Andrew Elefanty

Professor

1987 …2019
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Research Output 1987 2018

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2018

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

The International Stem Cell Initiative, 1 Dec 2018, In : Nature Communications. 9, 1, 15 p., 1925.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease

Gao, Y., Wilson, G. R., Bozaoglu, K., Elefanty, A. G., Stanley, E. G., Dottori, M. & Lockhart, P. J., 1 Apr 2018, In : Stem Cell Research. 28, p. 161-164 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Long-Term Maintenance of Human Pluripotent Stem Cells on cRGDfK-Presenting Synthetic Surfaces

Lambshead, J. W., Meagher, L., Goodwin, J., Labonne, T., Ng, E., Elefanty, A., Stanley, E., O'Brien, C. M. & Laslett, A. L., 1 Dec 2018, In : Scientific Reports. 8, 1, 16 p., 701.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Anderson, D. J., Kaplan, D. I., Bell, K. M., Koutsis, K., Haynes, J. M., Mills, R. J., Phelan, D. G., Qian, E. L., Leitoguinho, A. R., Arasaratnam, D., Labonne, T., Ng, E. S., Davis, R. P., Casini, S., Passier, R., Hudson, J. E., Porrello, E. R., Costa, M. W., Rafii, A., Curl, C. L. & 9 othersDelbridge, L. M., Harvey, R. P., Oshlack, A., Cheung, M. M., Mummery, C. L., Petrou, S., Elefanty, A. G., Stanley, E. G. & Elliott, D. A., 10 Apr 2018, In : Nature Communications. 9, 1, 13 p., 1373.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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WNT9A is a conserved regulator of hematopoietic stem and progenitor cell development

Richter, J., Stanley, E. G., Ng, E. S., Elefanty, A. G., Traver, D. & Willert, K., 1 Feb 2018, In : Genes. 9, 2, 66.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Efficiently specified ventral midbrain dopamine neurons from human pluripotent stem cells under Xeno-free conditions restore motor deficits in Parkinsonian rodents

Niclis, J. C., Gantner, C. W., Alsanie, W. F., McDougall, S. J., Bye, C. R., Elefanty, A. G., Stanley, E. G., Haynes, J. M., Pouton, C. W., Thompson, L. H. & Parish, C. L., 1 Mar 2017, In : Stem Cells Translational Medicine. 6, 3, p. 937-948 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

Workman, M. J., Mahe, M. M., Trisno, S., Poling, H. M., Watson, C. L., Sundaram, N., Chang, C. F., Schiesser, J., Aubert, P., Stanley, E. G., Elefanty, A. G., Miyaoka, Y., Mandegar, M. A., Conklin, B. R., Neunlist, M., Brugmann, S. A., Helmrath, M. A. & Wells, J. M., 1 Jan 2017, In : Nature Medicine. 23, 1, p. 49-59 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration

Xiang, Y., Tanaka, Y., Patterson, B., Kang, Y. J., Govindaiah, G., Roselaar, N., Cakir, B., Kim, K. Y., Lombroso, A. P., Hwang, S. M., Zhong, M., Stanley, E. G., Elefanty, A. G., Naegele, J. R., Lee, S. H., Weissman, S. M. & Park, I-H., 7 Sep 2017, In : Cell Stem Cell. 21, 3, p. 383-398 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

Bellmaine, S. F., Ovchinnikov, D. A., Manallack, D. T., Cuddy, C. E., Elefanty, A. G., Stanley, E. G., Wolvetang, E. J., Williams, S. J. & Pera, M., 8 Sep 2017, In : eLife. 6, 20 p., e24502.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination

Lee, J. Y., Kim, M. J., Deliyanti, D., Azari, M. F., Rossello, F., Costin, A., Ramm, G., Stanley, E. G., Elefanty, A. G., Wilkinson-Berka, J. L. & Petratos, S., 1 Nov 2017, In : EBioMedicine. 25, p. 122-135 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development

Meganathan, K., Lewis, E. M. A., Gontarz, P., Liu, S., Stanley, E. G., Elefanty, A. G., Huettner, J. E., Zhang, B. & Kroll, K. L., 26 Dec 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11180-E11189

Research output: Contribution to journalArticleResearchpeer-review

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling

Navarro-Montero, O., Ayllon, V., Lamolda, M., López-Onieva, L., Montes, R., Bueno, C., Ng, E., Guerrero-Carreno, X., Romero, T., Romero-Moya, D., Stanley, E., Elefanty, A., Ramos-Mejia, V., Menendez, P. & Real, P. J., 1 Nov 2017, In : Stem Cells. 35, 11, p. 2253-2266 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

