1994 …2020

Research output per year

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Article
2020

Synthesis and biological evaluation of a novel photo-activated histone deacetylase inhibitor

Sama, G. R., Liu, H., Mountford, S., Thompson, P., Robinson, A. & Dear, A. E., 15 Aug 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 16, 5 p., 127291.

Research output: Contribution to journalArticleResearchpeer-review

2019

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

Liu, H., Byrne, M., Perlmutter, P., Walker, A., Sama, G. R., Subbiah, J., Ozcelik, B., Widdop, R. E., Gaspari, T. A., Byron, K., Chen, Y-C., Kaye, D. M. & Dear, A. E., 30 Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 687-692 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Epigenetic treatment-mediated modulation of PD-L1 predicts potential therapy resistance over response markers in myeloid malignancies: A molecular mechanism involving effectors of PD-L1 reverse signaling

Liu, H., Hu, Y., Rimoldi, R., Von Hagt, C., Khong, E. W. C., Lee, N., Flemming, S., Spencer, A. & Dear, A. E., Feb 2019, In : Oncology Letters. 17, 2, p. 2543-2550 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)
2018

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis

Gaspari, T., Spizzo, I., Liu, H., Hu, Y., Simpson, R. W., Widdop, R. E. & Dear, A. E., 1 Jan 2018, In : Diabetes and Vascular Disease Research. 15, 1, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)
2017

Association between metformin prescription and growth rates of abdominal aortic aneurysms

Golledge, J., Moxon, J. V., Pinchbeck, J., Anderson, G., Rowbotham, S., Jenkins, J., Bourke, M., Bourke, B., Dear, A., Buckenham, T., Jones, R. & Norman, P. E., Oct 2017, In : British Journal of Surgery. 104, 11, p. 1486-1493 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2016

Epigenetic Modulators and the New Immunotherapies

Dear, A. E., 18 Feb 2016, In : The New England Journal of Medicine. 374, 7, p. 684-686 3 p.

Research output: Contribution to journalArticleOtherpeer-review

29 Citations (Scopus)

Epigenetic regulation of miRNA-124 and multiple downstream targets is associated with treatment response in myeloid malignancies

Liu, H. B., Pattie, P., Chandrasekara, S., Spencer, A. & Dear, A. E., Sep 2016, In : Oncology Letters. 12, 3, p. 2175-2180 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Erratum to: 'TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial' [Trials, (2016), 17:43]

Morris, D. R., Cunningham, M. A., Ahimastos, A. A., Kingwell, B. A., Pappas, E., Bourke, M., Reid, C. M., Stijnen, T., Dalman, R. L., Aalami, O. O., Lindeman, J. H., Norman, P. E., Walker, P. J., Fitridge, R., Bourke, B., Dear, A. E., Pinchbeck, J., Jaeggi, R. & Golledge, J., 20 Jan 2016, In : Trials. 17, 1, 1 p., 43.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis

Gaspari, T., Brdar, M., Lee, H. W., Spizzo, I., Hu, Y., Widdop, R. E., Simpson, R. W. & Dear, A. E., 2016, In : Diabetes and Vascular Disease Research. 13, 1, p. 56-68 13 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2015

TElmisartan in the management of abDominal aortic aneurYsm (TEDY): the study protocol for a randomized controlled trial

Morrissey, D., Cunningham, M. A., Ahimastos, A. A., Kingwell, B. A., Pappas, E., Bourke, M., Reid, C. M., Stijnen, T., Dalman, R. L., Aalami, O. O., Lindeman, J. H., Norman, P. E., Walker, P. J., Fitridge, R., Bourke, B. M., Dear, A. E., Pinchbeck, J., Jaeggi, R. & Golledge, J., 2015, In : Trials. 16, p. 1 - 10 10 p.

