Research Output 2003 2017

2017

Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: A pooled analysis

Gay, F. , Oliva, S. , Petrucci, M. T. , Montefusco, V. , Conticello, C. , Musto, P. , Catalano, L. , Evangelista, A. , Spada, S. , Campbell, P. , Ria, R. , Salvini, M. , Offidani, M. , Carella, A-M. , Omedé, P. , Liberati, A. M. , Troia, R. , Cafro, A. M. , Malfitano, A. , Falcone, A. P. & 7 others Caravita, T., Patriarca, F., Nagler, A., Spencer, A., Hajek, A. R., Palumbo, A. & Boccadoro, M. 1 Aug 2017 In : Leukemia. 31, 8, p. 1727-1734 8 p.

Research output: Research - peer-reviewArticle

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Hogg, S. J., Vervoort, S. J., Deswal, S., Ott, C. J., Li, J., Cluse, L. A., Beavis, P. A., Darcy, P. K., Martin, B. P., Spencer, A., Traunbauer, A. K., Sadovnik, I., Bauer, K., Valent, P., Bradner, J. E., Zuber, J., Shortt, J. & Johnstone, R. W. 28 Feb 2017 In : Cell Reports. 18, 9, p. 2162-2174 13 p.

Research output: Research - peer-reviewArticle

Open Access
File

Bisphosphonate guidelines for treatment and prevention of myeloma bone disease

Lee, O. L. , Horvath, N. , Lee, C. , Joshua, D. , Ho, J. , Szer, J. , Quach, H. , Spencer, A. , Harrison, S. J. , Mollee, P. , Roberts, A. W. , Talaulikar, D. , Brown, R. D. , Augustson, B. M. , Ling, S. , Jaksic, W. J. , Gibson, J. , Kalff, A. , Johnston, A. , Kalro, A. & 3 others Ward, C., Prince, H. M. & Zannettino, A. C. W. 1 Aug 2017 In : Internal Medicine Journal. 47, 8, p. 938-951 14 p.

Research output: Other - peer-reviewLetter

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

Mithraprabhu, S., Khong, T., Ramachandran, M., Chow, A., Klarica, D., Mai, L., Walsh, S., Broemeling, D., Marziali, A., Wiggin, M., Hocking, J., Kalff, A., Durie, B. & Spencer, A. 1 Aug 2017 In : Leukemia. 31, 8, p. 1695-1705 11 p.

Research output: Research - peer-reviewArticle

Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation

Yong, M. K., Cameron, P. U., Slavin, M., Morrissey, C. O., Bergin, K., Spencer, A., Ritchie, D., Cheng, A. C., Samri, A., Carcelain, G., Autran, B. & Lewin, S. R. 1 Jun 2017 In : Journal of Infectious Diseases. 215, 11, p. 1684-1694 11 p.

Research output: Research - peer-reviewArticle

Open Access

Management of adverse events associated with ixazomib plus lenalidomide/dexamethasone in relapsed/refractory multiple myeloma

Kumar, S. K., Moreau, P., Hari, P., Mateos, M-V., Ludwig, H., Shustik, C., Masszi, T., Spencer, A., Hájek, R., Romeril, K., Avivi, I., Liberati, A. M., Minnema, M. C., Einsele, H., Lonial, S., Berg, D., Lin, J., Gupta, N., Esseltine, D. L. & Richardson, P. G. 1 Aug 2017 In : British Journal of Haematology. 178, 4, p. 571-582 12 p.

Research output: Research - peer-reviewArticle

Myeloma in the real world: What is really happening?

Bergin, K., McQuilten, Z., Moore, E., Wood, E. & Spencer, A. 1 Mar 2017 In : Clinical Lymphoma, Myeloma & Leukemia. 17, 3, p. 133-144.e1 13 p.

