Projects per year
Personal profile
Biography
I did my Ph.D. at EMBL in Heidelberg, where I focused on the development of cryo-Electron Tomography and Subtomogram Averaging to allow large-scale structural studies on heterogeneous and pleomorphic samples. I then applied this technique to analyze different stages of the replication cycle in HIV-1.
Immediately after my Ph.D., I joined FEI Company (now ThermoFisher Scientific) where I have been responsible for the development of hardware and software solutions for Correlative Light and Electron Microscopy (CLEM).
Currently, I am working as A/Professor at Monash University. Here the main focus of my research is on the development of new methods (and associated hardware/software) to perform molecular resolution imaging in biological samples.
Research interests
The goal of my research is to allow structural biology on proteins directly in their native environment: the cell. In order to succeed, I combine a variety of imaging techniques: from super-resolution light microscopy to cryo-Electron Tomography; together with cutting-edge microfluidics.
Currently, the core of the lab is the "world-first" multigas plasma Focused Ion Beam. This unique instrument is capable of highly efficient direct lithography on a variety of materials, including cryo-preserved biological tissue.
The lab is currently composed of a mixture of biologists, physicists and engineers, therefore, the interests span from developing new methods, all the way to designing and prototyping microlenses.
For more information about the research activities and open position visit our Lab webpage
External positions
Honorary Associate Professor, University of Warwick
1 Oct 2015 → …Research area keywords
- Electron Microscopy
- Image Processing
- Image analysis
- Microfluidics
- Microscopy
- Structural Biology
- Technology development
- Nanotechnology
Network
Projects
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Developing high throughput single cell proteomics
de Marco, A., Neild, A. & Schittenhelm, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/21 → 31/12/24
Project: Research
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Developing new immunotherapeutics through studying immune effectors in situ
Law, R., Dunstone, M., de Marco, A. & Morgan, B.
1/01/21 → 31/12/23
Project: Research
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Time-resolving the mechanism of exocytosis in situ
Gallego, O., de Marco, A. & Castano-Diez, D.
Human Frontiers Science Program
1/11/20 → 31/10/23
Project: Research
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Automated high resolution and high contrast cryo-TEM for 3D structural biology
Kobe, B., Wepf, R., Parton, R. G., Hankamer, B. D., Landsberg, M. J., Martin, J. L., Itzstein, M. V., Jennings, M. P., Richard, D., Harris, J. M., Perrin, D., De Marco, R., Macdonald, J. & de Marco, A.
Monash University – Internal School Contribution, Monash University – Internal Faculty Contribution
29/03/18 → 31/12/18
Project: Other
Research Output
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Automated cryo-lamella preparation for high-throughput in-situ structural biology
Buckley, G., Gervinskas, G., Taveneau, C., Venugopal, H., Whisstock, J. C. & de Marco, A., 1 May 2020, In : Journal of Structural Biology. 210, 2, 8 p., 107488.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Axilenses: Refractive micro-optical elements with arbitrary exponential profiles
Gorelick, S., Paganin, D. M. & De Marco, A., 21 Oct 2020, In : APL Photonics. 5, 10, 7 p., 106110.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Capacitive sensing for monitoring of microfluidic protocols using nanoliter dispensing and acoustic mixing
Zhang, Y., Sesen, M., De Marco, A. & Neild, A., 4 Aug 2020, In : Analytical Chemistry. 92, 15, p. 10725-10732 8 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Cylindrical microlenses in lithium niobate with non-parabolic surface profiles
Gorelick, S. & De Marco, A., 2020. 8 p.Research output: Contribution to conference › Poster
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Hybrid refractive-diffractive axicons for Bessel-beam multiplexing and resolution improvement
Gorelick, S., Paganin, D. M., Korneev, D. & de Marco, A., 13 Apr 2020, In : Optics Express. 28, 8, p. 12174-12188 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile2 Citations (Scopus)