Personal profile
Biography
Dr Anh Nguyen is an ARC DECRA Fellow and Head of GPCR EcoPharmacology Lab within the Drug Discovery Biology Theme at the Monash Institute of Pharmaceutical Sciences. Her research focuses on decoding drug-receptor interactions at G protein-coupled receptors (GPCRs) to drive the discovery of next-generation therapeutics-particularly allosteric and biased ligands-for cardiovascular and neuronal diseases.
She leads a multidisciplinary, innovation-driven program that integrates molecular pharmacology, molecular modelling (docking, molecular dynamics, and virtual screening), high-throughput screening, and artificial intelligence to develop a GPCR-targeted drug discovery platform.
Dr Nguyen also pioneers research into how environmental pollutants, especially micro- and nanoplastics, interfere with GPCR signaling, aiming to uncover novel mechanisms linking pollution to cardiovascular and neurodegenerative diseases.
As a dedicated mentor, Dr Nguyen fosters a supportive, collaborative, and interdisciplinary environment where students can thrive at the intersection of pharmacology, environmental health, and AI-driven drug discovery. Prospective Honours, Masters, and PhD students with a passion for GPCR biology, computational pharmacology, or environmental toxicology are warmly encouraged to get in touch to explore available opportunities.
Monash teaching commitment
Lecturer (2022-current): Monash Enhanced Doctoral Training Program
Unit 5. Advanced receptor theory: allosterism and biased agonism.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
-
Adenosine A1 receptor negative allosteric modulators as novel pharmacological interventions for heart failure.
TN Nguyen, A. (Primary Chief Investigator (PCI)) & May, L. (Chief Investigator (CI))
10/01/25 → 31/12/25
Project: Research
-
G protein-coupled receptor Response Mechanisms to Environmental Pollutants
TN Nguyen, A. (Primary Chief Investigator (PCI))
ARC - Australian Research Council, Monash University – Internal School Contribution
1/01/25 → 31/12/27
Project: Research
-
Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P. (Primary Chief Investigator (PCI)), May, L. (Chief Investigator (CI)), Rollo, B. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Casillas-Espinosa, P. (Chief Investigator (CI)), Howden, S. (Chief Investigator (CI)), Christopoulos, A. (Chief Investigator (CI)), Gregory, K. (Chief Investigator (CI)), Scammells, P. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), Elliott, D. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Langmead, C. (Chief Investigator (CI)), Antonic-Baker, A. (Chief Investigator (CI)), Sumer, H. (Chief Investigator (CI)), Javaid, S. (Associate Investigator (AI)) & Gu, J. (Chief Investigator (CI))
1/06/22 → 31/05/27
Project: Research
-
Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L. (Primary Chief Investigator (PCI)), Webb, G. (Chief Investigator (CI)), Carlsson, J. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Christopoulos, A. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), O'Brien, T. (Associate Investigator (AI)), Rollo, B. (Associate Investigator (AI)), Casillas-Espinosa, P. (Associate Investigator (AI)), Gregory, K. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)) & Nguyen, T. (Associate Investigator (AI))
1/01/22 → 31/12/26
Project: Research
-
Identification of new compounds targeting CAD-associated inflammation
May, L. (Primary Chief Investigator (PCI)), TN Nguyen, A. (Chief Investigator (CI)), Drummond, G. (Chief Investigator (CI)) & Vinh, A. (Chief Investigator (CI))
14/09/22 → 31/03/23
Project: Research
-
Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists
Matricon, P., Nguyen, A. T., Vo, D. D., Baltos, J. A., Jaiteh, M., Luttens, A., Kampen, S., Christopoulos, A., Kihlberg, J., May, L. T. & Carlsson, J., 5 Sept 2023, In: European Journal of Medicinal Chemistry. 257, 115419.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
The application of artificial intelligence to accelerate G protein-coupled receptor drug discovery
Nguyen, A. T. N., Nguyen, D. T. N., Koh, H. Y., Toskov, J., MacLean, W., Xu, A., Zhang, D., Webb, G. I., May, L. T. & Halls, M. L., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2371-2384 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access26 Citations (Scopus) -
Small molecule allosteric modulation of the adenosine A1 receptor
Nguyen, A. T. N., Tran, Q. L., Baltos, J. A., McNeill, S. M., Nguyen, D. T. N. & May, L. T., 26 Jun 2023, In: Frontiers in Endocrinology. 14, 12 p., 1184360.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access15 Citations (Scopus) -
Targeting G protein-coupled receptors for heart failure treatment
Thai, B. S., Chia, L. Y., Nguyen, A. T. N., Qin, C., Ritchie, R. H., Hutchinson, D. S., Kompa, A., White, P. J. & May, L. T., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2270-2286 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access8 Citations (Scopus) -
Large language models for scientific discovery in molecular property prediction
Zheng, Y., Koh, H. Y., Ju, J., Nguyen, A. T. N., May, L. T., Webb, G. I. & Pan, S., Mar 2025, In: Nature Machine Intelligence. 7, 3, p. 437-447 23 p.Research output: Contribution to journal › Article › Research › peer-review
45 Citations (Scopus)
Prizes
-
Certara New Investigator Award
Nguyen, A. (Recipient), 2022
Prize: Prize (including medals and awards)
Activities
-
NHMRC Ideas Grant Review
TN Nguyen, A. (Fellow)
2025 → …Activity: External Academic Engagement › Grant review responsibilities
-
RSC Medicinal Chemistry (Journal)
TN Nguyen, A. (Peer reviewer)
2025 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
-
EMBO Molecular Medicine (Journal)
TN Nguyen, A. (Peer reviewer)
2025 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
-
Biochemical and Biophysical Research Communications (Journal)
TN Nguyen, A. (Peer reviewer)
2025Activity: Publication peer-review and editorial work types › Peer review responsibility
-
Nature Machine Intelligence (Journal)
TN Nguyen, A. (Peer reviewer)
2025 → …Activity: Publication peer-review and editorial work types › Peer review responsibility