Alistair Nichol

Professor

20052024

Research output per year

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Research Output

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2020

Characteristics and Outcomes of Critically Ill Trauma Patients in Australia and New Zealand (2005-2017)

Wilson, A. J., Magee, F., Bailey, M., Pilcher, D. V., French, C., Nichol, A., Udy, A., Hodgson, C. L., Cooper, D. J., Reade, M. C., Young, P. & Bellomo, R., May 2020, In : Critical Care Medicine. 48, 5, p. 717-724 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Stress Ulcer Prophylaxis with Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial

The PEPTIC Investigators & for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, 17 Jan 2020, In : JAMA - Journal of the American Medical Association. 323, 7, p. 616-626 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The effect of a low-dose naloxone infusion on the incidence of respiratory depression after intrathecal morphine administration for major open hepatobiliary surgery: a randomised controlled trial

Cosgrave, D., Vencken, S., Galligan, M., McGuinness, S., Soukhin, E., McMullan, V., Nair, S., Puttappa, A., Boylan, J., Hussain, R., Conlon, N., Doran, P. & Nichol, A., Jun 2020, In : Anaesthesia. 75, 6, p. 747-755 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Biomarker Predictors of Adverse Acute Kidney Injury Outcomes in Critically Ill Patients: The Dublin Acute Biomarker Group Evaluation Study

McMahon, B. A., Galligan, M., Redahan, L., Martin, T., Meaney, E., Cotter, E. J., Murphy, N., Hannon, C., Doran, P., Marsh, B., Nichol, A. & Murray, P. T., 1 Jul 2019, In : American Journal of Nephrology. 50, 1, p. 19-28 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial

Skrifvars, M. B., Moore, E., Mårtensson, J., Bailey, M., French, C., Presneill, J., Nichol, A., Little, L., Duranteau, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & The EPO-TBI Investigators and the ANZICS Clinical Trials Group, Feb 2019, In : Acta Anaesthesiologica Scandinavica. 63, 2, p. 200-207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Fresh red cells for transfusion in critically ill adults: an economic evaluation of the Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) clinical trial

Irving, A., Higgins, A., Ady, B., Bellomo, R., Cooper, D. J., French, C., Gantner, D., Harris, A., Irving, D. O., Murray, L., Nichol, A., Petrie, D., McQuilten, Z. K. & on behalf of the Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group, 1 Jul 2019, In : Critical Care Medicine. 47, 7, p. e572-e579 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP): A Phase II, Multicenter Randomized Controlled Clinical Trial

Hodgson, C. L., Cooper, D. J., Arabi, Y., King, V., Bersten, A., Bihari, S., Brickell, K., Davies, A., Fahey, C., Fraser, J., McGuinness, S., Murray, L., Parke, R., Paul, E., Tuxen, D., Vallance, S., Young, M. & Nichol, A., Dec 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 11, p. 1363-1372 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study

Pham, T., Serpa Neto, A., Pelosi, P., Laffey, J. G., De Haro, C., Lorente, J. A., Bellani, G., Fan, E., Brochard, L. J., Pesenti, A., Schultz, M. J., Artigas, A. & on behalf of the LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group, Feb 2019, In : Anesthesiology. 130, 2, p. 263-283 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Priority Needs for Conducting Pandemic-relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician-researchers

Gal, M., Gobat, N., Francis, N. A., Hood, K., Butler, C. C., Bielicki, J., Fraaij, P. L., Sharland, M., Jarvis, J., van Rossum, A. M. C., Heikkinen, T., Martinon-Torres, F., Herberg, J., Watkins, A., Webb, S. A. R., Moore, R., Sukumar, P. & Nichol, A., 1 May 2019, In : Journal of Pediatric Infectious Diseases. 38, 5, p. e82-e86 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Quality of life and 1-year survival in patients with early septic shock: long-term follow-up of the Australasian Resuscitation in Sepsis Evaluation Trial

Higgins, A. M., Peake, S. L., Bellomo, R., Cooper, D. J., Delaney, A., Harris, A. H., Howe, B. D., Nichol, A. D., Webb, S. A., Williams, T., on behalf of the Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators & on behalf of the ANZICS Clinical Trials Group, Jun 2019, In : Critical Care Medicine. 47, 6, p. 765-773 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): A randomized clinical trial—Rationale and design

Dankiewicz, J., Cronberg, T., Lilja, G., Jakobsen, J. C., Bělohlávek, J., Callaway, C., Cariou, A., Eastwood, G., Erlinge, D., Hovdenes, J., Joannidis, M., Kirkegaard, H., Kuiper, M., Levin, H., Morgan, M. P. G., Nichol, A. D., Nordberg, P., Oddo, M., Pelosi, P., Rylander, C. & 8 others, Saxena, M., Storm, C., Taccone, F., Ullén, S., Wise, M. P., Young, P., Friberg, H. & Nielsen, N., Nov 2019, In : American Heart Journal. 217, p. 23-31 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
6 Citations (Scopus)

What the public think about participation in medical research during an influenza pandemic: an international cross-sectional survey

