Anna Hearps

Miss

20062018
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Research Output 2006 2018

2018

Adaptive reprogramming of NK cells in X-Linked lymphoproliferative syndrome

Opat, S., Hearps, A. C., Thia, K., Yuen, A., Rogers, B., Chachage, M., Moore, G., Shortt, J., Ryland, G., Blombery, P., Schwarer, A. P., Noori, T., Trapani, J. A., Jaworowski, A. & Voskoboinik, I., 8 Feb 2018, In : Blood. 131, 6, p. 699-702 4 p.

Research output: Contribution to journalLetterOtherpeer-review

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., 1 Jan 2018, (Accepted/In press) In : Cellular Microbiology. 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

2017

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

Trevillyan, J. M., Gardiner, E. E., Andrews, R. K., Maisa, A., Hearps, A. C., Al-Tamimi, M., Crowe, S. M. & Hoy, J. F., 3 Apr 2017, In : Platelets. 28, 3, p. 301-304 4 p.

Research output: Contribution to journalArticleResearchpeer-review

High levels of transmitted HIV drug resistance in a study in Papua New Guinea

Lavu, E., Kave, E., Mosoro, E., Markby, J., Aleksic, E., Gare, J., Elsum, I. A., Nano, G., Kaima, P., Dala, N., Gurung, A., Bertagnolio, S., Crowe, S. M., Myatt, M., Hearps, A. C. & Jordan, M. R., 1 Feb 2017, In : PLoS ONE. 12, 2, 12 p., e0170265.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Persistence of activated and adaptive-like NK cells in HIV+ individuals despite 2 Years of suppressive combination antiretroviral therapy

Hearps, A. C., Agius, P. A., Zhou, J., Brunt, S., Chachage, M., Angelovich, T. A., Cameron, P. U., Giles, M., Price, P., Elliott, J. & Jaworowski, A., 30 Jun 2017, In : Frontiers in Immunology. 8, JUN, 12 p., 731.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Porphyromonas gingivalis antibody levels and diagnosis of coronary artery disease in HIV-positive individuals

Berquist, V. L., Hearps, A. C., Ford, P., Jaworowski, A., Leishman, S. J., Hoy, J. F. & Trevillyan, J. M., Oct 2017, In : Journal of Periodontal Research. 52, 5, p. 930-935 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition

Hearps, A. C., Tyssen, D., Srbinovski, D., Bayigga, L., Diaz, D. J. D., Aldunate, M., Cone, R. A., Gugasyan, R., Anderson, D. J. & Tachedjian, G., 1 Nov 2017, In : Mucosal Immunology. 10, 6, p. 1480-1490 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Ex vivo foam cell formation is enhanced in monocytes from older individuals by both extrinsic and intrinsic mechanisms

Angelovich, T. A., Shi, M. D. Y., Zhou, J., Maisa, A., Hearps, A. C. & Jaworowski, A., 1 Jul 2016, In : Experimental Gerontology. 80, p. 17-26 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase

Telwatte, S., Brumme, C. J., Hearps, A. C., Latham, C. F. M., Hayward, J. A., Sonza, S., Sluis-Cremer, N., Harrigan, P. R. & Tachedjian, G., 28 Nov 2016, In : AIDS. 30, 18, p. 2787-2793 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

An NK cell population lacking FcRgamma is expanded in chronically infected HIV patients

Zhou, J., Amran, F. S., Kramski, M., Angelovich, T. A., Elliott, J., Hearps, A. C., Price, P. & Jaworowski, A., 2015, In : Journal of Immunology. 194, 10, p. 4688 - 4697 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

Aldunate, M. C., Srbinovski, D., Hearps, A. C., Latham, C. F., Ramsland, P. A., Gugasyan, R., Cone, R. A. & Tachedjian, G., 2015, In : Frontiers in Physiology. 6, 23 p., 164.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Factors influencing antiretroviral adherence and virological outcomes in people living with HIV in the highlands of Papua New Guinea

Gare, J., Kelly-Hanku, A. M., Ryan, C. E., David, M., Kaima, P., Imara, U., Lote, N., Crowe, S. M. & Hearps, A. C., 2015, In : PLoS ONE. 10, 8, 14 p., e0134918.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inflammation-induced foam cell formation in chronic inflammatory disease

Angelovich, T. A., Hearps, A. C. & Jaworowski, A., 19 Sep 2015, In : Immunology and Cell Biology. 93, 8, p. 683-693 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration

Maisa, A., Hearps, A. C., Angelovich, T. A., Pereira, C. F., Zhou, J., Shi, M. D. Y., Palmer, C. S., Muller, W. A., Crowe, S. M. & Jaworowski, A., 31 Jul 2015, In : AIDS. 29, 12, p. 1445-1457 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

