20052018

Research output per year

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Research Output

2018

DUSP5 is methylated in CIMP high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

Tögel, L., Nightingale, R., Wu, R., Chüeh, A. C., Al-Obaidi, S., Luk, I., Dávalos-Salas, M., Chionh, F., Murone, C., Buchanan, D. D., Chatterton, Z., Sieber, O. M., Arango, D., Tebbutt, N. C., Williams, D., Dhillon, A. S. & Mariadason, J. M., 29 Jan 2018, In : Scientific Reports. 8, 1, 11 p., 1767.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)
2017

ATF3 repression of BCL-XL determines apoptotic sensitivity to HDAC inhibitors across tumor types

Chüeh, A. C., Tse, J. W. T., Dickinson, M., Ioannidis, P., Jenkins, L., Togel, L., Tan, B. S., Luk, I., Davalos-Salas, M., Nightingale, R., Thompson, M. R., Williams, B. R. G., Lessene, G., Lee, E. F., Fairlie, W. D., Dhillon, A. S. & Mariadason, J. M., 15 Sep 2017, In : Clinical Cancer Research. 23, 18, p. 5573-5584 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Advani, G., Lim, Y. C., Catimel, B., Lio, D. S. S., Ng, N. L. Y., Chüeh, A. C., Tran, M., Anasir, M. I., Verkade, H., Zhu, H. J., Turk, B. E., Smithgall, T. E., Ang, C-S., Griffin, M. & Cheng, H. C., 7 Aug 2017, In : Cell Communication and Signaling. 15, 1, 22 p., 29.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer

Chüeh, A. C., Liew, M. S., Russell, P. A., Walkiewicz, M., Jayachandran, A., Starmans, M. H. W., Boutros, P. C., Wright, G., Barnett, S. A., Mariadason, J. M. & John, T., 23 May 2017, In : Oncotarget. 8, 43, p. 74036-74048 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)
2016

A beacon of hope in stroke therapy - Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Hoque, A., Hossain, M. I., Ameen, S. S., Ang, C-S., Williamson, N., Ng, D. C. H., Chueh, A. C., Roulston, C. & Cheng, H. C., Apr 2016, In : Pharmacology and Therapeutics. 160, p. 159-179 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

CSK-Homologous Kinase

Cheng, H-C., Advani, G., Hossain, M. I., Ng, N. LY., Lim, Y. C., Chueh, A. C., Kamaruddin, M. A. & Chong, Y-P., 2016, Encyclopedia of Signaling Molecules. Choi, S. (ed.). New York, NY: Springer

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

Togel, L., Nightingale, R., Chueh, A. C., Jayachandran, A., Tran, H., Phesse, T., Wu, R., Sieber, O. M., Arango, D., Dhillon, A. S., Dawson, M. A., Diez-Dacal, B., Gahman, T. C., Filippakopoulos, P., Shiau, A. K. & Mariadason, J. M., Jun 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1217-1226 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
39 Citations (Scopus)

Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells

Jayachandran, A., Lo, P. H., Chueh, A. C., Prithviraj, P., Molania, R., Davalos-Salas, M., Anaka, M., Walkiewicz, M., Cebon, J. & Behren, A., 22 Feb 2016, In : BMC Cancer. 16, 1, 15 p., 134.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)
2015

Advances in zinc finger nuclease and its applications

Tang, L-M., Zhou, C-L., Guo, Z-F., Xiao, L. & Chueh, A. C., Mar 2015, In : Gene and Gene Editing. 1, 1, p. 3-15 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Correction: The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner (Journal of Biological Chemistry)

Shin, J., Carr, A., Corner, G. A., Tögel, L., Dávalos-Salas, M., Tran, H., Chueh, A. C., Al-Obaidi, S., Chionh, F., Ahmed, N., Buchanan, D. D., Young, J. P., Malo, M. S., Hodin, R. A., Arango, D., Sieber, O. M., Augenlicht, L. H., Dhillon, A. S., Weber, T. K. & Mariadason, J. M., 19 Jun 2015, In : Journal of Biological Chemistry. 290, 25, p. 15392 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

3 Citations (Scopus)

Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression

Advani, G., Chueh, A. C., Lim, Y. C., Dhillon, A. & Cheng, H. C., 27 Jun 2015, In : Frontiers in Biology. 10, 3, p. 195-202 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells

Chueh, A. C., Tse, J. W. T., Tögel, L. & Mariadason, J. M., 19 Jun 2015, In : Antioxidants and Redox Signaling. 23, 1, p. 66-84 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

Gilan, O., Diesch, J., Amalia, M., Jastrzebski, K., Chueh, A. C., Verrills, N. M., Pearson, R. B., Mariadason, J. M., Tulchinsky, E., Hannan, R. D. & Dhillon, A. S., 5 Mar 2015, In : Oncogene. 34, 10, p. 1340 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

Gilan, O., Diesch, J., Amalia, M., Jastrzebski, K., Chueh, A. C., Verrills, N., Pearson, R. B., Mariadason, J. M., Tulchinsky, E., Hannan, R. D. & Dhillon, A. S., 2015, In : Oncogene. 34, 10, p. 1333-1339 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)
2014

FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis

Tan, B. S., Anaka, M., Deb, S., Freyer, C., Ebert, L. M., Chueh, A. C., Al-Obaidi, S., Behren, A., Jayachandran, A., Cebon, J., Chen, W. & Mariadason, J. M., 2014, In : Oncotarget. 5, 1, p. 264-276 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
31 Citations (Scopus)

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like Factor 5 (KLF5)-defendent manner

Shin, J., Carr, A., Corner, G. A., Tögel, L., Dávaos-Salas, M., Tran, H., Chueh, A. C., Al-Obaidi, S., Chionh, F., Ahmed, N., Buchanan, D. D., Young, J. P., Malo, M. S., Hodin, R. A., Arango, D., Sieber, O. M., Augenlicht, L. H., Dhillon, A. S., Weber, T. K. & Mariadason, J. M., 5 Sep 2014, In : Journal of Biological Chemistry. 289, 36, p. 25306-25316 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
23 Citations (Scopus)
2013

Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008

Burvenich, I. J. G., Lee, F. T., Cartwright, G. A., O'Keefe, G. J., Makris, D., Cao, D., Gong, S., Chueh, A. C., Mariadason, J. M., Brechbiel, M. W., Beckman, R. A., Fujiwara, K., Von Roemeling, R. & Scott, A. M., 1 Nov 2013, In : Clinical Cancer Research. 19, 21, p. 5984-5993 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)
2012

Epigenetic silencing of the negative feedback regulator of mitogen-activated protein kinase (MAPK) signalling, DUSP5, in colorectal cancer

Tögel, L., Arango, D., Chueh, A., Sieber, O. & Mariadason, J. M., Jul 2012, In : European Journal of Cancer. 48, S5, p. S155 1 p., 654.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

2010

Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction

Wilson, A. J., Chueh, A. C., Tögel, L., Corner, G. A., Ahmed, N., Goel, S., Byun, D. S., Nasser, S., Houston, M. A., Jhawer, M., Smartt, H. J. M., Murray, L. B., Nicholas, C., Heerdt, B. G., Arango, D., Augenlicht, L. H. & Mariadason, J. M., 15 Jan 2010, In : Cancer Research. 70, 2, p. 609-620 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
72 Citations (Scopus)
2009

Human Centromere and Neocentromere

Choo, K. H., Marshall, O. J., Chueh, A., Chan, L. & Wong, L., May 2009, In : Chromosome Research. 17, 4, p. 542-542 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin

Chueh, A. C., Northrop, E. L., Brettingham-Moore, K. H., Choo, K. H. A. & Wong, L. H., Jan 2009, In : PLoS Genetics. 5, 1, e1000354.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)
2008

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

Marshall, O. J., Chueh, A. C., Wong, L. H. & Choo, K. H. A., 8 Feb 2008, In : American Journal of Human Genetics. 82, 2, p. 261-282 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

237 Citations (Scopus)
2005

BAC-based PCR fragment microarray: High-resolution detection of chromosomal deletion and duplication breakpoints

Ren, H., Francis, W., Boys, A., Chueh, A. C., Wong, N., La, P., Wong, L. H., Ryan, J., Slater, H. R. & Choo, K. H. A., May 2005, In : Human Mutation. 25, 5, p. 476-482 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere

Chueh, A. C., Wong, L. H., Wong, N. & Choo, K. H. A., 1 Jan 2005, In : Human Molecular Genetics. 14, 1, p. 85-93 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)