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Personal profile

Biography

I did my Ph.D. at EMBL in Heidelberg, where I focused on the development of cryo-Electron Tomography and Subtomogram Averaging to allow large-scale structural studies on heterogeneous and pleomorphic samples. I then applied this technique to analyze different stages of the replication cycle in HIV-1.

Immediately after my Ph.D., I joined FEI Company (now ThermoFisher Scientific) where I have been responsible for the development of hardware and software solutions for Correlative Light and Electron Microscopy (CLEM).

Currently, I am working as A/Professor at Monash University. Here the main focus of my research is on the development of new methods (and associated hardware/software) to perform molecular resolution imaging in biological samples.

 

Research interests

The goal of my research is to allow structural biology on proteins directly in their native environment: the cell. In order to succeed, I combine a variety of imaging techniques: from super-resolution light microscopy to cryo-Electron Tomography; together with cutting-edge microfluidics.

Currently, the core of the lab is the "world-first" multigas plasma Focused Ion Beam. This unique instrument is capable of highly efficient direct lithography on a variety of materials, including cryo-preserved biological tissue. 

The lab is currently composed of a mixture of biologists, physicists and engineers, therefore, the interests span from developing new methods, all the way to designing and prototyping microlenses. 

 

For more information about the research activities and open position visit our Lab webpage

www.demarco-lab.com

 

External positions

Honorary Associate Professor, University of Warwick

1 Oct 2015 → …

Research area keywords

  • Electron Microscopy
  • Image Processing
  • Image analysis
  • Microfluidics
  • Microscopy
  • Structural Biology
  • Technology development
  • Nanotechnology

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2018 2018

Automated high resolution and high contrast cryo-TEM for 3D structural biology

Kobe, B., Wepf, R., Parton, R. G., Hankamer, B. D., Landsberg, M. J., Martin, J., Itzstein, M. V., Jennings, M. P., Richard, D., Harris, J. M., Perrin, D., De Marco, R., Macdonald, J. & de Marco, A.

Monash University – Internal School Contribution, Monash University – Internal Faculty Contribution

29/03/1831/12/18

Project: Other

Research Output 2008 2019

Hybrid refractive-diffractive microlenses in glass by focused Xe ion beam

Gorelick, S. & de Marco, A., 1 Sep 2019, In : Journal of Vacuum Science and Technology B: Nanotechnology and Microelectronics. 37, 5, 5 p., 051601.

Research output: Contribution to journalArticleResearchpeer-review

Nanofluidic and monolithic environmental cells for cryogenic microscopy

Gorelick, S., Alan, T., Sadek, A. Z., Tjeung, R. T. & de Marco, A., 22 Feb 2019, In : Nanotechnology. 30, 8, 8 p., 085301.

Research output: Contribution to journalArticleResearchpeer-review

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

Gorelick, S., Buckley, G., Gervinskas, G., Johnson, T. K., Handley, A., Caggiano, M. P., Whisstock, J. C., Pocock, R. & de Marco, A., 1 Jul 2019, In : eLife. 8, 15 p., e45919.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Tailoring surface acoustic wave atomisation for cryo-electron microscopy sample preparation

Ashtiani, D., De Marco, A. & Neild, A., 1 Jan 2019, In : Lab on a Chip. 19, 8, p. 1378-1385 8 p.

Research output: Contribution to journalArticleResearchpeer-review