Gobat, N., Butler, C. C., Mollison, J., Francis, N. A., Gal, M., Harris, V., Webb, S. A. R., Byrne, J. P., Watkins, A., Sukumar, P., Hood, K. & Nichol, A., Dec 2019, In : Public Health. 177, p. 80-94 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): Study protocol

Young, P. J., Bagshaw, S. M., Forbes, A., Nichol, A., Wright, S. E., Bellomo, R., Bailey, M. J., Beasley, R. W., Eastwood, G. M., Festa, M., Gattas, D., van Haren, F., Litton, E., Mouncey, P., Navarra, L., Pilcher, D., Mackle, D., McArthur, C. J., McGuinness, S. P., Saxena, M. K. & 4 others, Webb, S., Rowan, K. M., Australian and New Zealand Intensive Care Society Clinical Trials Group & The PEPTIC Investigators, 1 Sep 2018, In : Critical Care and Resuscitation. 20, 3, p. 182-189 8 p.

Research output: Contribution to journalArticleOtherpeer-review

8 Citations (Scopus)

Bending the pandemic curve: Improving decision-making with clinical research

Webb, S. A. & Nichol, A. D., Mar 2018, In : Critical Care Medicine. 46, 3, p. 442-446 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Cause and Timing of Death and Subgroup Differential Effects of Erythropoietin in the EPO-TBI Study

Skrifvars, M. B., French, C., Bailey, M., Presneill, J., Nichol, A., Little, L., Durantea, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & EPO-TBI Investigators and the ANZICS Clinical Trials Group, 15 Jan 2018, In : Journal of Neurotrauma. 35, 2, p. 333-340 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Changes in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial

Salter, R., Bailey, M., Bellomo, R., Eastwood, G., Goodwin, A., Nielsen, N., Pilcher, D., Nichol, A., Saxena, M., Shehabi, Y., Young, P. & Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE), 1 Nov 2018, In : Critical Care Medicine. 46, 11, p. 1722-1730 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post-hoc Dose-effect Analysis

Gantner, D., Bailey, M., Presneill, J., French, C. J., Nichol, A., Little, L. & Bellomo, R., Mar 2018, In : Annals of Surgery. 267, 3, p. 585-589 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Permissive hypercapnia, alveolar recruitment and low airway pressure (PHARLAP): A protocol for a phase 2 trial in patients with acute respiratory distress syndrome

Hodgson, C., Cooper, D. J., Arabi, Y., Bennett, V., Bersten, A., Brickell, K., Davies, A., Fahey, C., Fraser, J., McGuinness, S., Murray, L., Parke, R., Tuxen, D., Vallance, S., Young, M., Nichol, A. D. & on behalf of the PHARLAP Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, 1 Jun 2018, In : Critical Care and Resuscitation. 20, 2, p. 139-149 11 p.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)
6 Citations (Scopus)

Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries

Gobat, N. H., Gal, M., Butler, C. C., Webb, S. A. R., Francis, N. A., Stanton, H., Anthierens, S., Bastiaens, H., Godycki-ćwirko, M., Kowalczyk, A., Pons-Vigués, M., Pujol-Ribera, E., Berenguera, A., Watkins, A., Sukumar, P., Moore, R. G., Hood, K. & Nichol, A., 1 Feb 2018, In : Health Expectations. 21, 1, p. 387-395 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)
2017

Age of red cells for transfusion and outcomes in critically ill adults

Cooper, D. J., McQuilten, Z. K., Nichol, A., Ady, B., Aubron, C., Bailey, M., Bellomo, R., Gantner, D., Irving, D. O., Kaukonen, K-M., McArthur, C., Murray, L., Pettila, V. & French, C., 9 Nov 2017, In : The New England Journal of Medicine. 377, 19, p. 1858-1867 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
13 Citations (Scopus)

Erythropoietin in patients with traumatic brain injury and extracranial injury – A post hoc analysis of the EPO-TBI trial

Skrifvars, M. B. B., Bailey, M., French, C., Presneill, J., Nichol, A., Little, L., Duranteau, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & for the EPO-TBI investigators and the ANZICS Clinical Trials Group, Sep 2017, In : The Journal of Trauma and Acute Care Surgery. 83, 3, p. 449-456 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

The NAPRESSIM trial: The use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: A study protocol and statistical analysis plan for a randomised controlled trial

Cosgrave, D., Galligan, M., Soukhin, E., McMullan, V., McGuinness, S., Puttappa, A., Conlon, N., Boylan, J., Hussain, R., Doran, P. & Nichol, A., 29 Dec 2017, In : Trials. 18, 1, 10 p., 633.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
1 Citation (Scopus)

Venous thromboembolic events in critically ill traumatic brain injury patients

Skrifvars, M. B., Bailey, M., Presneill, J., French, C., Nichol, A., Little, L., Duranteau, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & For The Epo-Tbi Investigators, T. E-T. I., Mar 2017, In : Intensive Care Medicine. 43, 3, p. 419-428 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2016

Status epilepticus: An intensive care medicine problem

O'Connor, C., Hanna, J. & Nichol, A., 1 Jan 2016, In : Anaesthesia and Intensive Care Medicine. 17, 1, p. 27-30 4 p.

