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Personal profile

Biography

Anissa Jabbour completed her PhD in 2005 chatracterising the function of caspase inhibitors and has since undertaken three post-doctoral positions in the field of cell death before starting her own group at the Australian Centre for Blood Diseases (ACBD), Monash University. Dr Jabbour's primary research focus is how cell death and survival signalling cascades are regulated by cytokines, in particular Interleukin-3 (IL-3) and GM-CSF. Her laboratory is interested in how IL-3 and GMCSF signal cell survival and proliferation, and how these survival pathways are deregulated in Acute Myeloid Leukaemia.

Dr Jabbour's postdoctoral research investigated

  • The affect of TRAIL and known chemotherapeutics on ex vivo glioma specimens
  • The regulation of pro-apoptotic Bcl-2 protein Puma in myeloid cells
  • The role of the transcription factor p53 in initiating cell death in response to a non DNA damaging stimulus (loss of Interleukin-3) in myeloid cells

Dr Jabbour and her teams current primary research focus is to analyse

  • How cytokines, in particular, Interleukin (IL)-3 and GM-CSF regulate cell survival mechanisms
  • The role of the kinases JAK2, AKT and IKK play in maintaining cell survival in the presence of IL-3 or GM-CSF
  • The role IL-3/GM-CSF dependent pathways play in normal haematopoiesis and in disease, primarily Acute Myeloid Leukaemia

Keywords

  • Apoptosis
  • Bcl-2
  • Myeloid leukaemia
  • Interleukin-3
  • GM-CSF

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Projects 2013 2016

Research Output 2002 2018

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh, T. C., Nguyen, N. Y., Moujalled, D. M., Segal, D., Pomilio, G., Rijal, S., Jabbour, A., Cummins, K., Lackovic, K., Blombery, P., Thompson, E., Ekert, P. G., Lessene, G., Glaser, S. P., Huang, D. C. S., Roberts, A. W., Guthridge, M. A. & Wei, A. H., 1 Feb 2018, In : Leukemia. 32, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Modeling metazoan apoptotic pathways in yeast

Bloomer, D. T., Kitevska, T., Brand, I. L., Jabbour, A. M., Nguyen, H. & Hawkins, C. J., 2016, Programmed Cell Death: Methods and Protocols. Puthalakath, H. & Hawkins, C. J. (eds.). New York NY USA: Humana Press, p. 161 - 183 23 p. (Methods in Molecular Biology; vol. 1419).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

Green, B. D., Jabbour, A. M., Sandow, J. J., Riffkin, C. D., Masouras, D., Daunt, C. P., Salmanidis, M., Brumatti, G., Hemmings, B., Guthridge, M. A., Pearson, R. B. & Ekert, P. G., 2013, In : Cell Death and Differentiation. 20, 10, p. 1341 - 1349 9 p.

Research output: Contribution to journalArticleResearchpeer-review

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

Brumatti, G., Salmanidis, M., Kok, C. H., Bilardi, R. A., Sandow, J. J., Silke, N., Mason, K. D., Visser, J. A. L., Jabbour, A., Glaser, S. P., Okamoto, T., Bouillet, P., D'Andrea, R. J. & Ekert, P. G., 2013, In : Oncotarget. 4, 11, p. 1933 - 1947 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Hoxb8 regulates expression of microRNAs to control cell death and differentiation

Salmanidis, M., Brumatti, G., Narayan, N., Green, B. D., van den Bergen, J. A., Sandow, J. J., Bert, A. G., Silke, N., Sladic, R., Puthalakath, H., Rohrbeck, L., Okamoto, T., Bouillet, P., Herold, M. J., Goodall, G. J., Jabbour, A. & Ekert, P. G., 2013, In : Cell Death and Differentiation. 20, 10, p. 1370 - 1380 11 p.

Research output: Contribution to journalArticleResearchpeer-review