Alfons Lawen

Dr

1985 …2018

Research output per year

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Research Output

2018

Cross-talk categorisations in data-driven models of signalling networks: a system-level view

Azad, A. K. M., Lawen, A. & Keith, J. M., 21 Feb 2018, Gene Expression and Regulation in Mammalian Cells: Transcription From General Aspects. Uchiumi, F. (ed.). London UK: In-Tech, p. 81-93 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Research

Open Access
File

Integration of intracellular signaling: Biological analogues of wires, processors and memories organized by a centrosome 3D reference system

Barvitenko, N., Lawen, A., Aslam, M., Pantaleo, A., Saldanha, C., Skverchinskaya, E., Regolini, M. & Tuszynski, J. A., Nov 2018, In : BioSystems. 173, p. 191-206 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2017

Bayesian model of signal rewiring reveals mechanisms of gene dysregulation in acquired drug resistance in breast cancer

Azad, A. K. M., Lawen, A. & Keith, J. M., 1 Mar 2017, In : PLoS ONE. 12, 3, 37 p., e0173331.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2015

Biosynthesis of cyclosporins and other natural peptidyl prolyl cis/trans isomerase inhibitors

Lawen, A., 2015, In : Biochimica et Biophysica Acta. General Subjects. 1850, 10, p. 2111 - 2120 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Effects of oxygen depletion on transmembrane protein activities

Barvitenko, N. N., Aslam, M., Lawen, A., Pantaleo, A., Saldanha, C. & Matteucci, E., 2015, In : Current Organic Chemistry. 19, 20, p. 2002 - 2010 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Is erythroferrone finally the long sought-after systemic erythroid regulator of iron?

Lawen, A., 2015, In : World Journal of Biological Chemistry. 6, 3, p. 78 - 82 5 p.

Research output: Contribution to journalLetterOther

Prediction of signaling cross-talks contributing to acquired drug resistance in breast cancer cells by Bayesian statistical modeling

Azad, AKM., Lawen, A. & Keith, J. M., 2015, In : BMC Systems Biology. 9, 2, p. 1-17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)
2014

A rapid and specific microplate assay for the determination of intra- and extracellular ascorbate in cultured cells

Lane, D. J. R. & Lawen, A., 2014, In : Journal of Visualized Experiments. 86, p. 1 - 10 10 p., e51322.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Cyclosporines: Biosynthesis and beyond

Velkov, T. & Lawen, A., 2014, Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites. Martin, J-F., Garcia-Estrada, C. & Zeilinger, S. (eds.). 2nd ed. New York NY USA: Springer, 65 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2013

Mammalian iron homeostasis in health and disease: uptake, storage, transport, and molecular mechanisms of action

Lawen, A. & Lane, D. JR., 2013, In : Antioxidants and Redox Signaling. 18, 18, p. 2473 - 2507 35 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)
20 Citations (Scopus)
2011

Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase

Velkov, T., Horne, J., Scanlon, M., Capuano, B., Yuriev, E. & Lawen, A., 2011, In : Chemistry and Biology. 18, 4, p. 464 - 475 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron

Fernandes, S., Dringen, R., Lawen, A. & Robinson, S., 2011, In : Neuroscience Letters. 490, 1, p. 27 - 30 4 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2010

A role for Na+/H+ exchangers and intracellular pH in regulating vitamin C-driven electron transport across the plasma membrane

Lane, D. J. R., Robinson, S. R., Czerwinska, H. B. & Lawen, A., 2010, In : Biochemical Journal. 428, 2, p. 191 - 200 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein

Kerr, M. L., Gasperini, R., Gibbs, M. E., Hou, X., Shepherd, C. E., Strickland, D. K., Foa, L., Lawen, A. & Small, D. H., 2010, In : Journal of Neurochemistry. 112, p. 1199 - 1209 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Neurones express glutamine synthetase when deprived of glutamine or interaction with astrocytes