Research output: Research - peer-reviewReview Article

Pharmacokinetics and safety of carfilzomib in patients with relapsed multiple myeloma and end-stage renal disease (ESRD): an open-label, single-arm, phase I study

Quach, H., White, D. J., Spencer, A., Ho, P. J., Bhutani, D., White, M., Inamdar, S., Morris, C., Ou, Y. & Gyger, M. 1 Jun 2017 In : Cancer Chemotherapy and Pharmacology. 79, 6, p. 1067-1076 10 p.

Research output: Research - peer-reviewArticle

The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study

Tan, P., Tiong, I. S., Fleming, S., Pomilio, G., Cummings, N., Droogleever, M., McManus, J., Schwarer, A., Catalano, J., Patil, S., Avery, S., Spencer, A. & Wei, A. 2017 In : OncoTarget. 8, 32, p. 52269-52280 12 p.

Research output: Research - peer-reviewArticle

Open Access
2016

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): And randomised, phase 3, open-label, multicentre study

Dimopoulos, M. A. , Moreau, P. , Palumbo, A. , Joshua, D. E. , Pour, L. , Hájek, R. , Facon, T. , Ludwig, H. , Oriol, A. , Goldschmidt, H. , Rosiñol, L. , Straub, J. , Suvorov, A. , Araujo, C. , Rimashevskaya, E. , Pika, T. , Gaidano, G. , Weisel, K. C. , Goranova-Marinova, V. , Schwarer, A. & 11 others Minuk, L., Masszi, T., Karamanesht, I., Offidani, M., Hungria, V., Spencer, A., Orlowski, R. Z., Gillenwater, H. H., Mohamed, N., Feng, S. & Chng, W. J. 1 Jan 2016 In : Lancet Oncology. 17, 1, p. 27-38 12 p.

Research output: Research - peer-reviewArticle

Changes in bone turnover marker levels and clinical outcomes in patients with advanced cancer and bone metastases treated with bone antiresorptive agents

Lipton, A., Smith, M. R., Fizazi, K., Stopeck, A. T., Henry, D. A., Brown, J. E., Shore, N. D., Saad, F., Spencer, A., Zhu, L. & Warner, D. J. 1 Dec 2016 In : Clinical Cancer Research. 22, 23, p. 5713-5721 9 p.

Research output: Research - peer-reviewArticle

Daratumumab, bortezomib, and dexamethasone for multiple myeloma

Palumbo, A., Chanan-Khan, A., Weisel, K. C., Nooka, A. K., Masszi, T., Beksac, M., Spicka, I., Hungria, V., Munder, M., Mateos, M-V., Mark, T. M., Qi, M., Schecter, J., Amin, H., Qin, X., Deraedt, W., Ahmadi, T., Spencer, A. & Sonneveld, P. 25 Aug 2016 In : New England Journal of Medicine. 375, 8, p. 754-766 13 p.

Research output: Research - peer-reviewArticle

Design and development of the Australian and New Zealand (ANZ) myeloma and related diseases registry

Bergin, K., Moore, E., McQuilten, Z., Wood, E., Augustson, B., Blacklock, H., Ho, J., Horvath, N., King, T., McNeil, J., Mollee, P., Quach, H., Reid, C. M., Rosengarten, B., Walker, P. & Spencer, A. 9 Nov 2016 In : BMC Medical Research Methodology. 16, 1, 8 p., 151

Research output: Research - peer-reviewArticle

Epigenetics in the biology and treatment of multiple myeloma

Spencer, A. & Mithraprabhu, S. 2016 In : European Oncology & Haematology. 12, 2, p. 96-102 7 p.

