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Research Output 2006 2019

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2019

Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Moujalled, D. M., Pomilio, G., Ghiurau, C., Ivey, A., Salmon, J., Rijal, S., Macraild, S., Zhang, L., Teh, T. C., Tiong, I. S., Lan, P., Chanrion, M., Claperon, A., Rocchetti, F., Zichi, A., Kraus-Berthier, L., Wang, Y., Halilovic, E., Morris, E., Colland, F. & 7 othersSegal, D., Huang, D., Roberts, A. W., Maragno, A. L., Lessene, G., Geneste, O. & Wei, A. H., 1 Apr 2019, In : Leukemia. 33, a, p. 905-917 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genomic subtyping and therapeutic targeting of acute erythroleukemia

Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., Carmichael, C. L., Masih, K. E., Morris, S. M., Lindsley, R. C., Janke, L. J., Alexander, T. B., Song, G., Qu, C., Li, Y., Payne-Turner, D., Tomizawa, D., Kiyokawa, N., Valentine, M., Valentine, V. & 28 othersBasso, G., Locatelli, F., Enemark, E. J., Kham, S. K. Y., Yeoh, A. E. J., Ma, X., Zhou, X., Sioson, E., Rusch, M., Ries, R. E., Stieglitz, E., Hunger, S. P., Wei, A. H., To, L. B., Lewis, I. D., D’Andrea, R. J., Kile, B. T., Brown, A. L., Scott, H. S., Hahn, C. N., Marlton, P., Pei, D., Cheng, C., Loh, M. L., Ebert, B. L., Meshinchi, S., Haferlach, T. & Mullighan, C. G., Apr 2019, In : Nature Genetics. 51, 4, p. 694-704 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

McKenzie, M. D., Ghisi, M., Oxley, E. P., Ngo, S., Cimmino, L., Esnault, C., Liu, R., Salmon, J. M., Bell, C. C., Ahmed, N., Erlichster, M., Witkowski, M. T., Liu, G. J., Chopin, M., Dakic, A., Simankowicz, E., Pomilio, G., Vu, T., Krsmanovic, P., Su, S. & 21 othersTian, L., Baldwin, T. M., Zalcenstein, D. A., DiRago, L., Wang, S., Metcalf, D., Johnstone, R. W., Croker, B. A., Lancaster, G. I., Murphy, A. J., Naik, S. H., Nutt, S. L., Pospisil, V., Schroeder, T., Wall, M., Dawson, M. A., Wei, A. H., de Thé, H., Ritchie, M. E., Zuber, J. & Dickins, R. A., 1 Aug 2019, In : Cell Stem Cell. 25, 2, p. 258-272.e9 24 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies

Caenepeel, S., Brown, S. P., Belmontes, B., Moody, G., Keegan, K. S., Chui, D., Whittington, D. A., Huang, X., Poppe, L., Cheng, A. C., Cardozo, M., Houze, J., Li, Y., Lucas, B., Paras, N. A., Wang, X., Taygerly, J. P., Vimolratana, M., Zancanella, M., Zhu, L. & 18 othersCajulis, E., Osgood, T., Sun, J., Damon, L., Egan, R. K., Greninger, P., McClanaghan, J. D., Gong, J., Moujalled, D., Pomilio, G., Beltran, P., Benes, C. H., Roberts, A. W., Huang, D. C., Wei, A., Canon, J., Coxon, A. & Hughes, P. E., 1 Dec 2018, In : Cancer Discovery. 8, 12, p. 1582-1597 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh, T. C., Nguyen, N. Y., Moujalled, D. M., Segal, D., Pomilio, G., Rijal, S., Jabbour, A., Cummins, K., Lackovic, K., Blombery, P., Thompson, E., Ekert, P. G., Lessene, G., Glaser, S. P., Huang, D. C. S., Roberts, A. W., Guthridge, M. A. & Wei, A. H., 1 Feb 2018, In : Leukemia. 32, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Accelerating Early Drug Development: Come on Down Under

Wei, A., Jul 2017, In : Annals of Oncology. 28, 7, p. 1655-1657 3 p., mdx101.

