Projects per year
Personal profile
Biography
I did my Ph.D. at EMBL in Heidelberg, where I focused on the development of cryo-Electron Tomography and Subtomogram Averaging to allow large-scale structural studies on heterogeneous and pleomorphic samples. I then applied this technique to analyze different stages of the replication cycle in HIV-1.
Immediately after my Ph.D., I joined FEI Company (now ThermoFisher Scientific) where I have been responsible for the development of hardware and software solutions for Correlative Light and Electron Microscopy (CLEM).
Currently, I am working as A/Professor at Monash University. Here the main focus of my research is on the development of new methods (and associated hardware/software) to perform molecular resolution imaging in biological samples.
Research interests
The goal of my research is to allow structural biology on proteins directly in their native environment: the cell. In order to succeed, I combine a variety of imaging techniques: from super-resolution light microscopy to cryo-Electron Tomography; together with cutting-edge microfluidics.
Currently, the core of the lab is the "world-first" multigas plasma Focused Ion Beam. This unique instrument is capable of highly efficient direct lithography on a variety of materials, including cryo-preserved biological tissue.
The lab is currently composed of a mixture of biologists, physicists and engineers, therefore, the interests span from developing new methods, all the way to designing and prototyping microlenses.
For more information about the research activities and open position visit our Lab webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Associate Professor, University of Warwick
1 Oct 2015 → …
Research area keywords
- Electron Microscopy
- Image Processing
- Image analysis
- Microfluidics
- Microscopy
- Structural Biology
- Technology development
- Nanotechnology
Network
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Developing new immunotherapeutics through studying immune effectors in situ
Law, R., Dunstone, M., de Marco, A. & Morgan, B.
1/01/21 → 31/12/23
Project: Research
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Developing high throughput single cell proteomics
de Marco, A., Neild, A. & Schittenhelm, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/21 → 31/12/24
Project: Research
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Time-resolving the mechanism of exocytosis in situ
Gallego, O., de Marco, A. & Castano-Diez, D.
Human Frontier Science Program
1/11/20 → 31/10/23
Project: Research
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Anisotropic epitaxial stabilization of a low-symmetry ferroelectric with enhanced electromechanical response
Paull, O., Xu, C., Cheng, X., Zhang, Y., Xu, B., Kelley, K. P., de Marco, A., Vasudevan, R. K., Bellaiche, L., Nagarajan, V. & Sando, D., Jan 2022, In: Nature Materials. 21, 1, p. 74–80 8 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
New Insights Into Sperm Ultrastructure Through Enhanced Scanning Electron Microscopy
Korneev, D., Merriner, D. J., Gervinskas, G., de Marco, A. & O’Bryan, M. K., 22 Apr 2021, In: Frontiers in Cell and Developmental Biology. 9, 13 p., 672592.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy
Vargas-Ordaz, E. J., Gorelick, S., York, H. M., Liu, B., Halls, M. L., Arumugam, S., Neild, A., de Marco, A. & Cadarso, V. J., 3 Jun 2021, In: Lab on a Chip. 21, 15, p. 2945-2954 10 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Ultradeep microaxicons in lithium niobate by focused Xe ion beam milling
Gorelick, S. & De Marco, A., Sep 2021, In: Journal of Vacuum Science and Technology Part B: Nanotechnology and Microelectronics. 39, 5, 6 p., 052602.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Automated cryo-lamella preparation for high-throughput in-situ structural biology
Buckley, G., Gervinskas, G., Taveneau, C., Venugopal, H., Whisstock, J. C. & de Marco, A., 1 May 2020, In: Journal of Structural Biology. 210, 2, 8 p., 107488.Research output: Contribution to journal › Article › Research › peer-review
24 Citations (Scopus)