Projects per year
Personal profile
Biography
Dr Alberto Roselló-Díez’s main question is why the whole is more than the sum of the parts. In other words, how do cells integrate external and internal information to make decisions that lead to complex outcomes, such as organogenesis. He has studied vertebrate development, mainly focused on the limbs, to address this question. Alberto received his PhD in molecular biology from Autonomous University of Madrid (Spain) for his work in the group of Dr. Miguel Torres, where he studied early limb development in chicken and mouse.
As a postdoctoral fellow in the Joyner laboratory at Memorial Sloan Kettering Cancer Center (New york, USA), Alberto developed mouse genetic models of unilateral insults, to study regulation of limb growth. These models led to the discovery that local and systemic mechanisms interact during the response to developmental insults, giving rise to a new holistic view of organ repair, where multiple tissues interact.
In 2017 he was appointed Junior Group Leader at the Australian Regenerative Medicine Institute at Monash University in Melbourne, Australia. His current work is centred on understanding the short- and long-range communication mechanisms that regulate growth within and between organs, during vertebrate limb development and regeneration. The laboratory started operating late May 2018, addressing two main topics:
1- Local compensatory mechanisms that cope with perturbations in growing bones
2- Inter-organ communication mechanisms that maintain body proportions when individual organs are damaged during development
In the long term, the goal of the lab is to learn how to re-activate or boost the responses uncovered by these studies. This will lead to new regenerative medicine approaches for disorders such as achondroplasia or foetal growth restriction.
Research interests
Regulation of organ size
Catch-up growth
Bone growth
Inter-organ communication
Regenerative medicine
Supervision interests
Accepting students
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Developmental biology
- Regenerative Medicine
- catch-up growth
- Organ Size and Pattern
- Inter-tissue communication
- mouse models
- Genetic Models
- Growth Control
Network
Projects
- 2 Active
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Identification of novel mediators of bone catch-up growth
Rosello Diez, A., Hng, C. H., Serralbo, O., Ramialison, M. & Rossello, F.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/21 → 31/12/24
Project: Research
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Chasing entelechy: cell interactions and collective behaviours underlying organ growth regulation
1/05/19 → 30/12/23
Project: Research
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Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice
Rosello-Diez, A., Madisen, L., Bastide, S., Zeng, H. & Joyner, A. L., 26 Jun 2018, In: PLoS Biology. 16, 6, 28 p., e2005086.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile25 Citations (Scopus) -
Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth
Rosello-Diez, A., Stephen, D. & Joyner, A. L., 25 Jul 2017, In: eLife. 6, 24 p., e27210.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile7 Citations (Scopus) -
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
Zheng, H. F., Forgetta, V., Hsu, Y. H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C. T., Uggla, C., Evans, D. S., Nielson, C. M., Walter, K., Pettersson-Kymmer, U., McCarthy, S., Eriksson, J., & 136 others , 1 Oct 2015, In: Nature. 526, 7571, p. 112-117 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile357 Citations (Scopus) -
Diffusible signals and epigenetic timing cooperate in late proximo-distal limb patterning
Rosello-Diez, A., Arques, C. G., Delgado, I., Giovinazzo, G. & Torres, M., 1 Apr 2014, In: Development. 141, 7, p. 1534-1543 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile48 Citations (Scopus) -
Diffusible signals, not autonomous mechanisms, determine the main proximodistal limb subdivision
Rosello-Diez, A., Ros, M. A. & Torres, M., 27 May 2011, In: Science. 332, 6033, p. 1086-1088 3 p.Research output: Contribution to journal › Article › Research › peer-review
106 Citations (Scopus)
Prizes
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John Haddad Young Investigator Award
Rosello Diez, Alberto (Recipient), 2020
Prize: Prize (including medals and awards)
Activities
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International Conference on Limb Development and Regeneration
Alberto Rosello Diez (Speaker)
2022Activity: Participating in or organising an event types › Contribution to conference
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UROP supervisor, Sarah Yang
Alberto Rosello Diez (Supervisor)
2022 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Mentor/ Internship supervision
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npj Regenerative Medicine (Journal)
Alberto Rosello Diez (Associate editor)
2022 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
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Supervisor of Ehsan Razmara
Alberto Rosello Diez (Supervisor)
2021 → 2025Activity: Examination types › Thesis Examination
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Current Biology (Journal)
Alberto Rosello Diez (Peer reviewer)
2021 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
Press/Media
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It's all smiles as Australia’s tallest man takes life in his stride
16/02/19
1 Media contribution
Press/Media: Expert Comment