Projects per year
Personal profile
Monash teaching commitment
BMS1062 Molecular Biology
BMS2062 Introduction to Bioinformatics (unit convenor and lecturer)
BCH3052 Advanced Protein Biology: from Sequence to Structure and Disease
MIC3032 Pathogenesis of Bacterial Infectious Diseases
Biography
A/Professor Anna Roujeinikova leads a research group at Monash University's Biomedicine Discovery Institute. Her research focuses on bacteria of medical importance. She received interdisciplinary education; she studied Natural Sciences (BSc cum laude) and Applied Physics and Mathematics (MSc with distinct.) at the Moscow Institute of Physics and Technology. She obtained a PhD in Structural Biology from the University of Sheffield (UK). Prior to joining Monash University (Australia) as an Associate Professor, Anna gained postdoctoral experience at the Institute for Cancer Studies (Sheffield, UK), Leicester University (UK) and Manchester University (UK). She has determined and published ~90 different crystal structures and her work has led to a significant advance of knowledge about human pathogens. For example, her work unravelling the molecular mechanism of action of a common antiseptic triclosan (Nature, 1999) provided evidence supporting the World Health Organisation Global Guidelines for the Prevention of Surgical Site Infection. Her subsequent work on essential bacterial proteins and mechanisms of their inhibition by commercial drugs has attracted significant interest from pharmaceutical companies, and the structures she published have subsequently been used as templates for the design of novel drug candidates for antibacterial, antiparasite and HIV treatment. More recently her main focus has been on bacterial motility and its control by chemoreceptors. Her group uses an interdisciplinary approach combining microbiology and physics to study the structure, function and regulation of the bacterial flagellar motor. Her achievements in this area have been recognised by the awards of Fellowships (a Wellcome Trust (UK) Career Development Fellowship (2006) and ARC Research Fellowship (2010)) and grants from ARC, NHMRC and NIH.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- bacterial flagellar motor
- structural biology
- Helicobacter pylori
- crystallography
- biocatalysis
- bacterial chemotaxis
- antibiotic resistance
- molecular basis of disease
- Campylobacter jejuni
- protein biochemistry
- biophysics
- bacterial pathogenicity
- membrane proteins
- enzyme activity
- protein-protein interactions
- antimicrobials
Collaborations and top research areas from the last five years
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Structural and functional studies of Helicobacter pylori flagellar motor
8/11/21 → 7/11/25
Project: Research
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The function of chemotactic signal transduction during colonization and disease
Ottemann, K. & Roujeinikova, A.
17/09/21 → 31/08/26
Project: Research
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Laws of attraction and repulsion: a novel family of bacterial chemosensors
Roujeinikova, A., Norton, R. & Smith, B. J.
1/01/18 → 31/12/22
Project: Research
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Understanding the structural basis for catalysis and substrate specificity in non-heme diiron medium-chain alkane hydroxylases
Roujeinikova, A. & De Voss, J.
Australian Research Council (ARC)
9/09/13 → 31/12/16
Project: Research
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Bacterial flagella hijack type IV pili proteins to control motility
Liu, X., Tachiyama, S., Zhou, X., Mathias, R. A., Bonny, S. Q., Khan, M. F., Xin, Y., Roujeinikova, A., Liu, J. & Ottemann, K. M., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 4, 7 p., e2317452121.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Biochemical characterization of paralyzed flagellum proteins A (PflA) and B (PflB) from Helicobacter pylori flagellar motor
Zhou, X., Khan, M., Xin, Y., Chan, K. L. & Roujeinikova, A., Sept 2024, In: Bioscience Reports. 44, 9, 11 p., BSR20240692.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Campylobacter jejuni virulence factors: update on emerging issues and trends
Tikhomirova, A., McNabb, E. R., Petterlin, L., Bellamy, G. L., Lin, K. H., Santoso, C. A., Daye, E. S., Alhaddad, F. M., Lee, K. P. & Roujeinikova, A., Dec 2024, In: Journal of Biomedical Science. 31, 1, 20 p., 45.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance
Tikhomirova, A., Rahman, M. M., Kidd, S. P., Fererro, R. L. & Roujeinikova, A., Jan 2024, In: Trends in Microbiology. 32, 1, p. 93-104 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access13 Citations (Scopus) -
Functional and biochemical characterisation of remote homologues of type IV pili proteins PilN and PilO in Helicobacter pylori
Bonny, S. Q., Zhou, X., Khan, M. F., Rahman, M. M., Xin, Y., Vankadari, N., Tikhomirova, A., Homman-Ludiye, J. & Roujeinikova, A., Oct 2024, In: IUBMB Life. 76, 10, p. 780-787 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access