20122020

Research output per year

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Personal profile

Biography

Dr Winship obtained her PhD in 2016 at the Hudson Institute of Medical Research and Monash University, which focused on the role of cytokines in the female reproductive tract and reproductive cancer. She found that the cytokine, IL-11 was upregulated in maternal serum during the first trimester of pregnancy in women that subsequently developed the severe pregnancy complication, preeclampsia and based on this, developed an animal model of preeclampsia characterised by IL-11 overexpression during placental formation in mice (PNAS 2015; 112(52):15928-33). She also established that IL-11 drives uterine cancer growth, but that an IL-11 receptor blocking antibody could prevent tumour growth and metastasis in preclinical xenograft models (Molecular Cancer Therapeutics 2016; 15(4):720-30; Oncotarget 2017; 4;8(14):22716-22729), whilst preserving fertility in female mice (Reproductive Biomedicine Online 2018;36:250-258). In 2016 she received a Cancer Council Victoria Postdoctoral Fellowship to continue research on this novel, fertility-preserving therapeutic strategy for treating uterine cancer and was awarded a commendation at the Victorian Premier’s Awards for Health and Medical Research. Dr Winship was awarded a NHMRC ECF (2017-2020) to begin research with Dr Hutt in the Ovarian Biology Laboratory at the Monash Biomedicine Discovery Institute to examine the importance of DNA damage repair for oocyte quality, female fertility and offspring health (Reviewed: Human Reproduction Update. 2018; 24(2):119-134). This research is highly relevant to population health in Australia in context of fertility of female cancer survivors and maternal ageing.

Research area keywords

  • Ovarian biology
  • DNA repair
  • Female reproduction

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Projects

Research Output

Do cancer therapies damage the uterus and compromise fertility?

Griffiths, M. J., Winship, A. L. & Hutt, K. J., 28 Feb 2020, In : Human Reproduction Update. 26, 2, p. 161-173 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health

Stringer, J. M., Winship, A., Zerafa, N., Wakefield, M. & Hutt, K., 7 May 2020, (Accepted/In press) In : Proceedings of the National Academy of Sciences of the United States of America. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Reproductive health research in Australia and New Zealand: Highlights from the Annual Meeting of the Society for Reproductive Biology, 2019

Winship, A., Donoghue, J., Houston, B. J., Martin, J. H., Lord, T., Adwal, A., Gonzalez, M., Desroziers, E., Ahmad, G., Richani, D. & Bromfield, E. G., 1 Apr 2020, (Accepted/In press) In : Reproduction, Fertility and Development. 32, 7, p. 637-647 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study

Winship, A. L., Willson, C., Hansen, K. R., Hutt, K. J. & Hickey, M., 25 Nov 2019, In : BMJ Open. 9, 11, 7 p., e033810.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice

Winship, A. L., Carpenter, M., Griffiths, M. & Hutt, K. J., 1 May 2019, In : Toxicological Sciences. 169, 1, p. 43-53 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Press / Media

Future Science Early Career Interview: Amy Winship

Amy Winship

3/05/19

1 Media contribution

Press/Media: Profile/Interview

RRR 'Einstein A Go-Go' Radio Program Interview

Amy Winship

4/06/17

1 Media contribution

Press/Media: Expert Comment

Herald Sun News Article: Villain protein may be saviour

Amy Winship

11/04/17

1 Media contribution

Press/Media: Article/Feature

ABC Drive Radio: Uncovering a potential cause and cure for preeclampsia

Amy Winship

11/04/17

1 Media contribution

Press/Media: Expert Comment