If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Associate Professor Ann Chidgey obtained her BSc and Dip.Ed at the University of Melbourne. She subsequently developed her interest in Immunology while on a professional Federal Govt Aid Program in Zimbabwe (Africa), during a time when the HIV/AIDS epidemic was being discovered. Ann returned to Melbourne to complete her Honours degree and PhD (1998) in the Dept of Immunology, Monash University.

Ann established her expertise in Thymus and T cell biology, working in the laboratory of Prof Richard Boyd at Monash University (MISCL, Monash Immunology and Stem Cell Laboratories) and during her extended research training at MIT (Boston, USA), Amgen Institute (Toronto, Canada), Basel Institute and University of Basel (Basel, Switzerland) and the MRC Centre for Immune Regulation (University of Birmingham, UK). During this period, while assisting in the management of the laboratory's commercial programs, she began to develop her own research group focusing on characterising postnatal thymic epithelial stem cells.

Ann became Head of the Thymus Development, Ageing and Regeneration Laboratory in the Department of Anatomy and Developmental Biology in 2016. Her research group investigates the mechanisms underpinning early thymus ageing with a current focus on the role of postnatal thymic epithelial stem cells in ageing and recovery from chemotherapy damage, and influences from surrounding resident stromal cells on their state of quiescence and differentiation. Her research interfaces immunology, stem cell biology and biomaterials engineering in developing strategic approaches for thymus and T cell rejuvenation.

The clinical relevance of this research lies in the fact that our immune system naturally diminishes in function as we age, predominantly due to the early degeneration of thymus tissue - the primary immune organ that produces T cells. This can lead to an increased susceptibility to infections, cancers and autoimmunity. Adult vaccines are less efficacious and immune recovery following damaging chemotherapy/irradiation treatments associated with cancer therapy or from chronic infections such as HIV, becomes increasingly compromised in older patients, often not recovering for years if at all in the aged/elderly. Regeneration of the damaged thymus will be important to replenish the T cell repertoire following cytoablative treatments for overall immune recovery, and also may be important for enhancing the success of immunotherapy approaches that are currently being developed for cancer eradication. There are currently no immune regeneration approaches used in the clinic.

Ann and her team’s recent research highlights include: identifying and characterizing a post-natal thymic epithelial progenitor/stem cell population in the adult thymus (Wong et al, Cell Reports 2014); developing an in vitro 3D culture system to investigate the nature of thymic epithelial stem cells and role of the stromal cell niche for their self-renewal and differentiation, using biomaterials engineering approaches (Hun et al, Biomaterials 2017; Truong/Hun et al, Biomaterials Science 2016); generating a Foxn1-GFP reporter mouse line and identifying the role of  Bmp4 in thymus development and ageing (Barsanti/Lim et al, Eur J Immunol 2017);  identifying an interplay between Bmp4 and Activin A in thymus involution and regeneration (Lepletier/Hun, Cell Reports 2019); identifying the role of HSC function/bone marrow in thymus ageing and steroid hormone blockade-induced immune regeneration (Khong/Dudakov et al, Stem Cell Reports 2015); and generating a protocol for the differentiation of pluripotent stem cells into the thymic epithelial cell lineage (Soh et al, Stem Cell Reports 2014).

 

Research area keywords

  • thymus
  • thymic epithelial cells
  • immune ageing
  • stem cells
  • stem cell niche
  • immune regeneration

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2000 2019

Research Output 1997 2019

Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation

Hun, M., Barsanti, M., Wong, K., Ramshaw, J., Werkmeister, J. & Chidgey, A. P., Feb 2017, In : Biomaterials. 118, p. 1-15 15 p., 145253.

Research output: Contribution to journalArticleResearchpeer-review

A novel Foxn1eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations

Barsanti, M., Lim, J. M. C., Hun, M. L., Lister, N., Wong, K., Hammett, M. V., Lepletier, A., Boyd, R. L., Giudice, A. & Chidgey, A. P., Feb 2017, In : European Journal of Immunology. 47, 2, p. 291-304 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus

Wong, K. Y. P., Seach, N. L., Barsanti, M., Lim, J. M. C., Hammett, M. V., Khong, D. M., Siatskas, C., Gray, D. H. D., Boyd, R. L. & Chidgey, A. P., 2014, In : Cell Reports. 8, 4, p. 1198 - 1209 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

FOXN1GFP/w reporter hESCs enable identification of integrin-a4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1 + thymic epithelial progenitors

Soh, C-L., Giudice, A., Jenny, R. A., Elliott, D. A., Hatzistavrou, T., Micallef, S. J., Kianizad, K., Seach, N. L., Zuniga-Pflucker, J. C., Chidgey, A. P., Trounson, A. O., Nilsson, S. S. K., Haylock, D. N., Boyd, R. L., Elefanty, A. G. & Stanley, E. G., 2014, In : Stem Cell Reports. 2, 6, p. 925 - 937 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade

Khong, D. M., Dudakov, J. A., Hammett, M. V., Jurblum, M. I., Khong, S. M. L., Goldberg, G. L., Ueno, T., Spyroglou, L. G., Young, L. F., van den Brink, M. R. M., Boyd, R. L. & Chidgey, A. P., 2015, In : Stem Cell Reports. 4, 3, p. 445 - 458 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

Australian Federal Government Centenary Medal

Ann Chidgey (Recipient), 2001

Prize: Prize (including medals and awards)

Mollie Hollman Medal

Ann Chidgey (Recipient), 1998

Prize: Prize (including medals and awards)

Monash University Overseas Study Grant-in-Aid Award

Ann Chidgey (Recipient), 1995

Prize: Prize (including medals and awards)

Monash University Postgraduate Publications Award

Ann Chidgey (Recipient), 1998

Prize: Prize (including medals and awards)

Nairn Medal in Immunology

Ann Chidgey (Recipient), 1993

Prize: Prize (including medals and awards)

Activities 1995 2019

  • 7 Contribution to conference
  • 1 Editorial responsibility

Frontiers in Immunology (Journal)

Ann Chidgey (Guest editor), Nicolai Stanislas Van Oers (Guest editor), Jarrod A. Dudakov (Guest editor), Dong-Ming Su (Guest editor)
1 Sep 20192 May 2020

Activity: Publication peer-review and editorial work typesEditorial responsibility

ThymE: T cell and Thymus Biology-EMBO international conference

Ann Chidgey (Invited speaker)
2019 → …

Activity: Participating in or organising an event typesContribution to conference

Australian Biology of Ageing Conference

Ann Chidgey (Speaker)
2018 → …

Activity: Participating in or organising an event typesContribution to conference

Australasian Society of Biomaterials and Tissue Engineering Conference

Ann Chidgey (Invited speaker)
2018 → …

Activity: Participating in or organising an event typesContribution to conference

ThymOz 8

Ann Chidgey (Organiser)
2018 → …

Activity: Participating in or organising an event typesContribution to conference

Press / Media

Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus.

Ann Chidgey

18/08/1426/09/14

1 item of Media coverage, 1 Media contribution

Press/Media: Article/Feature