Fernandes, S., Dringen, R., Lawen, A. & Robinson, S., 2010, In : Journal of Neurochemistry. 114, 5, p. 1527 - 1536 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Two routes of iron accumulation in astrocytes: Ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

Lane, D., Robinson, S., Czerwinska, H., Bishop, G. & Lawen, A., 2010, In : Biochemical Journal. 432, 1, p. 123 - 132 10 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Voltage-dependent anion-selective channel (VDAC) in the plasma membrane

De Pinto, V., Messina, A., Lane, D. J. R. & Lawen, A., 2010, In : FEBS Letters. 584, 9, p. 1793 - 1799 7 p.

Research output: Contribution to journalArticleResearchpeer-review

118 Citations (Scopus)
2009

Ascorbate and plasma membrane electron transport-Enzymes vs efflux

Lane, D. J. R. & Lawen, A., 2009, In : Free Radical Biology and Medicine. 47, 5, p. 485 - 495 11 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Targeting mitochondrial permeability in cancer drug development

Berridge, M. V., Herst, P. M. & Lawen, A., 2009, In : Molecular Nutrition and Food Research. 53, p. 76 - 86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Transplasma membrane electron transport comes in two flavors

Lane, D. J. R. & Lawen, A., 2009, In : BioFactors. 34, 3, p. 191 - 200 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
2008
16 Citations (Scopus)

Non-transferrin iron reduction and uptake are regulated by transmembrane ascorbate cycling in K562 cells

Lane, D. J. R. & Lawen, A., 2008, In : The Journal of Biological Chemistry. 283, 19, p. 12701 - 12708 8 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)
2007

Another piece of the puzzle of apoptotic cytochrome c release

Lawen, A., 2007, In : Molecular Microbiology. 66, 3, p. 553 - 556 4 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2006

An improved purification procedure for cyclosporin synthetase

Velkov, T., Singaretnam, L. G. & Lawen, A., 2006, In : Protein Expression and Purification. 45, 2, p. 275 - 287 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents.

Ralph, S. J., Low, P., Dong, L., Lawen, A. & Neuzil, J., 2006, In : Recent Patents on Anti-Cancer Drug Discovery. 1, 3, p. 327 - 346 20 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)
2005

Voltage-dependent anion-selective channel 1 (VDAC1) - A mitochondrial protein, rediscovered as a novel enzyme in the plasma membrane

Lawen, A., Ly Huynh, J. D., Lane, D. J. R., Zarschler, K., Messina, A. & De Pinto, V., 2005, In : International Journal of Biochemistry and Cell Biology. 37, 2, p. 277 - 282 6 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Characterization of VDAC1 as a plasma membrane NADH-oxidoreductase

Baker, M. A., Ly Huynh, J. D. & Lawen, A., 2004, In : BioFactors. 21, 1-4, p. 215 - 221 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Plasma membrane NADH-oxidoreductase in cells carrying mitochondrial DNA G11778A mutation and in cells devoid of mitochondrial DNA (0)

Malik, S. G., Vaillant, F. & Lawen, A., 2004, In : BioFactors. 20, 4, p. 189 - 198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma membrane NADH-oxidoreductase in cells carrying mitochondrial DNA G11778A mutation and in cells devoid of mitochondrial DNA (ρ0)

Malik, S. G., Vaillant, F. & Lawen, A., 1 Jan 2004, In : BioFactors. 20, 4, p. 189-198 10 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

7 Citations (Scopus)

VDAC1 is a transplasma membrane NADH: ferricyanide reductase

Baker, M. A., Lane, D. J. R., Ly Huynh, J. D., De Pinto, V. & Lawen, A., 2004, In : The Journal of Biological Chemistry. 279, 6, p. 4811 - 4819 9 p.

Research output: Contribution to journalArticleResearchpeer-review

145 Citations (Scopus)
2003

Apoptosisan introduction

Lawen, A., 2003, In : BioEssays. 25, 9, p. 888 - 896 9 p.

