Projects per year
Personal profile
Biography
I obtained a First Class Honours Bachelor of Science [BSc (Hons)] degree in Biochemistry from the Department of Biochemistry (now known as Molecular Medicine), Faculty of Medicine, University of Malaya (UM), Kuala Lumpur (1987). Following this, I was appointed as a research fellow at the Department of Biochemistry, Faculty of Medicine, UM, where I completed the Master of Science (MSc) Degree (1990).
I secured the prestigious Shell-Cambridge Commonwealth Trust Scholarship from the Cambridge Commonwealth Trust (CCT) and the Overseas Research Scholarship (ORS) Award from the United Kingdom (UK) government, which allowed me to pursue my Doctor of Philosophy (PhD) degree at the Department of Pathology (Immunology Division), University of Cambridge, UK. Upon completion of my PhD, I was appointed as a post-doctoral researcher at the Sir William Dunn School of Pathology, University of Oxford, UK.
Upon returning to Malaysia in 1994, I join a newly established private biotechnology company as a senior scientist-cum-acting research manager. A year later, I joined the International Medical College (IMC) as a lecturer. The IMC was transformed to a full-fledged university, i.e. International Medical University (IMU) in 1999. During my 22-year at the IMU, I was promoted to the rank of senior lecturer (1999), Associate Professor (2005) and Professor (2008). At the IMU, I held several academic administrative positions such as Associate Dean (Academic and International Affairs) in the School of Medicine, International Medical University (IMU) as well as Head, Pathology section.
My main research areas are in the area of immuno-regulation and immunotherapy in cancer as well as the use of natural compounds to enhance immune response to cancer. I have successfully supervised several post-graduate students at the doctoral and masters’ levels as well as final year under-graduate research students. I have published in several Tier 1 and 2 ISI and other peer-reviewed journals.
I am a Fellow of the Cambridge Commonwealth Trust and the Cambridge Philosophical Society as well as Life-member in several societies.
I was elected as a Fellow of the Royal Society of Biology, UK on 1 Jan 2023.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Immunology, PhD, The CD2 Antigen as a Target for Immunosuppression, University of Cambridge
2 Oct 1989 → 15 Nov 1993
Award Date: 19 Mar 1994
Biochemistry, MSc, Comparative properties of D2 cyclic nucleotide phosphodiesterase from Rhizobium fredii and Rhizobium meliloti, Universiti Malaya (University of Malaya)
Jul 1987 → Jul 1989
Award Date: 11 Aug 1990
Biochemistry, BSc (Hons) Class 1, Partial Purification and characterisation of D2 Cyclic Nucleotide Phosphodiesterase from Rhizobium fredii., Universiti Malaya (University of Malaya)
Jul 1983 → May 1987
Award Date: 1 Aug 1987
External positions
Committee member of Sub-committee of the National Candidate COVID-19 Vaccine, Kementerian Kesihatan (Malaysia) (Ministry of Health)
24 Nov 2020 → …
Research area keywords
- Immune System, Protein chemistry, structural biology, Natural killer cell receptors, T cell receptor, innate immunity, cryo-electron microscopy
- Immunotherapy
- immunomodulation
- Bioactive Compounds
- Cancer Immunology
- Cancer Biology
- Cancer epigenetics
- Tocotrienol
- Neurobiology
- immune responses
Collaborations and top research areas from the last five years
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Postbiotics and IBS (Irritable Bowel Syndrome) – A Randomised Control Trial
Tan, S. S. (Primary Chief Investigator (PCI)), Radhakrishnan, A. (Chief Investigator (CI)), Kew, S. T. (Chief Investigator (CI)), Lim, W. W. D. (Chief Investigator (CI)), Ramadas, A. (Chief Investigator (CI)) & Palanisamy, U. (Chief Investigator (CI))
1/10/24 → 30/09/26
Project: Research
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Alterations in skin hydration, moisture and genomic in patients with dry skin conditions following daily oral palm tocotrienol and squalene (STGAIA) supplementation
Bai, K. (Primary Chief Investigator (PCI)), Radhakrishnan, A. (Chief Investigator (CI)), Pillai, B. S. B. (Chief Investigator (CI)), Arumugam, M. (Chief Investigator (CI)), Jamil, A. (Chief Investigator (CI)) & See, B. (Partner Investigator (PI))
15/05/24 → 30/06/25
Project: Research
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Elucidating the mechanisms of differentially expressed proteins underlying the bidirectional interactions of co-cultured glioblastoma and differentiated cholinergic cells.
