Anitha Kopinathan

Research Fellow, Medicinal Chemistry

https://orcid.org/0000-0002-8519-075X

Emailanitha.kopinathan@monash.edu

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1 Active

Synthesis of 19F-13C labelled aromatic amino acid probes for the investigation of protein structure and dynamics by 19F-TROSY-NMR spectroscopy.
Kopinathan, A.
1/10/20 → 31/12/21
Project: Research

5 Article
1 Review Article

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole
Klein Herenbrink, C., Verma, R., Lim, H. D., Kopinathan, A., Keen, A., Shonberg, J., Draper-Joyce, C. J., Scammells, P. J., Christopoulos, A., Javitch, J. A., Capuano, B., Shi, L. & Lane, J. R., 16 Aug 2019, In : ACS Chemical Biology. 14, 8, p. 1780-1792 13 p.
Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)
Subtle modifications to the indole-2-carboxamide motif of the negative allosteric modulator N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) yield dramatic changes in pharmacological activity at the dopamine D₂ receptor
Kopinathan, A., Draper-Joyce, C., Szabo, M., Christopoulos, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 371-377 7 p.
Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)
The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions
Draper-Joyce, C. J., Verma, R. K., Michino, M., Shonberg, J., Kopinathan, A., Klein Herenbrink, C., Scammells, P. J., Capuano, B., Abramyan, A. M., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 1208.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
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8 Citations (Scopus)
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D₂ receptor
Draper-Joyce, C. J., Michino, M., Verma, R. K., Klein Herenbrink, C., Shonberg, J., Kopinathan, A., Scammells, P. J., Capuano, B., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 315-328 14 p.
Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)
Multivalent approaches and beyond: novel tools for the investigation of dopamine D₂ receptor pharmacology
Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.
Research output: Contribution to journal › Review Article › Research › peer-review

3 Citations (Scopus)

Synthesis of 19F-13C labelled aromatic amino acid probes for the investigation of protein structure and dynamics by 19F-TROSY-NMR spectroscopy.

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

Subtle modifications to the indole-2-carboxamide motif of the negative allosteric modulator N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) yield dramatic changes in pharmacological activity at the dopamine D2 receptor

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology

Subtle modifications to the indole-2-carboxamide motif of the negative allosteric modulator N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) yield dramatic changes in pharmacological activity at the dopamine D₂ receptor

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D₂ receptor

Multivalent approaches and beyond: novel tools for the investigation of dopamine D₂ receptor pharmacology