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Personal profile

Biography

Our laboratory specialises in targeted and global quantitative proteomics of complex biological samples, with a specific focus on identifying targets of the immune response and host-pathogen interactions. The laboratory has an outstanding track record in delivering high end outcomes including recent publications in highly regarding peer reviewed journals including Nature (4), Nature Immunol (4), Nat Struc Mol Biol, PNAS (12), J Exp Med (8), Immunity (8), Mol Cell Proteomics (3), Proteomics (4) and J Proteomics Res (3). We combine cutting edge proteomics with human immunology, molecular virology, structural and functional immunology to address a wide variety of immune questions.

External positions

Visiting Professor, University of Southampton

1 Jan 201631 Dec 2018

Keywords

  • immunology and inflammation
  • Mass Spectrometry
  • Autoimmunity
  • Cancer And Immunity
  • Bioinformatics

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Projects 2005 2022

Research Output 1998 2018

Identification of native and posttranslationally modified HLA-B*57:01- restricted HIV envelope derived epitopes using immunoproteomics

Ramarathinam, S. H., Gras, S., Alcantara, S., Yeung, A. W. S., Mifsud, N. A., Sonza, S., Illing, P., Glaros, E. N., Center, R. J., Thomas, S. R., Kent, S. J., Ternette, N., Purcell, D. F. J., Rossjohn, J. & Purcell, A. W. Jun 2018 In : Proteomics. 18, 12, 11 p., 1700253

Research output: Contribution to journalArticleResearchpeer-review

Inability to detect cross-reactive memory T cells challenges the frequency of heterologous immunity among common viruses

Rowntree, L. C., Nguyen, T. H. O., Halim, H., Purcell, A. W., Rossjohn, J., Gras, S., Kotsimbos, T. C. & Mifsud, N. A. 15 Jun 2018 In : Journal of Immunology. 200, 12, p. 3993-4003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

In Immunopeptidomics We Need a Sniper Instead of a Shotgun

Faridi, P., Purcell, A. W. & Croft, N. P. 2018 (Accepted/In press) In : Proteomics. 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Tubb, V. M., Schrikkema, D. S., Croft, N. P., Purcell, A. W., Linnemann, C., Freriks, M. R., Chen, F., Long, H. M., Lee, S. P. & Bendle, G. M. 13 Jul 2018 In : Journal for ImmunoTherapy of Cancer. 6, 1, 14 p., 70

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Quokka: A comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome

Li, F., Li, C., Marquez-Lago, T. T., Leier, A., Akutsu, T., Purcell, A. W., Smith, A. I., Lithgow, T., Daly, R. J., Song, J. & Chou, K-C. 27 Jun 2018 (Accepted/In press) In : Bioinformatics. 9 p., bty522

Research output: Contribution to journalArticleResearchpeer-review

Activities 2018 2018

  • 1 Membership of industry collaboration/ network

Biochemistry & Molecular Biology (Organisational unit)

Purcell, A. W. (Member), Quenette, S. M. (Member), Bonnington, C. P. (Member), Stephen Tate (Member), Nick Koletsas (Member), Croft, N. P. (Member)
1 Apr 201831 Dec 2020

Activity: Membership of industry collaboration/ network

Press / Media