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Research Output 2010 2019

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2019

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

Konttinen, H., Gureviciene, I., Oksanen, M., Grubman, A., Loppi, S., Huuskonen, M. T., Korhonen, P., Lampinen, R., Keuters, M., Belaya, I., Tanila, H., Kanninen, K. M., Goldsteins, G., Landreth, G., Koistinaho, J. & Malm, T., Jan 2019, In : GLIA. 67, 1, p. 146-159 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

CuII(atsm) Attenuates Neuroinflammation

Choo, X. Y., Liddell, J. R., Huuskonen, M. T., Grubman, A., Moujalled, D., Roberts, J., Kysenius, K., Patten, L., Quek, H., Oikari, L. E., Duncan, C., James, S. A., Mcinnes, L. E., Hayne, D. J., Donnelly, P. S., Pollari, E., Vähätalo, S., Lejavová, K., Kettunen, M. I., Malm, T. & 3 othersKoistinaho, J., White, A. R. & Kanninen, K. M., 24 Sep 2018, In : Frontiers in Neuroscience. 12, 14 p., 668.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Failure of autophagy-lysosomal pathways in rod photoreceptors causes the early retinal degeneration phenotype observed in Cln6nclf-mice

von Eisenhart-Rothe, P., Grubman, A., Greferath, U., Fothergill, L. J., Jobling, A. I., Phipps, J. A., White, A. R., Fletcher, E. L. & Vessey, K. A., 1 Oct 2018, In : Investigative Ophthalmology and Visual Science. 59, 12, p. 5082-5097 16 p.

Research output: Contribution to journalArticleResearchpeer-review

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage

Loppi, S., Kolosowska, N., Kärkkäinen, O., Korhonen, P., Huuskonen, M., Grubman, A., Dhungana, H., Wojciechowski, S., Pomeshchik, Y., Giordano, M., Kagechika, H., White, A., Auriola, S., Koistinaho, J., Landreth, G., Hanhineva, K., Kanninen, K. & Malm, T., 1 Oct 2018, In : Brain, Behavior, and Immunity. 73, p. 670-681 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

Savchenko, E., Singh, Y., Konttinen, H., Lejavova, K., Santos, L. M., Grubman, A., Karkkainen, V., Keksa-Goldsteine, V., Naumenko, N., Tavi, P., White, A. R., Malm, T., Koistinaho, J. & Kanninen, K. M., 1 Sep 2017, In : Disease Models and Mechanisms. 10, 9, p. 1089-1100 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

Moujalled, D., Grubman, A., Acevedo, K., Yang, S., Ke, Y. D., Moujalled, D. M., Duncan, C., Caragounis, A., Perera, N. D., Turner, B. J., Prudencio, M., Petrucelli, L., Blair, I., Ittner, L. M., Crouch, P. J., Liddell, J. R. & White, A. R., 1 May 2017, In : Human Molecular Genetics. 26, 9, p. 1732-1746 15 p., ddx093.

Research output: Contribution to journalArticleResearchpeer-review

The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Huuskonen, M. T., Tuo, Q. Z., Loppi, S., Dhungana, H., Korhonen, P., McInnes, L. E., Donnelly, P. S., Grubman, A., Wojciechowski, S., Lejavova, K., Pomeshchik, Y., Periviita, L., Kosonen, L., Giordano, M., Walker, F. R., Liu, R., Bush, A. I., Koistinaho, J., Malm, T., White, A. R. & 2 othersLei, P. & Kanninen, K. M., Apr 2017, In : Neurotherapeutics. 14, 2, p. 519 - 532 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets

Grubman, A., Kanninen, K. M. & Malm, T., Nov 2016, In : Journal of Molecular Neuroscience. 60, 3, p. 390-404 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Restoration of intestinal function in an MPTP model of Parkinson's Disease

Ellett, L. J., Hung, L. W., Munckton, R., Sherratt, N. A., Culvenor, J., Grubman, A., Furness, J. B., White, A. R., Finkelstein, D. I., Barnham, K. J. & Lawson, V. A., 29 Jul 2016, In : Scientific Reports. 6, 11 p., 30269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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X-ray fluorescence microscopic measurement of elemental distribution in the mouse retina with age

Grubman, A., Guennel, P., Vessey, K. A., Jones, M. W. M., James, S. A., De Jonge, M. D., White, A. R. & Fletcher, E. L., 1 Oct 2016, In : Metallomics. 8, 10, p. 1110-1121 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Moujalled, D., James, J. L., Yang, S., Zhang, K., Duncan, C., Moujalled, D. M., Parker, S. J., Caragounis, A., Lidgerwood, G., Turner, B. J., Atkin, J. D., Grubman, A., Liddell, J. R., Proepper, C., Boeckers, T. M., Kanninen, K. M., Blair, I., Crouch, P. J. & White, A. R., 15 Mar 2015, In : Human Molecular Genetics. 24, 6, p. 1655-1669 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

McAllum, E. J., Roberts, B. R., Hickey, J. L., Dang, T. N., Grubman, A., Donnelly, P. S., Liddell, J. R., White, A. R. & Crouch, P. J., 1 Sep 2015, In : Neurobiology of Disease. 81, p. 20-24 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Deregulation of biometal homeostasis: The missing link for neuronal ceroid lipofuscinoses?

