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Research Output

2014
Open Access
11 Citations (Scopus)

Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma

San Miguel, J. F., Blade, J., Shpilberg, O., Grosicki, S., Maloisel, F., Min, C-K., Zarzuela, M. P., Robak, T., Prasad, S. V. S. S., Goh, Y. T., Laubach, J. P., Spencer, A., Mateos, M. V., Palumbo, A., Puchalski, T. A., Reddy, M. P., Uhlar, C. M., Qin, X., van de Velde, H., Xie, H. & 1 others, Orlowski, R. Z., 2014, In : Blood. 123, 26, p. 4136 - 4142 7 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

Reducing TNF receptor 2+ regulatory T cells via the combined action of azacitidine and the HDAC inhibitor, panobinostat for clinical benefit in acute myeloid leukemia patients

Govindaraj, C., Tan, P., Walker, P. A., Wei, A., Spencer, A. & Plebanski, M., 2014, In : Clinical Cancer Research. 20, 3, p. 724 - 735 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
41 Citations (Scopus)

Safe and effective use of outpatient non-myeloablative allogeneic stem cell transplantation for myeloma

Campbell, P., Walker, P. A., Avery, S., Curtis, D. J., Schwarer, A., Wei, A., Kalff, A., Muirhead, J. L. & Spencer, A., 2014, In : Blood Cancer Journal. 4, 5, p. e213 - e213 3 p.

Research output: Contribution to journalLetterOther

6 Citations (Scopus)

Second cancer risk in adults receiving autologous haematopoietic SCT for cancer: A population-based cohort study

Bilmon, I. A., Ashton, L. J., Le Marsney, R. E., Dodds, A. J., O'Brien, T. A., Wilcox, L., Nivison-Smith, I., Daniels, B., Vajdic, C. M. & CAST study group, May 2014, In : Bone Marrow Transplantation. 49, 5, p. 691-698 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

Second primary malignancies with lenalidomide therapy for newly diagnosed myeloma: a meta-analysis of individual patient data

Palumbo, A., Bringhen, S., Kumar, S. K., Lupparelli, G., Usmani, S. Z., Waage, A., Larocca, A. T., Van Der Holt, B. R., Musto, P., Offidani, M., Petrucci, M. T., Evangelista, A., Zweegman, S., Nooka, A. K., Spencer, A., Dimopoulos, M. A., Hajek, R., Cavo, M. M., Richardson, P. G., Lonial, S. & 6 others, Ciccone, G., Boccadoro, M., Anderson, K. C., Barlogie, B. M., Sonneveld, P. & McCarthy, P. L., 2014, In : The Lancet Oncology. 15, 3, p. 333 - 342 10 p.

Research output: Contribution to journalArticleResearchpeer-review

172 Citations (Scopus)

Thalidomide and prednisolone versus prednisolone alone as consolidation therapy after autologous stem-cell transplantation in patients with newly diagnosed multiple myeloma: Final analysis of the ALLG MM6 multicentre, open-label, randomised phase 3 study

Kalff, A., Kennedy, N., Smiley, A., Miles Prince, H., Roberts, A. W., Bradstock, K., de Abreu Lourenço, R., Frampton, C. & Spencer, A., 2014, In : The Lancet Haematology. 1, 3, p. e112-e119 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma

Spencer, A., Yoon, S-S., Harrison, S., Morris, S. R., Smith, D. A., Brigandi, R. A., Gauvin, J. L. S., Kumar, R., Opalinska, J. B. & Chen, C., 2014, In : Blood. 124, 14, p. 2190 - 2195 6 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)
2013

A single-arm, phase II study of the anti-Blys monoclonal antibody belimumab in symptomatic Waldenstrom macroglobulinemia

Bishton, M. J., Spencer, A., Dickinson, M. J. & Ritchie, D., 2013, In : Clinical Lymphoma, Myeloma & Leukemia. 13, 5, p. 575 - 578 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Central nervous system multiple myeloma - potential roles for intrathecal therapy and measurement of cerebrospinal fluid light chains

Lee, D., Kalff, A., Low, M., Gangatharan, S., Ho, P., Bajel, A., Ritchie, D., Grigg, A. & Spencer, A., 2013, In : British Journal of Haematology. 162, 3, p. 371 - 375 5 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Effectiveness of a single fixed dose of rasburicase 3 mg in the management of tumour lysis syndrome

Coutsouvelis, J., Wiseman, M., Hui, L., Poole, S., Dooley, M., Patil, S., Avery, S., Wei, A. & Spencer, A., Feb 2013, In : British Journal of Clinical Pharmacology. 75, 2, p. 565-568 4 p.

