19962019
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Personal profile

Biography

Dr. Andrew Laslett is a Research Team Leader with the CSIRO Manufacturing business unit, where he leads a human pluripotent stem cell biology research team; He also holds an Adjunct Associate Professor position with the Australian Regenerative Medicine Institute at Monash University and is an Honorary Senior Fellow with the School of BioSciences at Melbourne University. Since 2001, Andrew and his laboratory have focused on elucidating the complex biology of human embryonic stem cells (hESC), examined methods for the differentiation of hESC to renal progenitor cells and more recently begun comparing hESC to reprogrammed human cells termed induced pluripotent stem (iPS) cells. His laboratory is currently focused on exploiting the basic biology of these cell types to create novel cell lines and tools that enhance human pluripotent cell research translation within CSIRO, Australia and internationally.Current projects include:

(i) functional uses of monoclonal antibodies to cell surface proteins on human pluripotent stem cells

(ii) the production of a "disease in a dish" model of human breast cancer

(iii) optimisation of human hepatocyte production conditions for use in bio-artificial liver devices

Prior to his current role with CSIRO, Andrew was a Senior Scientist and Group Leader of the Human Embryonic Stem Cell Technology Laboratory at the Australian Stem Cell Centre (ASCC) following Senior Research Fellow appointments in the Laboratory of Embryonic Stem Cell Biology and the Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University. He obtained his BSc (Hons) and PhD (1996) from Monash University prior to undertaking postdoctoral positions in both Hong Kong and Philadelphia, USA.

External positions

Research Team Leader, CSIRO Manufacturing and Infrastructure Technology

1 Aug 2009 → …

Keywords

  • embryonic stem cells
  • induced pluripotent stem cells
  • stem cells
  • antibodies
  • breast cancer
  • hepatocyte

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Projects 2011 2019

Research Output 1996 2018

Cell surface markers for the identification and study of human naive pluripotent stem cells

Trusler, O., Huang, Z., Goodwin, J. & Laslett, A. L. Jan 2018 In : Stem Cell Research. 26, p. 36-43 8 p.

Research output: Contribution to journalArticle

Open Access
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Long-Term Maintenance of Human Pluripotent Stem Cells on cRGDfK-Presenting Synthetic Surfaces

Lambshead, J. W., Meagher, L., Goodwin, J., Labonne, T., Ng, E., Elefanty, A., Stanley, E., O'Brien, C. M. & Laslett, A. L. Jan 2018 In : Scientific Reports. 8, 1, 16 p., 701

Research output: Contribution to journalArticle

Open Access
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Physiological oxygen culture reveals retention of metabolic memory in human induced pluripotent stem cells

Harvey, A. J., O'Brien, C., Lambshead, J., Sheedy, J. R., Rathjen, J., Laslett, A. L. & Gardner, D. K. 1 Mar 2018 In : PLoS ONE. 13, 3, 19 p., e0193949

Research output: Contribution to journalArticle

Open Access
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Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Liu, X. , Nefzger, C. M. , Rossello, F. J. , Chen, J. , Knaupp, A. S. , Firas, J. , Ford, E. , Pflueger, J. , Paynter, J. M. , Chy, H. S. , O'Brien, C. M. , Huang, C. , Mishra, K. , Hodgson-Garms, M. , Jansz, N. , Williams, S. M. , Blewitt, M. E. , Nilsson, S. K. , Schittenhelm, R. B. , Laslett, A. L. & 2 others Lister, R. & Polo, J. M. 31 Oct 2017 In : Nature Methods. 14, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

Open Access
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New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

O'Brien, C. M. , Chy, H. S. , Zhou, Q. , Blumenfeld, S. , Lambshead, J. W. , Liu, X. , Kie, J. , Capaldo, B. D. , Chung, T-L. , Adams, T. E. , Phan, T. , Bentley, J. D. , McKinstry, W. J. , Oliva, K. , McMurrick, P. J. , Wang, Y-C. , Rossello, F. J. , Lindeman, G. J. , Chen, D. , Jarde, T. & 7 others Clark, A. T., Abud, H. E., Visvader, J. E., Nefzger, C. M., Polo, J. M., Loring, J. F. & Laslett, A. L. 1 Mar 2017 In : Stem Cells. 35, 3, p. 626-640 15 p.

Research output: Contribution to journalArticle

Open Access
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