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Research Output

Abstract

Resistance to Nutrient Deprivation Via Metabolic Re-Programming As Mechanism of 'Metastasis' Promotion in Multiple Myeloma

Savvidou, I., Khong, T. T. F., Spencer, A., Chen, M., Kalff, A., Masoumi Moghaddam, S., Chandrasekara, S. & Brown, A., Dec 2018.

Research output: Contribution to conferenceAbstract

TOP2A knockdown resensitizes carfilzomib-resistant Hmcls to carfilzomib

Reale, A., Khong, T. T., Mithraprabhu, S., Savvidou, I., Ramachandran, M. & Spencer, A., Dec 2015, p. 4215. 1 p.

Research output: Contribution to conferenceAbstract

Article

A comparison of the efficacy of immunomodulatory-free regimens in relapsed or refractory multiple myeloma: a network meta-analysis

Weisel, K., Sonneveld, P., Spencer, A., Beksac, M., Rizzo, M., Xu, Y., Fahrbach, K., Gaudig, M., Slavcev, M., Dearden, L. & Lam, A., 1 Jan 2019, In : Leukemia and Lymphoma. 60, 19, p. 151–162 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Adjuvant rituximab causes prolonged hypogammaglobulinaemia following autologous stem cell transplant for non-Hodgkin's lymphoma

Shortt, J. & Spencer, A., 2006, In : Bone Marrow Transplantation. 38, 6, p. 433 - 436 4 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma

Nair, A. P., Walker, P., Kalff, A., Bergin, K., Hocking, J., Avery, S., Curtis, D. J., Patil, S., Das, T., Klarica, D., Morgan, S., Muirhead, J., Gorniak, M. B., Reynolds, J. & Spencer, A., 1 Jun 2017, In : Bone Marrow Transplantation. 52, 6, p. 839-845 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A phase 1 clinical trial evaluating marizomib, pomalidomide and low-dose dexamethasone in relapsed and refractory multiple myeloma (NPI-0052-107): final study results

Spencer, A., Harrison, S., Zonder, J., Badros, A., Laubach, J., Bergin, K., Khot, A., Zimmerman, T., Chauhan, D., Levin, N., MacLaren, A., Reich, S. D., Trikha, M. & Richardson, P., 1 Jan 2018, In : British Journal of Haematology. 180, 1, p. 41-51 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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28 Citations (Scopus)

A phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma

Bensinger, W., Maziarz, R. T., Jagannath, S., Spencer, A., Durrant, S., Becker, P. S., Ewald, B., Bilic, S., Rediske, J., Baeck, J. & Stadtmauer, E. A., Oct 2012, In : British Journal of Haematology. 159, 1, p. 58-66 9 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

A single-arm, phase II study of the anti-Blys monoclonal antibody belimumab in symptomatic Waldenstrom macroglobulinemia

Bishton, M. J., Spencer, A., Dickinson, M. J. & Ritchie, D., 2013, In : Clinical Lymphoma, Myeloma & Leukemia. 13, 5, p. 575 - 578 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Asparaginase in the management of adult acute lymphoblastic leukaemia: Is it used appropriately?

Patil, S., Coutsouvelis, J. & Spencer, A., 2011, In : Cancer Treatment Reviews. 37, 3, p. 202 - 207 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: A pooled analysis

Gay, F., Oliva, S., Petrucci, M. T., Montefusco, V., Conticello, C., Musto, P., Catalano, L., Evangelista, A., Spada, S., Campbell, P., Ria, R., Salvini, M., Offidani, M., Carella, A-M., Omedé, P., Liberati, A. M., Troia, R., Cafro, A. M., Malfitano, A., Falcone, A. P. & 7 others, Caravita, T., Patriarca, F., Nagler, A., Spencer, A., Hajek, A. R., Palumbo, A. & Boccadoro, M., 1 Aug 2017, In : Leukemia. 31, 8, p. 1727-1734 8 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Hogg, S. J., Vervoort, S. J., Deswal, S., Ott, C. J., Li, J., Cluse, L. A., Beavis, P. A., Darcy, P. K., Martin, B. P., Spencer, A., Traunbauer, A. K., Sadovnik, I., Bauer, K., Valent, P., Bradner, J. E., Zuber, J., Shortt, J. & Johnstone, R. W., 28 Feb 2017, In : Cell Reports. 18, 9, p. 2162-2174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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94 Citations (Scopus)