Howden, S. E., McColl, B. K., Glaser, A., Vadolas, J., Petrou, S., Little, M. H., Elefanty, A. G. & Stanley, E. G., 13 Sep 2016, In : Stem Cell Reports. 7, 3, p. 508-517 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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ALPK3-deficient cardiomyocytes generated from patient-derived induced pluripotent stem cells and mutant human embryonic stem cells display abnormal calcium handling and establish that ALPK3 deficiency underlies familial cardiomyopathy

Phelan, D. G., Anderson, D. J., Howden, S. E., Wong, R. C. B., Hickey, P. F., Pope, K., Wilson, G. R. A-M., Pebay, A., Davis, A. M., Petrou, S., Elefanty, A. G., Stanley, E. G., James, P. A., Macciocca, I., Bahlo, M., Cheung, M. M. H., Amor, D. J., Elliott, D. A. & Lockhart, P. J., 2016, In : European Heart Journal. 37, 33, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells

Skelton, R. J. P., Brady, B., Khoja, S., Sahoo, D., Engel, J., Arasaratnam, D., Saleh, K. K., Abilez, O. J., Zhao, P., Stanley, E. G., Elefanty, A. G., Kwon, M., Elliott, D. A. & Ardehali, R., 12 Jan 2016, In : Stem Cell Reports. 6, 1, p. 95-108 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Differentiation of human embryonic stem cells to HOXA + hemogenic vasculature that resembles the aorta-gonad-mesonephros

Ng, E., Azzola, L., Bruveris, F. F., Calvanese, V., Phipson, B., Vlahos, K., Hirst, C., Jokubaitis, V. J., Yu, Q. C., Maksimovic, J., Liebscher, S., Januar, V., Zhang, Z., Williams, B., Conscience, A., Durnall, J., Jackson, S., Costa, M., Elliott, D., Haylock, D. N. & 7 othersNilsson, S. K., Saffery, R., Schenke-Layland, K., Oshlack, A., Mikkola, H. K. A., Stanley, E. G. & Elefanty, A. G., 1 Nov 2016, In : Nature Biotechnology. 34, 11, p. 1168-1179 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Enforced expression of hoxb4 in human embryonic stem cells enhances the production of hematopoietic progenitors but has no effect on the maturation of red blood cells

Jackson, M., Ma, R., Taylor, H., Axton, R. A., Easterbrook, J., Kydonaki, M., Olivier, E., Marenah, L., Stanley, E. G., Elefanty, A. G., Mountford, J. C. & Forrester, L. M., 1 Aug 2016, In : Stem Cells Translational Medicine. 5, 8, p. 981-990 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives

Kao, T., Labonne, T., Niclis, J. C., Chaurasia, R., Lokmic, Z., Qian, E., Bruveris, F. F., Howden, S. E., Motazedian, A., Schiesser, J. V., Costa, M., Sourris, K., Ng, E., Anderson, D., Giudice, A., Farlie, P., Cheung, M. M. H., Lamande, S. R., Penington, A. J., Parish, C. L. & 5 othersThomson, L. H., Rafii, A., Elliott, D. A., Elefanty, A. G. & Stanley, E. G., 13 Sep 2016, In : Stem Cell Reports. 7, 3, p. 518-526 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Magnetic resonance imaging of iron oxide-labeled human embryonic stem cell-derived cardiac progenitors

Skelton, R. J. P., Khoja, S., Almeida, S., Rapacchi, S., Han, F., Engel, J., Zhao, P., Hu, P., Stanley, E. G., Elefanty, A. G., Kwon, M., Elliott, D. A. & Ardehali, R., 2016, In : Stem Cells Translational Medicine. 5, 1, p. 67-74 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Spatio-temporal re-organization of replication foci accompanies replication domain consolidation during human pluripotent stem cell lineage specification

Wilson, K. A., Elefanty, A. G., Stanley, E. G. & Gilbert, D. M., 16 Sep 2016, In : Cell Cycle. 15, 18, p. 2464-2475 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Efficient generation of NKX6-1(+) pancreatic progenitors from multiple human pluripotent stem cell lines

Nostro, M. C., Sarangi, F., Yang, C., Holland, A. M., Elefanty, A. G., Stanley, E. G., Greiner, D. L. & Keller, G., 2015, In : Stem Cell Reports. 4, 4, p. 591 - 604 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

Ditadi, A., Sturgeon, C. M., Tober, J., Awong, G., Kennedy, M., Yzaguirre, A. D., Azzola, L., Ng, E. S. S., Stanley, E. G., French, D. L., Cheng, X., Gadue, P. J., Speck, N. A., Elefanty, A. G. & Keller, G. M., 2015, In : Nature Cell Biology. 17, 5, p. 580 - 591 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Lokmic, Z., Stadler, E. S. S., Burton, M. D., Stanley, E. G., Penington, A. J. & Elefanty, A. G., 2015, In : Journal of Visualized Experiments. 99, e52691, p. 1-8 8 p.

