20032023
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Personal profile

Biography

The human brain is an extraordinarily complex network comprised of billions of nerve cells interconnected by trillions of axonal fibers. Interactions unfolding within this intricate web of connectivity form the basis of all our thoughts, emotions and behavior, and their derailment can lead to mental illnesses such as schizophrenia, depression and obsessive-compulsive disorder. Accordingly, generating an accurate and comprehensive wiring diagram for the brain-the so-called human connectome-has become a major goal in neuroscience, comparable in scale to the Human Genome Project.

Magnetic resonance imaging (MRI) has emerged as an important tool in these efforts because it provides a unique window into large-scale brain structure and function in living humans. My research concentrates on developing new MRI techniques for mapping human brain connectivity and applying these methods to understand brain function in health and disease. Key emphases involve uncovering major principles of brain organization; understanding their genetic basis; characterizing brain connectivity disturbances in psychiatric disorders such as schizophrenia; and mapping how brain networks dynamically reconfigure themselves in response to changing task demands.

 

 

To achieve these goals, my team at the Brain and Mental Health Lab uses techniques from a range of disciplines, spanning complex network science, mathematics, psychology and psychiatry, neuroscience and genetics. A major focus is on the application of graph theoretic methods to MRI data, particularly functional and diffusion MRI, and its integration with behavioral and clinical information. By leveraging this multi-disciplinary approach, we hope to generate novel insights into the inner workings of the brain and how its dysfunction gives rise to mental illness.

 

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Keywords

  • magnetic resonance imaging (MRI)
  • connectome
  • schizophrenia
  • neuroimaging
  • networks

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2023

Research Output 2003 2019

A Neuroethics Framework for the Australian Brain Initiative

Fornito, A. & Australian Brain Alliance, 6 Feb 2019, In : Neuron. 101, 3, p. 365-369 5 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

A practical guide to linking brain-wide gene expression and neuroimaging data

Arnatkevic̆iūtė, A., Fulcher, B. D. & Fornito, A., 1 Apr 2019, In : NeuroImage. 189, p. 353-367 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Bridging the Gap between Connectome and Transcriptome

Fornito, A., Arnatkevičiūtė, A. & Fulcher, B. D., 1 Jan 2019, In : Trends in Cognitive Sciences. 23, 1, p. 34-50 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Functional connectivity of corticostriatal circuitry and psychosis-like experiences in the general community

Sabaroedin, K., Tiego, J., Parkes, L., Sforazzini, F., Finlay, A., Johnson, B., Pinar, A., Cropley, V., Harrison, B. J., Zalesky, A., Pantelis, C., Bellgrove, M. & Fornito, A., 21 Feb 2019, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticleResearchpeer-review

Neurodevelopmental correlates of the emerging adult self

Davey, C. G., Fornito, A., Pujol, J., Breakspear, M., Schmaal, L. & Harrison, B. J., Apr 2019, In : Developmental Cognitive Neuroscience. 36, 7 p., 100626.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Prizes

AW Campbell Young Scientist Award

Alex Fornito (Recipient), 2013

Prize: Prize (including medals and awards)

Club Melbourne Fellowship Finalist

Alex Fornito (Recipient), 2016

Prize: National/international honour

Dena's Honours List

Alex Fornito (Recipient), 1999

Prize: National/international honour

Dwight Final Examination Prize

Alex Fornito (Recipient), 2002

Prize: Prize (including medals and awards)

Lundbeck Institute Early Career Researcher Award

Alex Fornito (Recipient), 2011

Prize: Prize (including medals and awards)