Projects per year
Personal profile
Biography
Ana Traven is a Professor and NHMRC Investigator Fellow in the Biomedicine Discovery Institute at Monash University, where she founded the Infection Program and established and co-led an international postdoctoral training program in antimicrobial resistance within the Monash-Warwick Alliance. Ana obtained her PhD in 2002 from the University of Zagreb, Croatia. As a postdoctoral fellow, she trained at the St. Vincent’s Institute of Medical Research in Melbourne, supported by the NHMRC Peter Doherty Postdoctoral Fellowship. After a sabbatical in the Department of Microbiology at Columbia University (supported by a Short-Term Postdoctoral Fellowship from the Human Frontier Science Program), in 2009 Ana started her own research group at Monash University, focusing on infectious diseases caused by pathogenic fungi. She has been recognised by the Georgina Sweet Award for Women in Quantitative Biomedical Science (2018), a Level 3 ARC Future Fellowship (2019), a Leadership 2 NHMRC Investigator Grant (2024), and internationally by election as a Fellow of the European Confederation of Medical Mycology and Fellow of the American Academy of Microbiology.
Research interests
Microbial pathogens are responsible for millions of deaths globally. In addition to bacteria, fungi are important pathogens of hositalised patients. Cancer, HIV, organ transplants and intensive care hospitalisation are predisposing factors for life-threatening fungal infections. Although 2.5 million people die from fungal infections every year, there are no vaccines and we have only a handful of antifungal drugs classes to treat these deadly infections.
In 2022, the WHO published a call to action, the first Fungal Pathogens Priority list. The Traven lab focuses on two pathogens that are classified as of "critical" priority by the WHO: Candida albicans and Candida auris. The lab is using advanced molecular approaches, coupled with imaging and infection models to understand how these pathogens cause infections and their evasion of host immunity. The overarching goal is to identify strategies that could improve infection survival by inhibiting virulence pathways, improving immune control of fungi and promoting disease tolerance.
Research area keywords
- Infection
- Innate immunity
- Host-Pathogen Interactions
- antimicrobial drug resistance
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Harnessing disease tolerance and immune protection to treat fungal sepsis
Traven, A. (Primary Chief Investigator (PCI))
1/01/25 → 31/12/29
Project: Research
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NHMRC Equipment Grant - PIXUL Multi-Sample Megasonicator (ProtiFi)
Schittenhelm, R. (Primary Chief Investigator (PCI)), Faridi, P. (Chief Investigator (CI)), Creek, D. (Chief Investigator (CI)), Steele, J. (Chief Investigator (CI)), Li, J. (Chief Investigator (CI)), Traven, A. (Chief Investigator (CI)), Lahoud, M. (Chief Investigator (CI)), Daly, R. (Chief Investigator (CI)) & Lim, T. (Chief Investigator (CI))
1/11/23 → 31/12/24
Project: Research
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Exploiting microbial metabolites to understand fungal biology
Traven, A. (Primary Chief Investigator (PCI)) & Challis, G. (Chief Investigator (CI))
13/05/22 → 31/12/25
Project: Research
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Immuno-metabolic interactions of the fungal superbug Candida auris
Traven, A. (Primary Chief Investigator (PCI)), Ben-Ami, R. (Chief Investigator (CI)), McConville, M. J. (Associate Investigator (AI)), Vince, J. E. (Associate Investigator (AI)) & Herold, M. (Associate Investigator (AI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/21 → 31/12/24
Project: Research
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An investigation into metabolic competition between host and pathogen in infection.