Research output: Contribution to journalArticleOtherpeer-review

Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia

Kantarjian, H. M., Stein, A., Gökbuget, N., Fielding, A. K., Schuh, A. C., Ribera, J. M., Wei, A., Dombret, H., Foà, R., Bassan, R., Arslan, Ö., Sanz, M. A., Bergeron, J., Demirkan, F., Lech-Maranda, E., Rambaldi, A., Thomas, X., Horst, H-A., Brüggemann, M., Klapper, W. & 6 othersWood, B. L., Fleishman, A., Nagorsen, D., Holland, C. J., Zimmerman, Z. & Topp, M. S., 2 Mar 2017, In : New England Journal of Medicine. 376, 9, p. 836-847 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Idarubicin Dose Escalation During Consolidation Therapy for Adult Acute Myeloid Leukemia

Bradstock, K. F., Link, E., Di Iulio, J., Szer, J., Marlton, P., Wei, A., Enno, A., Schwarer, A., Lewis, I. D., Rozario, J. D., Coyle, L., Cull, G., Campbell, P., Leahy, M. F., Hahn, U. H., Cannell, P., Tiley, C., Lowenthal, R. M., Moore, J. & Cartwright, K., 20 May 2017, In : Journal of Clinical Oncology. 35, 15, p. 1678 - 1685 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Improving the Transition to Palliative Care for Patients With Acute Leukemia: A Coordinated Care Approach

Hopkins, B., Gold, M., Wei, A. & Grigoriadis, G., May 2017, In : Cancer Nursing. 40, 3, p. E17-E23 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein, N., Cameron, D. P., Hannan, K. M., Nguyen, N. Y. N., Fong, C. Y., Sornkom, J., Wall, M., Pavy, M., Cullinane, C. M., Diesch, J., Devlin, J. R., George, A. J., Sanij, E., Quin, J. E., Poortinga, G., Verbrugge, I., Baker, A., Drygin, D. J., Harrison, S. J., Rozario, J. D. & 10 othersPowell, J. A., Pitson, S. M., Zuber, J., Johnstone, R. W., Dawson, M. A., Guthridge, M. A., Wei, A., McArthur, G. A., Pearson, R. B. & Hannan, R. D., 25 May 2017, In : Blood. 129, 21, p. 2882-2895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Partial response after induction chemotherapy has clinical relevance in acute myeloid leukaemia

Fleming, S., Ong, D. M., Jackson, K., Avery, S., Mollee, P. N., Marlton, P., Kennedy, G. A. & Wei, A. H., Apr 2017, In : British Journal of Haematology. 177, 2, p. 328-330 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Powell, J. A., Lewis, A. C., Zhu, W., Toubia, J., Pitman, M. R., Wallington-Beddoe, C. T., Moretti, P. A. B., Iarossi, D., Samaraweera, S. E., Cummings, N., Ramshaw, H. S., Thomas, D., Wei, A. H., Lopez, A. F., D'Andrea, R. J., Lewis, I. D. & Pitson, S. M., 9 Feb 2017, In : Blood. 129, 6, p. 771-782 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study

Tan, P., Tiong, I. S., Fleming, S., Pomilio, G., Cummings, N., Droogleever, M., McManus, J., Schwarer, A., Catalano, J., Patil, S., Avery, S., Spencer, A. & Wei, A., 2017, In : Oncotarget. 8, 32, p. 52269-52280 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The Patients’ Perspective: Hematological Cancer Patients’ Experiences of Adverse Events as Part of Care

Bryant, J., Carey, M., Sanson-Fisher, R., Turon, H., Wei, A. & Kuss, B., 17 Mar 2017, (Accepted/In press) In : Journal of Patient Safety.

Research output: Contribution to journalArticleResearchpeer-review

Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia

Casan, J. M. L., Ghoth, S., Wei, A. H., Ting, S. B. & Morgan, S., 2017, In : Annals of Hematology and Oncology. 4, 3, 1141.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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2016

Design of the randomized, Phase III, QUAZAR AML Maintenance trial of CC-486 (oral azacitidine) maintenance therapy in acute myeloid leukemia

Roboz, G. J., Montesinos, P., Selleslag, D., Wei, A., Jang, J. H., Falantes, J., Voso, M. T., Sayar, H., Porkka, K., Marlton, P., Almeida, A., Mohan, S., Ravandi, F., Garcia-Manero, G., Skikne, B. & Kantarjian, H. M., 1 Feb 2016, In : Future Oncology. 12, 3, p. 293-302 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Isavuconazole as salvage therapy for mucormycosis

Graves, B., Morrissey, C. O., Wei, A., Coutsouvelis, J., Ellis, S. J., Pham, A., Gooi, J. & Ananda-Rajah, M., 1 Mar 2016, In : Medical Mycology Case Reports. 11, p. 36-39 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study

Swords, R. T., Greenberg, P. L., Wei, A. H., Durrant, S., Advani, A. S., Hertzberg, M. S., Lewis, I. D., Rivera, G., Gratzinger, D., Fan, A. C., Felsher, D. W., Cortes, J. E., Watts, J. M., Yarranton, G. T., Walling, J. M. & Lancet, J. E., 1 Nov 2016, In : Leukemia Research. 50, p. 123-131 9 p.

