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Personal profile


Our laboratory specialises in targeted and global quantitative proteomics of complex biological samples, with a specific focus on identifying targets of the immune response and host-pathogen interactions. The laboratory has an outstanding track record in delivering high end outcomes including recent publications in highly regarding peer reviewed journals including Nature (5), Nature Immunol (9), Science Immunology, Nat Struc Mol Biol (2), Nature Comunications (5), PNAS (14), J Exp Med (8), Immunity (8), Nature Protocols, Mol Cell Proteomics (5), Proteomics (7) and J Proteomics Res (3). We combine cutting edge proteomics with human immunology, molecular virology, structural and functional immunology to address a wide variety of immune questions.

External positions

Associate Editor, Molecular Immunology (Elsevier)

1 Oct 201930 Sep 2022

Councillor Human Proteome Organisation, HuPO

1 Jan 201731 Dec 2023

Editorial Board Member, Molecular and Cellular Proteomics

1 Jan 201631 Dec 2025

Visiting Professor, University of Southampton

1 Jan 201631 Dec 2019

Research area keywords

  • immunology and inflammation
  • Mass Spectrometry
  • Autoimmunity
  • Cancer And Immunity
  • Bioinformatics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2005 2022

Research Output 1989 2020

Human Plasma Protein Corona of Aβ Amyloid and Its Impact on Islet Amyloid Polypeptide Cross-Seeding

Nandakumar, A., Xing, Y., Aranha, R. R., Faridi, A., Kakinen, A., Javed, I., Koppel, K., Pilkington, E. H., Purcell, A. W., Davis, T. P., Faridi, P., Ding, F. & Ke, P. C., 10 Feb 2020, In : Biomacromolecules. 21, 2, p. 988-998 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Petersen, J., Ciacchi, L., Tran, M. T., Loh, K. L., Kooy-Winkelaar, Y., Croft, N. P., Hardy, M. Y., Chen, Z., McCluskey, J., Anderson, R. P., Purcell, A. W., Tye-Din, J. A., Koning, F., Reid, H. H. & Rossjohn, J., Jan 2020, In : Nature Structural and Molecular Biology. 27, p. 49-61 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction

Mei, S., Li, F., Leier, A., Marquez-Lago, T. T., Giam, K., Croft, N. P., Akutsu, T., Smith, A. I., Li, J., Rossjohn, J., Purcell, A. W. & Song, J., 14 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bbz051.

Research output: Contribution to journalReview ArticleResearchpeer-review

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Lim Kam Sian, T. C. C., Indumathy, S., Halim, H., Greule, A., Cryle, M. J., Bowness, P., Rossjohn, J., Gras, S., Purcell, A. W. & Schittenhelm, R. B., 27 Dec 2019, In : Journal of Biological Chemistry. 294, 52, p. 20185-20195 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2018 2018

  • 1 Membership of industry collaboration/ network

Biochemistry & Molecular Biology (Organisational unit)

Anthony Purcell (Member), Steve Quenette (Member), Craig Paul Bonnington (Member), Stephen Tate (Member), Nick Koletsas (Member), Nathan Paul Croft (Member)
1 Apr 201831 Dec 2020

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network

Press / Media