Personal profile
Biography
I obtained a First Class Honours Bachelor of Science [BSc (Hons)] degree in Biochemistry from the Department of Biochemistry (now known as Molecular Medicine), Faculty of Medicine, University of Malaya (UM), Kuala Lumpur (1987). Following this, I was appointed as a research fellow at the Department of Biochemistry, Faculty of Medicine, UM, where I completed the Master of Science (MSc) Degree (1990).
I secured the prestigious Shell-Cambridge Commonwealth Trust Scholarship from the Cambridge Commonwealth Trust (CCT) and the Overseas Research Scholarship (ORS) Award from the United Kingdom (UK) government, which allowed me to pursue my Doctor of Philosophy (PhD) degree at the Department of Pathology (Immunology Division), University of Cambridge, UK. Upon completion of my PhD, I was appointed as a post-doctoral researcher at the Sir William Dunn School of Pathology, University of Oxford, UK.
Upon returning to Malaysia in 1994, I join a newly established private biotechnology company as a senior scientist-cum-acting research manager. A year later, I joined the International Medical College (IMC) as a lecturer. The IMC was transformed to a full-fledged university, i.e. International Medical University (IMU) in 1999. During my 22-year at the IMU, I was promoted to the rank of senior lecturer (1999), Associate Professor (2005) and Professor (2008). At the IMU, I held several academic administrative positions such as Associate Dean (Academic and International Affairs) in the School of Medicine, International Medical University (IMU) as well as Head, Pathology section.
My main research areas are in the area of immuno-regulation and immunotherapy in cancer as well as the use of natural compounds to enhance immune response to cancer. I have successfully supervised several post-graduate students at the doctoral and masters’ levels as well as final year under-graduate research students. I have published in several Tier 1 and 2 ISI and other peer-reviewed journals.
I am a Fellow of the Cambridge Commonwealth Trust and the Cambridge Philosophical Society as well as Life-member in several societies.
I was elected as a Fellow of the Royal Society of Biology, UK on 1 Jan 2023.
Education/Academic qualification
Immunology, PhD, The CD2 Antigen as a Target for Immunosuppression, University of Cambridge
2 Oct 1989 → 15 Nov 1993
Award Date: 19 Mar 1994
Biochemistry, MSc, Comparative properties of D2 cyclic nucleotide phosphodiesterase from Rhizobium fredii and Rhizobium meliloti, Universiti Malaya (University of Malaya)
Jul 1987 → Jul 1989
Award Date: 11 Aug 1990
Biochemistry, BSc (Hons) Class 1, Partial Purification and characterisation of D2 Cyclic Nucleotide Phosphodiesterase from Rhizobium fredii., Universiti Malaya (University of Malaya)
Jul 1983 → May 1987
Award Date: 1 Aug 1987
External positions
Committee member of Sub-committee of the National Candidate COVID-19 Vaccine, Kementerian Kesihatan (Malaysia) (Ministry of Health)
24 Nov 2020 → …
Research area keywords
- Immune System, Protein chemistry, structural biology, Natural killer cell receptors, T cell receptor, innate immunity, cryo-electron microscopy
- Immunotherapy
- immunomodulation
- Bioactive Compounds
- Cancer Immunology
- Cancer Biology
- Cancer epigenetics
- Tocotrienol
- Neurobiology
- immune responses
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 7 Affordable and Clean Energy
Collaborations and top research areas from the last five years
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The effects of daily tocotrienol-rich fraction (TRF) supplementation on the immune system and incidence of common infections: a population-based randomized control trial.
Ahmad, B. (Primary Chief Investigator (PCI)), Radhakrishnan, A. (Associate Investigator (AI)) & Moideen, M. A. (Associate Investigator (AI))
23/02/26 → 22/02/29
Project: Research
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Dendritic cell-based immunotherapy adjuvanted with tocotrienol-rich fraction as a therapeutic regime for human metastatic breast cancer patients.
Radhakrishnan, A. (Chief Investigator (CI)) & Ahmad, B. (Primary Chief Investigator (PCI))
30/01/26 → 29/01/29
Project: Research
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Postbiotics and IBS (Irritable Bowel Syndrome) – A Randomised Control Trial
Tan, S. S. (Primary Chief Investigator (PCI)), Radhakrishnan, A. (Chief Investigator (CI)), Kew, S. T. (Chief Investigator (CI)), Lim, W. W. D. (Chief Investigator (CI)), Ramadas, A. (Chief Investigator (CI)) & Palanisamy, U. (Chief Investigator (CI))
1/10/24 → 30/09/26
Project: Research
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Elucidating the mechanisms of differentially expressed proteins underlying the bidirectional interactions of co-cultured glioblastoma and differentiated cholinergic cells.
