Alistair Nichol

Professor

20052024

Research output per year

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Research Output

2020

Characteristics and Outcomes of Critically Ill Trauma Patients in Australia and New Zealand (2005-2017)

Wilson, A. J., Magee, F., Bailey, M., Pilcher, D. V., French, C., Nichol, A., Udy, A., Hodgson, C. L., Cooper, D. J., Reade, M. C., Young, P. & Bellomo, R., May 2020, In : Critical Care Medicine. 48, 5, p. 717-724 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Stress Ulcer Prophylaxis with Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial

The PEPTIC Investigators & for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, 17 Jan 2020, In : JAMA - Journal of the American Medical Association. 323, 7, p. 616-626 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The effect of a low-dose naloxone infusion on the incidence of respiratory depression after intrathecal morphine administration for major open hepatobiliary surgery: a randomised controlled trial

Cosgrave, D., Vencken, S., Galligan, M., McGuinness, S., Soukhin, E., McMullan, V., Nair, S., Puttappa, A., Boylan, J., Hussain, R., Conlon, N., Doran, P. & Nichol, A., Jun 2020, In : Anaesthesia. 75, 6, p. 747-755 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Biomarker Predictors of Adverse Acute Kidney Injury Outcomes in Critically Ill Patients: The Dublin Acute Biomarker Group Evaluation Study

McMahon, B. A., Galligan, M., Redahan, L., Martin, T., Meaney, E., Cotter, E. J., Murphy, N., Hannon, C., Doran, P., Marsh, B., Nichol, A. & Murray, P. T., 1 Jul 2019, In : American Journal of Nephrology. 50, 1, p. 19-28 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial

Skrifvars, M. B., Moore, E., Mårtensson, J., Bailey, M., French, C., Presneill, J., Nichol, A., Little, L., Duranteau, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & The EPO-TBI Investigators and the ANZICS Clinical Trials Group, Feb 2019, In : Acta Anaesthesiologica Scandinavica. 63, 2, p. 200-207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Fresh red cells for transfusion in critically ill adults: an economic evaluation of the Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) clinical trial

Irving, A., Higgins, A., Ady, B., Bellomo, R., Cooper, D. J., French, C., Gantner, D., Harris, A., Irving, D. O., Murray, L., Nichol, A., Petrie, D., McQuilten, Z. K. & on behalf of the Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group, 1 Jul 2019, In : Critical Care Medicine. 47, 7, p. e572-e579 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP): A Phase II, Multicenter Randomized Controlled Clinical Trial

Hodgson, C. L., Cooper, D. J., Arabi, Y., King, V., Bersten, A., Bihari, S., Brickell, K., Davies, A., Fahey, C., Fraser, J., McGuinness, S., Murray, L., Parke, R., Paul, E., Tuxen, D., Vallance, S., Young, M. & Nichol, A., Dec 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 11, p. 1363-1372 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

O2, do we know what to do?

Young, P. J., Bagshaw, S. M., Bailey, M., Bellomo, R., Mackle, D., Pilcher, D., Landoni, G., Nichol, A. & Martin, D., Dec 2019, In : Critical Care and Resuscitation. 21, 4, p. 230-232 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study

Pham, T., Serpa Neto, A., Pelosi, P., Laffey, J. G., De Haro, C., Lorente, J. A., Bellani, G., Fan, E., Brochard, L. J., Pesenti, A., Schultz, M. J., Artigas, A. & on behalf of the LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group, Feb 2019, In : Anesthesiology. 130, 2, p. 263-283 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Priority Needs for Conducting Pandemic-relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician-researchers

Gal, M., Gobat, N., Francis, N. A., Hood, K., Butler, C. C., Bielicki, J., Fraaij, P. L., Sharland, M., Jarvis, J., van Rossum, A. M. C., Heikkinen, T., Martinon-Torres, F., Herberg, J., Watkins, A., Webb, S. A. R., Moore, R., Sukumar, P. & Nichol, A., 1 May 2019, In : Journal of Pediatric Infectious Diseases. 38, 5, p. e82-e86 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Prophylactic Hypothermia for Severe Traumatic Brain Injury-Reply

Cooper, D. J., Nichol, A. D. & McArthur, C., 7 May 2019, In : JAMA. 321, 17, p. 1726 1 p.