Research output: Other - peer-reviewReview Article

Open Access
File

Evaluating results from the multiple myeloma patient subset treated with denosumab or zoledronic acid in a randomized phase 3 trial

Raje, N., Vadhan-Raj, S., Willenbacher, W., Terpos, E., Hungria, V., Spencer, A., Alexeeva, Y., Facon, T., Stewart, A. K., Feng, A., Braun, A., Balakumaran, A. & Roodman, G. D. 8 Jan 2016 In : Blood Cancer Journal. 6, e378

Research output: Research - peer-reviewArticle

Open Access
File

Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma

Orlowski, R. Z., Nagler, A., Sonneveld, P., Bladé, J., Hajek, R., Spencer, A., Robak, T., Dmoszynska, A., Horvath, N., Spicka, I., Sutherland, H. J., Suvorov, A. N., Xiu, L., Cakana, A., Parekh, T. & San-Miguel, J. F. 1 Jul 2016 In : Cancer. 122, 13, p. 2050-2056 7 p.

Research output: Research - peer-reviewArticle

International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma

Kumar, S. K. , Paiva, B. , Anderson, K. C. , Durie, B. , Landgren, O. , Moreau, P. , Munshi, N. , Lonial, S. , Bladé, J. , Mateos, M-V. , Dimopoulos, M. A. , Kastritis, E. , Boccadoro, M. , Orlowski, R. Z. , Goldschmidt, H. , Spencer, A. , Hou, J. , Chng, W. J. , Usmani, S. Z. , Zamagni, E. & 20 others Shimizu, K., Jagannath, S., Johnsen, H. E., Terpos, E., Reiman, A., Kyle, R. A., Sonneveld, P., Richardson, P. G., McCarthy, P. L., Ludwig, H., Chen, W., Cavo, M. M., Harousseau, J. L., Lentzsch, S., Hillengass, J., Palumbo, A., Orfao, A., Rajkumar, S. V., Miguel, J. S. & Avet-Loiseau, H. 1 Aug 2016 In : Lancet Oncology. 17, 8, p. e328-e346

Research output: Research - peer-reviewReview Article

Open Access
File

Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients

Levin, N., Spencer, A., Harrison, S. J., Chauhan, D., Burrows, F. J., Anderson, K. C., Reich, S. D., Richardson, P. G. & Trikha, M. 1 Sep 2016 In : British Journal of Haematology. 174, 5, p. 711-720 10 p.

Research output: Research - peer-reviewArticle

Open Access
File

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee, W. T. Y., Cain, J. E., Cuddihy, A. R., Dickinson, A., Yeung, K-Y., Kumar, B., Johns, T. G., Watkins, D. N., Spencer, A., St John, J. C. & Johnson, J. 2016 In : Cell Death Discovery. 2, p. 1 - 11 11 p., 16016

Research output: Research - peer-reviewArticle

Open Access
File

Myeloma of the central nervous system - an ongoing conundrum!

Harrison, S. J., Spencer, A. & Quach, H. 2016 In : Leukemia and Lymphoma. 57, 7, p. 1505 - 1506 2 p.

Research output: Other - peer-reviewComment / Debate

Phase i clinical trial of marizomib (NPI-0052) in patients with advanced malignancies including multiple myeloma: Study NPI-0052-102 final results

Harrison, S. J., Mainwaring, P., Price, T., Millward, M. J., Padrik, P., Underhill, C. R., Cannell, P. K., Reich, S. D., Trikha, M. & Spencer, A. 15 Sep 2016 In : Clinical Cancer Research. 22, 18, p. 4559-4566 8 p.

Research output: Research - peer-reviewArticle

Primary antifungal prophylaxis in adult patients with acute lymphoblastic leukaemia: A multicentre audit

Doan, T. N., Kirkpatrick, C. M. J., Walker, P., Slavin, M. A., Ananda-Rajah, M. R., Morrissey, C. O., Urbancic, K. F., Grigg, A. P., Spencer, A., Szer, J., Seymour, J. F. & Kong, D. C. M. 1 Feb 2016 In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 497-505 9 p., dkv343

Research output: Research - peer-reviewArticle

Open Access
File

Second Cancer Risk and Late Mortality in Adult Australians Receiving Allogeneic Hematopoietic Stem Cell Transplantation: A Population-Based Cohort Study