Research output: Contribution to journalArticleOtherpeer-review

2015

Acute kidney injury and the critically ill

Ahmed, B., Hanna, J. & Nichol, A., 1 Apr 2015, In : Anaesthesia and Intensive Care Medicine. 16, 4, p. 186-190 5 p.

Research output: Contribution to journalArticleOtherpeer-review

Acute pancreatitis: An intensive care perspective

Dooley, N., Hew, S. & Nichol, A., 1 Apr 2015, In : Anaesthesia and Intensive Care Medicine. 16, 4, p. 191-196 6 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Inflammation, immunity and allergy

O'Connor, C. & Nichol, A., 1 Jul 2015, In : Anaesthesia and Intensive Care Medicine. 16, 7, p. 328-333 6 p.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

Key stakeholder perceptions about consent to participate in acute illness research: A rapid, systematic review to inform epi/pandemic research preparedness

Gobat, N. H., Gal, M., Francis, N. A., Hood, K., Watkins, A., Turner, J., Moore, R., Webb, S. A. R., Butler, C. C. & Nichol, A., 29 Dec 2015, In : Trials. 16, 1, 21 p., 591.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)
2014

A randomised controlled trial of standard transfusion versus fresher red blood cell use in intensive care (TRANSFUSE): protocol and statistical analysis plan

Kaukonen, K-M., Bailey, M. J., Ady, B., Aubron, C., French, C., Gantner, D., Irving, D., Murray, L. J., Nichol, A. D., Pettila, V., McQuilten, Z. & Cooper, D. J., 2014, In : Critical Care and Resuscitation. 16, 4, p. 255 - 261 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Shock: Causes, initial assessment and investigations

Nichol, A. D. & Ahmed, B., 2014, In : Anaesthesia and Intensive Care Medicine. 15, 2, p. 64 - 67 4 p.

Research output: Contribution to journalArticleOther

1 Citation (Scopus)
2013

Age of red blood cells and transfusion in critically ill patients

Aubron, C., Nichol, A. D., Cooper, J. & Bellomo, R., 2013, In : Annals of Intensive Care. 3, 2, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
82 Citations (Scopus)

A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis

Kruger, P. S., Bailey, M. J., Bellomo, R., Cooper, D. J., Harward, M., Higgins, A., Howe, B. D., Jones, D. A., Joyce, C., Kostner, K., McNeil, J. J., Nichol, A. D., Roberts, M. S., Syres, G. A. & Venkatesh, B., 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 7, p. 743 - 750 8 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Hypoxaemic rescue therapies in acute respiratory distress syndrome: Why, when, what and which one?

Hodgson, C. L., Carteaux, G., Tuxen, D. V., Davies, A. R., Pellegrino, V., Capellier, G., Cooper, D. J. & Nichol, A. D., 2013, In : Injury. 44, 12, p. 1700-1709 - 1709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2012

Acute pancreatitis: an intensive care perspective

Hew, S. & Nichol, A. D., 2012, In : Anaesthesia and Intensive Care Medicine. 13, 4, p. 171 - 175 5 p.

Research output: Contribution to journalArticleOther

Acute renal failure and the critically ill

Hanna, J. & Nichol, A. D., 2012, In : Anaesthesia and Intensive Care Medicine. 13, p. 166 - 170 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients

Aubron, C., Syres, G., Nichol, A. D., Bailey, M., Board, J., Magrin, G., Murray, L. J., Presneill, J. J., Sutton, J., Vallance, S., Morrison, S., Bellomo, R. & Cooper, D., 2012, In : Transfusion. 52, 6, p. 1196 - 1202 7 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study

Praeger, A. J., Westbrook, A., Nichol, A. D., Wijemunige, R., Davies, A. R., Lyon, S. M., Wills, J. L., Bailey, M. J., Rosenfeld, J. V. & Cooper, J., 2012, In : Critical Care and Resuscitation. 14, 1, p. 10 - 13 4 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia

Hodgson, C. L., Hayes, K., Everard, T., Nichol, A. D., Davies, A. R., Bailey, M. J., Tuxen, D. V., Cooper, D. J. & Pellegrino, V., 2012, In : Critical Care. 16, 5 (Art. No.: R202), p. 1 - 34 34 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
83 Citations (Scopus)

Status epilepticus: an intensive care medicine problem

Hanna, J. & Nichol, A. D., 2012, In : Anaesthesia and Intensive Care Medicine. 13, 4, p. 148 - 151 4 p.

Research output: Contribution to journalArticleOther

The association between early arterial oxygenation and mortality in ventilated patients with acute ischaemic stroke

Young, P. M., Beasley, R., Bailey, M. J., Bellomo, R., Eastwood, G. M., Nichol, A. D., Pilcher, D. V., Yunos, N., Egi, M., Hart, G. K., Reade, M. C. & Cooper, D. J., Mar 2012, In : Critical Care and Resuscitation. 14, 1, p. 14-19 6 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The meaning of acute kidney injury and its relevance to intensive care and anaesthesia

Moore, E. M., Bellomo, R. & Nichol, A. D., 2012, In : Anaesthesia and intensive care. 40, 6, p. 929 - 948 20 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)