Projects per year
Personal profile
Biography
Anissa Jabbour completed her PhD in 2005 chatracterising the function of caspase inhibitors and has since undertaken three post-doctoral positions in the field of cell death before starting her own group at the Australian Centre for Blood Diseases (ACBD), Monash University. Dr Jabbour's primary research focus is how cell death and survival signalling cascades are regulated by cytokines, in particular Interleukin-3 (IL-3) and GM-CSF. Her laboratory is interested in how IL-3 and GMCSF signal cell survival and proliferation, and how these survival pathways are deregulated in Acute Myeloid Leukaemia.
Dr Jabbour's postdoctoral research investigated
- The affect of TRAIL and known chemotherapeutics on ex vivo glioma specimens
- The regulation of pro-apoptotic Bcl-2 protein Puma in myeloid cells
- The role of the transcription factor p53 in initiating cell death in response to a non DNA damaging stimulus (loss of Interleukin-3) in myeloid cells
Dr Jabbour and her teams current primary research focus is to analyse
- How cytokines, in particular, Interleukin (IL)-3 and GM-CSF regulate cell survival mechanisms
- The role of the kinases JAK2, AKT and IKK play in maintaining cell survival in the presence of IL-3 or GM-CSF
- The role IL-3/GM-CSF dependent pathways play in normal haematopoiesis and in disease, primarily Acute Myeloid Leukaemia
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Apoptosis
- Bcl-2
- Myeloid leukaemia
- Interleukin-3
- GM-CSF
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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Signals that are deregulated in leukaemia
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/16
Project: Research
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Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation
Fischer, K. C., Daunt, C. P., Tremblay, C. S., Dias, S., Vince, J. E. & Jabbour, A. M., Jan 2021, In: Cell Death & Disease. 12, 1, 16 p., 28.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1
Teh, T. C., Nguyen, N. Y., Moujalled, D. M., Segal, D., Pomilio, G., Rijal, S., Jabbour, A., Cummins, K., Lackovic, K., Blombery, P., Thompson, E., Ekert, P. G., Lessene, G., Glaser, S. P., Huang, D. C. S., Roberts, A. W., Guthridge, M. A. & Wei, A. H., 1 Feb 2018, In: Leukemia. 32, 2, p. 303-312 10 p.Research output: Contribution to journal › Article › Research › peer-review
101 Citations (Scopus) -
Modeling metazoan apoptotic pathways in yeast
Bloomer, D. T., Kitevska, T., Brand, I. L., Jabbour, A. M., Nguyen, H. & Hawkins, C. J., 2016, Programmed Cell Death: Methods and Protocols. Puthalakath, H. & Hawkins, C. J. (eds.). New York NY USA: Humana Press, p. 161 - 183 23 p. (Methods in Molecular Biology; vol. 1419).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
5 Citations (Scopus) -
Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations
Green, B. D., Jabbour, A. M., Sandow, J. J., Riffkin, C. D., Masouras, D., Daunt, C. P., Salmanidis, M., Brumatti, G., Hemmings, B., Guthridge, M. A., Pearson, R. B. & Ekert, P. G., 2013, In: Cell Death and Differentiation. 20, 10, p. 1341 - 1349 9 p.Research output: Contribution to journal › Article › Research › peer-review
34 Citations (Scopus) -
HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
Brumatti, G., Salmanidis, M., Kok, C. H., Bilardi, R. A., Sandow, J. J., Silke, N., Mason, K. D., Visser, J. A. L., Jabbour, A., Glaser, S. P., Okamoto, T., Bouillet, P., D'Andrea, R. J. & Ekert, P. G., 2013, In: Oncotarget. 4, 11, p. 1933 - 1947 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access42 Citations (Scopus)