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Research Output

2020

Patient-reported outcome measures in multiple myeloma: Real-time reporting to improve care (My-PROMPT) - a pilot randomized controlled trial

Moore, E. M., King, T. A., Wood, E. M., Ruseckaite, R., Klarica, D., Spencer, A., Ho, P. J., Quach, H., Prince, M. & McQuilten, Z. K., Jul 2020, In : American Journal of Hematology. 95, 7, p. E178-E181 4 p.

Research output: Contribution to journalLetterResearchpeer-review

Open Access
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2019

A comparison of the efficacy of immunomodulatory-free regimens in relapsed or refractory multiple myeloma: a network meta-analysis

Weisel, K., Sonneveld, P., Spencer, A., Beksac, M., Rizzo, M., Xu, Y., Fahrbach, K., Gaudig, M., Slavcev, M., Dearden, L. & Lam, A., 1 Jan 2019, In : Leukemia and Lymphoma. 60, 19, p. 151–162 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

DNA-repair gene mutations are highly prevalent in circulating tumour dna from multiple myeloma patients

Mithraprabhu, S., Hocking, J., Ramachandran, M., Choi, K., Klarica, D., Khong, T., Reynolds, J. & Spencer, A., 29 Jun 2019, In : Cancers. 11, 7, 14 p., 917.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Epigenetic treatment-mediated modulation of PD-L1 predicts potential therapy resistance over response markers in myeloid malignancies: A molecular mechanism involving effectors of PD-L1 reverse signaling

Liu, H., Hu, Y., Rimoldi, R., Von Hagt, C., Khong, E. W. C., Lee, N., Flemming, S., Spencer, A. & Dear, A. E., Feb 2019, In : Oncology Letters. 17, 2, p. 2543-2550 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patients

Mithraprabhu, S., Morley, R., Khong, T., Kalff, A., Bergin, K., Hocking, J., Savvidou, I., Bowen, K. M., Ramachandran, M., Choi, K., Wong, B. K. L., Reynolds, J. & Spencer, A., Aug 2019, In : Leukemia. 33, 8, p. 2022-2033 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Oral azacitidine (CC-486) in combination with lenalidomide and dexamethasone in advanced, lenalidomide-refractory multiple myeloma (ROAR study)

Kalff, A., Khong, T., Mithraprabhu, S., Bergin, K., Reynolds, J., Bowen, K. M., Thakurta, A., Guzman, R., Wang, M., Couto, S., Ren, Y. & Spencer, A., 29 Jul 2019, In : Leukemia and Lymphoma. 60, 9, p. 2143-2151 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Phase 2 study of all-oral ixazomib, cyclophosphamide and low-dose dexamethasone for relapsed/refractory multiple myeloma

Kumar, S. K., Grzasko, N., Delimpasi, S., Jedrzejczak, W. W., Grosicki, S., Kyrtsonis, M. C., Spencer, A., Gupta, N., Teng, Z., Byrne, C., Labotka, R. & Dimopoulos, M. A., 1 Feb 2019, In : British Journal of Haematology. 184, 4, p. 536-546 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Renal impairment at diagnosis in myeloma: Patient characteristics, treatment, and impact on outcomes. Results from the Australia and New Zealand Myeloma and Related Diseases Registry

Ho, P. J., Moore, E. M., McQuilten, Z. K., Wellard, C., Bergin, K., Augustson, B., Blacklock, H., Harrison, S. J., Horvath, N., King, T., Mollee, P., Quach, H., Reid, C., Rosengarten, B., Walker, P., Wood, E. M. & Spencer, A., Aug 2019, In : Clinical Lymphoma, Myeloma and Leukemia. 19, 8, p. E415-E424 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Utility of circulating cell-free RNA analysis for the characterization of global transcriptome profiles of multiple myeloma patients

Chen, M., Mithraprabhu, S., Ramachandran, M., Choi, K., Khong, T. & Spencer, A., 1 Jun 2019, In : Cancers. 11, 6, 19 p., 887.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)
2018