Research output: Contribution to journalArticleOtherpeer-review

Productive infection of human embryonic stem cell-derived NKX2.1+ respiratory progenitors with human rhinovirus

Jenny, R. A., Hirst, C. E., Lim, S. M., Goulburn, A. L., Micallef, S. J., Labonne, T., Kicic, A., Ling, K-M., Stick, S., Ng, E. S. S., Trounson, A. O., Giudice, A., Elefanty, A. G. & Stanley, E. G., 2015, In : Stem Cells Translational Medicine. 4, 6, p. 603 - 614 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Simultaneous reprogramming and gene correction of patient fibroblasts

Howden, S. E., Maufort, J. P., Duffin, B. M., Elefanty, A. G., Stanley, E. G. & Thomson, J. A., 2015, In : Stem Cell Reports. 5, 6, p. 1109 - 1118 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Derivation of insulin-producing beta-cells from human pluripotent stem cells

Schiesser, J. V., Micallef, S. J., Hawes, S. M., Elefanty, A. G. & Stanley, E., 2014, In : The Review of Diabetic Studies. 11, 1, p. 6 - 18 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

Takasato, M., Er, P. X., Becroft, M., Vanslambrouck, J. M., Stanley, E., Elefanty, A. G. & Little, M. H., 2014, In : Nature Cell Biology. 16, 1, p. 118 - 126 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations

Loh, K. M., Ang, L. T., Zhang, J., Kumar, V., Ang, J., Auyeong, J. Q., Lee, K. L., Choo, S. H., Lim, C. Y. Y., Nichane, M., Tan, J., Noghabi, M. S., Azzola, L., Ng, E. S-S., Duruthy-Duruthy, J., Sebastiano, V., Poellinger, L., Elefanty, A. G., Stanley, E., Qingfeng, C. & 3 othersPrabhakar, S., Weissman, I. L. & Lim, B., 2014, In : Cell Stem Cell. 14, 2, p. 237 - 252 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Fourier transform infrared microspectroscopy reveals unique phenotypes for human embryonic and induced pluripotent stem cell lines and their progeny

Cao, J., Ng, E. S. S., McNaughton, D., Stanley, E., Elefanty, A. G., Tobin, M. J. & Heraud, P. R., 2014, In : Journal of Biophotonics. 7, 10, p. 767 - 781 15 p.

Research output: Contribution to journalArticleResearchpeer-review

FOXN1GFP/w reporter hESCs enable identification of integrin-a4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1 + thymic epithelial progenitors

Soh, C-L., Giudice, A., Jenny, R. A., Elliott, D. A., Hatzistavrou, T., Micallef, S. J., Kianizad, K., Seach, N. L., Zuniga-Pflucker, J. C., Chidgey, A. P., Trounson, A. O., Nilsson, S. S. K., Haylock, D. N., Boyd, R. L., Elefanty, A. G. & Stanley, E. G., 2014, In : Stem Cell Reports. 2, 6, p. 925 - 937 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development

Skelton, R. J. P., Costa, M., Anderson, D. J., Bruveris, F., Finnin, B. W., Koutsis, K., Arasaratnam, D., White, A. J., Rafii, A., Ng, E. S-S., Elefanty, A. G., Stanley, E. G., Pouton, C. W., Haynes, J. M., Ardehali, R., Davis, R. P., Mummery, C. L. & Elliott, D. A., 2014, In : Stem Cell Research. 13, 1, p. 172 - 179 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

β-cell regeneration and differentiation: How close are we to the ‘holy grail’?

Tan, G., Elefanty, A. G. & Stanley, E. G., 1 Dec 2014, In : Journal of Molecular Endocrinology. 53, 3, p. R119-R129 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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2013

Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization

Costa, M., Sourris, K., Lim, S. M., Yu, Q. C., Hirst, C. E., Parkington, H. C., Jameson-Jokubaitis, V. J., Dear, A. E., Liu, H. B., Micallef, S. J., Koutsis, K., Elefanty, A. G. & Stanley, E., 2013, In : Stem Cell Research. 10, 1, p. 103 - 117 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells

Maroof, A. M., Keros, S., Tyson, J., Ying, S-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A. L., Stanley, E., Elefanty, A. G., Widmer, H. R., Eggan, K., Goldstein, P. A., Anderson, S. A. & Studer, L., 2013, In : Cell Stem Cell. 12, 5, p. 559 - 572 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Fourier transform infrared microspectroscopy reveals that tissue culture conditions affect the macromolecular phenotype of human embryonic stem cells

