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Research Output 1988 2017

2017
7 Citations (Scopus)

Cytotoxic lymphocytes and atherosclerosis: Significance, mechanisms and therapeutic challenges

Kyaw, T., Peter, K., Li, Y., Tipping, P., Toh, B. H. & Bobik, A., Nov 2017, In : British Journal of Pharmacology. 174, 22, p. 3956–3972 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Killer cells in atherosclerosis

Kyaw, T., Tipping, P., Toh, B-H. & Bobik, A., 5 Dec 2017, In : European Journal of Pharmacology. 816, p. 67-75

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Opposing roles of B lymphocyte subsets in atherosclerosis

Kyaw, T., Tipping, P., Bobik, A. & Toh, B. H., 2 Jan 2017, In : Autoimmunity. 50, 1, p. 52-56 5 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

9 Citations (Scopus)

Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury

Ziegler, M., Wang, X., Lim, B., Leitner, E., Klingberg, F., Ching, V., Yao, Y., Huang, D., Gao, X. M., Kiriazis, H., Du, X. J., Haigh, J. J., Bobik, A., Hagemeyer, C. E., Ahrens, I. & Peter, K., 2017, In : Theranostics. 7, 13, p. 3192-3206 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
19 Citations (Scopus)

A CD1d-dependent lipid antagonist to NKT cells ameliorates atherosclerosis in ApoE-/- mice by reducing lesion necrosis and inflammation

Li, Y., Kanellakis, P., Hosseini, H., Cao, A., Deswaerte, V., Tipping, P., Toh, B. H., Bobik, A. & Kyaw, T., 1 Feb 2016, In : Cardiovascular Research. 109, 2, p. 305-317 13 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Atherosclerotic Plaque Rupture: Identifying the Straw That Breaks the Camel?s Back

Chen, Y. C., Huang, A. L., Kyaw, T. S., Bobik, A. & Peter, K., 1 Aug 2016, In : Arteriosclerosis, Thrombosis and Vascular Biology. 36, 8, p. e63-e72

Research output: Contribution to journalArticleOtherpeer-review

24 Citations (Scopus)

B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation

Tay, C., Liu, Y. H., Hosseini, H., Kanellakis, P., Cao, A., Peter, K., Tipping, P., Bobik, A., Toh, B. H. & Kyaw, T., 1 Sep 2016, In : Cardiovascular Research. 111, 4, p. 385-397 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Foxp3+CD4+ Regulatory T-Cell Subtypes and Atherosclerosis

Kyaw, T., Toh, B. H. & Bobik, A., 11 Nov 2016, In : Circulation Research. 119, 11, p. 1151-1153 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

16 Citations (Scopus)

Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets

Ziegler, M., Alt, K., Paterson, B. M., Kanellakis, P., Bobik, A., Donnelly, P. S., Hagemeyer, C. E. & Peter, K., 2 Dec 2016, In : Scientific Reports. 6, p. 1-10 10 p., 38161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
17 Citations (Scopus)

Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet

Montes, VN., Subramanian, S., Goodspeed, L., Wang, SA., Omer, M., Bobik, A., Teshigawara, K., Nishibori, M. & Chait, A., 15 Jun 2015, In : Nutrition and Diabetes. 5, 4 p., e161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
98 Citations (Scopus)

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

Kraakman, M. J., Kammoun, H. L., Allen, T. L., Deswaerte, V., Henstridge, D. C., Estevez, E., Matthews, V. B., Neill, B. A., White, D. A., Murphy, A. J., Peijs, L., Yang, C., Risis, S., Bruce, C. R., Du, X-J., Bobik, A., Lee-Young, R. S., Kingwell, B. A., Vasanthakumar, A., Shi, W. & 4 others, Kallies, A., Lancaster, G. I., Rose-John, S. & Febbraio, M. A., 3 Mar 2015, In : Cell Metabolism. 21, 3, p. 403-416 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
28 Citations (Scopus)

CD4+ natural killer T cells potently augment aortic root atherosclerosis by perforin- and granzyme B-dependent cytotoxicity

Li, Y., To, K., Kanellakis, P., Hosseini, H., Deswaerte, V., Tipping, P. G., Smyth, M. J., Toh, B-H., Bobik, A. & Kyaw, T. S., 2015, In : Circulation Research. 116, 2, p. 245 - 254 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

