Van Els, C. A. C. M., Heck, A. J. R., De Souza, G. A., Sollid, L. M., Admon, A., Stevanovic, S., Rammensee, H. G., Thibault, P., Perreault, C., Bassani-Sternberg, M., Aebersold, R. & Caron, E., 1 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1237-D1247 11 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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39 Citations (Scopus)

The use of CRISPR/Cas9 gene editing to confirm congenic contaminations in host-pathogen interaction studies

Ferrand, J., Croft, N. P., Pépin, G., Diener, K. R., Wu, D., Mangan, N. E., Pedersen, J., Behlke, M. A., Hayball, J. D., Purcell, A. W., Ferrero, R. L. & Gantier, M. P., 19 Mar 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 10 p., 87.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response

Rawlinson, S. M., Zhao, T., Rozario, A. M., Rootes, C. L., McMillan, P. J., Purcell, A. W., Woon, A., Marsh, G. A., Lieu, K. G., Wang, L-F., Netter, H. J., Bell, T. D. M., Stewart, C. R. & Moseley, G. W., 3 Aug 2018, In : Nature Communications. 9, 1, 12 p., 3057.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2017

Comparative transcriptomics highlights the role of the activator protein 1 transcription factor in the host response to Ebolavirus

Wynne, J. W., Todd, S., Boyd, V., Tachedjian, M., Klein, R., Shiell, B., Dearnley, M., McAuley, A. J., Woon, A. P., Purcell, A. W., Marsh, G. A. & Baker, M. L., 1 Dec 2017, In : Journal of Virology. 91, 23, 21 p., e01174-17.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 others, Holdsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

Keller, A. N., Eckle, S. B. G., Xu, W., Liu, L., Hughes, V. A., Mak, J. Y. W., Meehan, B. S., Pediongco, T., Birkinshaw, R. W., Chen, Z., Wang, H., D'Souza, C., Kjer-Nielsen, L., Gherardin, N. A., Godfrey, D. I., Kostenko, L., Corbett, A. J., Purcell, A. W., Fairlie, D. P., McCluskey, J. & 1 others, Rossjohn, J., Apr 2017, In : Nature Immunology. 18, 4, p. 402-411 14 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

HIVed, a knowledgebase for differentially expressed human genes and proteins during HIV infection, replication and latency

Li, C., Ramarathinam, S. H., Revote, J., Khoury, G., Song, J. & Purcell, A. W., 30 Mar 2017, In : Scientific Reports. 7, 45509.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Hormone-like peptides in the venoms of marine cone snails

Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A., Norton, R. S. & Safavi-Hemami, H., 1 Apr 2017, In : General and Comparative Endocrinology. 244, p. 11-18 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

Ramdzan, Y. M., Trubetskov, M. M., Ormsby, A. R., Newcombe, E. A., Sui, X., Tobin, M. J., Bongiovanni, M. N., Gras, S. L., Dewson, G., Miller, J. M. L., Finkbeiner, S., Moily, N. S., Niclis, J., Parish, C. L., Purcell, A. W., Baker, M. J., Wilce, J. A., Waris, S., Stojanovski, D., Böcking, T. & 4 others, Ang, C-S., Ascher, D. B., Reid, G. E. & Hatters, D. M., 2 May 2017, In : Cell Reports. 19, 5, p. 919-927 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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40 Citations (Scopus)

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Pymm, P., Illing, P. T., Ramarathinam, S. H., O'Connor, G. M., Hughes, V. A., Hitchen, C., Price, D. A., Ho, B. K., McVicar, D. W., Brooks, A. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., Apr 2017, In : Nature Structural & Molecular Biology. 24, 4, p. 387-394 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Structural and regulatory diversity shape HLA-C protein expression levels

Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortes, A., Barber, T., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., Carrington, M., McVean, G., Purcell, A. W., Rossjohn, J. & Fugger, L., 26 Jun 2017, In : Nature Communications. 8, 12 p., 15924.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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32 Citations (Scopus)

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C∗06: 02 molecule

Mobbs, J. I., Illing, P. T., Dudek, N. L., Brooks, A. G., Baker, D. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., 20 Oct 2017, In : Journal of Biological Chemistry. 292, 42, p. 17203-17215 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)