Research output: Contribution to journalArticleResearchpeer-review

307 Citations (Scopus)

Bioethics needs a distinct voice if it is to aid science

Lawen, A., 2003, In : Nature. 425, 6960, p. 763 - 763 1 p.

Research output: Contribution to journalLetterOther

Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells

Macho, A., Sancho, R., Minassi, A., Appendino, G., Lawen, A. & Munoz, E., 2003, In : Free Radical Research. 37, 6, p. 611 - 619 9 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Mapping and molecular modeling of S-adenosyl-L-methionine binding site in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase

Velkov, T. & Lawen, A., 2003, In : The Journal of Biological Chemistry. 278, 2, p. 1137 - 1148 12 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

New functions of an old protein: the eukaryotic porin or voltage dependent anion selective channel (VDAC)

De Pinto, V., Messina, A., Accardi, R., Aiello, R., Guarino, F., Tomasello, M. F., Tommasino, M., Tasco, G., Casadio, R., Benz, R., De Giorgi, F., Ichas, F., Baker, M. & Lawen, A., 2003, In : Italian Journal of Biochemistry. 52, 1, p. 17 - 24 8 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)
20 Citations (Scopus)

Novel effects on memory observed following unilateral intracranial administration of okadaic acid, cyclosporin A, FK506 and [MeVal4]CyA

Bennett, P. C., Moutsoulas, P., Lawen, A., Perini, E. & Ng, K. T., 2003, In : Brain Research. 988, p. 56 - 68 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Photoaffinity labeling of the N-methyltransferase domains of cyclosporin synthetase

Velkov, T. & Lawen, A., 2003, In : Photochemistry and Photobiology. 77, 2, p. 129 - 137 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The mitochondrial membrane potential (m) in apoptosis; an update

Ly Huynh, J. D., Grubb, D. R. & Lawen, A., 2003, In : Apoptosis: an international journal of programmed cell death. 8, 2, p. 115 - 128 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1022 Citations (Scopus)

Transplasma membrane electron transport: enzymes involved and biological function

Ly Huynh, J. D. & Lawen, A., 2003, In : Redox Report. 8, 1, p. 3 - 21 19 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)
2002

Cyclosporin A, FK506 and rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick

Bennett, P. C., Schmidt, L., Lawen, A., Moutsoulas, P. & Ng, K. T., 2002, In : Brain Research. 927, 2, p. 180 - 194 15 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Didemnin B induces apoptosis in proliferating but not resting peripheral blood mononuclear cells

Baker, M., Grubb, D. R. & Lawen, A., 2002, In : Apoptosis: an international journal of programmed cell death. 7, 5, p. 407 - 412 6 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2001

Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin b-induced apoptosis

Grubb, D. R., Ly, J. D., Vaillant, F., Johnson, K. L. & Lawen, A., 5 Jul 2001, In : Oncogene. 20, 30, p. 4085-4094 10 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrila permeability transition in didemnin B-induced apoptosis

Grubb, D. R., Ly Huynh, J. D., Vaillant, F., Johnson, K. L. & Lawen, A., 2001, In : Oncogene. 20, 30, p. 4085 - 4094 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Peptidyl-Prolyl cis/trans-Isomerase Activity May Be Necessary for Memory Formation...

Singaretnam, L. G., Bennett, P. C., Zhao, W-Q., Ng, K. T. & Lawen, A., 2000, Immunophilins in the Brain. Barcelona Spain: Prous Science, p. 75 - 89 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Plasma membrane NADH-oxidoreductase system: A critical review of the structural and functional data

Baker, M. & Lawen, A., 2000, In : Antioxidants and Redox Signaling. p. 197 - 212 16 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)
1999

Adaptive responses of the plasma membrane oxidoreductase system of cells defective in oxidative phosphorylation (rho>0)

Tan, A. S., Malik, S., Lawen, A. & Berridge, M. V., 1999, p. P14 - P14. 1 p.

Research output: Contribution to conferenceAbstract