Research output: Contribution to journalLetterOtherpeer-review

Quality of life and 1-year survival in patients with early septic shock: long-term follow-up of the Australasian Resuscitation in Sepsis Evaluation Trial

Higgins, A. M., Peake, S. L., Bellomo, R., Cooper, D. J., Delaney, A., Harris, A. H., Howe, B. D., Nichol, A. D., Webb, S. A., Williams, T., on behalf of the Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators & on behalf of the ANZICS Clinical Trials Group, Jun 2019, In : Critical Care Medicine. 47, 6, p. 765-773 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): A randomized clinical trial—Rationale and design

Dankiewicz, J., Cronberg, T., Lilja, G., Jakobsen, J. C., Bělohlávek, J., Callaway, C., Cariou, A., Eastwood, G., Erlinge, D., Hovdenes, J., Joannidis, M., Kirkegaard, H., Kuiper, M., Levin, H., Morgan, M. P. G., Nichol, A. D., Nordberg, P., Oddo, M., Pelosi, P., Rylander, C. & 8 others, Saxena, M., Storm, C., Taccone, F., Ullén, S., Wise, M. P., Young, P., Friberg, H. & Nielsen, N., Nov 2019, In : American Heart Journal. 217, p. 23-31 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
6 Citations (Scopus)

What is the optimal approach to weaning and liberation from mechanical ventilation?

Nichol, A. D., Geoghegan, P., Duff, S., Cooper, D. J. & Devlin, D., 6 Sep 2019, Evidence-based practice of critical care. Deutschman, C. S. & Neligan, P. J. (eds.). 3rd ed. Philadelphia PA USA: Elsevier - Medicine Publishing Company, p. 57-67.e1 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

What the public think about participation in medical research during an influenza pandemic: an international cross-sectional survey

Gobat, N., Butler, C. C., Mollison, J., Francis, N. A., Gal, M., Harris, V., Webb, S. A. R., Byrne, J. P., Watkins, A., Sukumar, P., Hood, K. & Nichol, A., Dec 2019, In : Public Health. 177, p. 80-94 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): Study protocol

Young, P. J., Bagshaw, S. M., Forbes, A., Nichol, A., Wright, S. E., Bellomo, R., Bailey, M. J., Beasley, R. W., Eastwood, G. M., Festa, M., Gattas, D., van Haren, F., Litton, E., Mouncey, P., Navarra, L., Pilcher, D., Mackle, D., McArthur, C. J., McGuinness, S. P., Saxena, M. K. & 4 others, Webb, S., Rowan, K. M., Australian and New Zealand Intensive Care Society Clinical Trials Group & The PEPTIC Investigators, 1 Sep 2018, In : Critical Care and Resuscitation. 20, 3, p. 182-189 8 p.

Research output: Contribution to journalArticleOtherpeer-review

8 Citations (Scopus)

Acute kidney injury and the critically ill

Flood, L. & Nichol, A., Mar 2018, In : Anaesthesia and Intensive Care Medicine. 19, 3, p. 113-118 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Acute pancreatitis: an intensive care perspective

Flood, L. & Nichol, A., Mar 2018, In : Anaesthesia and Intensive Care Medicine. 19, 3, p. 119-124 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Bending the pandemic curve: Improving decision-making with clinical research

Webb, S. A. & Nichol, A. D., Mar 2018, In : Critical Care Medicine. 46, 3, p. 442-446 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Cause and Timing of Death and Subgroup Differential Effects of Erythropoietin in the EPO-TBI Study

Skrifvars, M. B., French, C., Bailey, M., Presneill, J., Nichol, A., Little, L., Durantea, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & EPO-TBI Investigators and the ANZICS Clinical Trials Group, 15 Jan 2018, In : Journal of Neurotrauma. 35, 2, p. 333-340 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Changes in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial

Salter, R., Bailey, M., Bellomo, R., Eastwood, G., Goodwin, A., Nielsen, N., Pilcher, D., Nichol, A., Saxena, M., Shehabi, Y., Young, P. & Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE), 1 Nov 2018, In : Critical Care Medicine. 46, 11, p. 1722-1730 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Decompressive craniectomy in diffuse injury: Interpretation and implications of the international decra randomized trial

Cooper, J. D., Udy, A., Nichol, A., Rosenfeld, J. V. & Hunn, M., 1 Jan 2018, Decompressive Craniectomy. Nova Science Publishers, p. 217-226 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis

McQuilten, Z. K., French, C. J., Nichol, A., Higgins, A. & Cooper, D. J., 1 Apr 2018, In : Transfusion Medicine Reviews. 32, 2, p. 77-88 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)

Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post-hoc Dose-effect Analysis

Gantner, D., Bailey, M., Presneill, J., French, C. J., Nichol, A., Little, L. & Bellomo, R., Mar 2018, In : Annals of Surgery. 267, 3, p. 585-589 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Hyperlactataemia in critical illness

Cosgrave, D. W., Higgins, A. M., Cooper, D. J. & Nichol, A. D., 15 Aug 2018, Oh’s Intensive Care Manual. Bersten, A. D. & Handy, J. M. (eds.). 8th ed. The Netherlands: Elsevier, p. 171-177.e4 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Inflammation, immunity and allergy

Stewart, D. & Nichol, A., 1 Oct 2018, In : Anaesthesia and Intensive Care Medicine. 19, 10, p. 534-539 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

4 Citations (Scopus)

Pathophysiology of severe traumatic brain injury

O’Leary, R. A. & Nichol, A. D., 1 Oct 2018, In : Journal of Neurosurgical Sciences. 62, 5, p. 542-548 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Permissive hypercapnia, alveolar recruitment and low airway pressure (PHARLAP): A protocol for a phase 2 trial in patients with acute respiratory distress syndrome

Hodgson, C., Cooper, D. J., Arabi, Y., Bennett, V., Bersten, A., Brickell, K., Davies, A., Fahey, C., Fraser, J., McGuinness, S., Murray, L., Parke, R., Tuxen, D., Vallance, S., Young, M., Nichol, A. D. & on behalf of the PHARLAP Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, 1 Jun 2018, In : Critical Care and Resuscitation. 20, 2, p. 139-149 11 p.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)
6 Citations (Scopus)

Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries

Gobat, N. H., Gal, M., Butler, C. C., Webb, S. A. R., Francis, N. A., Stanton, H., Anthierens, S., Bastiaens, H., Godycki-ćwirko, M., Kowalczyk, A., Pons-Vigués, M., Pujol-Ribera, E., Berenguera, A., Watkins, A., Sukumar, P., Moore, R. G., Hood, K. & Nichol, A., 1 Feb 2018, In : Health Expectations. 21, 1, p. 387-395 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

The undiscovered country: Therapeutic targeting of carbon dioxide levels in critically ill patients

Nichol, A. D., 1 Jun 2018, In : Critical Care and Resuscitation. 20, 2, p. 81-82 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

2017

Age of red cells for transfusion and outcomes in critically ill adults

Cooper, D. J., McQuilten, Z. K., Nichol, A., Ady, B., Aubron, C., Bailey, M., Bellomo, R., Gantner, D., Irving, D. O., Kaukonen, K-M., McArthur, C., Murray, L., Pettila, V. & French, C., 9 Nov 2017, In : The New England Journal of Medicine. 377, 19, p. 1858-1867 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Co-enrolment for the TAME and TTM-2 trials: The cerebral option

Parke, R. L., McGuinness, S., Eastwood, G. M., Nichol, A., Nielsen, N., Dankiewicz, J. & Bellomo, R., 2017, In : Critical Care and Resuscitation. 19, 2, p. 99-100 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

4 Citations (Scopus)

Comment on Rishu et al. Time required to initiate outbreak and pandemic observational research

Gobat, N. H., Butler, C. C., Webb, S. A. R., Nichol, A. & on behalf of the PREPARE-EARL Study Team, 1 Aug 2017, In : Journal of Critical Care. 40, p. 271 1 p.