Grubman, A., Pollari, E., Duncan, C., Caragounis, A., Blom, T., Volitakis, I., Wong, A. M. S., Cooper, J. D., Crouch, P. J., Koistinaho, J., Jalanko, A., White, A. R. & Kanninen, K. M., 6 Mar 2014, In : Metallomics. 6, 4, p. 932-943 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Grubman, A., Lidgerwood, G., Duncan, C., Bica, L., Tan, J. L., Parker, S. J., Caragounis, A., Meyerowitz, J., Volitakis, I., Moujalled, D., Liddell, J. R., Hickey, J. L., Horne, M., Longmuir, S., Koistinaho, J., Donnelly, P. S., Crouch, P. J., Tammen, I., White, A. R. & Kanninen, K. M., 28 Feb 2014, In : Acta neuropathologica communications. 2, 14 p., 25.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Dang, T. N. T., Lim, N. K. H., Grubman, A., Li, Q-X., Volitakis, I., White, A. R. & Crouch, P. J., 11 Feb 2014, In : Frontiers in Aging Neuroscience. 6, 8 p., 15.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation

Bica, L., Liddell, J. R., Donnelly, P. S., Duncan, C., Caragounis, A., Volitakis, I., Paterson, B. M., Cappai, R., Grubman, A., Camakaris, J., Crouch, P. J. & White, A. R., 28 Feb 2014, In : PLoS ONE. 9, 2, 13 p., e90070.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

Roberts, B. R., Lim, N. K. H., McAllum, E. J., Donnelly, P. S., Hare, D., Doble, P., Turner, B. J., Price, K. A., Lim, S. C., Paterson, B. M., Hickey, J. L., Rhoads, T. W., Williams, J. R., Kanninen, K. M., Hung, L. W., Liddell, J. R., Grubman, A., Monty, J-F., Llanos, R. M., Kramer, D. R. & 9 othersMercer, J. F. B., Bush, A. I., Masters, C. L., Duce, J. A., Li, Q. X., Beckman, J. S., Barnham, K. J., White, A. R. & Crouch, P. J., 4 Jun 2014, In : Journal of Neuroscience. 34, 23, p. 8021-8031 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

Grubman, A., James, S. A., James, J., Duncan, C., Volitakis, I., Hickey, J. L., Crouch, P. J., Donnelly, P. S., Kanninen, K. M., Liddell, J. R., Cotman, S. L., de Jonge, M. D. & White, A. R., 7 Apr 2014, In : Chemical Science. 5, 6, p. 2503-2516 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Kanninen, K. M., Grubman, A., Caragounis, A., Duncan, C., Parker, S. J., Lidgerwood, G. E., Volitakis, I., Ganio, G., Crouch, P. J. & White, A. R., 15 Jun 2013, In : Biology Open. 2, 6, p. 635-646 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Copper modulates the large dense core vesicle secretory pathway in PC12 cells

Duncan, C., Bica, L., Crouch, P. J., Caragounis, A., Lidgerwood, G. E., Parker, S. J., Meyerowitz, J., Volitakis, I., Liddell, J. R., Raghupathi, R., Paterson, B. M., Duffield, M. D., Cappai, R., Donnelly, P. S., Grubman, A., Camakaris, J., Keating, D. J. & White, A. R., Jun 2013, In : Metallomics. 5, 6, p. 700-714 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

Kanninen, K. M., Grubman, A., Meyerowitz, J., Duncan, C., Tan, J. L., Parker, S. J., Crouch, P. J., Paterson, B. M., Hickey, J. L., Donnelly, P. S., Volitakis, I., Tammen, I., Palmer, D. N. & White, A. R., 14 Mar 2013, In : PLoS ONE. 8, 3, p. 1-10 10 p., e58644.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Moujalled, D., James, J. L., Parker, S. J., Lidgerwood, G. E., Duncan, C., Meyerowitz, J., Nonaka, T., Hasegawa, M., Kanninen, K. M., Grubman, A., Liddell, J. R., Crouch, P. J. & White, A. R., 26 Jun 2013, In : PLoS ONE. 8, 6, 14 p., e67433.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Nucleotide oligomerization domain 1 enhances IFN-gamma signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity

Allison, C. C., Ferrand, J. F. P., McLeod, L., Hassan, M., Kaparakis-Liaskos, M., Grubman, A., Bhathal, P. S., Dev, A. T., Sievert, W., Jenkins, B. J. & Ferrero, R. L., 2013, In : Journal of Immunology. 190, 7, p. 3706-3715 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

Hare, D. J., Grubman, A., Ryan, T. M., Lothian, A., Liddell, J. R., Grimm, R., Matsude, T., Doble, P., Cherny, R. A., Bush, A. I., White, A. R., Masters, C. L. & Roberts, B. R., Dec 2013, In : Metallomics. 5, 12, p. 1656-1662 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides

Grubman, A., Liaskos, M., Viala, J., Allison, C. C., Badea, L., Karrar, A., Boneca, I. G., Le Bourhis, L., Reeve, S. B., Smith, A. I., Hartland, E. L., Philpott, D. J. & Ferrero, R. L., 2010, In : Cellular Microbiology. 12, 5, p. 626-639 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Vitamin B 6 is required for full motility and virulence in Helicobacter pylori

Grubman, A., Phillips, A., Thibonnier, M., Kaparakis-Liaskos, M., Johnson, C., Thiberge, J. -M., Radcliffe, F. J., Ecobichon, C., Labigne, A., de Reuse, H., Mendz, G. L. & Ferrero, R. L., 2010, In : mBio. 1, 3, 9 p., e00112-10.

Research output: Contribution to journalArticleResearchpeer-review