If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Dr Ellisdon is a mid-career researcher (PhD 2007) and Head of the Structural Biology of Signalling and Cancer Laboratory at the Monash Biomedicine Discovery Institute (BDI) where he runs a team of two postdoctoral research fellows, two research assistants, and one PhD student. His team has a particular research focus on capturing an atomic resolution view of “signalling in action” by observing protein complexes formed by critical tumour-suppressor proteins and oncogenes. This resolution is enabled by combining recent advances in single-particle cryo-electron microscopy with crystallography and classical biochemistry.

Current projects include characterisation of the activation of the metastatic factor P-Rex1 at the plasma membrane by G-beta gamma, gaining a mechanistic understanding of the inhibitory complex formed between the tumour-suppressor protein PTEN and P-Rex2, and understanding the structural basis of dysregulation of the tuberous sclerosis complex (TSC). The team is also part of a major research and development partnership with Roche towards the commercialisation of the anti-inflammatory activity of Interleukin-37 (Hoffman-La Roche, Switzerland; Prof Marcel Nold, Hudson Institute; Prof James Whisstock, Monash BDI). Other collaborations include structural characterisation of the gene-regulatory SAGA complex (A/Prof Hans Elmlund, Monash BDI), single-cell FRET studies to characterise GPCR signalling (Dr Michelle Halls, MIPS).

Research area keywords

  • Cancer
  • Structural Biology
  • Crystallography
  • Electron Microscopy
  • Immunity
  • Drug development

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or
If you made any changes in Pure these will be visible here soon.