Research output: Contribution to journalLetterOtherpeer-review

13 Citations (Scopus)

Erythropoietin in patients with traumatic brain injury and extracranial injury – A post hoc analysis of the EPO-TBI trial

Skrifvars, M. B. B., Bailey, M., French, C., Presneill, J., Nichol, A., Little, L., Duranteau, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & for the EPO-TBI investigators and the ANZICS Clinical Trials Group, Sep 2017, In : The Journal of Trauma and Acute Care Surgery. 83, 3, p. 449-456 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Shock: causes, initial assessment and investigations

Teirney, P., Ahmed, B. & Nichol, A., 1 Mar 2017, In : Anaesthesia and Intensive Care Medicine. 18, 3, p. 118-121 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Targeted therapeutic mild hypercapnia after cardiac arrest

Eastwood, G. M., Nichol, A. & Wise, M. P., 31 Jul 2017, In : Critical Care. 21, 1, 196.

Research output: Contribution to journalLetterOtherpeer-review

2 Citations (Scopus)

The NAPRESSIM trial: The use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: A study protocol and statistical analysis plan for a randomised controlled trial

Cosgrave, D., Galligan, M., Soukhin, E., McMullan, V., McGuinness, S., Puttappa, A., Conlon, N., Boylan, J., Hussain, R., Doran, P. & Nichol, A., 29 Dec 2017, In : Trials. 18, 1, 10 p., 633.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
1 Citation (Scopus)

Venous thromboembolic events in critically ill traumatic brain injury patients

Skrifvars, M. B., Bailey, M., Presneill, J., French, C., Nichol, A., Little, L., Duranteau, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & For The Epo-Tbi Investigators, T. E-T. I., Mar 2017, In : Intensive Care Medicine. 43, 3, p. 419-428 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2016

Craniectomy for traumatic intracranial hypertension

Cooper, D. J., Nichol, A. & Hodgson, C., 15 Dec 2016, In : The New England Journal of Medicine. 375, 24, p. 2402 1 p.

Research output: Contribution to journalLetterOtherpeer-review

1 Citation (Scopus)

Hypothermia for Intracranial Hypertension after Traumatic Brain Injury

Cooper, D. J., Nichol, A. & Presneill, J., 7 Apr 2016, In : The New England Journal of Medicine. 374, 14, p. 1384 1 p.

Research output: Contribution to journalLetterOtherpeer-review

2 Citations (Scopus)

Status epilepticus: An intensive care medicine problem

O'Connor, C., Hanna, J. & Nichol, A., 1 Jan 2016, In : Anaesthesia and Intensive Care Medicine. 17, 1, p. 27-30 4 p.

Research output: Contribution to journalArticleOtherpeer-review

To the editor

Cooper, D. J., Nichol, A. & Presneill, J., 7 Apr 2016, In : The New England Journal of Medicine. 374, 14, p. 1384 1 p.

Research output: Contribution to journalLetterOtherpeer-review

What is the optimal approach to weaning and liberation from mechanical ventilation?

Nichol, A., Duff, S., Pettila, V. & Cooper, D. J., 2016, Evidence-based practice of critical care . Deutschman, C. S. & Neligan, P. J. (eds.). 2nd ed. Philadelphia PA USA: Elsevier - Medicine Publishing Company, p. 52-60 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Who says there is no "i" in team? Achieving individual success in collaborative clinical research in critical care

Bartz, R. R., Gantner, D., Gordon, A. C., Leligdowicz, A., McNamee, J. J., Murthy, S., Nichol, A. & Webb, S., 1 Oct 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 7, p. 911-912 2 p.

Research output: Contribution to journalLetterOtherpeer-review