Projects per year
Personal profile
Biography
Dr Adam Rose studied Exercise Science at Griffith University. He went on to complete an Honours degree and PhD at Deakin University with Prof. Mark Hargreaves studying exercise metabolism, biochemistry and skeletal muscle signalling. He conducted his junior post-doctoral training with Prof. Erik Richter at Copenhagen University continuing on studies of skeletal muscle signalling, adaptation and metabolism. He then joined Prof. Stephan Herzig at the German Cancer Research Center as a Senior Scientist and subsequent Sub-Group Leader studying liver metabolic-hormonal signalling and systemic metabolic control in health and disease. He joined Monash University in August 2017 as a Senior Research Fellow and Head of the Nutrient Metabolism and Signalling Laboratory within the Dept. of Biochemistry and Molecular Biology as part of the Biomedicine Discovery Institute Metabolism, Diabetes and Obesity Program.
Research interests
In general, we adopt an integrated systems approach to further the understanding of adaptive/maladaptive metabolism and the molecular mechanisms involved therein, with the eventual aim to discover new therapies for diseases with a metabolic basis such as obesity, diabetes, and perhaps cancer. Our particular interest lies in the complex interaction between nutrients, hormones, and signalling pathways which connect these to ultimately coordinate systemic metabolic control. Our particular projects aim to further understand:
1. Nutrient-hormonal-signalling nodes controlling metabolic homeostasis
2. Stress-signalling pathways in adaptive metabolic control
3. Inter-organ metabolic cross-talk in health and disease
Supervision interests
We are continually seeking motivated and talented people to join our group to synergise with the team to make new and exciting discoveries in metabolism. For unsolicited applications email: [email protected]
PhD Scholarship opportunities
Multiple projects available. We attempt to tailor the project to the student after presentation of the research topic backgrounds and ideas. We typically conduct whole animal metabolic physiology as well as cell/tissue culture using genetic and viral-transduction approaches to conduct gain-and loss-of-function experiments.
Candidate requirements
Candidates with a background in physiology or biochemistry/molecular biology with a strong interest in our topic are encouraged to apply. Candidates with, or in the process of completing, an experimental background in Physiology or Biochemistry/Molecular Biology should have H1 honours degree or equivalent. Students intending to apply for competitive scholarships /fellowships should contact Dr. Rose directly.
Availability
One PhD scholarship position is currently available.
Honours project opportunities
Applications
To apply, please ensure to include with your application:
• A cover letter including a brief outline detailing your intestest and suitability
• A detailed CV/resume including academic transcripts
• Names and contact details of two referees
Email all applications to [email protected]
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- metabolism
- stress signalling
- nutrition
- exercise
- hormones
- obesity
- adaptation
- diabetes
- liver
- muscle
Collaborations and top research areas from the last five years
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Role of liver amino acid metabolism in glucagon pharmacotherapies for type 2 diabetes
Rose, A. (Primary Chief Investigator (PCI)) & Wu, W. (Associate Investigator (AI))
1/01/25 → 31/12/26
Project: Research
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Preventing a nephron deficit in premature offspring
Bertram, J. (Primary Chief Investigator (PCI)), Cullen-McEwen, L. (Chief Investigator (CI)), Charlton, J. (Chief Investigator (CI)), Simpson, S. J. (Associate Investigator (AI)), Solon-Biet, S. (Associate Investigator (AI)), Rose, A. (Associate Investigator (AI)), Schittenhelm, R. (Associate Investigator (AI)), Barlow, C. (Associate Investigator (AI)), Combes, A. (Associate Investigator (AI)), Tan, K. (Associate Investigator (AI)), Johnstone, L. (Associate Investigator (AI)), Wlodek, M. (Associate Investigator (AI)) & Stanford, K. I. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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NHMRC Equipment Grant - Danish Myo-Technology Organ Bath 820MO and electrical stimulator
Rose, A., Mitchell, C., Tiganis, T., Mcgrath, M., Lockie, S., Harrison, C. & Eynon, N.
1/11/23 → 31/12/24
Project: Research
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Exploring the mechanisms of glucagon resistance
Wu, W. (Primary Chief Investigator (PCI)) & Rose, A. (Supervisor)
1/08/21 → 31/12/21
Project: Research
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LMCD: Liver-muscle crosstalk links muscle atrophy with hyperglycaemia in type 2 diabetes
1/06/20 → 31/05/21
Project: Research
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Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance
Maida, A., Zota, A., Vegiopoulos, A., Appak-Baskoy, S., Augustin, H. G., Heikenwalder, M., Herzig, S. & Rose, A. J., 1 Jul 2018, In: Journal of Nutritional Biochemistry. 57, p. 189-196 8 p.Research output: Contribution to journal › Article › Research › peer-review
32 Citations (Scopus) -
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution
Maida, A., Zota, A., Sjøberg, K. A., Schumacher, J., Sijmonsma, T. P., Pfenninger, A., Christensen, M. M., Gantert, T., Fuhrmeister, J., Rothermel, U., Schmoll, D., Heikenwälder, M., Iovanna, J. L., Stemmer, K., Kiens, B., Herzig, S. & Rose, A. J., 1 Sept 2016, In: The Journal of Clinical Investigation. 126, 9, p. 3263-3278 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile143 Citations (Scopus) -
Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health
Fuhrmeister, J., Zota, A., Sijmonsma, T. P., Seibert, O., Cingir, Ş., Schmidt, K., Vallon, N., de Guia, R. M., Niopek, K., Berriel Diaz, M., Maida, A., Blüher, M., Okun, J. G., Herzig, S. & Rose, A. J., 1 Jun 2016, In: EMBO Molecular Medicine. 8, 6, p. 654-669 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile33 Citations (Scopus) -
Molecular regulation of urea cycle function by the liver glucocorticoid receptor
Okun, J. G., Conway, S., Schmidt, K. V., Schumacher, J., Wang, X., de Guia, R., Zota, A., Klement, J., Seibert, O., Peters, A., Maida, A., Herzig, S. & Rose, A. J., 1 Oct 2015, In: Molecular Metabolism. 4, 10, p. 732-740 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile40 Citations (Scopus) -
Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor
Rose, A. J., Díaz, M. B., Reimann, A., Klement, J., Walcher, T., Krones-Herzig, A., Strobel, O., Werner, J., Peters, A., Kleyman, A., Tuckermann, J. P., Vegiopoulos, A. & Herzig, S., 6 Jul 2011, In: Cell Metabolism. 14, 1, p. 123-130 8 p.Research output: Contribution to journal › Article › Research › peer-review
81 Citations (Scopus)
Prizes
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Copenhagen Muscle Research Centre Presentation prize
Rose, Adam (Recipient), 2005
Prize: Other distinction
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Copenhagen Muscle Research Centre Presentation prize
Rose, Adam (Recipient), 2006
Prize: Other distinction
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FASEB SRC Poster presentation award
Rose, A. (Recipient), 2012
Prize: Prize (including medals and awards)
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Griffith University Award for Academic Excellence
Rose, Adam (Recipient), 1998
Prize: Other distinction
Activities
- 1 Peer review responsibility
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Journal of Applied Physiology (Journal)
Rose, A. (Peer reviewer)
2005 → 2007Activity: Publication peer-review and editorial work types › Peer review responsibility