Projects per year
Dr Angus Johnston is an ARC Future Fellow who's work focuses on developing better ways to deliver drugs, making them more therapeutically active and limiting side effects. He has extensive knowledge and expertise in nanomaterials assembly, material characterisation, cellular interactions and advanced imaging techniques.
His group is interested in understanding how nanoengineered materials interact with biological systems. This work involves developing molecular sensors to determine the internalisation, trafficking and local environment that nanoparticles are exposed to in living cells. With a better understudying of how these material interact with cells, we can engineer smarter materials for improved drug and vaccine delivery.
For more information, visit the NanoMaterials for Biology group website - www.nanomb.org
Nanomaterials for Biology Group: Using Nanotechnology to Unravel the Secrets of Biology
Targeted delivery of drugs to the specific areas in the body where they are active has the potential to greatly improve the way we treat diseases such as cancer, HIV and diabetes. Recent advances in nanotechnology allow us to synthesise nanoparticles that encapsulate drugs, protecting the body from their harmful side effects and also protecting the drugs from being degraded in the body. Using targeting molecules such as antibodies, these nanoparticles can be delivered to specific cells where the drug is active. While this field shows great promise, our understanding of how these particles interact with biological systems is still very limited.
Our group is focused on developing a fundamental understanding of how nanoengineered materials interact with biological systems, with the goal to develop improved methods of drug and vaccine delivery.
One of the main challenges of understanding how nanomaterials interact with cells is determining exactly where the material is located inside the cell. Cells contain hundreds of sub-compartments that have different chemical and enzymatic environments, and understanding what these environments are like is critical to designing materials that will respond in a desirable fashion once they are inside the cell. We are developing molecular sensors that can detect the local environment that the capsules are exposed to.
Using these sensors we are also investigating the mechanisms of how nanocapsules enter cells and looking at the role that particle size, surface functionality and targeting molecules play in this process.
The work in our group includes:
- engineering new materials with bio-responsive properties,
- developing molecular sensors for biological sensing,
- studying the in vitro behaviour of nanomaterials, and
- applying super-resoluting imaging techniques for material characterisation.
-Targeted Vaccine Therapy
-Sensors for Cellular Imaging
-Understanding Cellular Processing of Nanoparticles
-Self assembling peptides as drug carriers
-Toxicology of Nanomaterials
Research area keywords
- nanomaterials assembly
- material characterisation
- cellular interactions
- advanced imaging
1/04/17 → 31/03/20
29/04/21 → 29/04/24
25/06/20 → 24/06/21
Davis, T., Boyd, B., Bunnett, N., Porter, C., Crampin, E., Caruso, F., Kent, S., Thordarson, P., Kearnes, M., Gooding, J., Kavallaris, M., Thurecht, K., Whittaker, A., Parton, R., Corrie, S. R., Johnston, A., McGhee, J., Greguric, I. D., Stevens, M., Lewis, J., Lee, D. S., Alexander, C., Dawson, K., Hawker, C., Haddleton, D., Thierry, B., Prestidge, C. A., Meyer, A., Jones-Jayasinghe, N., Voelcker, N. H., Nann, T. & McLean, K.
Australian Research Council (ARC), Monash University, University of Melbourne, University of New South Wales, University of Queensland , University of South Australia, Monash University – Internal Faculty Contribution, University of Wisconsin-Madison, Memorial Sloan Kettering Cancer Center, University of California System, University College Dublin, Imperial College London, University of Warwick, SungKyunKwan University, Australian Nuclear Science and Technology Organisation (ANSTO) (Australia), University of Nottingham United Kingdom
30/06/14 → 29/06/21
Adenovirus terminal protein contains a bipartite nuclear localisation signal essential for its import into the nucleusAl-Wassiti, H. A., Thomas, D. R., Wagstaff, K. M., Fabb, S. A., Jans, D. A., Johnston, A. P. & Pouton, C. W., 1 Apr 2021, In: International Journal of Molecular Sciences. 22, 7, 18 p., 3310.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access
Cifuentes-Rius, A., Desai, A., Yuen, D., Johnston, A. P. R. & Voelcker, N. H., 2021, In: Nature Nanotechnology. 16, 1, p. 37–46 10 p.
Research output: Contribution to journal › Review Article › Research › peer-reviewOpen Access
Johnston, A. P. R., 2021, (Accepted/In press) In: Advanced Healthcare Materials. 8 p.
Research output: Contribution to journal › Article › Research › peer-review
It's what's on the inside that counts: Techniques for investigating the uptake and recycling of nanoparticles and proteins in cellsFitzGerald, L. I. & Johnston, A. P. R., Apr 2021, In: Journal of Colloid and Interface Science. 587, p. 64-78 15 p.
Research output: Contribution to journal › Review Article › Other › peer-review
Johnston, A. P. R. & Parton, R. G., Mar 2021, In: Nature Nanotechnology. 16, 3, p. 266-276 11 p.
Research output: Contribution to journal › Review Article › Other › peer-reviewOpen Access