Research output: Contribution to journalArticleOther

22 Citations (Scopus)
2014

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia

Rahmatzadeh, M., Liu, H. B., Krishna, S. M., Gaspari, T. A., Spizzo, I., Widdop, R. E. & Dear, A. E., 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 395 - 406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

Tan, P., Wei, A., Mithraprabhu, S., Cummings, N. J., Liu, H. B., Perugini, M., Reed, K. D., Avery, S., Patil, S., Walker, P. A., Mollee, P. N., Grigg, A. P., D'Andrea, R. J., Dear, A. E. & Spencer, A., 2014, In : Blood Cancer Journal. 4, 1, p. 1 - 8 8 p., e170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
73 Citations (Scopus)

Mechanisms and potential molecular markers of early response to combination epigenetic therapy in patients with myeloid malignancies

Liu, H. B., Urbanavicius, D. B., Tan, P., Spencer, A. & Dear, A. E., 2014, In : International journal of oncology. 45, 4, p. 1742 - 1748 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2013

Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization

Costa, M., Sourris, K., Lim, S. M., Yu, Q. C., Hirst, C. E., Parkington, H. C., Jameson-Jokubaitis, V. J., Dear, A. E., Liu, H. B., Micallef, S. J., Koutsis, K., Elefanty, A. G. & Stanley, E., 2013, In : Stem Cell Research. 10, 1, p. 103 - 117 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

Wightman, F., Lu, H. K., Solomon, A., Saleh, S. M., Harman, A. N., Cunningham, A. L., Gray, L. R., Churchill, M., Cameron, P. U., Dear, A. E. & Lewin, S. R., 2013, In : AIDS. 27, 18, p. 2853 - 2862 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
47 Citations (Scopus)

GLP-1-dependent and independent effects and molecular mechanisms of a dipeptidyl peptidase 4 inhibitor in vascular endothelial cells

Hu, Y., Liu, H. B., Simpson, R. & Dear, A. E., 2013, In : Molecular Biology Reports. 40, 3, p. 2273 - 2279 7 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

Krishna, S. M., Dear, A. E., Craig, J., Norman, P. & Golledge, J., 2013, In : Atherosclerosis. 228, 2, p. 295 - 305 11 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)
2011

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model

Gaspari, T., Liu, H., Welungoda, I., Hu, Y., Widdop, R., Knudsen, L., Simpson, R. & Dear, A., 2011, In : Diabetes and Vascular Disease Research. 8, 2, p. 117 - 124 8 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)

PPAR(gamma)-independent thiazolidinedione-mediated inhibition of NUR77 expression in vascular endothelial cells

Hu, Y., Liu, H., Simpson, R. & Dear, A., 2011, In : Journal of Endocrinology. 208, 1, p. R1 - R7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The anti-leukemic effect and molecular mechanisms of novel hydroxamate and benzamide histone deacetylase inhibitors with 5-aza-cytidine

Liu, H. B., Mayes, P. A., Perlmutter, P., McKendrick, J. & Dear, A. E., 2011, In : International journal of oncology. 38, 5, p. 1421 - 1425 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2010

Association of statin prescription with small abdominal aortic aneurysm progression

Ferguson, C. D., Clancy, P., Bourke, B., Walker, P. J., Dear, A., Buckenham, T., Norman, P. & Golledge, J., 2010, In : American Heart Journal. 159, 2, p. 307 - 313 7 p.

Research output: Contribution to journalArticleResearchpeer-review

128 Citations (Scopus)

Genetic and epigenetic mechanisms and their possible role in abdominal aortic aneurysm

Krishna, S. M., Dear, A. E., Norman, P. & Golledge, J., 2010, In : Atherosclerosis. 212, 1, p. 16 - 29 14 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
2009

A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules

Liu, H. B., Dear, A. E., Knudsen, L. B. & Simpson, R., 2009, In : Journal of Endocrinology. 201, 1, p. 59 - 66 8 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

A novel histone deacetylase inhibitor augments tamoxifen-mediated attenuation of breast carcinoma growth

Restall, C., Doherty, J., Liu, H. B., Genovese, R., Paiman, L., Byron, K., Anderson, R. & Dear, A. E., 2009, In : International Journal of Cancer. 125, 2, p. 483 - 487 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression

Liu, H. B., Voso, M. T., Gumiero, D., Duong, J., McKendrick, J. & Dear, A. E., 2009, In : International journal of oncology. 34, 2, p. 573 - 579 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells

Shehu-Xhilaga, M., Rhodes, D., Wightman, F., Liu, H. B., Solomon, A., Saleh, S. M., Dear, A. E., Cameron, P. U. & Lewin, S. R., 2009, In : AIDS. 23, 15, p. 2047 - 2050 3 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2008

