Projects per year
Personal profile
Biography
Dr Nguyen completed her PhD in 2017 (co-supervised by Prof Arthur Christopoulos and Dr Lauren May, Monash University). Her research focuses on understanding the drug-receptor interactions at the adenosine receptors, with the goal of facilitating the discovery of novel therapeutic strategies (allosteric and biased compounds) for the treatment of cardiovascular and neuronal diseases. She employs a combination of molecular pharmacology, molecular modelling (docking, molecular dynamics simulation, virtual ligand screening), high-throughput screening, and artificial intelligence approaches to build a drug discovery pipeline for adenosine receptors.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
-
Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P., May, L., Rollo, B., O'Brien, T., Casillas-Espinosa, P., Howden, S., Christopoulos, A., Gregory, K., Scammells, P., Baltos, J., Elliot, D., TN Nguyen, A., Langmead, C., Antonic-Baker, A., Sumer, H., Javaid, S. & Gu, J.
1/06/22 → 31/05/27
Project: Research
-
Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L., Webb, G., Carlsson, J., Baltos, J., TN Nguyen, A., Christopoulos, A., Miao, Y., O'Brien, T., Rollo, B., Casillas-Espinosa, P., Gregory, K., Scammells, P. & Nguyen, T.
1/01/22 → 31/12/25
Project: Research
-
Identification of new compounds targeting CAD-associated inflammation
May, L., TN Nguyen, A., Drummond, G. & Vinh, A.
14/09/22 → 31/03/23
Project: Research
-
Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists
Matricon, P., Nguyen, A. TN., Vo, D. D., Baltos, J. A., Jaiteh, M., Luttens, A., Kampen, S., Christopoulos, A., Kihlberg, J., May, L. T. & Carlsson, J., 5 Sept 2023, In: European Journal of Medicinal Chemistry. 257, 115419.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
The application of artificial intelligence to accelerate G protein-coupled receptor drug discovery
Nguyen, A. T. N., Nguyen, D. T. N., Koh, H. Y., Toskov, J., MacLean, W., Xu, A., Zhang, D., Webb, G. I., May, L. T. & Halls, M. L., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2371-2384 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access14 Citations (Scopus) -
Small molecule allosteric modulation of the adenosine A1 receptor
Nguyen, A. T. N., Tran, Q. L., Baltos, J. A., McNeill, S. M., Nguyen, D. T. N. & May, L. T., 26 Jun 2023, In: Frontiers in Endocrinology. 14, 12 p., 1184360.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access6 Citations (Scopus) -
Targeting G protein-coupled receptors for heart failure treatment
Thai, B. S., Chia, L. Y., Nguyen, A. T. N., Qin, C., Ritchie, R. H., Hutchinson, D. S., Kompa, A., White, P. J. & May, L. T., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2270-2286 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Citations (Scopus) -
Biased receptor signalling and intracellular trafficking profiles of structurally distinct formylpeptide receptor 2 agonists
Peng, C., Vecchio, E. A., Nguyen, A. T. N., De Seram, M., Tang, R., Keov, P., Woodman, O. L., Chen, Y. C., Baell, J., May, L. T., Zhao, P., Ritchie, R. H. & Qin, C. X., Nov 2024, In: British Journal of Pharmacology. 181, 22, p. 4677-4692 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)
Prizes
-
Certara New Investigator Award
TN Nguyen, Anh (Recipient), 2022
Prize: Prize (including medals and awards)