Personal profile

Biography

Dr Ellisdon is a mid-career researcher (PhD 2007) and Head of the Structural Biology of Signalling and Cancer Laboratory at the Monash Biomedicine Discovery Institute (BDI) where he runs a team of two postdoctoral research fellows, two research assistants, and one PhD student. His team has a particular research focus on capturing an atomic resolution view of “signalling in action” by observing protein complexes formed by critical tumour-suppressor proteins and oncogenes. This resolution is enabled by combining recent advances in single-particle cryo-electron microscopy with crystallography and classical biochemistry.

Current projects include characterisation of the activation of the metastatic factor P-Rex1 at the plasma membrane by G-beta gamma, gaining a mechanistic understanding of the inhibitory complex formed between the tumour-suppressor protein PTEN and P-Rex2, and understanding the structural basis of dysregulation of the tuberous sclerosis complex (TSC). The team is also part of a major research and development partnership with Roche towards the commercialisation of the anti-inflammatory activity of Interleukin-37 (Hoffman-La Roche, Switzerland; Prof Marcel Nold, Hudson Institute; Prof James Whisstock, Monash BDI). Other collaborations include structural characterisation of the gene-regulatory SAGA complex (A/Prof Hans Elmlund, Monash BDI), single-cell FRET studies to characterise GPCR signalling (Dr Michelle Halls, MIPS).

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research area keywords

  • Cancer
  • Structural Biology
  • Crystallography
  • Electron Microscopy
  • Immunity
  • Drug development

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or