Research output: Contribution to journalLetterOtherpeer-review

17 Citations (Scopus)

Fludarabine, cytarabine, granulocyte-colony stimulating factor and amsacrine: an effective salvage therapy option for acute myeloid leukemia at first relapse

Fong, C. Y., Grigoriadis, G., Hocking, J., Coutsouvelis, J., Muirhead, J. L., Campbell, P., Paul, E., Walker, P. A., Avery, S., Patil, S., Spencer, A., Schwarer, A. & Wei, A., 2013, In : Leukemia and Lymphoma. 54, 2, p. 336 - 341 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

High-dose cytarabine (24g/m2) in combination with idarubicin (HiDAC-3) results in high first-cycle response with limited gastrointestinal toxicity in adult acute myeloid leukaemia

Low, M., Lee, D., Coutsouvelis, J., Patil, S., Opat, S., Walker, P. A., Schwarer, A., Salem, H. H., Avery, S., Spencer, A. & Wei, A., 2013, In : Internal Medicine Journal. 43, 3, p. 294 - 297 4 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
26 Citations (Scopus)

International myeloma working group recommendations for the treatment of multiple myeloma-related bone disease

Terpos, E., Morgan, G., Dimopoulos, M. A., Drake, M. T., Lentzsch, S., Raje, N., Sezer, O., García-Sanz, R., Shimizu, K., Turesson, I., Reiman, T., Jurczyszyn, A., Merlini, G., Spencer, A., Leleu, X., Cavo, M. M., Munshi, N., Rajkumar, S. V., Durie, B. G. M. & Roodman, G. D., 20 Jun 2013, In : Journal of Clinical Oncology. 31, 18, p. 2347-2357 11 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
205 Citations (Scopus)

MEK inhibitors as a chemotherapeutic intervention in multiple myeloma

Leow, C. C-Y., Gerondakis, S. D. & Spencer, A., 2013, In : Blood Cancer Journal. 3, p. 1 - 8 8 p., e105.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
40 Citations (Scopus)

Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies

Deangelo, D. J., Spencer, A., Bhalla, K. N., Prince, H. M., Fischer, T., Kindler, T., Giles, F. J., Scott, J. W., Parker, K., Liu, A., Woo, M., Atadja, P., Mishra, K. K. & Ottmann, O. G., Aug 2013, In : Leukemia. 27, 8, p. 1628-1636 9 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind study

Dimopoulos, M., Siegel, D. S. D., Lonial, S., Qi, J., Hajek, R., Facon, T., Rosinol, L., Williams, C., Blacklock, H. A., Goldschmidt, H., Hungria, V., Spencer, A., Palumbo, A., Graef, T., Eid, J. E., Houp, J., Sun, L., Vuocolo, S. C. & Anderson, K. C., 2013, In : The Lancet Oncology. 14, 11, p. 1129 - 1140 12 p.

Research output: Contribution to journalArticleResearchpeer-review

178 Citations (Scopus)
2012

A phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma

Bensinger, W., Maziarz, R. T., Jagannath, S., Spencer, A., Durrant, S., Becker, P. S., Ewald, B., Bilic, S., Rediske, J., Baeck, J. & Stadtmauer, E. A., Oct 2012, In : British Journal of Haematology. 159, 1, p. 58-66 9 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Failure of haematopoietic recovery overcome by SCT despite invasive mucormycosis infection

Grigoriadis, G., Chang, C. C., Walker, P., Patil, S., Avery, S., Morrissey, O. & Spencer, A., 2012, In : Bone Marrow Transplantation. 47, p. 591 - 592 2 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

How to manage neutropenia in multiple myeloma

Palumbo, A., Blade, J., Boccadoro, M., Palladino, C., Davies, F., Dimopoulos, M., Dmoszynska, A., Einsele, H., Moreau, P., Sezer, O., Spencer, A., Sonneveld, P. & Miguel, J., 2012, In : Clinical Lymphoma, Myeloma & Leukemia. 12, 1, p. 5 - 11 7 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

IMWG consensus on maintenance therapy in multiple myeloma

Ludwig, H., Durie, B. G. M., McCarthy, P. L., Palumbo, A., San Miguel, J., Barlogie, B. M., Morgan, G., Sonneveld, P., Spencer, A., Andersen, K. C., Facon, T., Stewart, A. K., Einsele, H., Mateos, M-V., Wijermans, P., Waage, A., Beksac, M., Richardson, P. G., Hulin, C., Niesvizky, R. & 7 others, Lokhorst, H., Landgren, O., Leif Bergsagel, P., Orlowski, R. Z., Hinke, A., Cavo, M. M. & Attal, M., 29 Mar 2012, In : Blood. 119, 13, p. 3003-3015 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