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): And randomised, phase 3, open-label, multicentre study

Dimopoulos, M. A., Moreau, P., Palumbo, A., Joshua, D. E., Pour, L., Hájek, R., Facon, T., Ludwig, H., Oriol, A., Goldschmidt, H., Rosiñol, L., Straub, J., Suvorov, A., Araujo, C., Rimashevskaya, E., Pika, T., Gaidano, G., Weisel, K. C., Goranova-Marinova, V., Schwarer, A. & 11 others, Minuk, L., Masszi, T., Karamanesht, I., Offidani, M., Hungria, V., Spencer, A., Orlowski, R. Z., Gillenwater, H. H., Mohamed, N., Feng, S. & Chng, W. J., 1 Jan 2016, In : The Lancet Oncology. 17, 1, p. 27-38 12 p.

Research output: Contribution to journalArticleResearchpeer-review

418 Citations (Scopus)

Carfilzomib–dexamethasone versus subcutaneous or intravenous bortezomib in relapsed or refractory multiple myeloma: secondary analysis of the phase 3 ENDEAVOR study

Goldschmidt, H., Moreau, P., Ludwig, H., Niesvizky, R., Chng, W. J., Joshua, D., Weisel, K., Spencer, A., Orlowski, R. Z., Feng, S., Iskander, K. S. & Dimopoulos, M. A., 2018, In : Leukemia and Lymphoma. 59, 6, p. 1364-1374 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Central nervous system graft-versus-host disease post allogeneic stem cell transplant [2]

Shortt, J., Hutton, E., Faragher, M. & Spencer, A., 2006, In : British Journal of Haematology. 132, 2, p. 245 - 247 3 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Central nervous system multiple myeloma - potential roles for intrathecal therapy and measurement of cerebrospinal fluid light chains

Lee, D., Kalff, A., Low, M., Gangatharan, S., Ho, P., Bajel, A., Ritchie, D., Grigg, A. & Spencer, A., 2013, In : British Journal of Haematology. 162, 3, p. 371 - 375 5 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Changes in bone turnover marker levels and clinical outcomes in patients with advanced cancer and bone metastases treated with bone antiresorptive agents

Lipton, A., Smith, M. R., Fizazi, K., Stopeck, A. T., Henry, D. A., Brown, J. E., Shore, N. D., Saad, F., Spencer, A., Zhu, L. & Warner, D. J., 1 Dec 2016, In : Clinical Cancer Research. 22, 23, p. 5713-5721 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)
36 Citations (Scopus)

Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: A randomised, multicentre, phase 3 trial

Gay, F., Oliva, S., Petrucci, M. T., Conticello, C., Catalano, L., Corradini, P., Siniscalchi, A., Magarotto, V., Pour, L., Carella, A-M., Malfitano, A., Petrò, D., Evangelista, A., Spada, S., Pescosta, N., Omedè, P., Campbell, P., Liberati, A. M., Offidani, M., Ria, R. & 6 others, Pulini, S., Patriarca, F., Hajek, R., Spencer, A., Boccadoro, M. & Palumbo, A., 2015, In : The Lancet Oncology. 16, 16, p. 1617-1629 13 p.

Research output: Contribution to journalArticleResearchpeer-review

168 Citations (Scopus)

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

Mithraprabhu, S., Khong, T., Ramachandran, M., Chow, A., Klarica, D., Mai, L., Walsh, S., Broemeling, D., Marziali, A., Wiggin, M., Hocking, J., Kalff, A., Durie, B. & Spencer, A., 1 Aug 2017, In : Leukemia. 31, 8, p. 1695-1705 11 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)
7 Citations (Scopus)

Clinical and immunohistochemical features associated with a response to bortezomib in patients with multiple myeloma

Dawson, M., Opat, S., Taouk, Y., Donovan, M., Zammit, M., Monaghan, K., Horvath, N., Roberts, A., Prince, M., Hertzberg, M., McLean, C. A. & Spencer, A., 2009, In : Clinical Cancer Research. 15, 2, p. 714 - 722 9 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Comparison of biosimilar filgrastim with originator filgrastim for peripheral blood stem cell mobilization and engraftment in patients with multiple myeloma undergoing autologous stem cell transplantation

Pham, T., Patil, S., Fleming, S. A., Avery, S., Walker, P. A., Wei, A., Curtis, D. J., Stuart, G., Klarica, D., O'Brien, M., Morris, K., Das, T. P., Bollard, G. M., Muirhead, J., Coutsouvelis, J. & Spencer, A., 2015, In : Transfusion. 55, 11, p. 2709 - 2713 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Comparison of the probability of target attainment of anidulafungin against Candida spp. in patients with acute leukaemia

Doan, T. N., Kong, D. C. M., Patel, K., Walker, P. A., Spencer, A. & Kirkpatrick, C. M. J., 2014, In : International Journal of Antimicrobial Agents. 44, 5, p. 450 - 457 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Considerations for pre-transfusion immunohaematology testing in patients receiving the anti-CD38 monoclonal antibody daratumumab for the treatment of multiple myeloma

Quach, H., Benson, S., Haysom, H., Wilkes, A. M., Zacher, N., Cole-Sinclair, M., Miles Prince, H., Mollee, P., Spencer, A., Joy Ho, P., Harrison, S. J., Lee, C., Augustson, B. & Daly, J., 1 Feb 2018, In : Internal Medicine Journal. 48, 2, p. 210-220 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Consolidation Therapy With Low-Dose Thalidomide and Prednisolone Prolongs the Survival of Multiple Myeloma Patients Undergoing a Single Autologous Stem-Cell Transplantation Procedure

Spencer, A., Prince, H. M., Roberts, A. W., Prosser, I. W., Bradstock, K. F., Coyle, L., Gill, D. S., Horvath, N., Reynolds, J. & Kennedy, N., 10 Apr 2009, In : Journal of Clinical Oncology. 27, 11, p. 1788-1793 6 p.

Research output: Contribution to journalArticleResearchpeer-review

273 Citations (Scopus)

Contemporary analysis of functional immune recovery to opportunistic and vaccine-preventable infections after allogeneic haemopoietic stem cell transplantation

De Silva, H., Ffrench, R. A., Korem, M., Orlowski-Oliver, E., Curtis, D. J., Spencer, A., Avery, S., Patil, S. & Morrissey, C. O., 1 Jan 2018, In : Clinical & Translational Immunology. 7, 10, 16 p., e1040.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CYT997 causes apoptosis in human multiple myeloma

Monaghan, K., Khong, T., Smith, G. & Spencer, A., 2011, In : Investigational New Drugs. 29, 2, p. 232 - 238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Dimopoulos, M. A., Weisel, K. C., Song, K. W., Delforge, M., Karlin, L., Goldschmidt, H., Moreau, P., Banos, A., Oriol, A., Garderet, L., Cavo, M. M., Ivanova, V., Alegre, A., Martinez-Lopez, J., Chen, C., Spencer, A., Knop, S., Bahlis, N. J., Renner, C., Yu, X. & 5 others, Hong, K., Sternas, L., Jacques, C., Zaki, M. & San Miguel, J. F., 2015, In : Haematologica: the hematology journal. 100, 10, p. 1327 - 1333 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
54 Citations (Scopus)