Ahrens, I., Chen, Y-C., Topcic, D., Bode, M., Haenel, D., Hagemeyer, C. E., Seeba, H., Duerschmied, D., Bassler, N., Jandeleit-Dahm, K., Sweet, M. J., Agrotis, A., Bobik, A. & Peter, K., 2015, In : Thrombosis and Haemostasis. 114, 5, p. 994 - 1003 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Obligatory role for B cells in the development of angiotensin II-dependent hypertension

Chan, C. T-L., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. H. A., Krishnan, S. M., Lewis, C. V., Salimova, E., Tipping, P. G., Vinh, A., Samuel, C. S., Peter, K., Guzik, T. J., Kyaw, T. S., Toh, B-H., Bobik, A. & Drummond, G. R., 2015, In : Hypertension. 66, 5, p. 1023 - 1033 11 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Phosphatidylserine liposomes mimic apoptotic cells to attenuate atherosclerosis by expanding polyreactive IgM producing B1a lymphocytes

Hosseini, H., Li, Y., Kanellakis, P., Tay, C., Cao, A., Tipping, P. G., Bobik, A., Toh, B-H. & Kyaw, T. S., 2015, In : Cardiovascular Research. 106, 3, p. 443 - 452 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
15 Citations (Scopus)

Antibodies in the pathogenesis of hypertension

Chan, C., Lieu, M., Toh, B-H., Kyaw, T. S., Bobik, A., Sobey, C. G. & Drummond, G. R., 2014, In : BioMed Research International. 2014, (Art. No: 504045), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Atherosclerosis

Toh, B-H., Kyaw, T. S., Tipping, P. G. & Bobik, A., 2014, The Autoimmune Diseases. Rose, N. R. & Mackay, I. R. (eds.). 5th ed. USA: Elsevier, p. 1049 - 1066 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Immune mechanisms in vascular disease and stroke

Toh, B-H., Bobik, A., Kyaw, T. S., Drummond, G. R., Sobey, C. G. & Guzik, T. J., 2014, In : BioMed Research International. 2014, p. e730691 - e730691 3 p.

Research output: Contribution to journalLetterOther

3 Citations (Scopus)

M1 macrophages, key contributors to lymphoid neogenesis in atherosclerotic aorta

Bobik, A., Kyaw, T. S., Tipping, P. G. & Toh, B-H., 2014, In : Cardiovascular Research. 101, 3, p. 339 - 341 3 p.

Research output: Contribution to journalLetterOther

39 Citations (Scopus)

Natural killer (NK) cells augment atherosclerosis by cytotoxic-dependent mechanisms

Selathurai, A., Deswaerte, V., Kanellakis, P., Tipping, P. G., Toh, B-H., Bobik, A. & Kyaw, T. S., 2014, In : Cardiovascular Research. 102, 1, p. 128 - 137 10 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice

Koulis, C., Chen, Y-C., Hausding, C., Ahrens, I., Kyaw, T. S., Tay, C., Allen, T. J., Jandeleit-Dahm, K. A. M., Sweet, M. J., Akira, S., Bobik, A., Peter, K. & Agrotis, A., 2014, In : Arteriosclerosis, Thrombosis and Vascular Biology. 34, 3, p. 516 - 525 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Raised soluble P-selectin moderately accelerates atherosclerotic plaque progression

Woollard, K. J., Lumsden, N. G., Andrews, K. L., Aprico, A., Harris, E., Irvine, J. C., Jefferis, A., Fang, L., Kanellakis, P., Bobik, A. & Chin-Dusting, J. P. F., 20 May 2014, In : PLoS ONE. 9, 5, 10 p., e97422.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013
88 Citations (Scopus)

A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Chen, Y-C., Bui, A. V., Diesch, J., Manasseh, R., Hausding, C., Rivera, J., Haviv, I., Agrotis, A., Htun, N. M., Jowett, J. B. M., Hagemeyer, C. E., Hannan, R. D., Bobik, A. & Peter, K., 2013, In : Circulation Research. 113, 3, p. 252 - 265 14 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE{-/-} mice

