20112019
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Research Output 2011 2019

2019

Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore

Sun, Y., Kakinen, A., Zhang, C., Yang, Y., Faridi, A., Davis, T. P., Cao, W., Ke, P. C. & Ding, F., 28 Jun 2019, In : Nanoscale. 11, 24, p. 11933-11945 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, α-Helix to β-Sheet Transition, and Formation of β-Barrel Intermediates

Sun, Y., Kakinen, A., Xing, Y., Faridi, P., Nandakumar, A., Purcell, A. W., Davis, T. P., Ke, P. C. & Ding, F., May 2019, In : Small. 15, 18, 10 p., 1805166.

Research output: Contribution to journalArticleResearchpeer-review

Mitigation of Amyloidosis with Nanomaterials

Ke, P. C., Pilkington, E. H., Sun, Y., Javed, I., Kakinen, A., Peng, G., Ding, F. & Davis, T. P., 11 Jun 2019, (Accepted/In press) In : Advanced Materials. 7 p., 1901690.

Research output: Contribution to journalReview ArticleResearchpeer-review

Nucleation of β-rich oligomers and β-barrels in the early aggregation of human islet amyloid polypeptide

Sun, Y., Kakinen, A., Xing, Y., Pilkington, E. H., Davis, T. P., Ke, P. C. & Ding, F., 1 Feb 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 2, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Physical and toxicological profiles of human IAPP amyloids and plaques

Kakinen, A., Sun, Y., Javed, I., Faridi, A., Pilkington, E. H., Faridi, P., Purcell, A. W., Zhou, R., Ding, F., Lin, S., Ke, P. C. & Davis, T. P., 15 Jan 2019, In : Science Bulletin. 64, 1, p. 26-35 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the Aggregation and Immune Response of Human Islet Amyloid Polypeptides with Ligand-Stabilized Gold Nanoparticles

Javed, I., He, J., Kakinen, A., Faridi, A., Yang, W., Davis, T. P., Ke, P. C. & Chen, P., 20 Mar 2019, In : ACS Applied Materials and Interfaces. 11, 11, 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide

Kakinen, A., Xing, Y., Hegoda Arachchi, N., Javed, I., Feng, L., Faridi, A., Douek, A. M., Sun, Y., Kaslin, J., Davis, T. P., Higgins, M. J., Ding, F. & Ke, P. C., 11 Sep 2019, In : Nano Letters. 19, 9, p. 6535-6546 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Graphene quantum dots against human IAPP aggregation and toxicity in vivo

Wang, M., Sun, Y., Cao, X., Peng, G., Javed, I., Kakinen, A., Davis, T. P., Lin, S., Liu, J., Ding, F. & Ke, P. C., 14 Nov 2018, In : Nanoscale. 10, 42, p. 19995-20006 12 p.

Research output: Contribution to journalArticleResearchpeer-review

In Vivo Mitigation of Amyloidogenesis through Functional-Pathogenic Double-Protein Coronae

Javed, I., Yu, T., Peng, G., Sánchez-Ferrer, A., Faridi, A., Kakinen, A., Zhao, M., Mezzenga, R., Davis, T. P., Lin, S. & Ke, P. C., 12 Sep 2018, In : Nano Letters. 18, 9, p. 5797-5804 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

Faridi, A., Sun, Y., Okazaki, Y., Peng, G., Gao, J., Kakinen, A., Faridi, P., Zhao, M., Javed, I., Purcell, A. W., Davis, T. P., Lin, S., Oda, R., Ding, F. & Ke, P. C., 22 Nov 2018, In : Small. 14, 47, 13 p., 1802825.

Research output: Contribution to journalArticleResearchpeer-review

Nanoparticle-Proteome In Vitro and In Vivo

Wang, M., Gustafsson, O. J. R., Pilkington, E. H., Kakinen, A., Javed, I., Faridi, A., Davis, T. P. & Ke, P. C., 1 Jan 2018, In : Journal of Materials Chemistry B. 6, 38, p. 6026-6041 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules

Kakinen, A., Adamcik, J., Wang, B., Ge, X., Mezzenga, R., Davis, T. P., Ding, F. & Ke, P. C., Jul 2018, In : Nano Research. 11, 7, p. 3636-3647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide

Pilkington, E. H., Gustafsson, O. J. R., Xing, Y., Hernandez-Fernaud, J., Zampronio, C., Kakinen, A., Faridi, A., Ding, F., Wilson, P., Ke, P. C. & Davis, T. P., 26 Jun 2018, In : ACS Nano. 12, 6, p. 6066-6078 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein

Kakinen, A., Javed, I., Faridi, A., Davis, T. P. & Ke, P. C., Sep 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 9, p. 1803-1809 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an: In vitro blood brain barrier model

Ivask, A., Pilkington, E. H., Blin, T., Käkinen, A., Vija, H., Visnapuu, M., Quinn, J. F., Whittaker, M. R., Qiao, R., Davis, T. P., Ke, P. C. & Voelcker, N. H., 1 Feb 2018, In : Biomaterials Science. 6, 2, p. 314-323 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Brushed Polyethylene Glycol and Phosphorylcholine as Promising Grafting Agents against Protein Binding