Vajdic, C. M. , Mayson, E. , Dodds, A. J. , O'Brien, T. , Wilcox, L. , Nivison-Smith, I. , Le Marsney, R. , Daniels, B. , Ashton, L. J. , Tan, J. , Bilmon, I. , Aarons, D. , Tran, S. , Gibson, J. , Johnston, A. , Greenwood, M. , Forbes, K. M. , Hertzberg, M. , Huang, J. G. , Spencer, A. & 28 others Muirhead, J. L., Szer, J., Mason, K., Lewis, I., To, C., Durrant, S., Western, R., Cannell, P., Buffery, S., Oswald, C., Nelson, A., Shaw, P., Pearson, L., Tiedemann, K., Scoyne, M., Fraser, C., Seljak, J., Cole, N. C., Rowland, K., Gough, K. H., Tapp, H., Green, N., Moa, A., McRae, J., Jenkins, M., Hicks, J., Chaplin, K. & CAST study investigators 1 May 2016 In : Biology of Blood and Marrow Transplantation. 22, 5, p. 949-956 8 p.

Research output: Research - peer-reviewArticle

2015

A rare case of IGH/MYC and IGH/BCL2 double hit primary plasma cell leukemia

Kalff, A., Khong, T., Wall, M., Gorniak, M., Mithraprabhu, S., Campbell, L. J. & Spencer, A. 2015 In : Haematologica: the hematology journal. 100, 2, p. e60-e62 3 p.

Research output: Other - peer-reviewLetter

Open Access

Comparison of biosimilar filgrastim with originator filgrastim for peripheral blood stem cell mobilization and engraftment in patients with multiple myeloma undergoing autologous stem cell transplantation

Pham, T., Patil, S., Fleming, S. A., Avery, S., Walker, P. A., Wei, A., Curtis, D. J., Stuart, G., Klarica, D., O'Brien, M., Morris, K., Das, T. P., Bollard, G. M., Muirhead, J., Coutsouvelis, J. & Spencer, A. 2015 In : Transfusion. 55, 11, p. 2709 - 2713 5 p.

Research output: Research - peer-reviewArticle

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Dimopoulos, M. A. , Weisel, K. C. , Song, K. W. , Delforge, M. , Karlin, L. , Goldschmidt, H. , Moreau, P. , Banos, A. , Oriol, A. , Garderet, L. , Cavo, M. M. , Ivanova, V. , Alegre, A. , Martinez-Lopez, J. , Chen, C. , Spencer, A. , Knop, S. , Bahlis, N. J. , Renner, C. , Yu, X. & 5 others Hong, K., Sternas, L., Jacques, C., Zaki, M. & San Miguel, J. F. 2015 In : Haematologica: the hematology journal. 100, 10, p. 1327 - 1333 7 p.

Research output: Research - peer-reviewArticle

Elotuzumab therapy for relapsed or refractory multiple myeloma

Lonial, S. , Dimopoulos, M. A. , Palumbo, A. , White, D. J. , Grosicki, S. , Spicka, I. , Walter-Croneck, A. , Moreau, P. , Mateos, M-V. , Magen, H. , Belch, A. R. , Reece, D. E. , Beksac, M. , Spencer, A. , Oakervee, H. , Orlowski, R. Z. , Taniwaki, M. , Rollig, C. , Einsele, H. , Wu, K. L. & 8 others Singhal, A., San Miguel, J. F., Matsumoto, M., Katz, J., Bleickardt, E., Poulart, V., Anderson, K. C. & Richardson, P. G. 2015 In : New England Journal of Medicine. 373, 7, p. 621 - 631 11 p.

Research output: Research - peer-reviewArticle

Maintenance lenalidomide in combination with 5-azacitidine as post-remission therapy for acute myeloid leukaemia

Wei, A., Tan, P. T. G., Perruzza, S. N., Govindaraj, C., Fleming, S. A., McManus, J. F., Avery, S., Patil, S., Stevenson, W. C., Plebanski, M. & Spencer, A. 2015 In : British Journal of Haematology. 169, 2, p. 199 - 210 12 p.