158 Citations (Scopus)

Lenalidomide in multiple myeloma: current status and future potential

Quach, H., Kalff, A. & Spencer, A., 2012, In : American Journal of Hematology. 87, 12, p. 1089 - 1095 7 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

MyelomA genetics international consortium

Morgan, G., Johnsen, H., Goldschmidt, H., Palumbo, A., Cavo, M., Sonneveld, P., Migel, J., Chim, C. S., Browne, P., Einsele, H., Waage, A., Turesson, I., Spencer, A., Hajek, R., Ludwig, H., Hemminki, K. & Houlston, R., 2012, In : Leukemia and Lymphoma. 53, 5, p. 796 - 800 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination

Millward, M. J., Price, T., Townsend, A., Sweeney, C., Spencer, A., Sukumaran, S., Longenecker, A., Lee, L., Lay, A., Sharma, G., Gemmill, R. M., Drabkin, H. A., Lloyd, G. K., Neuteboom, S. T. C., McConkey, D. J., Palladino, M. A. & Spear, M. A., 2012, In : Investigational New Drugs. 30, 6, p. 2303 - 2317 15 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Thalidomide consolidation improves progression-free survival in myeloma with normal but not up-regulated expression of fibroblast growth factor receptor 3: Analysis from the Australasian Leukaemia and Lymphoma Group MM6 clinical trial

Ho, P. J., Brown, R. D., Spencer, A., Jeffels, M., Daniher, D., Gibson, J. & Joshua, D. E., Sep 2012, In : Leukemia and Lymphoma. 53, 9, p. 1728-1734 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The t(4;14) translocation and FGFR3 overexpression in multiple myeloma: prognostic implications and current clinical strategies

Kalff, A. & Spencer, A., 2012, In : Blood Cancer Journal. 2, 9, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
51 Citations (Scopus)
2011

Asparaginase in the management of adult acute lymphoblastic leukaemia: Is it used appropriately?

Patil, S., Coutsouvelis, J. & Spencer, A., 2011, In : Cancer Treatment Reviews. 37, 3, p. 202 - 207 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

CYT997 causes apoptosis in human multiple myeloma

Monaghan, K., Khong, T., Smith, G. & Spencer, A., 2011, In : Investigational New Drugs. 29, 2, p. 232 - 238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Efficacy and safety of pegylated liposomal doxorubicin in combination with bortezomib for multiple myeloma: Effects of adverse prognostic factors on outcome

Blade, J., Sonneveld, P., San Miguel, J., Sutherland, H., Hajek, R., Nagler, A., Spencer, A., Robak, T., Lantz, K., Zhuang, S., Harousseau, J. & Orlowski, R., 2011, In : Clinical Lymphoma, Myeloma & Leukemia. 11, 1, p. 44 - 49 6 p.

Research output: Contribution to journalArticleOther

27 Citations (Scopus)

Managing multiple myeloma in the elderly: Are we making progress?

Quach, H., Prince, M. & Spencer, A., 2011, In : Expert Review of Hematology. 4, 3, p. 301 - 315 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Personalized therapy in multiple myeloma according to patient age and vulnerability: A report of the European Myeloma Network (EMN)

Palumbo, A., Bringhen, S., Ludwig, H., Dimopoilos, M., Blade, J., Mateos, M., Rosinol, L., Boccadoro, M., Cavo, M., Lokhorst, H., Zweegman, S., Terpos, E., Davies, F., Driessen, C., Gimsing, P., Gramatzki, M., Hajek, R., Johnsen, H., Leal Da Costa, F., Sezer, O. & 6 others, Spencer, A., Beksac, M., Morgan, G., Einsele, H., San Miguel, J. & Sonneveld, P., 2011, In : Blood. 118, 17, p. 4519 - 4529 11 p.

Research output: Contribution to journalArticleResearchpeer-review

221 Citations (Scopus)

Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma

Henry, D., Costa, L., Goldwasser, F., Hirsh, V., Hungria, V., Prausova, J., Scagliotti, G., Sleeboom, H., Spencer, A., Vadhan-Raj, S., von Moos, R., Willenbacher, W., Woll, P., Wang, J., Qi, J., Jun, S., Dansey, R. & Yeh, H., 2011, In : Journal of Clinical Oncology. 29, 9, p. 1125 - 1132 8 p.