Kamarudin, M. (Primary Chief Investigator (PCI)), Naidu, R. (Chief Investigator (CI)), Asnawi, S. (Chief Investigator (CI)), Radhakrishnan, A. (Chief Investigator (CI)), SyedHassan, S. (Chief Investigator (CI)) & Pillai, B. S. B. (Chief Investigator (CI))
1/10/23 → 30/09/26
Project: Research
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Alterations in skin hydration, moisture and genomic in patients with dry skin conditions following daily oral palm tocotrienol and squalene (STGAIA) supplementation
Bai, K. (Primary Chief Investigator (PCI)), Radhakrishnan, A. (Chief Investigator (CI)), Pillai, B. S. B. (Chief Investigator (CI)), Arumugam, M. (Chief Investigator (CI)), Jamil, A. (Chief Investigator (CI)) & See, B. (Partner Investigator (PI))
15/05/24 → 30/06/25
Project: Research
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Optimising the method to develop spheroids from MDA-MB-468 human triple negative breast cancer cells
Mohamedahmed, S. M., Kamarudin, M. N. A., Ramdas, P., Sundralingam, U. & Radhakrishnan, A. K., Dec 2026, In: Molecular Biology Reports. 53, 1, 13 p., 322.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Carotenoids Modulate FoxO-Induced Cell Cycle Arrest in Human Cancer Cell Lines: A Scoping Review
Lee, Z. X., Guo, H., Looi, A. D., Bhuvanendran, S., Magalingam, K. B., Lee, W. L. & Radhakrishnan, A. K., Apr 2025, In: Food Science and Nutrition. 13, 4, 20 p., e70100.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Daily Supplementation of High Doses of Tocotrienol-Rich Fraction From Palm Oil Produced No Toxic Effects in Healthy Mice
Morgan, N. R., Bhuvanendran, S., Krishnappa, P. & Radhakrishnan, A. K., 2025, In: Journal of Toxicology. 2025, 1, 8 p., 9464952.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
Delta- and Gamma-Tocotrienols Inhibit the Proliferation of HCC2998 Human Colorectal Carcinoma Cells via Modulation of Histone Modification Pathways Involved in DNA Damage Response
Khalid, A. Q. (Leading Author), Bhuvanendran, S., Magalingam, K. B., Ramdas, P. & Radhakrishnan, A. K. (Leading Author), Dec 2025, In: Cell Biology International. 49, 12, p. 1751-1763 13 p.Research output: Contribution to journal › Article › Research › peer-review
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Dysregulation of Ceruloplasmin, α2-Macroglobulin, and Alpha-2-HS-Glycoprotein in Transfusion-Dependent Thalassemia
Sumera, A., Radhakrishnan, A. K., Cheong, S. K. & Baba, A. A., 2025, In: Advances in Hematology. 2025, 1, 9 p., 2179600.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Prizes
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Best e-poster presentation entitled Enhancing Medical Students’ Understanding of Basic Immunology through Innovative Approaches
SyedHassan, S. (Recipient), Radhakrishnan, A. (Recipient), Pillai, B. S. B. (Recipient), Pallath, V. (Recipient), Balasubramaniam, V. (Recipient), Naidu, R. (Recipient), Yap, P. (Recipient), Ming, L. W. (Recipient) & Abdul Kadar, N. (Recipient), 2024
Prize: Prize (including medals and awards)
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PVC's Commendation Award for Innovation in Teaching and Learning
SyedHassan, S. (Recipient), Yap, P. (Recipient), Pallath, V. (Recipient), Tha, K. K. (Recipient), Pillai, B. S. B. (Recipient), Naidu, R. (Recipient), Ming, L. W. (Recipient), Radhakrishnan, A. (Recipient) & Abdul Kadar, N. S. (Recipient), 2025
Prize: Prize (including medals and awards)
Activities
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Clinical Trials of Polyphenols in Breast Cancer: Evaluating Therapeutic Outcomes and Patient Benefits
Farghadani, R. (Supervisor) & Radhakrishnan, A. (Supervisor)
10 Mar 2025 → 18 Apr 2025Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Triple Negative Breast Cancer (TNBC): Update on Treatment
Farghadani, R. (Supervisor) & Radhakrishnan, A. (Supervisor)
15 Sept 2025 → 24 Oct 2025Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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National Cancer Congress Malaysia
Lee, J. S. Y. (Speaker), Bai, K. (Speaker), Palanisamy, U. (Speaker), Farghadani, R. (Organiser) & Radhakrishnan, A. (Speaker)
21 Jun 2024 → 23 Jun 2024Activity: Participating in or organising an event types › Contribution to conference
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Unraveling the Enigma of Cachexia in Breast Cancer: A Comprehensive Narrative Review
Radhakrishnan, A. (Supervisor), Ramdas, P. (Supervisor) & Farghadani, R. (Supervisor)
3 Mar 2024 → 12 Apr 2024Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Natural Products as Modulators of ABC Transporters in breast cancer
Farghadani, R. (Supervisor) & Radhakrishnan, A. (Supervisor)
28 Jul 2024 → 6 Sept 2024Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions