Projects per year
Personal profile
Biography
Our laboratory specialises in targeted and global quantitative proteomics of complex biological samples, with a specific focus on identifying targets of the immune response and host-pathogen interactions. The laboratory has an outstanding track record in delivering high end outcomes including recent publications in highly regarding peer reviewed journals including Nature (5), Nature Immunol (9), Science Immunology, Nat Struc Mol Biol (2), Nature Comunications (5), PNAS (14), J Exp Med (8), Immunity (8), Nature Protocols, Mol Cell Proteomics (5), Proteomics (7) and J Proteomics Res (3). We combine cutting edge proteomics with human immunology, molecular virology, structural and functional immunology to address a wide variety of immune questions.
External positions
Councillor Human Proteome Organisation, Human Proteome Organization
1 Jan 2017 → 31 Dec 2023
Visiting Professor, University of Southampton
1 Jan 2016 → 31 Dec 2019
Research area keywords
- immunology and inflammation
- Mass Spectrometry
- Autoimmunity
- Cancer And Immunity
- Bioinformatics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 14 Life Below Water
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Plasma immunopeptidomics for actionable target discovery in Acute Myeloid Leukaemia
Scull, K. (Primary Chief Investigator (PCI)), Pandey, K. (Chief Investigator (CI)), Yeh, P. (Chief Investigator (CI)) & Purcell, A. (Chief Investigator (CI))
1/06/26 → 1/06/28
Project: Research
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Harnessing the Plasma Immunopeptidome for Cancer Surveillance and Antigen Discovery
Purcell, A. (Primary Chief Investigator (PCI)) & Pandey, K. (Chief Investigator (CI))
1/05/26 → 30/04/27
Project: Research
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Identification of immune triggers for graft rejection in transplant recipients.
Mifsud, N. (Primary Chief Investigator (PCI)), Purcell, A. (Associate Investigator (AI)) & Muraduzzaman, M. (Associate Investigator (AI))
1/07/25 → 30/06/27
Project: Research
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Non-canonical antigen sources for cross-strain protective influenza immunity
Illing, P. (Primary Chief Investigator (PCI)), Braun, A. (Chief Investigator (CI)), Lahoud, M. (Associate Investigator (AI)), O'Keeffe, M. (Associate Investigator (AI)), Kedzierska, K. (Associate Investigator (AI)), Purcell, A. (Associate Investigator (AI)) & Mifsud, N. (Associate Investigator (AI))
1/01/24 → 31/12/27
Project: Research
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An integrated approach to antigen discovery in autoimmunity and cancer
Purcell, A. (Primary Chief Investigator (PCI))
1/01/23 → 31/12/27
Project: Research
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Atypical presentation of the immunodominant human PR3 T cell epitope by HLA-DR15 to CD4+ T cells induces autoimmune kidney injury
Lu, C., Shochet, L., Tran, M. T., Jones, C. M., Goh, S. J. R., Prakongtham, P., Loh, T. J., Lim, J.-J., Ryan, J., Fugger, L., Jenne, D., Purcell, A. W., la Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 19 Feb 2026, p. 13. 1 p.Research output: Contribution to conference › Abstract
Open Access -
The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites
Abdelaal, M. R. (Leading Author), Deng, J., McInerney, M. P., Ito, E., Purcell, A. W., Yamasaki, S., Villadangos, J. A., McWilliam, H. E. G., Gherardin, N. A., Rossjohn, J. (Leading Author) & Awad, W. (Leading Author), 2 Feb 2026, In: Journal of Experimental Medicine. 223, 2, 20 p., e20250711.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
Unconventional presentation of an immunodominant HLA-DR15-restricted nephritogenic proteinase 3 epitope implicated in vasculitis
Lu, C., Shochet, I. R., Lim, J.-J., Loh, T. J., Goh, S. J. R., Jones, C. M., Zhang, J. B., Allmannsberger, L., Prakongtham, P., Tran, M. T., Chisanga, D., Ryan, J., Fugger, L., Moser, M., Jenne, D., Reid, H. H., la Gruta, N. L., Purcell, A. W., Rossjohn, J. & Kitching, A. R., 22 Jul 2026, bioRxiv, 2026 51 p.Research output: Contribution to specialist publication › Article › Research
Open Access -
Correction to: π-HuB: the proteomic navigator of the human body (Nature, (2024), 636, 8042, (322-331), 10.1038/s41586-024-08280-5)
He, F., Aebersold, R., Baker, M. S., Bian, X., Bo, X., Chan, D. W., Chang, C., Chen, L., Chen, X., Chen, Y. J., Cheng, H., Collins, B. C., Corrales, F., Cox, J., E, W., Van Eyk, J. E., Fan, J., Faridi, P., Figeys, D. & Gao, G. F. & 86 others, , 16 Jan 2025, In: Nature. 637, 8046, p. E22 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells
Hill, A. E., Son, E. T., Paul-Heng, M., Wang, C., Ratnaseelan, S., Denkova, M., Faridi, P., Braun, A., Purcell, A. W., Mifsud, N. A. & Sharland, A. F., 29 Jan 2025, In: Frontiers in Transplantation. 4, 11 p., 1525003.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Link opens in a new tab Citations (Scopus)
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AB Sciex (Singapore) (External organisation)
Purcell, A. (Member)
1 Nov 2025Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
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Molecular Immunology (Journal)
Purcell, A. (Associate editor)
1 Oct 2019 → 30 Sept 2022Activity: Publication peer-review and editorial work types › Editorial responsibility
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Biochemistry & Molecular Biology (Organisational unit)
Purcell, A. (Member), Quenette, S. (Member), Bonnington, C. P. (Member), Tate, S. (Member), Koletsas, N. (Member) & Croft, N. P. (Member)
1 Apr 2018 → 31 Dec 2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
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Molecular and Cellular Proteomics (Journal)
Purcell, A. (Editorial board member)
1 Jan 2016 → 31 Dec 2025Activity: Publication peer-review and editorial work types › Editorial responsibility
Press/Media
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A$9.8 million fight against superbugs
Li, J., Charman, W. N., Song, J., Purcell, A. W., Hertzog, P. J., Creek, D. J., Nation, R. L., Bullita, J. & Boyce, J. D.
24/04/14
1 Media contribution
Press/Media: Public Engagement Activities