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Personal profile

Biography

Dr Ellisdon is a mid-career researcher (PhD 2007) and Head of the Structural Biology of Signalling and Cancer Laboratory at the Monash Biomedicine Discovery Institute (BDI) where he runs a team of two postdoctoral research fellows, two research assistants, and one PhD student. His team has a particular research focus on capturing an atomic resolution view of “signalling in action” by observing protein complexes formed by critical tumour-suppressor proteins and oncogenes. This resolution is enabled by combining recent advances in single-particle cryo-electron microscopy with crystallography and classical biochemistry.

Current projects include characterisation of the activation of the metastatic factor P-Rex1 at the plasma membrane by G-beta gamma, gaining a mechanistic understanding of the inhibitory complex formed between the tumour-suppressor protein PTEN and P-Rex2, and understanding the structural basis of dysregulation of the tuberous sclerosis complex (TSC). The team is also part of a major research and development partnership with Roche towards the commercialisation of the anti-inflammatory activity of Interleukin-37 (Hoffman-La Roche, Switzerland; Prof Marcel Nold, Hudson Institute; Prof James Whisstock, Monash BDI). Other collaborations include structural characterisation of the gene-regulatory SAGA complex (A/Prof Hans Elmlund, Monash BDI), single-cell FRET studies to characterise GPCR signalling (Dr Michelle Halls, MIPS).

Research area keywords

  • Cancer
  • Structural Biology
  • Crystallography
  • Electron Microscopy
  • Immunity
  • Drug development

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Projects

Research Output

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

Civciristov, S., Huang, C., Liu, B., Marquez, E. A., Gondin, A. B., Schittenhelm, R. B., Ellisdon, A. M., Canals, M. & Halls, M. L., 1 Nov 2019, In : The Journal of Biological Chemistry. 294, 44, p. 16198-16213 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

Civciristov, S., Ellisdon, A. M., Suderman, R., Pon, C. K., Evans, B. A., Kleifeld, O., Charlton, S. J., Hlavacek, W. S., Canals, M. & Halls, M. L., 9 Oct 2018, In : Science Signaling. 11, 551, 22 p., eaan1188.

Research output: Contribution to journalArticleResearchpeer-review

File
7 Citations (Scopus)

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File
7 Citations (Scopus)

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Yang, A. S. P., O'Neill, M. T., Jennison, C., Lopaticki, S., Allison, C. C., Armistead, J. S., Erickson, S. M., Rogers, K. L., Ellisdon, A. M., Whisstock, J. C., Tweedell, R. E., Dinglasan, R. R., Douglas, D. N., Kneteman, N. M. & Boddey, J. A., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3105-3116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
27 Citations (Scopus)

Prizes

Vice-Chancellor’s Award for Research Enterprise

Ellisdon, Andrew (Recipient), 2018

Prize: Prize (including medals and awards)

Press / Media

Deadly stonefish could improve lifesaving cancer transplants

Andrew Ellisdon

2/12/15

1 item of Media coverage

Press/Media: Research