Wang, B., Blin, T., Kakinen, A., Ge, X., Pilkington, E. H., Quinn, J., Whittaker, M. R., Davis, T. P., Ke, P. C. & Ding, F., 3 Feb 2017, In : Biophysical Journal. 112, 3

Research output: Contribution to journalLetterOtherpeer-review

Cofibrillization of Pathogenic and Functional Amyloid Proteins with Gold Nanoparticles against Amyloidogenesis

Javed, I., Sun, Y., Adamcik, J., Wang, B., Kakinen, A., Pilkington, E. H., Ding, F., Mezzenga, R., Davis, T. P. & Ke, P. C., 11 Dec 2017, In : Biomacromolecules. 18, 12, p. 4316-4322 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation

Wang, M., Kakinen, A., Pilkington, E. H., Davis, T. P. & Ke, P-C., 1 Mar 2017, In : Biomaterials Science. 5, 3, p. 485-493 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of protein corona on IAPP amyloid aggregation, fibril remodelling, and cytotoxicity

Pilkington, E. H., Xing, Y., Wang, B., Kakinen, A., Wang, M., Davis, T. P., Ding, F. & Ke, P-C., 1 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 2455.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Implications of peptide assemblies in amyloid diseases

Ke, P. C., Sani, M. A., Ding, F., Kakinen, A., Javed, I., Separovic, F., Davis, T. P. & Mezzenga, R., 7 Nov 2017, In : Chemical Society Reviews. 46, 21, p. 6492-6531 40 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide

Xing, Y., Pilkington, E. H., Wang, M., Nowell, C. J., Kakinen, A., Sun, Y., Wang, B., Davis, T. P., Ding, F. & Ke, P. C., 7 Dec 2017, In : Physical Chemistry Chemical Physics. 19, 45, p. 30627-30635 9 p.

Research output: Contribution to journalArticleResearchpeer-review

NanoEHS beyond toxicity-focusing on biocorona

Lin, S., Mortimer, M., Chen, R., Kakinen, A., Riviere, J. E., Davis, T. P., Ding, F. & Ke, P-C., 2017, In : Environmental Science: Nano. 4, 7, p. 1433-1454 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles

Wang, M., Siddiqui, G., Gustafsson, O. J. R., Käkinen, A., Javed, I., Voelcker, N. H., Creek, D. J., Ke, P. C. & Davis, T. P., 27 Sep 2017, In : Small. 13, 36, 1701528.

Research output: Contribution to journalArticleResearchpeer-review

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation

Pilkington, E. H., Lai, M., Ge, X., Stanley, W. J., Wang, B., Wang, M., Kakinen, A., Sani, M-A., Whittaker, M. R., Gurzov, E. N., Ding, F., Quinn, J., Davis, T. P. & Ke, P. C., 11 Dec 2017, In : Biomacromolecules. 18, 12, p. 4249-4260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Zinc-coordination and C-peptide complexation: A potential mechanism for the endogenous inhibition of IAPP aggregation

Ge, X., Kakinen, A., Gurzov, E. N., Yang, W., Pang, L., Pilkington, E. H., Nedumpully-Govindan, P., Chen, P., Separovic, F., Davis, T. P., Ke, P. C. & Ding, F., 2017, In : Chemical Communications. 53, 68, p. 9394-9397 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

An interlaboratory comparison of nanosilver characterisation and hazard identification: harmonising techniques for high quality data

Jemec, A., Kahru, A., Potthoff, A., Drobne, D., Heinlaan, M., Bohme, S., Geppert, M., Novak, S., Schirmer, K., Rekulapally, R., Singh, S., Aruoja, V., Sihtmae, M., Juganson, K., Kakinen, A. & Kuhnel, D., 2016, In : Environmental International. 87, p. 20 - 32 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

Wang, B., Blin, T., Kakinen, A., Ge, X., Pilkington, E. H., Quinn, J. F., Whittaker, M. R., Davis, T. P., Ke, P. C. & Ding, F., 7 Dec 2016, In : Polymer Chemistry. 7, 45, p. 6875-6879 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of hIAPP amyloid aggregation and pancreatic β-cell toxicity by OH-terminated PAMAM dendrimer

Gurzov, E., Wang, B., Pilkington, E. H., Chen, P., Kakinen, A., Stanley, W. J., Litwak, S. A., Hanssen, E. G., Davis, T. P., Ding, F. & Ke, P. C., 23 Mar 2016, In : Small. 12, 12, p. 1615-1626 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pancreatic β-cell membrane fluidity and toxicity induced by human islet amyloid polypeptide species

Pilkington, E. H., Gurzov, E., Kakinen, A., Litwak, S. A., Stanley, W. J., Davis, T. P. & Ke, P. C., 2016, In : Scientific Reports. 6, p. 1-10 10 p., 21274.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Solubility-driven toxicity of CuO nanoparticles to Caco2 cells and Escherichia coli: Effect of sonication energy and test environment

