Personal profile
Biography
Dr Andrew Fleetwood obtained a BSc (Hons) and a PhD from the Department of Medicine at The University of Melbourne. His doctoral work was completed in the laboratories of Professor John Hamilton (Melbourne University) and Professor Toby Lawrence at The Kennedy Institute of Rheumatology (London). Andrew’s work in this time focused on characterising the pathways controlling macrophage activation, leading to one of the first publications detailing the molecular pathways controlling macrophage polarisation (Journal of Immunology >340 citations).
Upon completion of his PhD, Andrew moved into the pharmaceutical industry where he spent four years as a postdoc working in the Inflammation and Autoimmunity Division at Novo Nordisk (Copenhagen, Denmark). This work focussed on the development of novel therapeutics to target aberrant myeloid cell function in chronic inflammatory conditions.
In 2012, Andrew returned to The University of Melbourne where he continued to interrogate the key role that monocytes and macrophages play in disease. His more recent work has been on exploring the ways in which metabolic pathways can influence immune cell function and epigenetic memory. He has over 30 publications including those in Journal of Immunology, Journal of Biological Chemistry and Journal of Clinical Investigation.
In July 2020, he joined Associate Professor Andrew Murphy’s laboratory at the Baker Institute. Andrew holds honorary appointments in the Baker Department of Cardiometabolic Health and the Department of Medicine at The University of Melbourne.
Research area keywords
- Chronic inflammatory conditions
- Monocytes
- Macrophages
- Immune cell function
- Epigenetic memory
- Cardiometabolic heatlh
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization
Ming-Chin Lee, K., Achuthan, A. A., De Souza, D. P., Lupancu, T. J., Binger, K. J., Lee, M. K. S., Xu, Y., McConville, M. J., de Weerd, N. A., Dragoljevic, D., Hertzog, P. J., Murphy, A. J., Hamilton, J. A. & Fleetwood, A. J., 19 Apr 2022, In: Cell Reports. 39, 3, 11 p., 110719.Research output: Contribution to journal › Article › Research › peer-review
Open Access44 Link opens in a new tab Citations (Scopus) -
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages
De Souza, D. P., Achuthan, A., Lee, M. K. S., Binger, K. J., Lee, M. C., Davidson, S., Tull, D. L., McConville, M. J., Cook, A. D., Murphy, A. J., Hamilton, J. A. & Fleetwood, A. J., 1 Oct 2019, In: The Journal of Clinical Investigation. 129, 10, p. 4239-4244 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access66 Link opens in a new tab Citations (Scopus) -
Glycolysis is required for LPS-induced activation and adhesion of human CD14+ CD16− monocytes
Lee, M. K. S., Al-Sharea, A., Shihata, W. A., Veiga, C. B., Cooney, O. D., Fleetwood, A. J., Flynn, M. C., Claeson, E., Palmer, C. S., Lancaster, G. I., Henstridge, D. C., Hamilton, J. A. & Murphy, A. J., 2019, In: Frontiers in Immunology. 10, 8, 10 p., 2054.Research output: Contribution to journal › Article › Research › peer-review
Open Access61 Link opens in a new tab Citations (Scopus) -
GM-CSF– and IRF4-dependent signaling can regulate myeloid cell numbers and the macrophage phenotype during inflammation
Lee, M. C., Lacey, D. C., Fleetwood, A. J., Achuthan, A., Hamilton, J. A. & Cook, A. D., May 2019, In: Journal of Immunology. 202, 10, p. 3033-3040 8 p.Research output: Contribution to journal › Article › Research › peer-review
31 Link opens in a new tab Citations (Scopus) -
CCL17 blockade as a therapy for osteoarthritis pain and disease
Lee, M. C., Saleh, R., Achuthan, A., Fleetwood, A. J., Förster, I., Hamilton, J. A. & Cook, A. D., 5 Apr 2018, In: Arthritis Research & Therapy. 20, 1, 10 p., 62.Research output: Contribution to journal › Article › Research › peer-review
Open Access78 Link opens in a new tab Citations (Scopus)