Research output: Research - peer-reviewArticle

Management of systemic AL amyloidosis: Recommendations of the Myeloma Foundation of Australia Medical and Scientific Advisory Group

Weber, N., Mollee, P., Augustson, B. M., Brown, R., Catley, L. P., Gibson, J., Harrison, S., Ho, P. J., Horvath, N., Jaksic, W. J., Joshua, D., Quach, H., Roberts, A. W., Spencer, A., Szer, J., Talaulikar, D., To, B., Zannettino, A. C. W. & Prince, H. M. 1 Apr 2015 In : Internal Medicine Journal. 45, 4, p. 371-382 12 p.

Research output: Research - peer-reviewReview Article

MDX-1097 induces antibody-dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide

Asvadi, P., Cuddihy, A. R., Dunn, R., Jiang, V., Wong, M. X., Jones, D. R., Khong, T. T. F. & Spencer, A. 2015 In : British Journal of Haematology. 169, 3, p. 333 - 343 11 p.

Research output: Research - peer-reviewArticle

Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma

Seggewiss-Bernhardt, R., Bargou, R. C., Goh, Y. T., Stewart, A. K., Spencer, A., Alegre, A., Blade, J., Ottman, O. G., Fernandez-Ibarra, C., Lu, H., Pain, S., Akimov, M. & Iyer, S. P. 2015 In : Cancer. 121, 13, p. 2185 - 2192 8 p.

Research output: Research - peer-reviewArticle

Phase 2 study of dovitinib in patients with relapsed or refractory multiple myeloma with or without t(4;14) translocation

Scheid, C., Reece, D. E., Beksac, M., Spencer, A., Callander, N. S., Sonneveld, P., Kalimi, G., Cai, C., Shi, M. M., Scott, J. W. & Stewart, A. K. 2015 In : European Journal of Haematology. 95, 4, p. 316 - 324 9 p.

Research output: Research - peer-reviewArticle

Revised international staging system for multiple myeloma: a report from international myeloma working group

Palumbo, A. , Avet-Loiseau, H. , Olivia, S. , Lokhorst, H. M. , Goldschmidt, H. , Rosinol, L. , Richardson, P. G. , Caltagirone, S. , Lahuerta, J. J. , Facon, T. , Bringhen, S. , Gay, F. , Attal, M. , Passera, R. , Spencer, A. , Offidani, M. , Kumar, S. K. , Musto, P. , Lonial, S. , Petrucci, M. T. & 11 others Orlowski, R. Z., Zamagni, E., Morgan, G., Dimopoulos, M. A., Durie, B. G. M., Anderson, K. C., Sonneveld, P., San Miguel, J. F., Cavo, M. M., Rajkumar, S. V. & Moreau, P. 2015 In : Journal of Clinical Oncology. 33, 26, p. 2863 - 2869 7 p.

Research output: OtherArticle

The addition of dexamethasone to bortezomib for patients with relapsed multiple myeloma improves outcome but ongoing maintenance therapy has minimal benefit

Harrison, S. J. A., Quach, H., Link, E. K., Feng, H., Dean, J., Copeman, M. B., van de Velde, H., Schwarer, A., Baker, B., Spencer, A., Catalano, J., Campbell, P., Augustson, B. M., Romeril, K. & Prince, H. M. 2015 In : American Journal of Hematology. 90, 5, p. 86 - 91 6 p.

Research output: OtherArticle

The role of denosumab in the prevention of hypercalcaemia of malignancy in cancer patients with metastatic bone disease

Diel, I. J., Body, J-J., Stopeck, A. T., Vadhan-Raj, S., Spencer, A., Steger, G., von Moos, R., Goldwasser, F., Feng, A. & Braun, A. H. 2015 In : European Journal of Cancer. 51, 11, p. 1467 - 1475 9 p.