Kyaw, T. S., Cui, P., Tay, C., Kanellakis, P., Hosseini, H., Liu, E., Rolink, A. G., Tipping, P. G., Bobik, A. & Toh, B-H., 2013, In : PLoS ONE. 8, 4 (Art. ID: e60430), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
109 Citations (Scopus)

Cytotoxic and proinflammatory CD8+ T lymphocytes promote development of vulnerable atherosclerotic plaques in ApoE-deficient mice

Kyaw, T., Winship, A., Tay, C., Kanellakis, P., Hosseini, H., Cao, A., Li, P., Tipping, P., Bobik, A. & Toh, B-H., 5 Mar 2013, In : Circulation. 127, 9, p. 1028 - 1039 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Immune regulation by CD52-expressing CD4 T cells

Toh, B-H., Kyaw, T. S., Tipping, P. G. & Bobik, A., 2013, In : Cellular & Molecular Immunology. 10, 5, p. 379 - 382 4 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2012
41 Citations (Scopus)

A pro-fibrotic role for interleukin-4 in cardiac pressure overload

Kanellakis, P., Ditiatkovski, M., Kostolias, G. & Bobik, A., 1 Jul 2012, In : Cardiovascular Research. 95, 1, p. 77-85 9 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis

Dinh, T. N., Kyaw, T. S., Kanellakis, P., To, K. Y-Y., Tipping, P. G., Toh, B-H., Bobik, A. & Agrotis, A., 2012, In : Circulation. 126, 10, p. 1256 - 1266 11 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE-/- mice attenuates atherosclerosis by potently ameliorating arterial inflammation

Kyaw, T. S., Tay, C., Hosseini, H., Kanellakis, P., Gadowski, T., Mackay-Fisson, F., Tipping, P. G., Bobik, A. & Toh, B-H., 2012, In : PLoS ONE. 7, 1, 10 p., e29371.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration

Kapustin, A., Stepanova, V., Aniol, N., Cines, D. B., Poliakov, A., Yarovoi, S., Lebedeva, T., Wait, R., Ryzhakov, G., Parfyonova, Y., Gursky, Y., Yanagisawa, H., Minashkin, M., Beabealashvilli, R., Vorotnikov, A., Bobik, A. & Tkachuk, V., 15 Apr 2012, In : Biochemical Journal. 443, 2, p. 491-503 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

HMGB1 signals danger in acute coronary syndrome: Emergence of a new risk marker for cardiovascular death?

Peter, K. & Bobik, A., Apr 2012, In : Atherosclerosis. 221, 2, p. 317-318 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

34 Citations (Scopus)

Inert 50-nm polystyrene nanoparticles that modify pulmonary dendritic cell function and inhibit allergic airway inflammation

Hardy, C., LeMasurier, J., Belz, G., Scalzo-Inguanti, K., Yao, J. J., Xiang, S., Kanellakis, P., Bobik, A., Strickland, D. H., Rolland, J., O'Hehir, R. & Plebanski, M., 2012, In : Journal of Immunology. 188, 3, p. 1431 - 1441 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Low-grade inflammation and arterial stiffness in the elderly

Bobik, A. & Grassi, G., Apr 2012, In : Journal of Hypertension. 30, 4, p. 679-681 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

38 Citations (Scopus)

Protective role of natural IgM-producing B1a cells in atherosclerosis

Kyaw, T. S., Tipping, P. G., Bobik, A. & Toh, B-H., 2012, In : Trends in Cardiovascular Medicine. 22, 2, p. 48 - 53 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Striatin-dependent membrane estrogen receptor signaling and vasoprotection by estrogens

Bobik, A., 16 Oct 2012, In : Circulation. 126, 16, p. 1941-1943 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

2011
179 Citations (Scopus)

B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions

Kyaw, T., Tay, C., Krishnamurthi, S., Kanellakis, P., Agrotis, A., Tipping, P., Bobik, A. & Toh, B-H., 2011, In : Circulation Research. 109, 8, p. 830 - 840 11 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

CD4{+}CD25{+}Foxp3{+} regulatory T cells suppress cardiac fibrosis in the hypertensive heart

Kanellakis, P., Dinh, T. N., Agrotis, A. & Bobik, A., 2011, In : Journal of Hypertension. 29, 9, p. 1820 - 1828 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis

Little, P. J., Chait, A. & Bobik, A., Sep 2011, In : Pharmacology and Therapeutics. 131, 3, p. 255-268 14 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

40 Citations (Scopus)

Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis

Kyaw, T., Tipping, P., Toh, B-H. & Bobik, A., 2011, In : Current Opinion in Lipidology. 22, 5, p. 373 - 379 7 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

Kowalski, G. M., Nicholls, H. T., Risis, S., Watson, N. K., Kanellakis, P., Bruce, C. R., Bobik, A., Lancaster, G. I. & Febbraio, M. A., 2011, In : Diabetologia. 54, 4, p. 888 - 899 12 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: A predominant role of anti-inflammation

Gao, X-M., Liu, Y., White, D., Su, Y-D., Drew, B., Bruce, C., Kiriazis, H., Xu, Q., Jennings, N., Bobik, A., Febbraio, M., Kingwell, B., Bucala, R., Fingerle-Rowson, G., Dart, A. M., Morand, E. & Du, X-J., 2011, In : Journal of Molecular and Cellular Cardiology. 50, 6, p. 991 - 999 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue

Nicholls, H. T., Kowalski, G., Kennedy, D. J., Risis, S., Zaffino, L. A., Watson, N., Kanellakis, P., Watt, M., Bobik, A., Bonen, A., Febbraio, M., Lancaster, G. I. & Febbraio, M. A., 2011, In : Diabetes. 60, 4, p. 1100 - 1110 11 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

High-Mobility Group Box Protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein E-deficient mice

Kanellakis, P., Agrotis, A., Kyaw, T. S., Koulis, C., Ahrens, I., Mori, S., Takahashi, H. K., Liu, K., Peter, K., Nishibori, M. & Bobik, A., Feb 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 2, p. 313-319 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Response to comment on "conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis"

Kyaw, T., Tay, C., Dumouchel, V., Cao, A., Tipping, P., Bobik, A. & Toh, B. H., 1 Jan 2011, In : Journal of Immunology. 186, 1, p. 4-5 2 p.

Research output: Contribution to journalLetterOtherpeer-review

2010
2 Citations (Scopus)

Circulating microparticles. Markers or participants in carotid artery remodelling?

Bobik, A., Apr 2010, In : Journal of Hypertension. 28, 4, p. 673-675 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

174 Citations (Scopus)

Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis

Kyaw, T., Tay, C., Khan, A., Dumouchel, V., Cao, A., To, K., Kehry, M., Dunn, R., Agrotis, A., Tipping, P., Bobik, A. & Toh, B-H., 2010, In : Journal of Immunology. 185, 7, p. 4410 - 4419 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common Ibeta-chain heteroreceptor

Kanellakis, P., Pomilio, G., Agrotis, A., Gao, X., Du, X-J., Curtis, D. J. & Bobik, A., 2010, In : British Journal of Pharmacology. 160, 8, p. 2085 - 2096 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
14 Citations (Scopus)

A novel antioxidant 3,7-dihydroxy-isoflav-3-ene (DHIF) inhibits neointimal hyperplasia after vessel injury attenuating reactive oxygen species and nuclear factor-κB signaling

Kanellakis, P., Pomilio, G., Walker, C., Husband, A. J., Huang, J. L., Nestel, P. J., Agrotis, A. & Bobik, A., May 2009, In : Atherosclerosis. 204, 1, p. 66-72 7 p.

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques

Eisenhardt, S. U., Habersberger, J., Murphy, A., Chen, Y-C., Woollard, K. J., Bassler, N., Qian, H., von zur Muhlen, C., Hagemeyer, C. E., Ahrens, I., Chin-Dusting, J., Bobik, A. & Peter, K., 17 Jul 2009, In : Circulation Research. 105, 2, p. 128-137 10 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

NKT cell subsets mediate differential proatherogenic effects in ApoE -/- mice

To, K. Y-Y., Agrotis, A., Besra, G. S., Bobik, A. & Toh, B-H., 2009, In : Arteriosclerosis, Thrombosis and Vascular Biology. 29, 5, p. 671 - 677 7 p.

Research output: Contribution to journalArticleResearchpeer-review