Research output: Contribution to journalArticleResearchpeer-review

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

Guirguis, A., Slape, C. I., Failla, L. M., Saw, J. M. Y., Tremblay, C., Powell, D. R., Rossello, F. J., Wei, A., Strasser, A. & Curtis, D. J., 2016, In : Cell Death and Differentiation. 23, 6, p. 1049 - 1059 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Lalaoui, N., Hanggi, K., Brumatti, G., Chau, D., Nguyen, N-Y. N., Vasilikos, L., Spilgies, L. M., Heckmann, D. A., Ma, C., Ghisi, M., Salmon, J. M., Matthews, G. M., de Valle, E., Moujalled, D. M., Menon, M. B., Spall, S. K., Glaser, S. P., Richmond, J., Lock, R. B., Condon, S. M. & 10 othersGugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W-L. & Silke, J., 2016, In : Cancer Cell. 29, 2, p. 145 - 158 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells

Saulep-Easton, D., Vincent, F. B., Quah, P. S., Wei, A., Ting, S. B., Croce, C. M., Tam, C. & Mackay, F., 2016, In : Leukemia. 30, 1, p. 163 - 172 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Brumatti, G., Ma, C., Lalaoui, N., Nguyen, N. Y., Navarro, M., Tanzer, M. C., Richmond, J., Ghisi, M., Salmon, J. M., Silke, N., Pomilio, G., Glaser, S. P., de Valle, E., Gugasyan, R., Gurthridge, M. A., Condon, S. M., Johnstone, R. W., Lock, R., Salvesen, G. S., Wei, A. & 3 othersVaux, D. L., Ekert, P. G. & Silke, J., 18 May 2016, In : Science Translational Medicine. 8, 339, 339ra69.

Research output: Contribution to journalArticleResearchpeer-review

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Kotschy, A., Szlavik, Z., Murray, J., Davidson, J., Maragno, A. L., Le Toumelin-Braizat, G., Chanrion, M., Kelly, G. L., Gong, J. N., Moujalled, D. M., Bruno, A., Csekei, M., Paczal, A., Szabo, Z. B., Sipos, S., Radics, G., Proszenyak, A., Balint, B., Ondi, L., Blasko, G. & 2 othersPomilio, G. & Wei, A. H., 2016, In : Nature. 538, 7626, p. 477-482 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

ABT-199 partners with azacitidine to contest myeloid malignancies

Wei, A., 2015, In : Leukemia and Lymphoma. 56, 1, p. 8 - 9 2 p.

Research output: Contribution to journalArticleOther

Comparison of biosimilar filgrastim with originator filgrastim for peripheral blood stem cell mobilization and engraftment in patients with multiple myeloma undergoing autologous stem cell transplantation

Pham, T., Patil, S., Fleming, S. A., Avery, S., Walker, P. A., Wei, A., Curtis, D. J., Stuart, G., Klarica, D., O'Brien, M., Morris, K., Das, T. P., Bollard, G. M., Muirhead, J., Coutsouvelis, J. & Spencer, A., 2015, In : Transfusion. 55, 11, p. 2709 - 2713 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Phillipson, L. J., Segal, D., Nero, T. L., Parker, M. W., Wan, S. S., de Silva, M., Guthridge, M. A., Wei, A. & Burns, C. J., 2015, In : Bioorganic & Medicinal Chemistry. 23, 19 (Art. No: 12539), p. 6280 - 6296 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Lee, E. M., Yee, D., Busfield, S. J., McManus, J. F., Cummings, N. J., Vairo, G., Wei, A., Ramshaw, H. S., Powell, J. A., Lopez, A. F., Lewis, I. D., McCall, M. N. & Lock, R. B., 2015, In : Haematologica: the hematology journal. 100, 7, p. 914 - 926 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

Rijal, S., Fleming, S., Cummings, N., Rynkiewicz, N., Ooms, L. M., Nguyen, N-Y. N., Teh, T-C., Avery, S., McManus, J., Papenfuss, A. T., McLean, C. A., Guthridge, M. A., Mitchell, C. A. & Wei, A., 30 Apr 2015, In : Blood. 125, 18, p. 2815-2824 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Maintenance lenalidomide in combination with 5-azacitidine as post-remission therapy for acute myeloid leukaemia