Käkinen, A., Kahru, A., Nurmsoo, H., Kubo, A. L. & Bondarenko, O. M., 1 Oct 2016, In : Toxicology in Vitro. 36, p. 172-179 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Stabilizing off-pathway oligomers by polyphenol nanoassemblies for IAPP aggregation inhibition

Nedumpully-Govindan, P., Kakinen, A., Pilkington, E. H., Davis, T. P., Ke, P. C. & Ding, F., 2016, In : Scientific Reports. 6, p. 1-12 12 p., 19463.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Synthesis and in vitro properties of iron oxide nanoparticles grafted with brushed phosphorylcholine and polyethylene glycol

Blin, T., Kakinen, A., Pilkington, E. H., Ivask, A., Ding, F., Quinn, J., Whittaker, M. R., Ke, P. C. & Davis, T. P., 2016, In : Polymer Chemistry. 7, 10, p. 1931-1944 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Toxicity of 11 metal oxide nanoparticles to three mammalian cell types in vitro

Ivask, A., Titma, T., Visnapuu, M., Vija, H., Kakinen, A., Sihtmae, M., Pokhrel, S., Madler, L., Heinlaan, M., Kisand, V., Shimmo, R. & Kahru, A., 2015, In : Environmental International. 15, 18, p. 1914 - 1929 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Selective performance of sol-gel synthesised titanium dioxide photocatalysts in aqueous oxidation of various type organic pollutants

Klauson, D., Budarnaja, O., Stepanova, K., Krichevskaya, M., Dedova, T., Kakinen, A. & Preise, S., 2014, In : Kinetics and Catalysis. 55, 1, p. 47 - 55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Size-dependent toxicity of silver nanoparticles to bacteria, yeast, algae, crustaceans and mammalian cells in vitro

Ivask, A., Kurvet, I., Kasemets, K., Blinova, I., Aruoja, V., Suppi, S., Vija, H., Kakinen, A., Titma, T., Heinlaan, M., Visnapuu, M., Koller, D., Kisand, V. & Kahru, A., 2014, In : PLoS ONE. 9, 7, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013

Aqueous photocatalytic oxidation of prednisolone

Klauson, D., Pilnik-Sudareva, J., Pronina, N., Budarnaja, O., Krichevskaya, M., Kakinen, A., Juganson, K. & Preise, S., 2013, In : Central European Journal of Chemistry. 11, 10, p. 1620 - 1633 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Competitive binding of natural amphiphiles with graphene derivatives

Radic, S., Geitner, N. K., Podila, R., Kakinen, A., Chen, P., Ke, P. C. & Ding, F., 24 Jul 2013, In : Scientific Reports. 3, 8 p., 2273.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Erratum to Toxicity of two types of silver nanoparticles to aquatic crustaceans Daphnia magna and Thamnocephalus platyurus (Environ Sci Pollut Res, 10.1007/s11356-012-1290-5)

Blinova, I., Niskanen, J., Kajankari, P., Kanarbik, L., Käkinen, A., Tenhu, H., Penttinen, O-P. & Kahru, A., Jun 2013, In : Environmental Science and Pollution Research. 20, 6, p. 4293-4293 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Interaction of firefly luciferase and silver nanoparticles and its impact on enzyme activity

Kakinen, A., Ding, F., Chen, P., Mortimer, M., Kahru, A. & Ke, P. C., 2013, In : Nanotechnology. 24, 34, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Particle-cell contact enhances antibacterial activity of silver nanoparticles

Bondarenko, O., Ivask, A., Kakinen, A., Kurvet, I. & Kahru, A., 2013, In : PLoS ONE. 8, 5, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Toxicity of two types of silver nanoparticles to aquatic crustaceans Daphnia magna and Thamnocephalus platyurus

Blinova, I., Niskanen, J., Kajankari, P., Kanarbik, L., Kakinen, A., Tenhu, H., Penttinen, O-P. & Kahru, A., 2013, In : Environmental Science and Pollution Research. 20, 5, p. 3456 - 3463 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Environmental hazard of oil shale combustion fly ash

Blinova, I., Bityukova, L., Kasemets, K., Ivask, A., Kakinen, A., Kurvet, I., Bondarenko, O., Kanarbik, L., Sihtmae, M., Aruoja, V., Schvede, H. & Kahru, A., 2012, In : Journal of Hazardous Materials. 229-230, p. 192 - 200 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Sub-toxic effects of CuO nanoparticles on bacteria: kinetics, role of Cu ions and possible mechanisms of action

Bondarenko, O., Ivask, A., Kakinen, A. & Kahru, A., 2012, In : Environmental Pollution. 169, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

The effect of composition of different ecotoxicological test media on free and bioavailable copper from CuSO4 and CuO nanoparticles: comparative evidence from a Cu selective electrode and a Cu-biosensor

Kakinen, A., Bondarenko, O., Ivask, A. & Kahru, A., 2011, In : Sensors. 11, 11, p. 10502 - 10521 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access