Telwatte, S., Hearps, A. C., Johnson, A. P., Latham, C. F., Moore, K. A., Agius, P. A., Tachedjian, M., Sonza, S., Sluis-Cremer, N., Harrigan, P. R. & Tachedjian, G., 2015, In : Nucleic Acids Research. 43, 6, p. 3256 - 3271 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Viremic and virologically suppressed HIV infection increases age-related changes to monocyte activation equivalent to 12 and 4 years of aging, respectively

Angelovich, T. A., Hearps, A. C., Maisa, A., Martin, G. E., Lichtfuss, G. F., Cheng, W-J., Palmer, C. S., Landay, A. L., Crowe, S. M. & Jaworowski, A., 1 May 2015, In : JAIDS. 69, 1, p. 11-17 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals

Westhorpe, C. L., Maisa, A., Spelman, T. D., Hoy, J. F., Dewar, E. M., Karapanagiotidis, S., Hearps, A., Cheng, W-J., Trevillyan, J. M., Lewin, S. R., Sviridov, D., Elliott, J., Jaworowski, A., Dart, A. M. & Crowe, S. M., 2014, In : Immunology and Cell Biology. 92, 2, p. 133 - 138 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

Palmer, C. P-S., Ostrowski, M., Gouillou, M., Tsai, L. M-C., Yu, D., Zhou, J., Henstridge, D. C., Maisa, A., Hearps, A. C., Lewin, S. R., Landay, A. L., Jaworowski, A., McCune, J. M. & Crowe, S. M., 2014, In : AIDS. 28, 3, p. 297 - 309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammatory co-morbidities in HIV+ individuals: learning lessons from healthy ageing

Hearps, A. C., Martin, G., Rajasuriar, R. & Crowe, S. M., 2014, In : Current HIV/AIDS Reports. 11, 1, p. 20 - 34 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Lactic Acid, a Vaginal Microbiota Metabolite, Elicits an Anti-inflammatory Response from Vaginal and Cervical Epithelial Cells

Hearps, A. C., Batista, F. (ed.), Gugasyan, R., Srbinovski, D., Tyssen, D. P., Aldunate, M. C., Anderson, D. J., Cone, R. & Tachedjian, G., 2014, p. 238 - 239. 2 p.

Research output: Contribution to conferenceAbstractOther

Presence of HIV drug resistance in antiretroviral therapy-naive and -experienced patients from Papua New Guinea

Gare, J., Ryan, C. E., David, M., Timbi, D., Kaima, P., Kombati, Z., Imara, U., Kelly-Hanku, A. M., Siba, P. M., Crowe, S. M. & Hearps, A. C., 1 Aug 2014, In : Journal of Antimicrobial Chemotherapy. 69, 8, p. 2183-2186 4 p., dku089.

Research output: Contribution to journalArticleResearchpeer-review

The importance of monocytes and macrophages in HIV pathogenesis,treatment,and cure

Campbell, J. H., Hearps, A. C., Martin, G. E., Williams, K. C. & Crowe, S. M., 24 Sep 2014, In : AIDS. 28, 15, p. 2175-2187 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2013

Acquisition of HIV by african-born residents of Victoria, Australia: Insights from molecular epidemiology

Lemoh, C., Ryan, C. E., Sekawi, Z., Hearps, A. C., Aleksic, E., Chibo, D., Grierson, J., Baho, S., Street, A., Hellard, M., Biggs, B. A. & Crowe, S. M., 31 Dec 2013, In : PLoS ONE. 8, 12, 10 p., e84008.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women

Martin, G., Gouillou, M., Hearps, A. C., Angelovich, T. A., Cheng, A. C-S., Lynch, F., Cheng, W-J., Paukovics, G., Palmer, C. P-S., Novak, R. M., Jaworowski, A., Landay, A. L. & Crowe, S. M., 2013, In : PLoS ONE. 8, 1, 7 p., e55279.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

First molecular epidemiology study of Mycobacterium tuberculosis in Kiribati

Aleksic, E., Merker, M., Cox, H. S., Reiher, B., Sekawi, Z., Hearps, A., Ryan, C., Lee, A. V., Goursaud, R., Malau, C., O'Connor, J., Cherry, C., Niemann, S. & Crowe, S. M., 2013, In : PLoS ONE. 8, 1, 9 p., e55423.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging

Leeansyah, E., Cameron, P. U., Solomon, A., Tennakoon, G. S., Velayudham, P., Gouillou, M., Spelman, T. D., Hearps, A. C., Fairley, C. K., Smit, D., Pierce, A., Armishaw, J., Crowe, S. M., Cooper, D. A., Koelsch, K. K., Liu, J-P., Chuah, J. & Lewin, S. R., 2013, In : Journal of Infectious Diseases. 207, 7, p. 1157 - 1165 9 p.

