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Research Output 2001 2017

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Article
2017

Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent

Ogunniyi, A. D., Khazandi, M., Stevens, A. J., Sims, S. K., Page, S. W., Garg, S., Venter, H., Powell, A., White, K., Petrovski, K. R., Laven-Law, G., Tótoli, E. G., Salgado, H. R., Pi, H., Coombs, G. W., Shinabarger, D. L., Turnidge, J. D., Paton, J. C., McCluskey, A. & Trott, D. J., 1 Sep 2017, In : PLoS ONE. 12, 9, 23 p., e0183457.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Drinkwater, N., Vinh, N. B., Mistry, S. N., Bamert, R. S., Ruggeri, C., Holleran, J. P., Loganathan, S., Paiardini, A., Charman, S. A., Powell, A. K., Avery, V. M., McGowan, S. & Scammells, P. J., 3 Mar 2016, In : European Journal of Medicinal Chemistry. 110, p. 43-64 22 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Simplified silvestrol analogues with potent cytotoxic activity

Hawkins, B. C., Lindqvist, L. M., Nhu, D. Q., Sharp, P. P., Segal, D., Powell, A. K., Campbell, M., Ryan, E., Chambers, J. M., White, J., Rizzacasa, M. A., Lessene, G., Huang, D. CS. & Burns, C. J., 2014, In : ChemMedChem. 9, 7, p. 1556 - 1566 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): An orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy

Williams, S. J., Zammit, S. C., Cox, A. J., Shackleford, D., Morizzi, J., Zhang, Y., Powell, A. K., Gilbert, R. E., Krum, H. & Kelly, D. J., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 24, p. 6868 - 6873 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomypathy

Zhang, Y., Edgley, A. J., Cox, A. J., Powell, A. K., Wang, B. H., Kompa, A. R., Stapleton, D. I., Zammit, S. C., Williams, S. J., Krum, H., Gilbert, R. E. & Kelly, D. J., 2012, In : European Journal of Heart Failure. 14, 5, p. 549 - 562 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The hypoxia imaging agent Cu ii(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

Hung, L., Villemagne, V., Cheng, L., Sherratt, N., Ayton, S., White, A., Crouch, P., Lim, S. C., Leong, S. L., Wilkins, S., George, J., Roberts, B., Pham, C., Liu, X., Chiu, F., Shackleford, D., Powell, A., Masters, C., Bush, A. I., O'Keefe, G. & 7 othersCulvenor, J., Cappai, R., Cherny, R., Donnelly, P., Hill, A., Finkelstein, D. & Barnham, K., 2012, In : Journal of Experimental Medicine. 209, 4, p. 837 - 854 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Soon, C., Donnelly, P., Turner, B., Hung, L., Crouch, P., Sherratt, N., Tan, J-L., Lim, N., Lam, L., Bica, L., Lim, S. C., Hickey, J., Morizzi, J., Powell, A., Finkelstein, D., Culvenor, J., Masters, C., Duce, J., White, A., Barnham, K. & 1 othersLin, Q-X., 2011, In : Journal of Biological Chemistry. 286, 51, p. 44035 - 44044 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The microtubule depolymerising agent CYT997 causes extensive ablation of tumor vasculature in vivo

Burns, C., Fantino, E., Powell, A., Shnyder, S., Cooper, P., Nelson, S., Christophi, C., Malcontenti-Wilson, C., Dubljevic, V., Harte, M., Joffe, M., Phillips, I., Segal, D., Wilks, A. & Smith, G., 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 3, p. 799 - 806 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Motility in the isolated mouse colon: migrating motor complexes, myoelectric complexes and pressure waves

Powell, A. K., Fida, R. & Bywater, R. A. R., 2003, In : Neurogastroenterology and Motility. 15, 3, p. 257 - 266 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Murine intestinal migrating motor complexes: longitudinal components

Powell, A. K. & Bywater, R. A. R., 2003, In : Neurogastroenterology and Motility. 15, 3, p. 245 - 256 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Neural integrity is essential for the propagation of colonic migrating motor complexes in the mouse

Powell, A. K., O'Brien, S. D., Fida, R. & Bywater, R. A. R., 2002, In : Neurogastroenterology and Motility. 14, 5, p. 495 - 504 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Endogenous nitric oxide release modulates the direction and frequency of colonic migrating motor complexes in the isolated mouse colon

Powell, A. K. & Bywater, R. A. R., 2001, In : Neurogastroenterology and Motility. 13, 3, p. 221 - 228 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Ongoing nicotinic and non-nicotinic inputs to inhibitory neurons in the mouse colon

Powell, A. K., Fida, R. & Bywater, R. A. R., 2001, In : Clinical and Experimental Pharmacology and Physiology. 28, 10, p. 792 - 798 7 p.

Research output: Contribution to journalArticleResearchpeer-review