Analysis of circulating tumor DNA

Mithraprabhu, S. & Spencer, A., 1 Jan 2018, Methods in Molecular Biology. Humana Press, p. 129-145 17 p. (Methods in Molecular Biology; vol. 1792).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

A phase 1 clinical trial evaluating marizomib, pomalidomide and low-dose dexamethasone in relapsed and refractory multiple myeloma (NPI-0052-107): final study results

Spencer, A., Harrison, S., Zonder, J., Badros, A., Laubach, J., Bergin, K., Khot, A., Zimmerman, T., Chauhan, D., Levin, N., MacLaren, A., Reich, S. D., Trikha, M. & Richardson, P., 1 Jan 2018, In : British Journal of Haematology. 180, 1, p. 41-51 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

Carfilzomib–dexamethasone versus subcutaneous or intravenous bortezomib in relapsed or refractory multiple myeloma: secondary analysis of the phase 3 ENDEAVOR study

Goldschmidt, H., Moreau, P., Ludwig, H., Niesvizky, R., Chng, W. J., Joshua, D., Weisel, K., Spencer, A., Orlowski, R. Z., Feng, S., Iskander, K. S. & Dimopoulos, M. A., 2018, In : Leukemia and Lymphoma. 59, 6, p. 1364-1374 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
7 Citations (Scopus)

Considerations for pre-transfusion immunohaematology testing in patients receiving the anti-CD38 monoclonal antibody daratumumab for the treatment of multiple myeloma

Quach, H., Benson, S., Haysom, H., Wilkes, A. M., Zacher, N., Cole-Sinclair, M., Miles Prince, H., Mollee, P., Spencer, A., Joy Ho, P., Harrison, S. J., Lee, C., Augustson, B. & Daly, J., 1 Feb 2018, In : Internal Medicine Journal. 48, 2, p. 210-220 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Contemporary analysis of functional immune recovery to opportunistic and vaccine-preventable infections after allogeneic haemopoietic stem cell transplantation

De Silva, H., Ffrench, R. A., Korem, M., Orlowski-Oliver, E., Curtis, D. J., Spencer, A., Avery, S., Patil, S. & Morrissey, C. O., 1 Jan 2018, In : Clinical & Translational Immunology. 7, 10, 16 p., e1040.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma: Updated analysis of CASTOR

Spencer, A., Lentzsch, S., Weisel, K., Avet-Loiseau, H., Mark, T. M., Spicka, I., Masszi, T., Lauri, B., Levin, M. D., Bosi, A., Hungria, V., Cavo, M., Lee, J. J., Nooka, A. K., Quach, H., Lee, C., Barreto, W., Corradini, P., Min, C. K., Scott, E. C. & 17 others, Chanan-Khan, A. A., Horvath, N., Capra, M., Beksac, M., Ovilla, R., Jo, J. C., Shin, H. J., Sonneveld, P., Soong, D., Casneuf, T., Chiu, C., Amin, H., Qi, M., Thiyagarajah, P., Sasser, A. K., Schecter, J. M. & Mateos, M. V., 30 Nov 2018, In : Haematologica: the hematology journal. 103, 12, p. 2079-2087 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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67 Citations (Scopus)

DCEP as a bridge to ongoing therapies for advanced relapsed and/or refractory multiple myeloma

Yuen, H. L. A., Low, M. S. Y., Fedele, P., Kalff, A., Walker, P., Bergin, K., Coutsouvelis, J., Grigoriadis, G. & Spencer, A., 2 Dec 2018, In : Leukemia and Lymphoma. 59, 12, p. 2842-2846 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Defibrotide for the treatment of sinusoidal obstruction syndrome: evaluation of response to therapy and patient outcomes

