1994 …2020

Research output per year

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Personal profile


Associate Professor Dear completed his medical degree, with honours, at Monash University. He continued his clinical training at the Alfred and Box Hill Hospital campuses and currently holds an appointment at Eastern Health as a clinical consultant in Vascular Medicine. Associate Professor Dear obtained his PhD from Monash University for research examining the molecular biological control of components of the plasminogen activating system.

Associate Professor Dear heads the Eastern Clinical Research Unit (ECRU) Translational Research Division Laboratory at Monash University, Department of Medicine, Eastern Health Clinical School.

Associate Professor Dear is involved in numerous scientific collaborations with national and international research groups focusing on translational research programmes in several clinical disciplines.

See more detail of Anthony's research and team at:


Research interests

The ECRU Translational Research Division laboratory is based at the Eastern Health Clinical School, Monash University Department of Medicine. Within the laboratory I supervise a research team involved in in vitro and in vivo evaluation of novel HDACi's and a number of other translational research projects. The research team consists of Dr Hong Bin Liu (Post Doctoral Research Fellow), Dr Yushan Hu (Post Doctoral Research Fellow), past and present BSc (Hons) and PhD students. The laboratory is funded through competitive granting agencies together with pharmaceutical company research grants.

Research area keywords

  • Cancer Biology
  • Cellular Biology
  • Clinical Trial
  • Demethylation Agents
  • Diabetes
  • Epigenetics
  • Glucagon-Like
  • Endothelial Cells
  • Histone Deacetylase Inhibitors
  • Molecular Biology
  • Translational Research
  • Vascular Biology
  • Vascular Disease

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Research Output

Synthesis and biological evaluation of a novel photo-activated histone deacetylase inhibitor

Sama, G. R., Liu, H., Mountford, S., Thompson, P., Robinson, A. & Dear, A. E., 15 Aug 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 16, 5 p., 127291.

Research output: Contribution to journalArticleResearchpeer-review

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

Liu, H., Byrne, M., Perlmutter, P., Walker, A., Sama, G. R., Subbiah, J., Ozcelik, B., Widdop, R. E., Gaspari, T. A., Byron, K., Chen, Y-C., Kaye, D. M. & Dear, A. E., 30 Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 687-692 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Epigenetic treatment-mediated modulation of PD-L1 predicts potential therapy resistance over response markers in myeloid malignancies: A molecular mechanism involving effectors of PD-L1 reverse signaling

Liu, H., Hu, Y., Rimoldi, R., Von Hagt, C., Khong, E. W. C., Lee, N., Flemming, S., Spencer, A. & Dear, A. E., Feb 2019, In : Oncology Letters. 17, 2, p. 2543-2550 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis

Gaspari, T., Spizzo, I., Liu, H., Hu, Y., Simpson, R. W., Widdop, R. E. & Dear, A. E., 1 Jan 2018, In : Diabetes and Vascular Disease Research. 15, 1, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)

Association between metformin prescription and growth rates of abdominal aortic aneurysms

Golledge, J., Moxon, J. V., Pinchbeck, J., Anderson, G., Rowbotham, S., Jenkins, J., Bourke, M., Bourke, B., Dear, A., Buckenham, T., Jones, R. & Norman, P. E., Oct 2017, In : British Journal of Surgery. 104, 11, p. 1486-1493 8 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Press / Media

New medical device may reduce risks in common medical procedure

Anthony Dear


1 Media contribution

Press/Media: Profile/Interview