Projects per year
Personal profile
Biography
A/Prof Andrew Ellisdon is a VCA Mid-Career Fellow and Head of the Structural Biology of Signalling and Cancer Laboratory at the Monash Biomedicine Discovery Institute (BDI) where he runs a team of three postdoctoral research fellows, one research assistants, and three PhD students. His team has a particular research focus on capturing an atomic resolution view of “signalling in action” by observing protein complexes formed by critical tumour-suppressor proteins and oncogenes. This resolution is enabled by combining recent advances in single-particle cryo-electron microscopy with crystallography and classical biochemistry.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Cancer
- Structural Biology
- Crystallography
- Electron Microscopy
- Immunity
- Drug development
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A novel, therapeutically actionable, signalling axis in poor prognosis cancers
Daly, R. (Primary Chief Investigator (PCI)), Ellisdon, A. (Associate Investigator (AI)), Lucet, I. (Associate Investigator (AI)), Stratton, M. (Associate Investigator (AI)), Tiganis, T. (Associate Investigator (AI)), Pajic, M. (Associate Investigator (AI)), Abud, H. (Associate Investigator (AI)), Shackleton, M. (Associate Investigator (AI)), Jarde, T. (Associate Investigator (AI)) & Swarbrick, A. (Associate Investigator (AI))
1/01/25 → 31/12/28
Project: Research
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Towards new therapeutics for neurofibromatosis-linked cancers and tumour growth
Ellisdon, A. (Primary Chief Investigator (PCI)) & Halls, M. (Chief Investigator (CI))
1/06/22 → 1/06/26
Project: Research
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NHMRC Equipment Grant - Alpine Direct Electron Detector
Ramm, G. (Primary Chief Investigator (PCI)), Lithgow, T. (Chief Investigator (CI)), Davidovich, C. (Chief Investigator (CI)), Ellisdon, A. (Chief Investigator (CI)), Dunstone, M. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Gully, B. (Chief Investigator (CI)), Wong, W. (Chief Investigator (CI)), Coulibaly, F. (Chief Investigator (CI)) & Knott, G. (Chief Investigator (CI))
1/11/23 → 31/12/24
Project: Research
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Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R. (Primary Chief Investigator (PCI)), Davidovich, C. (Chief Investigator (CI)), Purcell, A. (Chief Investigator (CI)), Ellisdon, A. (Chief Investigator (CI)), Li, J. (Chief Investigator (CI)), Aguilar, M. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Stone, M. (Chief Investigator (CI)), Lithgow, T. (Chief Investigator (CI)) & Zhang, Q. (Chief Investigator (CI))
1/10/21 → 31/12/22
Project: Research
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Defining NF1 clinical variation at the microscale to discover new therapeutic targets
Ellisdon, A. (Primary Chief Investigator (PCI)), Halls, M. (Chief Investigator (CI)), Schittenhelm, R. (Chief Investigator (CI)), Morand, E. (Associate Investigator (AI)), Whisstock, J. (Associate Investigator (AI)) & Sloan, E. (Associate Investigator (AI))
1/06/21 → 31/05/24
Project: Research
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LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR
Bayly-Jones, C. (Leading Author), Lupton, C. J. (Leading Author), Keen, A. C., Dong, S., Mastos, C., Luo, W., Qian, C., Jones, G. D., Venugopal, H., Chang, Y.-G., Clarke, R. J., Halls, M. L. (Leading Author) & Ellisdon, A. M. (Leading Author), 2 Oct 2024, In: Nature. 634, p. 1238-1244 30 p., 634.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Structure of the human TSC:WIPI3 lysosomal recruitment complex
Bayly-Jones, C. (Leading Author), Lupton, C. J. (Leading Author), D’Andrea, L. (Leading Author), Chang, Y.-G., Jones, G. D., Steele, J. R., Venugopal, H., Schittenhelm, R. B., Halls, M. L. & Ellisdon, A. M. (Leading Author), 22 Nov 2024, In: Science Advances. 10, 47, 10 p., eadr5807.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Cho, S. X., Rudloff, I., Ellisdon, A. M., Nold-Petry, C. A. & Nold, M. F., Feb 2024, In: Cellular & Molecular Immunology. 21, 2, p. 201-202 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
1 Citation (Scopus) -
Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
Bujotzek, A., Tiefenthaler, G., Lariviere, L., D'Andrea, L., Marquez, E. A., Rudloff, I., Cho, S. X., Deen, N. S., Richter, W., Regenass-Lechner, F., Poehler, A., Whisstock, J. C., Sydow-Andersen, J., Reiser, X., Schuster, S., Neubauer, J., Hoepfl, S., Richter, K., Nold, M. F. & Nold-Petry, C. A. & 2 others, , 21 Apr 2022, In: Cell Chemical Biology. 29, 4, p. 586-596.e4 15 p.Research output: Contribution to journal › Article › Research › peer-review
15 Citations (Scopus) -
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Chang, Y. G., Lupton, C. J., Bayly-Jones, C., Keen, A. C., D’Andrea, L., Lucato, C. M., Steele, J. R., Venugopal, H., Schittenhelm, R. B., Whisstock, J. C., Halls, M. L. & Ellisdon, A. M., Aug 2022, In: Nature Structural & Molecular Biology. 29, 8, p. 767–773 25 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)
Prizes
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Vice-Chancellor’s Award for Research Enterprise
Ellisdon, A. (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
- 4 Patents
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MONASH UNIVERSITY (Organisational unit)
Ellisdon, A. (Inventor), Whisstock, J. (Inventor), Nold, C. (Inventor) & Nold, M. (Inventor)
28 Jun 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Nold, C. (Inventor), Nold, M. (Inventor), Whisstock, J. (Inventor) & Ellisdon, A. (Inventor)
12 Apr 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Nold, C. (Inventor), Nold, M. (Inventor), Whisstock, J. (Inventor) & Ellisdon, A. (Inventor)
23 Mar 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Nold, M. (Inventor), Nold, C. (Inventor), Ellisdon, A. (Inventor) & Whisstock, J. (Inventor)
22 Dec 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Press/Media
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The ‘plant-like’ structure in humans that could block tumours
3/10/24
1 item of Media coverage
Press/Media: Article/Feature
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Deadly stonefish could improve lifesaving cancer transplants
2/12/15
1 item of Media coverage
Press/Media: Research