Coutsouvelis, J., Avery, S., Dooley, M., Kirkpatrick, C. & Spencer, A., 1 Mar 2018, In : Supportive Care in Cancer. 26, 3, p. 947-955 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Extending Circulating Tumor DNA Analysis to Ultralow Abundance Mutations: Techniques and Challenges

Rodda, A. E., Parker, B. J., Spencer, A. & Corrie, S. R., 23 Mar 2018, In : ACS Sensors. 3, 3, p. 540-560 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

Ibrutinib as treatment for patients with relapsed/refractory follicular lymphoma: Results from the open-label, multicenter, phase II DAWN study

Gopal, A. K., Schuster, S. J., Fowler, N. H., Trotman, J., Hess, G., Hou, J. Z., Yacoub, A., Lill, M., Martin, P., Vitolo, U., Spencer, A., Radford, J., Jurczak, W., Morton, J., Caballero, D., Deshpande, S., Gartenberg, G. J., Wang, S. S., Damle, R. N., Schaffer, M. & 4 others, Balasubramanian, S., Vermeulen, J., Cheson, B. D. & Salles, G., 10 Aug 2018, In : Journal of Clinical Oncology. 36, 23, p. 2405-2412 8 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Maintenance Treatment and Survival in Patients with Myeloma: A Systematic Review and Network Meta-analysis

Gay, F., Jackson, G., Rosiñol, L., Holstein, S. A., Moreau, P., Spada, S., Davies, F., Lahuerta, J. J., Leleu, X., Bringhen, S., Evangelista, A., Hulin, C., Panzani, U., Cairns, D. A., Di Raimondo, F., Macro, M., Liberati, A. M., Pawlyn, C., Offidani, M., Spencer, A. & 11 others, Hájek, R., Terpos, E., Morgan, G. J., Bladé, J., Sonneveld, P., San-Miguel, J., McCarthy, P. L., Ludwig, H., Boccadoro, M., Mateos, M. V. & Attal, M., 1 Oct 2018, In : JAMA Oncology. 4, 10, p. 1389-1397 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

25 Citations (Scopus)

Mining the plasma cell transcriptome for novel cell surface proteins

Trezise, S., Karnowski, A., Fedele, P. L., Mithraprabhu, S., Liao, Y., D’costa, K., Kueh, A. J., Hardy, M. P., Owczarek, C. M., Herold, M. J., Spencer, A., Shi, W., Willis, S. N., Nutt, S. L. & Corcoran, L. M., 1 Aug 2018, In : International Journal of Molecular Sciences. 19, 8, 2161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Panobinostat monotherapy and combination therapy in patients with acute myeloid leukemia: Results from two clinical trials

Schlenk, R. F., Krauter, J., Raffoux, E., Kreuzer, K. A., Schaich, M., Noens, L., Pabst, T., Vusirikala, M., Bouscary, D., Spencer, A., Candoni, A., Gil, J., Berkowitz, N., Weber, H. J. & Ottmann, O., 1 Jan 2018, In : Haematologica. 103, 1, p. E25-E28 4 p.

Research output: Contribution to journalLetterOtherpeer-review

6 Citations (Scopus)

Phase 2 Trial of the Combination of Ixazomib, Thalidomide and Dexamethasone (ITD) in Relapsed/Refractory Myeloma: Planned Preliminary Analysis

Bergin, K., Yuen, F., Wallington-Beddoe, C. T., Kalff, A., Sirdesai, S., Reynolds, J. & Spencer, A., 29 Nov 2018, In : Blood. 132, Suppl 1, 1 p., 3265.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Pomalidomide Alone or in Combination with Low Dose Dexamethasone As Maintenance Following Induction with Pomalidomide and Low Dose Dexamethasone in Relapsed and Refractory Myeloma (ALLG MM14)