Research output: Contribution to journalArticleResearchpeer-review

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients

Rezaei, S. D., Hearps, A. C., Mills, J., Pedersen, J. S. & Tachedjian, G., 2013, In : Virology Journal. 10, p. 1 - 9 9 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

Hearps, A. C., Martin, G., Angelovich, T. A., Cheng, W-J., Maisa, A., Landay, A. L., Jaworowski, A. & Crowe, S. M., 2012, In : Aging Cell. 11, 5, p. 867 - 875 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

HIV infection induces age-related changes to monocytes and innate immune activation in young males which persist despite cART

Hearps, A. C., Maisa, A., Cheng, W-J., Angelovich, T. A., Lichtfuss, G. F., Palmer, C. P-S., Landay, A. L., Jaworowski, A. & Crowe, S. M., 2012, In : AIDS. 26, 7, p. 843 - 853 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation

Lichtfuss, G. F., Cheng, W-J., Farsakoglu, Y., Paukovics, G., Rajasuriar, R., Velayudham, P., Kramski, M., Hearps, A., Cameron, P. U., Lewin, S. R., Crowe, S. M. & Jaworowski, A., 2012, In : Journal of Immunology. 189, 3, p. 1491 - 1499 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

An AlphaScreen-based assay for high-throughput screening for specific inhibitors of nuclear import

Wagstaff, K. M., Rawlinson, S. M., Hearps, A. & Jans, D. A., 2011, In : Journal of Biomolecular Screening. 16, 2, p. 192 - 200 9 p.

Research output: Contribution to journalArticleResearchpeer-review

HIV infection and aging of the innate immune system

Hearps, A., Angelovich, T. A., Jaworowski, A., Mills, J., Landay, A. L. & Crowe, S. M., 2011, In : Sexual Health. 8, 4, p. 453 - 464 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Premature onset of cardiovascular disease in HIV-infected individuals: the drugs and the virus

Maisa, A., Westhorpe, C., Elliott, J., Jaworowski, A., Hearps, A., Dart, A., Hoy, J. & Crowe, S., 2010, In : Future HIV Therapy. 4, 6, p. 675 - 692 18 p.

Research output: Contribution to journalArticleOther

Stability of dried blood spots for HIV-1 drug resistance analysis

Hearps, A. C., Ryan, C. E., Morris, L. M., Plate, M., Greengrass, V. & Crowe, S. M., Mar 2010, In : Current HIV Research. 8, 2, p. 134-140 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

An HIV-1 integrase genotype assay for the detection of drug resistance mutations

Hearps, A., Greengrass, V., Hoy, J. F. & Crowe, S. M., 2009, In : Sexual Health. 6, 4, p. 305 - 309 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of reverse transcriptase inhibitors and mutations on the low-cost Cavidi reverse transcriptase viral load assay

van Rooijen, L., Greengrass, V., Morris, L. M., Plate, M., Gouillou, M., Tachedjian, G., Sluis-Cremer, N., Hearps, A. & Crowe, S. M., 2009, In : JAIDS. 52, 4, p. 527 - 529 3 p.

Research output: Contribution to journalLetterOther

Evaluation of the blood stabilizers TransFixTM and Cyto-Chex(R) BCT for low-cost CD4 T-cell methodologies

Plate, M., Louzao, R., Steele, P. M., Greengrass, V., Morris, L. M., Lewis, J., Barnett, D., Warrino, D., Hearps, A., Denny, T. & Crowe, S. M., 2009, In : Viral Immunology. 22, 5, p. 329 - 332 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of the Cavidi ExaVir Load assay (version 3) for plasma human immunodeficiency virus type 1 load monitoring

Greengrass, V., Plate, M., Steele, P. M., Denholm, J., Cherry, C., Morris, L. M., Hearps, A. & Crowe, S. M., 2009, In : Journal of Clinical Microbiology. 47, 9, p. 3011 - 3013 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Regulating the functions of the HIV-1 matrix protein

Hearps, A. C. & Jans, D. A., 2007, In : AIDS Research and Human Retroviruses. 23, 3, p. 341 - 346 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The biarsenical dye lumiotrademark exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells

Hearps, A. C., Pryor, M. J., Kuusisto, H. V., Rawlinson, S. M., Piller, S. & Jans, D. A., 2007, In : Journal of Fluorescence. 17, 6, p. 593 - 597 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

HIV-1 integrase is capable of targeting DNA to the nucleus via an Importin alpha/beta-dependent mechanism

Hearps, A. C. & Jans, D. A., 2006, In : Biochemical Journal. 398, 3, p. 475 - 484 10 p.

Research output: Contribution to journalArticleResearchpeer-review