Personal profile

Biography

Dr. Andrew Laslett is a Research Team Leader with the CSIRO Manufacturing business unit, where he leads a human pluripotent stem cell biology research team; He also holds an Adjunct Associate Professor position with the Australian Regenerative Medicine Institute at Monash University and is an Honorary Senior Fellow with the School of BioSciences at Melbourne University. Since 2001, Andrew and his laboratory have focused on elucidating the complex biology of human embryonic stem cells (hESC), examined methods for the differentiation of hESC to renal progenitor cells and more recently begun comparing hESC to reprogrammed human cells termed induced pluripotent stem (iPS) cells. His laboratory is currently focused on exploiting the basic biology of these cell types to create novel cell lines and tools that enhance human pluripotent cell research translation within CSIRO, Australia and internationally.Current projects include:

(i) functional uses of monoclonal antibodies to cell surface proteins on human pluripotent stem cells

(ii) the production of a "disease in a dish" model of human breast cancer

(iii) optimisation of human hepatocyte production conditions for use in bio-artificial liver devices

Prior to his current role with CSIRO, Andrew was a Senior Scientist and Group Leader of the Human Embryonic Stem Cell Technology Laboratory at the Australian Stem Cell Centre (ASCC) following Senior Research Fellow appointments in the Laboratory of Embryonic Stem Cell Biology and the Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University. He obtained his BSc (Hons) and PhD (1996) from Monash University prior to undertaking postdoctoral positions in both Hong Kong and Philadelphia, USA.

External positions

Research Team Leader, CSIRO Manufacturing and Infrastructure Technology

1 Aug 2009 → …

Keywords

  • embryonic stem cells
  • induced pluripotent stem cells
  • stem cells
  • antibodies
  • breast cancer
  • hepatocyte

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Projects 2011 2019

Stem Cells Australia

Little, M., Kilpatrick, T., Gardner, D., Hilton, D., Polo, J. M., Hobbs, R. M., Bourne, J. A., Marcelle, C., Rosenthal, N. A., Stanley, E., Elefanty, A. G., Barberi, T., Gray, P., Cooper-White, J., Wainwight, B., Wolvetang, E., Nielsen, L., Bartlett, P., Wells, C., Harvey, R., Graham, R., Palpant, N., Alexander, W., Laslett, A. L., Nilsson, S., Haylock, D., Grimmond, S. & McDonald, V.

Australian Research Council (ARC), Monash University

1/01/1130/06/19

Project: Research

Research Output 1996 2017

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

Liu, X. , Nefzger, C. M. , Rossello, F. J. , Chen, J. , Knaupp, A. S. , Firas, J. , Ford, E. , Pflueger, J. , Paynter, J. M. , Chy, H. S. , O'Brien, C. M. , Huang, C. , Mishra, K. , Hodgson-Garms, M. , Jansz, N. , Williams, S. M. , Blewitt, M. E. , Nilsson, S. K. , Schittenhelm, R. B. , Laslett, A. L. & 2 others Lister, R. & Polo, J. M. 31 Oct 2017 In : Nature Methods. 14, 11, p. 1055-1062 8 p.

Research output: Research - peer-reviewArticle

Open Access
File

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

O'Brien, C. M. , Chy, H. S. , Zhou, Q. , Blumenfeld, S. , Lambshead, J. W. , Liu, X. , Kie, J. , Capaldo, B. D. , Chung, T-L. , Adams, T. E. , Phan, T. , Bentley, J. D. , McKinstry, W. J. , Oliva, K. , McMurrick, P. J. , Wang, Y-C. , Rossello, F. J. , Lindeman, G. J. , Chen, D. , Jarde, T. & 7 others Clark, A. T., Abud, H. E., Visvader, J. E., Nefzger, C. M., Polo, J. M., Loring, J. F. & Laslett, A. L. 1 Mar 2017 In : Stem Cells. 35, 3, p. 626-640 15 p.

Research output: Research - peer-reviewArticle

Open Access
File

Scaffolds for 3D in vitro culture of neural lineage cells

Murphy, A. R., Laslett, A., O'Brien, C. M. & Cameron, N. R. 1 May 2017 In : Acta Biomaterialia. 54, 20 p.

Research output: Other - peer-reviewReview Article

Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells

Wang, Y-C., Stein, J. W., Lynch, C. L., Tran, H. T., Lee, C-Y., Coleman, R., Hatch, A., Antontsev, V. G., Chy, H. S., O'Brien, C. M., Murthy, S. K., Laslett, A. L., Peterson, S. E. & Loring, J. F. 2015 In : Scientific Reports. 5, 13 p., 13317

Research output: Research - peer-reviewArticle

Open Access
File

Gene expression variability as a unifying element of the pluripotency network

Mason, E. A., Mar, J. C., Laslett, A. L., Pera, M. F., Quackenbush, J., Wolvetang, E. & Wells, C. A. 12 Aug 2014 In : Stem Cell Reports. 3, 2, p. 365-377 13 p.

Research output: Research - peer-reviewArticle

Open Access