Kalff, A., Kennedy, N., Reynolds, J., Quach, H., Ho, P. J., Horvath, N., Mollee, P., D'Rozario, J. M., Taylor, K., Estell, J. & Spencer, A., 21 Nov 2018, In : Blood. 132, Suppl 1, 1 p., 1986.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Preliminary Analysis of the Australasian Leukaemia and Lymphoma Group (ALLG) MM17 Trial: Response Adaptive Salvage Treatment with Carfilzomib-Thalidomide-Dexamethasone (KTd) for Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Failing Front-Line Bortezomib-Based Induction Therapy: Blood 2018 132:3279

Spencer, A., Quach, H., Horvath, N., Kerridge, I. H., Yuen, F., Lee, E. S-H., Morris, E. S., Kalff, A., Bergin, K., Sirdesai, S., Gorniak, M., Mithraprabhu, S., Khong, T. & Reynolds, J., 29 Nov 2018, In : Blood. 132, Suppl 1, 1 p., 3279.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Resistance to Nutrient Deprivation Via Metabolic Re-Programming As Mechanism of 'Metastasis' Promotion in Multiple Myeloma

Savvidou, I., Khong, T. T. F., Spencer, A., Chen, M., Kalff, A., Masoumi Moghaddam, S., Chandrasekara, S. & Brown, A., Dec 2018.

Research output: Contribution to conferenceAbstract

The Canonical Wnt/β-catenin Pathway as a Therapeutic Target in Multiple Myeloma

Savvidou, I., Khong, T., Spencer, A. & Alt, K. M., Jul 2018, In : Archives of Medical Research. 6, 7, p. 1-15 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The role of autophagy in multiple myeloma disease progression

Savvidou, I., Chandrasekara, S. D., Khong, T. T. F. & Spencer, A., Jul 2018, In : Cancer Research. 78, 13 Supplement, 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response

Mina, R., Petrucci, M. T., Corradini, P., Spada, S., Patriarca, F., Cerrato, C., De Paoli, L., Pescosta, N., Ria, R., Malfitano, A., Musto, P., Baldini, L., Guglielmelli, T., Gamberi, B., Mannina, D., Benevolo, G., Zambello, R., Falcone, A. P., Palumbo, A., Nagler, A. & 5 others, Calafiore, V., Hájek, R., Spencer, A., Boccadoro, M. & Bringhen, S., 1 Aug 2018, In : Clinical Lymphoma, Myeloma & Leukemia. 18, 8, p. 533-540 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2017

Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma

Nair, A. P., Walker, P., Kalff, A., Bergin, K., Hocking, J., Avery, S., Curtis, D. J., Patil, S., Das, T., Klarica, D., Morgan, S., Muirhead, J., Gorniak, M. B., Reynolds, J. & Spencer, A., 1 Jun 2017, In : Bone Marrow Transplantation. 52, 6, p. 839-845 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

An Evidence-Based Approach to Myeloma Bone Disease

Bingham, N., Reale, A. & Spencer, A., 1 Apr 2017, In : Current Hematologic Malignancy Reports. 12, 2, p. 109-118 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: A pooled analysis

Gay, F., Oliva, S., Petrucci, M. T., Montefusco, V., Conticello, C., Musto, P., Catalano, L., Evangelista, A., Spada, S., Campbell, P., Ria, R., Salvini, M., Offidani, M., Carella, A-M., Omedé, P., Liberati, A. M., Troia, R., Cafro, A. M., Malfitano, A., Falcone, A. P. & 7 others, Caravita, T., Patriarca, F., Nagler, A., Spencer, A., Hajek, A. R., Palumbo, A. & Boccadoro, M., 1 Aug 2017, In : Leukemia. 31, 8, p. 1727-1734 8 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Hogg, S. J., Vervoort, S. J., Deswal, S., Ott, C. J., Li, J., Cluse, L. A., Beavis, P. A., Darcy, P. K., Martin, B. P., Spencer, A., Traunbauer, A. K., Sadovnik, I., Bauer, K., Valent, P., Bradner, J. E., Zuber, J., Shortt, J. & Johnstone, R. W., 28 Feb 2017, In : Cell Reports. 18, 9, p. 2162-2174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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88 Citations (Scopus)