Wei, A., Tan, P. T. G., Perruzza, S. N., Govindaraj, C., Fleming, S. A., McManus, J. F., Avery, S., Patil, S., Stevenson, W. C., Plebanski, M. & Spencer, A., 2015, In : British Journal of Haematology. 169, 2, p. 199 - 210 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Protocol of a multi-centre randomised controlled trial of a web-based information intervention with nurse-delivered telephone support for haematological cancer patients and their support persons

Bryant, J., Sanson-Fisher, R. W., Stevenson, W., Smits, R., Henskens, F., Wei, A., Tzelepis, F., D'Este, C. A., Paul, C. L. & Carey, M., 2015, In : BMC Cancer. 15, (Art. No: 295), p. 1 - 13 13 p.

Research output: Contribution to journalArticleOther

Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): A randomised, controlled, double-blind, multinational, phase 3 study

Ravandi, F., Ritchie, E. K., Sayar, H., Lancet, J. E., Craig, M. D., Vey, N., Strickland, S. A., Schiller, G. J., Jabbour, E., Erba, H. P., Pigneux, A., Horst, H-A., Recher, C., Klimek, V. M., Cortes, J., Roboz, G. J., Odenike, O., Thomas, X., Havelange, V., Maertens, J. & 16 othersDerigs, H-G., Heuser, M., Damon, L., Powell, B. L., Gaidano, G., Carella, A-M., Wei, A., Hogge, D., Craig, A. R., Fox, J. A., Ward, R., Smith, J. A., Acton, G., Mehta, C., Stuart, R. K. & Kantarjian, H. M., 30 Jul 2015, In : Lancet Oncology. 16, 9, p. 1025 - 1036 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Cytokine-driven loss of plasmacytoid dendritic cell function in chronic lymphocytic leukemia

Saulep, D., Vincent, F., Le Page, M., Wei, A., Ting, S. B. N., Croce, C. M., Tam, C. & Mackay-Fisson, F., 2014, In : Leukemia. 28, 10, p. 2005 - 2015 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

Tan, P., Wei, A., Mithraprabhu, S., Cummings, N. J., Liu, H. B., Perugini, M., Reed, K. D., Avery, S., Patil, S., Walker, P. A., Mollee, P. N., Grigg, A. P., D'Andrea, R. J., Dear, A. E. & Spencer, A., 2014, In : Blood Cancer Journal. 4, 1, p. 1 - 8 8 p., e170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Have all-trans retinoic acid and arsenic trioxide replaced all-trans retinoic acid and anthracyclines in APL as standard of care

Iland, H. J., Wei, A. & Seymour, J. F., 2014, In : Best Practice and Research in Clinical Haematology. 27, 1, p. 39 - 52 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Health economic impact of high-dose versus standard-dose cytarabine induction chemotherapy for acute myeloid leukaemia

Fedele, P., Avery, S., Patil, S., Spencer, A., Haas, M. & Wei, A., 2014, In : Internal Medicine Journal. 44, 8, p. 757 - 763 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Lenalidomide-based maintenance therapy reduces TNF receptor 2 on CD4 T cells and enhances immune effector function in acute myeloid leukemia patients

Govindaraj, C., Madondo, M., Kong, Y. Y., Tan, P., Wei, A. & Plebanski, M., 2014, In : American Journal of Hematology. 89, 8, p. 795 - 802 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Optimal approach for high-risk acute promyelocytic leukemia

Iland, H. J., Seymour, J. F. & Wei, A., 2014, In : Current Opinion in Hematology. 21, 2, p. 102 - 113 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Reducing TNF receptor 2+ regulatory T cells via the combined action of azacitidine and the HDAC inhibitor, panobinostat for clinical benefit in acute myeloid leukemia patients

Govindaraj, C., Tan, P., Walker, P. A., Wei, A., Spencer, A. & Plebanski, M., 2014, In : Clinical Cancer Research. 20, 3, p. 724 - 735 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL

Sleebs, B., Kersten, W. J. A., Kulasegaram, S., Nikolakopoulos, G., Hatzis, E., Moss, R. M., Parisot, J. P., Yang, H., Czabotar, P. E., Fairlie, W. D., Lee, E. F., Adams, J. M., Chen, L., van Delft, M. F., Lowes, K. N., Wei, A., Huang, D. CS., Colman, P. M., Street, I. P., Baell, J. B. & 2 othersWatson, K. G. & Lessene, G., 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5514 - 5540 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma

Smeets, M. F. M. A., Chan, A. C. Y., Dagger, S., Bradley, C., Wei, A. & Izon, D. J., 2013, In : PLoS ONE. 8, 5, 12 p., e62346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fludarabine, cytarabine, granulocyte-colony stimulating factor and amsacrine: an effective salvage therapy option for acute myeloid leukemia at first relapse

Fong, C. Y., Grigoriadis, G., Hocking, J., Coutsouvelis, J., Muirhead, J. L., Campbell, P., Paul, E., Walker, P. A., Avery, S., Patil, S., Spencer, A., Schwarer, A. & Wei, A., 2013, In : Leukemia and Lymphoma. 54, 2, p. 336 - 341 6 p.

Research output: Contribution to journalArticleResearchpeer-review

GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations

Perugini, M., Iarossi, D. G., Kok, C. H., Cummings, N. J., Diakiw, S. M., Brown, A. L., Danner, S., Bardy, P., To, L. B., Wei, A., Lewis, I. D. & Andrea, R. J. D., 2013, In : Leukemia. 27, 7, p. 1588 - 1592 5 p.

Research output: Contribution to journalArticleResearchpeer-review

High-dose cytarabine (24g/m2) in combination with idarubicin (HiDAC-3) results in high first-cycle response with limited gastrointestinal toxicity in adult acute myeloid leukaemia

Low, M., Lee, D., Coutsouvelis, J., Patil, S., Opat, S., Walker, P. A., Schwarer, A., Salem, H. H., Avery, S., Spencer, A. & Wei, A., 2013, In : Internal Medicine Journal. 43, 3, p. 294 - 297 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Improving the transition of highly complex patients into the community: Impact of a pharmacist in an allogeneic stem cell transplant (SCT) outpatient clinic

Chieng, R., Coutsouvelis, J., Poole, S. G., Dooley, M. J., Booth, D. L. & Wei, A., 2013, In : Supportive Care in Cancer. 21, 12, p. 3491 - 3495 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylation of KLF5 contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival

Diakiw, S. M., Perugini, M., Kok, C. H., Engler, G., Cummings, N. J., To, L., Wei, A., Lewis, I. D., Brown, A. L. & D'Andrea, R. J., 2013, In : British Journal of Haematology. 161, 6, p. 884 - 888 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

Thomas, D., Powell, J. A., Green, B. D., Barry, E. F., Ma, Y., Woodcock, J. M., Fitter, S., Zannettino, A., Pitson, S. M., Hughes, T. P., Lopez, A. F., Shepherd, P. R., Wei, A., Ekert, P. G. & Guthridge, M. A., 2013, In : PLoS Biology. 11, 3 (Art. No: e1001515), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia

Kantarjian, H. M., Martinelli, G., Jabbour, E., Quintas-Cardama, A., Ando, K., Bay, J., Wei, A., Gropper, S., Papayannidis, C., Owen, K., Pike, L., Schmitt, N., Stockman, P. & Giagounidis, A. A. N., 2013, In : Cancer. 119, 14, p. 2611 - 2619 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Thomas, D., Powell, J. A., Vergez, F., Segal, D., Nguyen, N-Y. N., Baker, A., Teh, T-C., Barry, E. F., Sarry, J-E., Lee, E. M., Nero, T. L., Jabbour, A. M., Pomilio, G., Green, B. D., Manenti, S., Glaser, S. P., Parker, M. W., Lopez, A. F., Ekert, P. G., Lock, R. B. & 5 othersHuang, D. CS., Nilsson, S. K., Recher, C., Wei, A. & Guthridge, M. A., 2013, In : Blood. 122, 5, p. 738 - 748 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The regulation of mitochondrial metabolism by the Bcl-2 family of pro-survival proteins: new therapeutic opportunities for targeting cancer cells

Wei, A., Brown, M. & Guthridge, M. A., 2013, In : Journal of Hematology & Thromboembolic Diseases. 1, 4, p. 1 - 3 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Utility of a clinical risk score to identify high-risk patients with de novo acute myeloid leukaemia in first remission after high-dose cytarabine (HiDAC) based induction chemotherapy

Ling, V., Burnett, A., Bradstock, K. F., Seymour, J., Hills, R. K. & Wei, A., 2013, In : British Journal of Haematology. 160, 6, p. 861 - 863 3 p.

Research output: Contribution to journalArticleResearchpeer-review