Research output: Contribution to journalArticleResearchpeer-review

778 Citations (Scopus)

Reply to S.M. Sorscher et al

Henry, D. H., Costa, L., Goldwasser, F., Hirsh, V., Hungria, V., Prausova, J., Scagliotti, G. V., Sleeboom, H., Spencer, A., Vadhan-Raj, S., von Moos, R., Willenbacher, W., Wang, J., Jiang, Q-Z., Jun, S., Dansey, R. & Yeh, H., 1 Jul 2011, In : Journal of Clinical Oncology. 29, 19, p. 2736-2737 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma

Khong, T. & Spencer, A., 2011, In : Molecular Cancer Therapeutics. 10, 10, p. 1909 - 1917 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells

Monaghan, K., Khong, T., Burns, C. & Spencer, A., 2011, In : Leukemia. 25, 12, p. 1891 - 1899 9 p.

Research output: Contribution to journalArticleOther

53 Citations (Scopus)

The role of the bone marrow microenvironment in multiple myeloma

Monaghan, K. & Spencer, A., 2011, In : European Journal of Clinical & Medical Oncology. 3, 2, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Deactylase inhibition in myeloproliferative neoplasms

Mithraprabhu, S., Grigoriadis, G., Khong, T. & Spencer, A., 2010, In : Investigational New Drugs. 28, Suppl 1, p. 50 - 57 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Reduced-intensity conditioned allogeneic haematopoietic stem cell transplantation results in durable disease-free and overall survival in patients with poor prognosis myeloid and lymphoid malignancies: Eighty-month follow-up

Patil, S., Spencer, A., Schwarer, A., Lewis, I., Hertzberg, M. S., Avery, S., Wei, A., Noutsos, T., Paul, E., Taouk, Y. & Muirhead, J. L., 2010, In : Bone Marrow Transplantation. 45, p. 1154 - 1160 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2009

Clinical and immunohistochemical features associated with a response to bortezomib in patients with multiple myeloma

Dawson, M., Opat, S., Taouk, Y., Donovan, M., Zammit, M., Monaghan, K., Horvath, N., Roberts, A., Prince, M., Hertzberg, M., McLean, C. A. & Spencer, A., 2009, In : Clinical Cancer Research. 15, 2, p. 714 - 722 9 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Consolidation Therapy With Low-Dose Thalidomide and Prednisolone Prolongs the Survival of Multiple Myeloma Patients Undergoing a Single Autologous Stem-Cell Transplantation Procedure

Spencer, A., Prince, H. M., Roberts, A. W., Prosser, I. W., Bradstock, K. F., Coyle, L., Gill, D. S., Horvath, N., Reynolds, J. & Kennedy, N., 10 Apr 2009, In : Journal of Clinical Oncology. 27, 11, p. 1788-1793 6 p.

Research output: Contribution to journalArticleResearchpeer-review

273 Citations (Scopus)
2008

Laboratory tumor lysis syndrome complicating LBH589 therapy in a patient with acute myeloid leukaemia

Kalff, A., Shortt, J., Farr, J., McLennan, R., Lui, A., Scott, J. W. & Spencer, A., 2008, In : Haematologica: the hematology journal. 93, 1, p. 16 - 17 2 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2007

Immune recovery uveitis in an HIV-negative individual

Baker, M. L., Allen, P. J., Shortt, J., Lewin, S. R. & Spencer, A., 2007, In : Clinical and Experimental Ophthalmology. 35, 2, p. 189 - 190 2 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Inhibitors of the mevalonate pathway as potential therapeutic agents in multiple myeloma

Baulch-Brown, C., Molloy, T. J., Yeh, S. L., Ma, D. & Spencer, A., 2007, In : Leukemia Research. 31, 3, p. 341 - 352 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
2006

Adjuvant rituximab causes prolonged hypogammaglobulinaemia following autologous stem cell transplant for non-Hodgkin's lymphoma

Shortt, J. & Spencer, A., 2006, In : Bone Marrow Transplantation. 38, 6, p. 433 - 436 4 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Central nervous system graft-versus-host disease post allogeneic stem cell transplant [2]

Shortt, J., Hutton, E., Faragher, M. & Spencer, A., 2006, In : British Journal of Haematology. 132, 2, p. 245 - 247 3 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Focal MIBI uptake is a better indicator of active myeloma than diffuse uptake

Nandurkar, D., Kalff, V., Turlakow, A., Spencer, A., Bailey, M. J. & Kelly, M., 2006, In : European Journal of Haematology. 76, 2, p. 141 - 146 6 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Lack of evidence of disease contamination in ovarian tissue harvested for cryopreservation from patients with Hodgkin lymphoma and analysis of factors predictive of oocyte yield

Seshadri, T., Gook, D., Lade, J., Spencer, A., Grigg, A., Tiedemann, K., McKendrick, J., Mitchell, P., Stern, C. & Seymour, J. F., 2006, In : British Journal of Cancer. 94, 7, p. 1007 - 1010 4 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)