Bisphosphonate guidelines for treatment and prevention of myeloma bone disease

Lee, O. L., Horvath, N., Lee, C., Joshua, D., Ho, J., Szer, J., Quach, H., Spencer, A., Harrison, S. J., Mollee, P., Roberts, A. W., Talaulikar, D., Brown, R. D., Augustson, B. M., Ling, S., Jaksic, W. J., Gibson, J., Kalff, A., Johnston, A., Kalro, A. & 3 others, Ward, C., Prince, H. M. & Zannettino, A. C. W., 1 Aug 2017, In : Internal Medicine Journal. 47, 8, p. 938-951 14 p.

Research output: Contribution to journalLetterOtherpeer-review

10 Citations (Scopus)

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

Mithraprabhu, S., Khong, T., Ramachandran, M., Chow, A., Klarica, D., Mai, L., Walsh, S., Broemeling, D., Marziali, A., Wiggin, M., Hocking, J., Kalff, A., Durie, B. & Spencer, A., 1 Aug 2017, In : Leukemia. 31, 8, p. 1695-1705 11 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Circulating tumour DNA analysis in multiple myeloma

Mithraprabhu, S. & Spencer, A., 1 Jan 2017, In : Oncotarget. 8, 53, p. 90610-90611 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
2 Citations (Scopus)

Identification of Acetylation, Immune Cell Alterations and Gene Signature As Dynamic Biomarkers of Response to Panobinostat Treatment in Multiple Myeloma Patients

Mithraprabhu, S., Savvidou, I., Ramachandran, M., Kalff, A., Khong, T. T., Reed, K., Reynolds, J. & Spencer, A., 7 Dec 2017, In : Blood. 130, Suppl 1, 1 p., 1823.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation

Yong, M. K., Cameron, P. U., Slavin, M., Morrissey, C. O., Bergin, K., Spencer, A., Ritchie, D., Cheng, A. C., Samri, A., Carcelain, G., Autran, B. & Lewin, S. R., 1 Jun 2017, In : Journal of Infectious Diseases. 215, 11, p. 1684-1694 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Low T-cell responses to mitogen stimulation predicts poor survival in recipients of allogeneic hematopoietic stem cell transplantation

Yong, M. K., Cameron, P. U., Slavin, M. A., Cheng, A. C., Orla Morrissey, C., Bergin, K., Spencer, A., Ritchie, D. & Lewin, S. R., 9 Nov 2017, In : Frontiers in Immunology. 8, NOV, 9 p., 1506.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Management of adverse events associated with ixazomib plus lenalidomide/dexamethasone in relapsed/refractory multiple myeloma

Kumar, S. K., Moreau, P., Hari, P., Mateos, M-V., Ludwig, H., Shustik, C., Masszi, T., Spencer, A., Hájek, R., Romeril, K., Avivi, I., Liberati, A. M., Minnema, M. C., Einsele, H., Lonial, S., Berg, D., Lin, J., Gupta, N., Esseltine, D-L. & Richardson, P. G., Aug 2017, In : British Journal of Haematology. 178, 4, p. 571-582 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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30 Citations (Scopus)

Myeloma in the real world: What is really happening?

Bergin, K., McQuilten, Z., Moore, E., Wood, E. & Spencer, A., 1 Mar 2017, In : Clinical Lymphoma, Myeloma & Leukemia. 17, 3, p. 133-144.e1 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Pharmacokinetics and safety of carfilzomib in patients with relapsed multiple myeloma and end-stage renal disease (ESRD): an open-label, single-arm, phase I study

Quach, H., White, D., Spencer, A., Ho, P. J., Bhutani, D., White, M., Inamdar, S., Morris, C., Ou, Y. & Gyger, M., Jun 2017, In : Cancer Chemotherapy and Pharmacology. 79, 6, p. 1067-1076 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)