Kamarudin, M. (Primary Chief Investigator (PCI)), Naidu, R. (Chief Investigator (CI)), Asnawi, S. (Chief Investigator (CI)), Radhakrishnan, A. (Chief Investigator (CI)), SyedHassan, S. (Chief Investigator (CI)) & Pillai, B. S. B. (Chief Investigator (CI))
1/10/23 → 30/09/26
Project: Research
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Development of a universal antivenom using proteomic characterisation of antigenic and immunogenic snake venom proteins
Asnawi, S. (Primary Chief Investigator (PCI)), Naidu, R. (Chief Investigator (CI)), Othman, I. (Chief Investigator (CI)), Radhakrishnan, A. (Chief Investigator (CI)), Ismail, A. K. (Chief Investigator (CI)) & Pillai, B. S. B. (Chief Investigator (CI))
1/09/22 → 31/08/25
Project: Research
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Embelin-Poloxamer conjugate as a synergistic combination for neurodegenerative diseases
Radhakrishnan, A. (Primary Chief Investigator (PCI)), Shaikh, F. (Chief Investigator (CI)), Yusof, S. R. (Chief Investigator (CI)), Abdul Nasir, N. A. (Chief Investigator (CI)), Ansari, M. T. (Chief Investigator (CI)) & Date, A. (Chief Investigator (CI))
1/11/20 → 30/09/24
Project: Research
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Health Benefits of Palm Tocotrienol-Rich Fraction: A Systematic Review of Randomized Controlled Trials
Looi Deming, A., Palanisamy, U. D., Moorthy, M. & Radhakrishnan, A. K. C., Feb 2025, In: Nutrition Reviews. 83, 2, p. 307-328 22 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Insights into the Anticancer Mechanisms Modulated by Gamma and Delta Tocotrienols in Colorectal Cancers
Khalid, A. Q., Zaidan, T. N., Pillai, B. S. B., Magalingam, K. B., Mohamed Musa Mohamedahmed, S., Ramdas, P. & Radhakrishnan, A. K. C., Mar 2025, In: Nutrition Reviews. 83, 3, p. e1295-e1310 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma
Phon, B. W. S., Chelliah, S. S., Osman, D.E.-R. A., Pillai, B. S. B., Radhakrishnan, A. & Kamarudin, M., Jan 2025, In: Pharmaceuticals. 18, 1, 30 p., 102.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile -
TRF adjuvant enhances dendritic cell vaccine efficacy in a Murine breast cancer model
Hafid, S. R. A., Iran, N. & Radhakrishnan, A. K., 28 Jan 2025, AIP Conference Proceedings: 2nd International Conference on Industry-Academia Initiatives in Biotechnology and Chemistry (iCIABC2023). Ramli, R. A. B., Salim, N., Aluwi, M. F. F. M., Mahmud, N. B., Hui, T. J., Sabri, N. '. B., Zamri, N. B., Zulkifli, F. H. B., Hamid, H. B. A., Adzahar, N. S. B. & bin Kamarudin, K. F. (eds.). USA: American Institute of Physics, 10 p. 060005. (AIP Conference Proceedings; vol. 3275, no. 1).Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review
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Unveiling the synergistic potential: Palm vitamin E and cytarabine combination therapy in acute myeloid leukaemia cell models
Iran, N., Hafid, S. R. A., Radhakrishnan, A. K. & Baba, A. A., 28 Jan 2025, AIP Conference Proceedings: 2nd International Conference on Industry-Academia Initiatives in Biotechnology and Chemistry (iCIABC2023). Ramli, R. A. B., Salim, N., Aluwi, M. F. F. M., Mahmud, N. B., Hui, T. J., Sabri, N. '. B., Zamri, N. B., Zulkifli, F. H. B., Hamid, H. B. A., Adzahar, N. S. B. & bin Kamarudin, K. F. (eds.). American Institute of Physics, 10 p. 060004. (AIP Conference Proceedings; vol. 3275, no. 1).Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review
Prizes
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Best e-poster presentation entitled Enhancing Medical Students’ Understanding of Basic Immunology through Innovative Approaches
SyedHassan, S. (Recipient), Radhakrishnan, A. (Recipient), Pillai, B. S. B. (Recipient), Pallath, V. (Recipient), Balasubramaniam, V. (Recipient), Naidu, R. (Recipient), Yap, P. (Recipient), Ming, L. W. (Recipient) & Abdul Kadar, N. (Recipient), 2024
Prize: Prize (including medals and awards)
File
Activities
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Unraveling the Enigma of Cachexia in Breast Cancer: A Comprehensive Narrative Review
Radhakrishnan, A. (Supervisor), Ramdas, P. (Supervisor) & Farghadani, R. (Supervisor)
3 Mar 2024 → 12 Apr 2024Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Natural Products as Modulators of ABC Transporters in breast cancer
Farghadani, R. (Supervisor) & Radhakrishnan, A. (Supervisor)
28 Jul 2024 → 6 Sept 2024Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Non-coding RNA World 2024: Exploring Mechanisms, Designing Medicines
Lee, J. S. Y. (Speaker), Bai, K. (Speaker), Palanisamy, U. D. (Speaker), Farghadani, R. (Speaker) & Radhakrishnan, A. (Speaker)
7 Oct 2024 → 9 Oct 2024Activity: Participating in or organising an event types › Contribution to conference
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International Conference of the Asian Society Against Dementia (ASAD) 2024
Kasthuri Bai (Speaker) & Ammu Radhakrishnan (Speaker)
16 Aug 2024Activity: Participating in or organising an event types › Contribution to conference
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3rd Virtual International Conference on Carotenoids
Kasthuri Bai (Speaker) & Ammu Radhakrishnan (Speaker)
24 Jul 2024Activity: Participating in or organising an event types › Contribution to conference