Research output: Research - peer-reviewArticle

TOP2A knockdown resensitizes carfilzomib-resistant Hmcls to carfilzomib

Reale, A., Khong, T. T., Mithraprabhu, S., Savvidou, I., Ramachandran, M. & Spencer, A. Dec 2015 p. 4215 1 p.

Research output: OtherAbstract

Treatment of patients with multiple myeloma who are eligible for stem cell transplantation: Position statement of the Myeloma Foundation of Australia Medical and Scientific Advisory Group

Quach, H., Joshua, D., Ho, J., Szer, J., Spencer, A., Harrison, S. J., Mollee, P., Roberts, A. W., Horvath, N., Talulikar, D., To, B., Zannettino, A. C. W., Brown, R., Catley, L. P., Augustson, B. M., Jaksic, W. J., Gibson, J. & Prince, H. M. 1 Jan 2015 In : Internal Medicine Journal. 45, 1, p. 94-105 12 p.

Research output: Research - peer-reviewArticle

Treatment of patients with multiple myeloma who are not eligible for stem cell transplantation: Position statement of the myeloma foundation of Australia Medical and Scientific Advisory Group (

Quach, H., Joshua, D. E., Ho, J., Szer, J., Spencer, A., Harrison, S., Mollee, P. N., Roberts, A. W., Horvath, N., Talaulikar, D., To, B., Zannettino, A. C. W., Brown, R. D., Catley, L. P., Augustson, B. M., Jaksic, W. J., Gibson, J. L. & Prince, H. M. 2015 In : Internal Medicine Journal. 45, 3, p. 335-343 9 p.

Research output: Other - peer-reviewArticle

2014

Comparison of the probability of target attainment of anidulafungin against Candida spp. in patients with acute leukaemia

Doan, T. N., Kong, D. C. M., Patel, K., Walker, P. A., Spencer, A. & Kirkpatrick, C. M. J. 2014 In : International Journal of Antimicrobial Agents. 44, 5, p. 450 - 457 8 p.

Research output: Research - peer-reviewArticle

Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

Tan, P., Wei, A., Mithraprabhu, S., Cummings, N. J., Liu, H. B., Perugini, M., Reed, K. D., Avery, S., Patil, S., Walker, P. A., Mollee, P. N., Grigg, A. P., D'Andrea, R. J., Dear, A. E. & Spencer, A. 2014 In : Blood Cancer Journal. 4, 1 (Art. No.: e170), p. 1 - 8 8 p.

Research output: Research - peer-reviewArticle

Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

Mithraprabhu, S., Kalff, A., Chow, A., Khong, T. T. F. & Spencer, A. 2014 In : Epigenetics. 9, 11, p. 1511 - 1520 10 p.

Research output: Research - peer-reviewArticle

Fludarabine Melphalan reduced-intensity conditioning allotransplanation provides similar disease control in lymphoid and myeloid malignancies: Analysis of 344 patients

Bryant, R. A., Nivison-Smith, I., Pillai, E. S., Kennedy, G., Kalff, A., Ritchie, P. D., George, B., Hertzberg, M., Patil, S., Spencer, A., Fay, K., Cannell, P., Berkahn, L., Doocey, R., Spearing, R. & Moore, J. 2014 In : Bone Marrow Transplantation. 49, 1, p. 17-23 7 p.

Research output: Research - peer-reviewArticle

International Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation

Palumbo, A. , Rajkumar, S. V. , San Miguel, J. F. , Larocca, A. T. , Niesvizky, R. , Morgan, G. , Landgren, O. , Hajek, R. , Einsele, H. , Anderson, K. C. , Dimopoulos, M. A. , Richardson, P. G. , Cavo, M. M. , Spencer, A. , Stewart, A. K. , Shimizu, K. , Lonial, S. , Sonneveld, P. , Durie, B. G. M. , Moreau, P. & 1 others Orlowski, R. Z. 2014 In : Journal of Clinical Oncology. 32, 6, p. 587 - 600 14 p.

Research output: Research - peer-reviewArticle