Cytomegalovirus viral load monitoring after allogeneic bone marrow transplantation in patients receiving antiviral prophylaxis

Howden, B. P., Michaelides, A., Spelman, D. W., Spencer, A., Schwarer, A. P., Wesselingh, S. L. & Kotsimbos, T. C., 2003, In : Bone Marrow Transplantation. 32, 8, p. 795 - 800 6 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Daratumumab, bortezomib, and dexamethasone for multiple myeloma

Palumbo, A., Chanan-Khan, A., Weisel, K. C., Nooka, A. K., Masszi, T., Beksac, M., Spicka, I., Hungria, V., Munder, M., Mateos, M-V., Mark, T. M., Qi, M., Schecter, J., Amin, H., Qin, X., Deraedt, W., Ahmadi, T., Spencer, A. & Sonneveld, P., 25 Aug 2016, In : The New England Journal of Medicine. 375, 8, p. 754-766 13 p.

Research output: Contribution to journalArticleResearchpeer-review

613 Citations (Scopus)

Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma: Updated analysis of CASTOR

Spencer, A., Lentzsch, S., Weisel, K., Avet-Loiseau, H., Mark, T. M., Spicka, I., Masszi, T., Lauri, B., Levin, M. D., Bosi, A., Hungria, V., Cavo, M., Lee, J. J., Nooka, A. K., Quach, H., Lee, C., Barreto, W., Corradini, P., Min, C. K., Scott, E. C. & 17 others, Chanan-Khan, A. A., Horvath, N., Capra, M., Beksac, M., Ovilla, R., Jo, J. C., Shin, H. J., Sonneveld, P., Soong, D., Casneuf, T., Chiu, C., Amin, H., Qi, M., Thiyagarajah, P., Sasser, A. K., Schecter, J. M. & Mateos, M. V., 30 Nov 2018, In : Haematologica: the hematology journal. 103, 12, p. 2079-2087 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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77 Citations (Scopus)

DCEP as a bridge to ongoing therapies for advanced relapsed and/or refractory multiple myeloma

Yuen, H. L. A., Low, M. S. Y., Fedele, P., Kalff, A., Walker, P., Bergin, K., Coutsouvelis, J., Grigoriadis, G. & Spencer, A., 2 Dec 2018, In : Leukemia and Lymphoma. 59, 12, p. 2842-2846 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Deactylase inhibition in myeloproliferative neoplasms

Mithraprabhu, S., Grigoriadis, G., Khong, T. & Spencer, A., 2010, In : Investigational New Drugs. 28, Suppl 1, p. 50 - 57 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Defibrotide for the treatment of sinusoidal obstruction syndrome: evaluation of response to therapy and patient outcomes

Coutsouvelis, J., Avery, S., Dooley, M., Kirkpatrick, C. & Spencer, A., 1 Mar 2018, In : Supportive Care in Cancer. 26, 3, p. 947-955 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Design and development of the Australian and New Zealand (ANZ) myeloma and related diseases registry

Bergin, K., Moore, E., McQuilten, Z., Wood, E., Augustson, B., Blacklock, H., Ho, J., Horvath, N., King, T., McNeil, J., Mollee, P., Quach, H., Reid, C. M., Rosengarten, B., Walker, P. & Spencer, A., 9 Nov 2016, In : BMC Medical Research Methodology. 16, 1, 8 p., 151.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

DNA-repair gene mutations are highly prevalent in circulating tumour dna from multiple myeloma patients

Mithraprabhu, S., Hocking, J., Ramachandran, M., Choi, K., Klarica, D., Khong, T., Reynolds, J. & Spencer, A., 29 Jun 2019, In : Cancers. 11, 7, 14 p., 917.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

Tan, P., Wei, A., Mithraprabhu, S., Cummings, N. J., Liu, H. B., Perugini, M., Reed, K. D., Avery, S., Patil, S., Walker, P. A., Mollee, P. N., Grigg, A. P., D'Andrea, R. J., Dear, A. E. & Spencer, A., 2014, In : Blood Cancer Journal. 4, 1, p. 1 - 8 8 p., e170.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
73 Citations (Scopus)

Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

Mithraprabhu, S., Kalff, A., Chow, A., Khong, T. T. F. & Spencer, A., 2014, In : Epigenetics. 9, 11, p. 1511 - 1520 10 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Efficacy and safety of pegylated liposomal doxorubicin in combination with bortezomib for multiple myeloma: Effects of adverse prognostic factors on outcome

Blade, J., Sonneveld, P., San Miguel, J., Sutherland, H., Hajek, R., Nagler, A., Spencer, A., Robak, T., Lantz, K., Zhuang, S., Harousseau, J. & Orlowski, R., 2011, In : Clinical Lymphoma, Myeloma & Leukemia. 11, 1, p. 44 - 49 6 p.

Research output: Contribution to journalArticleOther

27 Citations (Scopus)

Elotuzumab therapy for relapsed or refractory multiple myeloma

Lonial, S., Dimopoulos, M. A., Palumbo, A., White, D. J., Grosicki, S., Spicka, I., Walter-Croneck, A., Moreau, P., Mateos, M-V., Magen, H., Belch, A. R., Reece, D. E., Beksac, M., Spencer, A., Oakervee, H., Orlowski, R. Z., Taniwaki, M., Rollig, C., Einsele, H., Wu, K. L. & 8 others, Singhal, A., San Miguel, J. F., Matsumoto, M., Katz, J., Bleickardt, E., Poulart, V., Anderson, K. C. & Richardson, P. G., 2015, In : The New England Journal of Medicine. 373, 7, p. 621 - 631 11 p.

Research output: Contribution to journalArticleResearchpeer-review

695 Citations (Scopus)

Epigenetic regulation of miRNA-124 and multiple downstream targets is associated with treatment response in myeloid malignancies

Liu, H. B., Pattie, P., Chandrasekara, S., Spencer, A. & Dear, A. E., Sep 2016, In : Oncology Letters. 12, 3, p. 2175-2180 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Epigenetic treatment-mediated modulation of PD-L1 predicts potential therapy resistance over response markers in myeloid malignancies: A molecular mechanism involving effectors of PD-L1 reverse signaling

Liu, H., Hu, Y., Rimoldi, R., Von Hagt, C., Khong, E. W. C., Lee, N., Flemming, S., Spencer, A. & Dear, A. E., Feb 2019, In : Oncology Letters. 17, 2, p. 2543-2550 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D., 8 Jan 2016, In : Blood Cancer Journal. 6, 5 p., e378.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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37 Citations (Scopus)

Failure of haematopoietic recovery overcome by SCT despite invasive mucormycosis infection

Grigoriadis, G., Chang, C. C., Walker, P., Patil, S., Avery, S., Morrissey, O. & Spencer, A., 2012, In : Bone Marrow Transplantation. 47, p. 591 - 592 2 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma

Orlowski, R. Z., Nagler, A., Sonneveld, P., Bladé, J., Hajek, R., Spencer, A., Robak, T., Dmoszynska, A., Horvath, N., Spicka, I., Sutherland, H. J., Suvorov, A. N., Xiu, L., Cakana, A., Parekh, T. & San-Miguel, J. F., 1 Jul 2016, In : Cancer. 122, 13, p. 2050-2056 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

Fludarabine, cytarabine, granulocyte-colony stimulating factor and amsacrine: an effective salvage therapy option for acute myeloid leukemia at first relapse

Fong, C. Y., Grigoriadis, G., Hocking, J., Coutsouvelis, J., Muirhead, J. L., Campbell, P., Paul, E., Walker, P. A., Avery, S., Patil, S., Spencer, A., Schwarer, A. & Wei, A., 2013, In : Leukemia and Lymphoma. 54, 2, p. 336 - 341 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)