Cao, J., Ng, E. S-S., McNaughton, D., Stanley, E., Elefanty, A. G., Tobin, M. J. & Heraud, P. R., 2013, In : The Analyst. 138, 14, p. 4147 - 4160 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development

Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D., Arnold, C. M., Chen, Y-J. J., Stanley, E., Elefanty, A. G., Sasai, Y., Alvarez-Buylla, A., Rubenstein, J. L. R. & Kriegstein, A. R., 2013, In : Cell Stem Cell. 12, 5, p. 573 - 586 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium

Pick, M., Azzola, L., Osborne, E., Stanley, E. & Elefanty, A. G., 2013, In : PLoS ONE. 8, 2, 11 p., e55530.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Human embryonic stem cell derived mesenchymal progenitors express cardiac markers but do not form contractile cardiomyocytes

Raynaud, C. M., Halabi, N., Elliott, D. A., Pasquier, J., Elefanty, A. G., Stanley, E. & Rafii, A., 2013, In : PLoS ONE. 8, 1, 13 p., e54524.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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PGC-1alpha and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function

Birket, M. J., Casini, S., Kosmidis, G., Elliott, D., Gerencser, A. A., Baartscheer, A., Schumacher, C., Mastroberardino, P. G., Elefanty, A. G., Stanley, E. & Mummery, C. L., 2013, In : Stem Cell Reports. 1, 6, p. 560 - 574 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The characterisation of pluripotent and multipotent stem cells using Fourier transform infrared microspectroscopy

Cao, J., Ng, E. S-S., McNaughton, D., Stanley, E., Elefanty, A. G., Tobin, M. J. & Heraud, P. R., 2013, In : International Journal of Molecular Sciences. 14, 9, p. 17453 - 17476 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

WNT3A promotes hematopoietic or mesenchymal differentiation from hESCs depending on the time of exposure

Gertow, K. A. M., Hirst, C. E., Yu, Q. C., Ng, E. S. S., Pereira, L. A., Davis, R. P. F., Stanley, E. & Elefanty, A. G., 2013, In : Stem Cell Reports. 1, 1, p. 53 - 65 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Analysis of mitochondrial function and localisation during human embryonic stem cell differentiation in vitro

Prowse, A. BJ., Chong, F., Elliott, D. A., Elefanty, A. G., Stanley, E., Gray, P. P., Munro, T. P. & Osborne, G. W., 2012, In : PLoS ONE. 7, 12, 11 p., e52214.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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APELIN promotes hematopoiesis from human embryonic stem cells

Yu, Q. C., Hirst, C. E., Costa, M., Ng, E. S. S., Schiesser, J. V., Gertow, K. AM., Stanley, E. G. & Elefanty, A. G., 2012, In : Blood. 119, 26, p. 6243 - 6254 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview

Mummery, C. L., Zhang, J., Ng, E. S. S., Elliott, D. A., Elefanty, A. G. & Kamp, T. J., 2012, In : Circulation Research. 111, 3, p. 344 - 358 15 p.

Research output: Contribution to journalArticleOther

Efficient generation of adipocytes in a dish

Elefanty, A. G. & Stanley, E. G., 2012, In : Nature Cell Biology. 14, 2, p. 126 - 127 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Five years of Stem Cell Research - Reflections on progress in the field

Elefanty, A., Nov 2012, In : Stem Cell Research. 9, 3, p. 277-283 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Generating GABAergic cerebral cortical interneurons from mouse and human embryonic stem cells

Goulburn, A. L., Stanley, E. G., Elefanty, A. G. & Anderson, S. A., 2012, In : Stem Cell Research. 8, 3, p. 416 - 426 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells

Umeda, K., Zhao, J., Simmons, P. J., Stanley, E. G., Elefanty, A. G. & Nakayama, N., 2012, In : Scientific Reports. 2, Art. No.: 455, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

INS (GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

Micallef, S. J., Li, X., Schiesser, J. V., Hirst, C. E., Yu, Q. C., Lim, S. M., Nostro, M. C., Elliott, D. A., Sarangi, F., Harrison, L. C., Keller, G., Elefanty, A. G. & Stanley, E. G., 2012, In : Diabetologia. 55, 3, p. 694 - 706 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation

Titmarsh, D. M., Hudson, J. E., Hidalgo, A., Elefanty, A. G., Stanley, E., Wolvetang, E. J. & Cooper-White, J. J., 2012, In : PLoS ONE. 7, 12, 12 p., e52405.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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