A novel histone deacetylase inhibitor reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice

Vinh, A., Gaspari, T. A., Liu, H., Dousha, L., Widdop, R. E. & Dear, A. E., 2008, In : Journal of Vascular Research. 45, p. 143 - 152 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin

Newbold, A., Lindemann, R. K., Cluse, L. A., Whitecross, K. F., Dear, A. E. & Johnstone, R. W., 2008, In : Molecular Cancer Therapeutics. 7, 5, p. 1066 - 1079 14 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Glucagon-like peptide-1 attenuates tumour necrosis factor-alpha-mediated induction of plasmogen activator inhibitor-1 expression

Liu, H., Hu, Y., Simpson, R. W. & Dear, A. E., 2008, In : Journal of Endocrinology. 196, 1, p. 57 - 65 9 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions

Golledge, J., Karan, M., Moran, C., Muller, J., Clancy, P., Dear, A. E. & Norman, P., 2008, In : European Heart Journal. 29, 5, p. 665 - 672 8 p.

Research output: Contribution to journalArticleResearchpeer-review

132 Citations (Scopus)
2007

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

Lindemann, R. K., Newbold, A., Whitecross, K. F., Cluse, L. A., Frew, A. J., Ellis, L., Williams, S., Wiegmans, A. P., Dear, A. E., Scott, C. L., Pellegrini, M., Wei, A., Richon, V. M., Marks, P. A., Lowe, S. W., Smyth, M. J. & Johnstone, R. W., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 19, p. 8071 - 8076 6 p.

Research output: Contribution to journalArticleResearchpeer-review

164 Citations (Scopus)

Association between osteopontin and human abdominal aortic aneurysm

Golledge, J., Muller, J., Shephard, N., Clancy, P., Smallwood, L., Moran, C., Dear, A. E., Palmer, L. J. & Norman, P., 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 3, p. 655 - 660 6 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)
2006

Conformational analogues of Oxamflatin as histone deacetylase inhibitors

Dear, A. E., Liu, H. B., Mayes, P. A. & Perlmutter, P., 2006, In : Organic and Biomolecular Chemistry. 4, 20, p. 3778 - 3784 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2005

Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation

Liu, H. B., Hu, Y. S., Medcalf, R. L., Simpson, R. W. & Dear, A. E., 2005, In : Biochemical and Biophysical Research Communications. 334, p. 30 - 37 8 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)
2004

Novel Inhibitors of Urokinase-type Plasminogen Activator and Matrix Metalloproteinase Expression in Metastatic Cancer Cell Lines

Cakarovski, K., Leung, J. Y., Restall, C., Carin-Carlson, A., Yang, E., Perlmutter, P., Anderson, R., Medcalf, R. L. & Dear, A. E., 2004, In : International Journal of Cancer. 110, 4, p. 610 - 616 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2003

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors

Peart, M. J., Tainton, K. M., Ruefli, A. A., Dear, A. E., Sedelies, K. A., O'Reilly, L. A., Waterhouse, N. J., Trapani, J. A. & Johnstone, R. W., 2003, In : Cancer Research. 63, 15, p. 4460 - 4471 12 p.

Research output: Contribution to journalArticleResearchpeer-review

232 Citations (Scopus)
1998

The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule

Dear, A. E. & Medcalf, R. L., 1998, In : Eur. J. Biochem. p. 185 - 193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)
1997
1 Citation (Scopus)
1996

Malignant pulmonary lymphoid disease: Case reports illustrating anatomical pattern of disease as a prognostic marker

Dear, A. E., Goldstein, D. & Hayman, J. A., 1996, In : Pathology. 28, 1, p. 20-24 5 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression

Dear, A. E., Shen, Y., Rüegg, M. & Medcalf, R. L., 1 Jan 1996, In : European Journal of Biochemistry. 241, 1, p. 93-100 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Urokinase-mediated, ap-1 associated, induction of plasminogen activator inhibitor type-2: A novel auto-regulatory loop

Dear, A. E. & Medcalf, R. L., 1 Dec 1996, In : Fibrinolysis. 10, SUPPL. 3, p. 90 1 p.

Research output: Contribution to journalArticleOtherpeer-review