Traven, A. (Primary Chief Investigator (PCI)), Naderer, T. (Associate Investigator (AI)), McConville, M. J. (Associate Investigator (AI)), Beilharz, T. (Associate Investigator (AI)) & Hickey, M. (Associate Investigator (AI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/19 → 31/12/22
Project: Research
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Staphylococcal toxin PVL ruptures model membranes under acidic conditions through interactions with cardiolipin and phosphatidic acid
Chow, S. H., Jeon, Y., Deo, P., Yeung, A. T. Y., Hale, C., Sridhar, S., Abraham, G., Nickson, J., Olivier, F. A. B., Jiang, J.-H., Ding, Y., Han, M.-L., Le Brun, A. P., Anderson, D., Creek, D., Tong, J., Gabriel, K., Li, J., Traven, A. & Dougan, G. & 2 others, , Apr 2025, In: PLoS Biology. 23, 4, 29 p., e3003080.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
A new model of endotracheal tube biofilm identifies combinations of matrix-degrading enzymes and antimicrobials able to eradicate biofilms of pathogens that cause ventilator-associated pneumonia
Walsh, D., Parmenter, C., Bakker, S. E., Lithgow, T., Traven, A. & Harrison, F., 1 Aug 2024, In: Microbiology. 170, 8, 16 p., 001480.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Link opens in a new tab Citations (Scopus) -
Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis
McCrory, C., Lenardon, M. & Traven, A., Nov 2024, In: Trends in Microbiology. 32, 11, p. 1106-1118 13 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access55 Link opens in a new tab Citations (Scopus) -
Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements
Simm, C., Lee, T. H., Weerasinghe, H., Walsh, D., Nakou, I. T., Shankar, M., Tse, W. C., Zhang, Y., Inman, R., Mulder, R. J., Harrison, F., Aguilar, M. I., Challis, G. L. & Traven, A., 13 Nov 2024, In: mBio. 15, 11, 19 p., e0261124.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems
Weerasinghe, H., Stölting, H., Rose, A. J. & Traven, A., Sept 2024, In: Microbiology and Molecular Biology Reviews. 88, 3, 26 p., e0017122.Research output: Contribution to journal › Review Article › Research › peer-review
18 Link opens in a new tab Citations (Scopus)
Prizes
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Australian Friends of Tel Aviv University-Monash University (AFTAM) Research Collaboration Awards
Traven, A. (Recipient), 2016
Prize: Other distinction
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Georgina Sweet Awards for Women in Quantitative Biomedical Science
Traven, A. (Recipient), 2018
Prize: Prize (including medals and awards)
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Activities
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Lorne Infection and Immunity Conference 2017
Traven, A. (Member of programme committee)
2019Activity: Participating in or organising an event types › Contribution to conference
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Victorian Infection and Immunity Network
Traven, A. (Executive Member)
2019 → …Activity: External Academic Engagement › Professional association or peak discipline body
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World Congress on Inflammation
Traven, A. (Member of programme committee)
2019Activity: Participating in or organising an event types › Contribution to conference
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FEBS Advanced Lecture Course on Human Fungal Pathogens
Traven, A. (Member of programme committee)
2019Activity: Participating in or organising an event types › Contribution to conference
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FEBS Advanced Lecture Course on Human Fungal Pathogens
Traven, A. (Organiser)
2019Activity: Participating in or organising an event types › Contribution to conference
Press/Media
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Superbugs: The health threat that has failed to capture public attention, Monash Lens, 18 November 2020, https://www.monash.edu/discovery-institute/news-and-events/news/2020-articles/superbugs-the-health-threat-that-has-failed-to-capture-public-attention
Davis, M., Naderer, T. & Traven, A.
20/11/20
1 Media contribution
Press/Media: Article/Feature
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Monash researchers reveal how a deadly fungal infection shape-shifts into an invasive monster
21/11/18
1 Media contribution
Press/Media: Research
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Monash study exposes key tactic used by deadly fungus
Naderer, T. & Traven, A.
1/05/18 → 7/05/18
2 Media contributions
Press/Media: Research
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Study exposes key tactic used by deadly fungus
Naderer, T. & Traven, A.
1/05/18
1 item of Media coverage, 1 Media contribution
Press/Media: Research