Research Output per year
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Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2011 2019
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole
Klein Herenbrink, C., Verma, R., Lim, H. D., Kopinathan, A., Keen, A., Shonberg, J., Draper-Joyce, C. J., Scammells, P. J., Christopoulos, A., Javitch, J. A., Capuano, B., Shi, L. & Lane, J. R., 16 Aug 2019, In : ACS Chemical Biology. 14, 8, p. 1780-1792 13 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
Subtle modifications to the indole-2-carboxamide motif of the negative allosteric modulator N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1 H)-yl)ethyl)cyclohexyl)-1 H-indole-2-carboxamide (SB269652) yield dramatic changes in pharmacological activity at the dopamine D2 receptor
Kopinathan, A., Draper-Joyce, C., Szabo, M., Christopoulos, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 371-377 7 p.Research output: Contribution to journal › Article › Research › peer-review
5
Citations
(Scopus)
The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions
Draper-Joyce, C. J., Verma, R. K., Michino, M., Shonberg, J., Kopinathan, A., Klein Herenbrink, C., Scammells, P. J., Capuano, B., Abramyan, A. M., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 1208.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
7
Citations
(Scopus)
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor
Draper-Joyce, C. J., Michino, M., Verma, R. K., Klein Herenbrink, C., Shonberg, J., Kopinathan, A., Scammells, P. J., Capuano, B., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 315-328 14 p.Research output: Contribution to journal › Article › Research › peer-review
3
Citations
(Scopus)
Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology
Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.Research output: Contribution to journal › Review Article › Research › peer-review